식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

A Study on the appropriate herbal medicine according to Sasang constitution using EAV

Choi,Jin-Wook,Lee,Su-kyung,Hong,Suck-chull,Koh,Byung-hee INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 1997 JOURNAL OF ORIENTAL MEDICINE Vol.2 No.1

1. Objective This is a basic study about the response of herbal medicine to EAV. The purpose was to investigate how the meridian of EAV responded to herbal medicine and how EAV was applied to the diagnosis of Sasang constitution. 2. Materials & Methods The subjects of this study were patients who were being treated in the Dept. of Constitutional Medicine ot Kyung-Hee Medical Center. The study examined how herbal medicine affected the maximum value and the indicator drop and how each constitution responded differently to the constitutional herb medicine. 3. Results & Conclusions 1) When comparing the maximum value and ID of the worst BAP before and after the experiment with herbal medicine, the maximum value significantly went up and the ID significantly went down in all the herbal medicines. So we confirmed that all the herbal medicines positively affected the change of the maximum value and ID. 2) The changes in the maximum value induced by herbal medicines were significantly different according to the constitution of Dokhual Jihwang Tang, and Hyangbuja Palmul Tang. Although Dokhual Jihwang Tang was soyangin's herb medicine in Sasang constitutional medicine, it raised the value of soeumin higher than that of soyangin. Hyangbuja Palmul Tang which was soeumin's herb medicine raised the value of soeumin higher than that of the other constitution. 3) The changes of ID were not significantly different in the constitution.

자궁근종 有無에 따른 素症 차이 연구

윤영진(Young-Jin Yoon),조정훈(Jung-Hoon Cho),장준복(Jun-Bock Jang),이경섭(Kyung-Sub Lee),이준희(Jun-Hee Lee) 대한한의학회 2009 대한한의학회지 Vol.30 No.2

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Interleukin-1β에 의한 사람 정상 코점막 상피세포의 분비기능 및 형태 변화

김경수,윤주헌,최진우,이정권,문형진,박준호,전희선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.11

5-〔3-(N-Substituted Piperazinyl)Propoxy〕Indan類의 合成과 中樞神經抑制效果

黃熙喆,閔庚鎭,文勝煜,李萬佶,徐丙天 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

Five new indans, 5-[3-(N-substitued piperaziny) propxy]indans, were synthesized by condensation of 5-(3-bromopropoxy)indan, the intermediate, and N-substituted piperazines. The structure of the compunds were determined by means of IR, NMR spectoscopy along with elemental analysis. Each compound was tested for antimorphine and antiamphetamine effects as part of CNS depressant effects and for muscle relaxant action in mice. Thes compound exhibited less potent activity compared to chlordiazepoxide on CNS depressant effect. Muscle reaxant action of the compounds, the side effect of tranquilizer, however, was much weaker than that of chlordiazepoxide.

토코페롤 급여가 돈육의 저장성 및 관능적 특성에 미치는 영향

진상근,김일석,송영민,하경희 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.4

비육후기 돼지 사료에 첨가되는 우지 함량 중 2%를 들깨유로 대체 급여한 돈육(T1), T1처리구에 비타민 E 250ppm 첨가 급여한 돈육(T2), 우지함량 중 2%를 오징어유로 대체 급여한 돈육(T3), T3에 비타민 E 250ppm 첨가 급여한 돈육 (T4)을 1±1℃에서 28일간 저장하면서 육질특성을 조사한 결과는 다음과 같다. TBARS, VBN, 총세균, 유산균, 대장균군은 저장기간에 따라 증가하였으며, 저장 28일째 총세균수는 10^7, 유산균수는 10^6, 대장균군은 10^4CFU/㎠ 수준이었다. 처리구간에 TBARS와 VBN은 들깨유를 급여한 처리구들(T1, T2)보다 낮았다. VBN에서는 비타민 첨가구들(T2, T4)이 첨가하지 않은 구들(T1, T3)보다 높게 나타났다. 신선육의 전단가는 T1구와 T3구는 저장기간에 따라 증가하였고, T2구와 T4구에서는 14일까지 증가한 이후 감소하였다. 가열육의 조직감에서 경도, 부착성, 응집성, 점착성 및 파쇄성은 14일까지 증가한 이후 감소하였다. 처리간에는 저장 28일째 비타민을 첨가한 구들(T2, T4)이 첨가하지 않은 구들(T1, T3)보다는 경도(hardness), 부착성(adhesiveness), 응집성(cohesiveness), 탄력성(springiness), 점착성(gumminess) 및 파쇄성(brittleness)에서 낮게 나타났다. 신선육의 관능 평가 결과 저장기간에 따라 지방색과 드립에서 낮은 점수를 얻어 전체적 기호도가 낮아졌으며, 처리간에는 육색, 상강도에서 T1, T2보다 T3, T4가 높게 나타났다. The equality of pork meat was determined as following treatments. The meat samples were obtained from how many which had been fed finishing pig diets containing 2% perilla seed oil in beef tallow(T1), 250ppm vitamin E in T1(T2), 2% squid oil substituted of beef tallow(T3) and 250ppm vitamin E in T3(T4). All of them was stored at 1±1℃ for 28 days until further evaluation for characteristics of the pork quality. The values of TBARS, VBN, total counts, lactic counts, E. coli counts were increased during the storage, and 10^7 of total counts, 10^6 of lactic counts. 10^4 E. coli counts were shown on the day 28. The treatments with perillar seed oil(T1, T2) showed lower TBARS and VBN than the treatments with squid oil did(T3, T4). Especially, vitamin fed pork meats showed higher VBN value than pork meat without vitamin feeding. In raw meat, the shear force of T1 and T3 fed pork meat increased during storage days while that of T2 and T4 fed one increased up to the day 14 then decreased. In cooked meat, hardness, adhesiveness, gumminess, and brittleness increased by th 14th day after storage then decrease. Also, the vitamin fed pork meats(T2, T4) showed less hardness, adhesiveness, cohesiveness, springiness, gumminess, and brittleness than vitamin non treated ones did(T1, T3). In sensory tests of the raw meat, the acceptance decreased due to low score of lipid color and drip loss. However, T3, T4 showed higher color and marbling score than T1, T2 did.

한우고기와 수입산 쇠고기의 목심과 등심 부위의 지방산 조성 비교

진상근,김일석,하경희 한국국제농업개발학회 2001 韓國國際農業開發學會誌 Vol.13 No.4

본 연구는 한우고기와 국내시장에 유통중인 수입산 쇠고기의 지방산 조성을 비교·분석한 것으로 이에 대한 기초적인 품질정보를 제공하고자 실시되었다. 냉동등심의 지방산 조성 중 쇠고기 풍미에 영향을 주는 oleic acid(C18:1 n9)는 한우 냉동등심이 가장 높게 나타났고(P<0.01), palmitic acid(C16:0)는 호주산 냉동등심이 높은 수준을 나타내었으며, arachidonic acid(C20:4, n6)는 한우 냉동등심이 가장 높은 수준을 나타내었다(P<0.05). 냉동 목심의 지방산 분석결과 oleic acid가 49.35∼38.85%수준으로 가장 높게 나타났고, palmitic acide(C16:0)가 23.40∼26.40%수준으로 관찰되었다. 포화지방산인 stearic acid(C18:0)는 호주산 냉동목심이 가장 높은 수준을 나타내었고, 필수지방산의 일종인 linoleic acid(C18:2, n6)는 4.05∼7.45%수준으로 나타났으며, 미국산이 가장 적게, 호주산이 가장 높게 나타났다(P<0.001). 냉장등심의 지방산 분석결과 oleic acid는 40.30∼49.60%범위로 한우 냉장등심이 가장 높게 나타난 반면, palmitic acid와 stearic acid는 한우가 가장 낮은 수준을 나타내었고, linoleic acid는 미국산이 다른 시료에 비해 높게 나타났으며(P<0.05), 단일불포화지방산은 43.05∼55.10%범위로 한우가 높게 나타났다(P<0.01). 냉장목심의 지방산 분석결과 쇠고기의 지방산 조성 중 가장 많은 부분을 차지하는 oleic acid는 41.20∼45.05%로 호주산이 다소 높게 나타났으며, linoleic acid는 5.90∼8.30%범위로 한우, 미국산, 호주산 순으로 그 함량의 차이를 보였다(P<0.001). 포화지방산은 미국산과 호주산이 높은 수준이였으며 한우가 가장 적게 포화지방산을 함유하고 있는 것으로 나타났다(P<0.01). This study was carried out to compare the compositions of fatty acid for imported beef(American, Australian) and Hanwoo. There were 4 samples which refrigerated were loins, chuck rolls chilled(4℃±1) and frozen loins, chuck rolls refrigerated(-20℃). In beef refrigerated loins, oleic acid(C18:1, n9) of Hanwoo loin showed the highest level. The three groups were significantly different(P<0.01). The palmitic acid(C16:0), which was a saturated fatty acid, appeared the lowest value in refrigerated American loins(P<0.01). Total saturated fatty acid contents showed in the ranges of 34.25∼50.45% and significantly higher in refrigerated Hanwoo and Australian beef loins(P<0.001). In refrigerated beef chuck rolls, linoleic acid(C18:2, n6) which was a poly unsaturated fatty acid, had the highest value in Australian chuck rolls(P<0.01). Poly unsaturated fatty acid contents were lower than monounsaturated fatty acid in all and there were which showed significant difference(P<0.001). In chilled beef loins, the content of oleic acid(C18:1, n9) were in the range of 40.30∼49.60% and significantly the highst in chilled Hanwoo loins(P<0.01). Whereas palmitic acid(C16:0) and stearic acid(C18:0) showed the lowest value in chilled Hanwoo loins. In chilled Hanwoo chuck rolls, oleic acid(C18:1, n9) contents of Australlian beef chuck rolls where in showed the highest value, but they were not statistically significant. American beef chuck rolls have the highest SFA(saturated fatty acid) contents(P<0.001).