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문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.
Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury
Lee, Eun-Mi,Lee, Young-Eun,Lee, Esder,Ryu, Gyeong Ryul,Ko, Seung-Hyun,Moon, Sung-Dae,Song, Ki-Ho,Ahn, Yu-Bae Korean Diabetes Association 2011 Diabetes and Metabolism Journal Vol.35 No.5
<P><B>Background</B></P><P>Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic β-cells. Heme oxygenase-1 (HO-1) has been identified as an anti-apoptotic and cytoprotective gene. The purpose of this study is to investigate whether HO-1 up-regulation when using metalloprotophyrin (cobalt protoporphyrin, CoPP) could protect pancreatic β-cells from high glucose-induced apoptosis.</P><P><B>Methods</B></P><P>Reverse transcription-polymerase chain reaction was performed to analyze the CoPP-induced mRNA expression of HO-1. Cell viability of INS-1 cells cultured in the presence of CoPP was examined by acridine orange/propidium iodide staining. The generation of intracellular reactive oxygen species (ROS) was measured using flow cytometry. Glucose stimulated insulin secretion (GSIS) was determined following incubation with CoPP in different glucose concentrations.</P><P><B>Results</B></P><P>CoPP increased HO-1 mRNA expression in both a dose- and time-dependent manner. Overexpression of HO-1 inhibited caspase-3, and the number of dead cells in the presence of CoPP was significantly decreased when exposed to high glucose conditions (HG). CoPP also decreased the generation of intracellular ROS by 50% during 72 hours of culture with HG. However, decreased GSIS was not recovered even in the presence of CoPP.</P><P><B>Conclusion</B></P><P>Our data suggest that CoPP-induced HO-1 up-regulation results in protection from high glucose-induced apoptosis in INS-1 cells; however, glucose stimulated insulin secretion is not restored.</P>
The Significant Decisions in Cold Chain Logistics
Sung-Ho RYU(Sung-Ho RYU) 동아시아경상학회 2023 The East Asian Journal of Business Economics Vol.11 No.1
Purpose – The prior literature has shown that there is a lack of a complete assessment of the key decisions in cold chain logistics. Such a study is required to offer recommendations for research in this expanding but underresearched topic with potentially significant management ramifications. Research design, Data, and methodology – The current researcher accumulated peer-reviewed sources from databases to augment each chosen study's validity. Selection varied between seminal works and much of the existing literature. The selection process was consistent with using a content checklist that established the inclusion and exclusion criteria. Result – The research findings indicate total five solutions regarding better decision in Cold Chain Logistics (CCL), such as (1) Pricing Decision in Cold Chain Logistics, (2) Decision on Temperature Control Decision in Cold Chain Logistics, (3) Supply Chain Network Design in Cold Chain Logistics, (4) Decision on Minimizing Inventory in Cold Chain Logistics, (5) Decision on Logistics Distribution. Conclusion – Stability of a cold chain should be maintained from manufacture or via logistical components and cold logistics products are susceptible to several variables, such as temperature, and degradation can easily harm food supply, product prices, and human health. Product safety infractions substantially impact human health, among other losses linked with a functioning CCL.
Comparative Morphological Characteristics of Mangrove Oysters
Yoo, Sung Kyoo,Ryu, Ho Young 한국수산학회 1984 한국수산과학회지 Vol.17 No.3
Three Kinds of mangrove oysters, highly commercial species in tropical waters, were collected in Cocineta Bay, Venezuella in 1976, at the mouth of Hoffman River, Liberia in 1978 and in West Coast of Benzina, Indonesia in 1984. Crassostrea rhizophorae from Venezuella showed some characteristics of most rounded shell form and greatest shell capacity. In addition, he fatness condition of 9.63% topped tht other two species. Crassostrea tulipa inhabiting Liberia was most elongated in outer shell form. Although shell capacity of this species was almost similar to Crassostrea rhizophorae, it took up intermediate position in fatness condition with 8.15%. Crassostrea belcheri from Indonesia, just rounded like C. rhizophorae, showed the biggest values in total weight and outer shell weight but fatness the least with 6.62%
Automated Lipid Membrane Formation Using a Polydimethylsiloxane Film for Ion Channel Measurements
Ryu, Hyunil,Choi, Sangbaek,Park, Joongjin,Yoo, Yeong-Eun,Yoon, Jae Sung,Seo, Young Ho,Kim, Young-Rok,Kim, Sun Min,Jeon, Tae-Joon American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.18
<P>A black lipid membrane (BLM) is a powerful platform for studying the electrophysiology of cell membranes as well as transmembrane proteins. However, BLMs have disadvantages in terms of stability, accessibility, and transportability, which preclude their industrial applications. To resolve these issues, frozen membrane precursor (MP) was devised to improve the transportability and storability of BLMs. As described previously, MP is a storable and transportable platform that can be delivered to the point-of-use, where BLMs are automatically formed upon thawing at room temperature. However, MP has an inconsistent thinning-out time, ranging from 30 min to 24 h, as well as a low success rate of BLM formation (∼27%), which make it undesirable for practical use. In our study, polydimethylsiloxane (PDMS) was introduced as a replacement for conventionally used Teflon film to control thinning-out time. As such, we used a PDMS thin-film, a porous-structured hydrophobic polymer, and squalene, a high viscosity solvent, to facilitate membrane formation, whereas the absorption rates of solvents were controlled to achieve consistent BLM formation time. We successfully reduced thinning-out time down to <1 h as well as enhanced the success rate of BLM formation to greater than 80%. Moreover, we demonstrated the feasibility of our platform for use in drug screening using gramicidin A and guanidine.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2014/ancham.2014.86.issue-18/ac501397t/production/images/medium/ac-2014-01397t_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac501397t'>ACS Electronic Supporting Info</A></P>
Sung-Yong Hong,Hyun-Ho Kim,Deock-Gil Oh,Joon-Gyu Ryu 한국전자파학회JEES 2016 Journal of Electromagnetic Engineering and Science Vol.16 No.2
This paper proposes the algorithm for forward link adaptive coding and modulation (ACM) and the detailed design for a satellite communication system to improve network reliability and system throughput. In the ACM scheme, the coding and modulation schemes are changed by as much as the channel can provide depending on the quality of the communication link. To implement the forward link ACM system in the Ka-band, channel prediction and modulation/coding decision methods are proposed and simulated. The parameters of the adaptive filter predictor based on the least mean square are optimized, the minimum mean square error of the channel predictor is 0.0608 when step size and the number of filter tap are 0.0001 and 4, respectively. A test-bed is set up to verify the forward link ACM system, and a test is performed using a Ka-band satellite (i.e., Communication, Ocean, and Meteorological Satellite [COMS]). This test verifies that the ACM scheme can increase the system throughput.
Ho-Sung Kim,Ju-Won Baek,Myung-Hyu Ryu,Jong-Hyun Kim,Jee-Hoon Jung IEEE 2014 IEEE transactions on power electronics Vol.29 No.8
<P>The power conversion efficiency of an isolated ac-dc converter is a dominant factor in the overall efficiency of dc distribution systems. To improve the power conversion efficiency of the dc distribution system, a three-phase interleaved full-bridge LLC resonant converter employing a Y-connected rectifier is proposed as the isolated ac-dc high-frequency-link power-conversion system. The proposed Y-connected rectifier has the capability of boosting the output voltage without increasing the transformer's turn ratio. Especially, the frequency of the rectifier's output ripple is six times higher than the switching frequency, thereby reducing the output capacitor and the secondary transformer's RMS current. However, the tolerance of the converter's resonant components in each primary stage causes the unbalance problem of output ripple current. It cannot be solved using conventional control techniques since the structure of the three-phase interleaving has the limitations of individual control capability for each converter. To solve the current unbalance problem, a current balancing method is proposed for the output rectifying current. The performance of the proposed converter and the current balancing method has been verified through experiments using a 10 kW (300 V/33.3 A) prototype converter.</P>