http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이혜임 ( Hyeim Lee ),강상조 ( Sang-jo Kang ) 한국체육학회 2021 한국체육학회지 Vol.60 No.3
이 연구는 세계적으로 유행하고 있는 COVID-19가 인간의 건강관련 삶의 질(Health-related quality of life: HRQOL)에 미치는 영향을 조사하는 데 목적이 있다. 이러한 목적을 달성하기 위해 18세 이상의 한국인 437명을 대상으로 두 개의 건강관련 요인(신체적, 정신적)과 이를 측정하는 8개 문항으로 구성된 ‘건강관련 삶의 질’ 척도(SF-8 scale)을 이용하여 COVID-19 전과 후에 그들이 지각하고 있는 건강관련 삶의 질 수준을 Online 방법을 이용하여 조사하였다. 이 연구에서 구명하고자 한 연구문제는 첫째, COVID-19가 발생하기 전, 후 간 HRQOL에 차이가 있는가? 둘째, 만일 전, 후 간에 차이가 있다면, 그러한 변화는 성별과 연령수준에 따라 차이가 있는가? 이다. 수집된 자료는 연구문제에 따라 t 검증방법, 반복측정 ANOVA, 효과크기, Pearson의 r을 적용하여 분석, 검증하였다. 분석결과 COVID-19 발생 전과 후, 응답자들이 지각한 전체적인 HRQOL의 평균은 4.42에서 3.61로 낮아졌다. 신체적, 정신적 건강요인과 SF-8의 모든 영역에서 COVID-19 전보다 후에 현저하게 낮아졌다. 특히 정신적 건강요인에 해당하는 사회적 기능(SF; M = -1.41)과 정신건강(MH; M = -1.23)영역에서 가장 크게 부정적으로 변화하였다. 응답자들이 지각한 COVID-19 발생 전과 후 전반적 HRQOL의 변화 정도는 남녀와 연령수준에 따라 차이가 있는 것으로 나타났다. 남자보다는 여자(M = -0.99), 그리고 31-50세의 중년집단(M = -0.91)에서 가장 크게 감소하였다. 이러한 HRQOL의 부정적인 변화에도 불구하고 척도의 중간점인 3.0보다 낮지 않다는 사실은 응답자들은 COVID-19을 매우 심각하게 받아들이지 않고 있다는 것이다. The purpose of the study is to investigate and analyze the change in health-related quality of life in Korean residents by comparing before and after COVID-19 outbreak. A total of 437 individuals (aged ≥18 years, Korean nationality) participated in this study, and all respondents completed the questionnaire by self-administrative method between June 15 and 30, 2020 in Korea. Health Related Quality of Life (HRQOL) was measured using the Short Form 8-item (SF-8) which involves both physical (PCS) and mental (MCS) health components, and general demographics including age and gender were collected. The descriptive statistics, including mean and standard deviation, were calculated for the subgroups and the entire sample. Paired t-tests and the Repeated-measure ANOVA, Cohen’s effect size (d and partial η<sup>2</sup>), and Pearson’s correlation (r) were used to analyze the mean differences and associations between before and after COVID-19 outbreak for SF-8 items and PCS and MCS domains. The result demonstrated a significant difference in overall SF-8 scores with large effect size between before and after the outbreak. Both PCS and MCS scores were significantly lower after COVID-19 outbreak. The mean change for MCS was greater than PCS (p < .001). The change in overall HRQOL before and after COVID-19 occurrence differed according to gender and age level. The mean change scores were greater for the female (M = -0.95) and for the age 31 - 50 group (M = -0.91). The study suggested that COVID-19 has negatively affected HRQOL, and the impact differs within age and gender groups. Understanding the influence of COVID-19 on both physiological and psychological health is essential to effectively address the issue and improve the future healthcare system.
Direct C–H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis
Mishra, Neeraj Kumar,Choi, Miji,Jo, Hyeim,Oh, Yongguk,Sharma, Satyasheel,Han, Sang Hoon,Jeong, Taejoo,Han, Sangil,Lee, Seok-Yong,Kim, In Su The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.97
<P>The rhodium(III)-catalyzed direct functionalization of aniline C-H bonds with alpha-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.</P>
Han, Sang Hoon,Suh, Hyo Sun,Jo, Hyeim,Oh, Yongguk,Mishra, Neeraj Kumar,Han, Sangil,Kim, Hyung Sik,Jung, Young Hoon,Lee, Byung Mu,Kim, In Su Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.10
<P><B>Abstract</B></P> <P>The iridium(III)-catalyzed <I>ortho</I>-C–H amidation of benzoic acids with sulfonyl azides is described. These transformations allow the facile generation of <I>N</I>-sulfonyl anthranilic acids, which are known as crucial scaffolds found in biologically active molecules. In addition, all synthetic products were evaluated for in vitro anti-inflammatory activity against interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) with lipopolysaccharide (LPS)-induced RAW264.7 cells. Notably, compounds <B>4c</B> and <B>4d</B>, generated from <I>p</I>-OMe- and <I>p</I>-Br-sulfonyl azides, were found to display potent anti-inflammatory property stronger than that of well-known NSAIDs ibuprofen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The iridium(III)-catalyzed <I>ortho</I>-C–H amidation of benzoic acids is described. </LI> <LI> Anti-inflammatory activity of synthetic anthranilic acids is evaluated. </LI> <LI> Some synthetic products display anti-inflammatory effect competitive with ibuprofen. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The iridium(III)-catalyzed <I>ortho</I>-C–H amidation of benzoic acids with sulfonyl azides is described. All synthetic products were evaluated for in vitro anti-inflammatory activity against interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) with lipopolysaccharide (LPS)-induced RAW264.7 cells. Notably, compounds <B>4c</B> and <B>4d</B> were found to display potent anti-inflammatory property stronger than that of NSAIDs ibuprofen.</P> <P>[DISPLAY OMISSION]</P>
Trifluoromethylallylation of Heterocyclic C–H Bonds with Allylic Carbonates under Rhodium Catalysis
Choi, Miji,Park, Jihye,Sharma, Satyasheel,Jo, Hyeim,Han, Sangil,Jeon, Mijin,Mishra, Neeraj Kumar,Han, Sang Hoon,Lee, Jong Suk,Kim, In Su American Chemical Society 2016 Journal of organic chemistry Vol.81 No.11
<P>The rhodium(III)-Catalyzed y-trifluoromethylallylation of various heterocyclic C-H bonds with CF3-substituted allylic carbonates is described. These reactions provide direct access to linear CF3-containing allyl frameworks with complete trans-selectivity via C-H bond activation followed by a formal SN-type reaction pathway.</P>
Sharma, Satyasheel,Oh, Yongguk,Mishra, Neeraj Kumar,De, Umasankar,Jo, Hyeim,Sachan, Richa,Kim, Hyung Sik,Jung, Young Hoon,Kim, In Su American Chemical Society 2017 Journal of organic chemistry Vol.82 No.7
<P>The rhodium(III)-catalyzed redox-neutral coupling reaction of N-acyl ketimines generated in situ from 3-hydro-xyisoindolinones with various activated olefins is described. This approach leads to the synthesis of bioactive spiroisoindolinone derivatives in moderate to high yields. In the case of internal olefins such as maleimides, maleates, fumarates, and cinnamates, spiroindanes were obtained by the [3 + 2] annulations reaction. In sharp contrast, acrylates and quinones displayed the beta-H elimination followed, by Prins-type cyclization furnishing spiroindenes. The synthetic compounds were evaluated for in vitro anticancer activity against androgen-sensitive human prostate adenocarcinoma cells (LNCaP), human prostate adenocarcinoma cells (DU145), human endometrial adenocarcinoma cells (Ichikawa), human breast cancer cell (MCF-7), and triple negative human breast cancer cells (MDA-MB-231). Notably, quinone-containing spiroindenes displayed potent anticancer activity about 2- to 3-fold stronger than that of anticancer agent doxorubicin.</P>
CHO, Suengmok,HAN, Daeseok,KIM, Seon-Bong,YOON, Minseok,YANG, Hyejin,JIN, Young-Ho,JO, Jinho,YONG, Hyeim,LEE, Sang-Hoon,JEON, You-Jin,SHIMIZU, Makoto Japan Society for Bioscience, Biotechnology, and A 2012 Bioscience, biotechnology, and biochemistry Vol.76 No.1
<P>Marine plants have been reported to possess various pharmacological properties; however, there have been few reports on their neuropharmacological effects. Terrestrial plants have depressive effects on the central nervous system (CNS) because of their polyphenols which make them effective as anticonvulsants and sleep inducers. We investigated in this study the depressive effects of the polyphenol-rich brown seaweed, <I>Ecklonia cava</I> (EC), on CNS. An EC enzymatic extract (ECEE) showed significant anticonvulsive (>500 mg/kg) and sleep-inducing (>500 mg/kg) effects on the respective mice seizure induced by picrotoxin and on the mice sleep induced by pentobarbital. The phlorotannin-rich fraction (PTRF) from ECEE significantly potentiated the pentobarbital-induced sleep at >50 mg/kg. PTRF had binding activity to the gamma aminobutyric acid type A (GABA<SUB>A</SUB>)-benzodiazepine (BZD) receptors. The sleep-inducing effects of diazepam (DZP, a well-known GABA<SUB>A</SUB>-BZD agonist), ECEE, and PTRF were completely blocked by flumazenil, a well-known antagonist of GABA<SUB>A</SUB>-BZD receptors. These results imply that ECEE produced depressive effects on CNS by positive allosteric modulation of its phlorotannins on GABA<SUB>A</SUB>-BZD receptors like DZP. Our study proposes EC as a candidate for the effective treatment of neuropsychiatric disorders such as anxiety and insomnia.</P>
Jeon, Mijin,Mishra, Neeraj Kumar,De, Umasankar,Sharma, Satyasheel,Oh, Yongguk,Choi, Miji,Jo, Hyeim,Sachan, Richa,Kim, Hyung Sik,Kim, In Su American Chemical Society 2016 Journal of organic chemistry Vol.81 No.20
<P>The rhodium(III)-catalyzed direct C-H functionalization of various indolines with 1,4,2-dioxazol-5-ones as new amidating agents is described. This transformation provides efficient preparation of C7-amidated indolines known to display potent anticancer activity. The synthetic compounds were evaluated for in vitro anticancer activity against human prostate adenocarcinoma cells (LNCaP), human endometrial adenocarcinoma cells (Ishikawa), and human ovarian carcinoma cells (SKOV3). Compound 4f was found to be highly cytotoxic, with activity competitive with that of anticancer agent doxorubicin.</P>
A Fist-In-Class Small Molecule Targeting 17-Beta-Hydroxysteroid Dehydrogenase 13
( Ji Won Choi ),( Jin Woo Jung ),( Chanwoo Park ),( Yang Hun Tae ),( Seung-chul Lee ),( Jiyeon Park ),( Hyeim Jo ),( Seong-il Choi ),( Somyi Park ),( Donghyun Ko ),( Dong-kyu Kim ) 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1