유지류 종류 및 혼입률 변화에 따른 보통콘크리트의 기초적 특성

한상윤(Han, Sang-Yoon),손호정(Son, Ho-Jung),백대현(Baek, Dae-Hyun),전충근(Jeon, Chung-Keun),한민철(Han, Min-Cheol),한천구(Han, Cheon-Goo) 대한건축학회 2010 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.30 No.1(구조계)

Selection of maize varieties adapted to high latitude (the south of Mt. Suyang)

Jae-Han Son,Hwan-Hee Bae,Young-Sam-Go,Jun-Young Ha,Bonil Ku,Man-Kee Baek,Beom-Young-Son,Tae-Wook Jung 한국육종학회 2023 한국육종학회 공동학술발표집 Vol.2023 No.-

학교 메신저를 통한 교사PC의 정보 유출 위험 및 대응방안 연구

손백한(Baek-Han Son),백정헌(Jeong-Heon Baek),백승진(Seung-Jin Baek),오준석(Jun-Seok Oh),황동화(Dong-Hwa Hwang) 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.12

Effect of Ar Plasma Treatment for Surface of Insert Metal on Property of TLP Bonding Joint for Power Module

Baek Seungju,Yu Dong-Yurl,Son Jun-Hyuk,Bang Junghwan,Kim Jungsoo,Kim Min-Su,Lee Han-Bo-Ram,고용호 대한용접접합학회 2020 대한용접·접합학회지 Vol.38 No.4

In this study, we investigated the effect of plasma treatment for the surface of an insert bonding metal on the prop�erties of a transient liquid phase (TLP) bonding joint for a power module. Sn preforms, as the insert bonding metal for the TLP bonding, were used with and without Ar plasma treatment. To investigate the effect of Ar plasma treat�ment, the TLP bonding for two structures of Cu-finished Si chip/Sn preform/organic solderability preservative (OSP)-finished direct bond copper (DBC) substrate (Cu/Sn/Cu), and Ni-finished Si chip/Sn preform/Ni(P)-finished DBC substrate (Ni/Sn/Ni) was performed with 1 MPa at 300 ℃ and the bonding times were 10, 30, and 60 min, respectively. After the TLP bonding, we observed interfacial reactions and formations of intermetallic compounds (IMCs) under various bonding conditions. To evaluate mechanical properties, a shear test was also performed. Compared to the TLP bonding joint that used bare Sn preforms without Ar plasma treatment, growth of IMCs at the bonding joint that used Sn preforms with Ar plasma treatment occurred faster, and the IMCs could be formed through the entire joint despite the bonding time of 10 min. Meanwhile, by increasing the bonding time, Cu6Sn5 and Cu3Sn were formed at the Cu/Sn/Cu TLP bonding joint, whereas Ni3Sn4, Ni-Sn-P, and Ni3P were observed at the Ni/Sn/Ni joint. In the case of the Cu/Sn/Cu joint, we observed that increasing Cu3Sn formation while increasing the bonding time could be beneficial to the shear strength of the joint. Further, shear strengths of the joint were not sig�nificantly changed under the bonding conditions after Ni3Sn4, Ni-Sn-P, and Ni3P IMCs were formed at the entire joint of the Ni/Sn/Ni.

조혈모세포이식 후 골성장인자의 변화 및 골대사에 미치는 영향 : Impact on Bone Mineral Metabolism

백기현,오은숙,오기원,이원영,김혜수,권순용,한제호,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 각종 장기이식의 시행이 많아지고 이식 후 생존율이 증가함에 따라 이식 후 합병증에 대한 관심 또한 높아지고 있다. 조혈모세포이식 후에도 다양한 내분비적 합병증이 발생할 수 있으며 골격에 대한 합병증도 문제점으로 대두되고 있다. 조혈모세포 이식 후 발생하는 골소실에는 이식 후 초기의 골형성 저하와 골흡수 증가가 중요한 역할을 담당하리라고 추측되는데 이러한 골재형성불일치(biochemical uncoupling)에 골 성장인자들이 미치는 영향에 대해서는 알려진 바가 없다. 본 연구에서는 조혈모세포이식 전, 후로 말초 혈액에서 IGF-I, FGF-2, M-CSF같은 성장인자의 변화를 알아보고, 이들 성장인자의 변화가 조혈모세포이식 후의 골형과 골흡수에 미치는 영향 및 이식 후 발생되는 골량 소실과의 연관성을 확인해 보고자 하였다. 방법: 여러 가지 혈액질환으로 인해 동종 골수이식을 시행 받은 환자들을 전향적으로 관찰하였으며 이식 전 및 이식 후 1주, 2주, 3주, 4주 및 3개월, 6개월 1년에 말초 혈액에서 골교체표지자를 측정하였다. 이식 전 및 이식1년 후에 요추골 및 대퇴골 골밀도를 측정할 수 있었던 36명의 환자들을 대상으로 냉동 보관되어 있던 혈청을 이용하여 IGF-I, FGF-2 및 M-CSF를 시기별로 측정하였으며 이들 성장인자와 골교체표지자의 변화 및 골밀도 변화 사이의 상관관계를 확인하였다. 결과: 골흡수 표지자인 혈청 ICTP는 이식 전에 비해 이식 후 4주까지 점차 의의 있게 증가하다가 이후 6개월까지 더욱 증가한 후 감소하였다. 골형성 표지자인 osteocalcin은 이식 후 3주까지는 점차 감소하다가 이후 증가하여 이식 후 3개월 및 6개월에 기저치보다 통계적으로 유의하게 증가한 후 감소하였다. 혈청 IGF-I과 FGF-2는 각각 이식 후 3주 및 1주까지 의미있게 감소하다가 이후 증가하였으며 혈청 M-CSF는 이식 후 1주째에 기저치에 비해 의미 있게 증가하였다가 이후 기저치로 회복되었다. 이식 1년 후 평균 요추부 골밀도는 5.2% 감소하였고 평균 근위대퇴골 골밀도는 11.6% 감소하였다. 이식 전 및 이식 후 3주에 측정한 IGF-I과 같은 시기에 측정한 오스테오칼신 사이에 유의한 상관관계가 관찰되었으며 이식 후 3주째의 M-CSF와 골흡수표지자인 M-CSF 사이에서 의미 있는 양의 상관관계를 관찰할 수 있었다. 이식 후 3주 및 3개월에 IGF-I이 낮은 환자일수록 이식 1년 후 근위대퇴골에서의 골소실이 많은 것으로 분석되었다. 결론: 조혈모세포이식 후 발생하는 골소실에는 기존에 알려진 기저질환의 영향, 성호르몬의 감소, 면역억제의 투여, 골수기질세포와 조골세포의 손상 및 이식초기 사이토카인의 변화이외에도 골성장인자가 관련이 있음을 확인하였고, 이는 이식 후 발생되는 골량소실에 중요한 역할을 할 것이라고 사료된다. Background: A loss of bone mass is usually detected after a bone marrow transplantation (BMT), especially during the early post-transplant period. We recently reported that enhanced bone resorption following a BMT was related to both the steroid dose and the increase in IL-6. We also suggested damage to the marrow stromal microenvironment, by myoablation, partly explains the impaired bone formation following a BMT. It is well known that some growth factor play important role in bone growth and osteogenesis. However, the pathogenetic role of bone growth factors in post-BMT bone loss is unknown and data on the changes in the growth factors, in accordance with bone turnover markers and bone mineral density (BMD) changes are scarce. We investigated changes in bone growth factors such as IGF-I (Insulin-like growth factor-I), fibroblast growth factor-2 (FGF-2) and Macrophage colony stimulating factor (M-CSF), during the post-BMT period, and assessed whether the growth factor changes influenced the bone turnover and post-BMT bone loss. The present study is the first prospective study to describe the changes in bone growth factors following a BMT. Methods: We prospectively investigated 110 patients undergoing a BMT, and analyzed 36 patients (32.4±1.3 years, 17 men and 19 women) whose BMDs were measured before, and 1 year after, the BMT. The serum biochemical markers of bone turnover were measured before, 1, 2, 3 and 4 weeks, 3 and 6 months, and 1 year, after the BMT. The serum, FGF-2, IGF-I and M-CSF levels were measured before and 1 and 3 weeks, and 3 months after the BMT. The correlation between the changes of growth factors and various bone parameters was analyzed. Results: The mean bone losses in the lumbar spine and total proximal femur, calculated as the percentage change from the baseline to the level at 1 year, were 5.2(p<0.05) and 11.6%(p<0.01), respectively. the serum type I carboxyterminal telopeptide(ICTP), a bone resorption marker, increased progressively until 6 months after the BMT, but thereafter decreased, to the base value after 1 year. Serum osteocalcin, a bone formation marker, decreased progressively, until 3 weeks after the BMT but then increased transiently, and finally returned to the base level at 1 year. The serum IGF-I and FGF-2 also decreased progressively until 3 weeks 1 week after the BMT, respectively, then increased to the base values at 3 months. The serum M-CSF increased briskly at 1 week post-BMT, then decreased to the base level. There were positive correlations between the percentage changes from the baseline proximal femur BMD and the IGF-I levels 3 weeks and 3 months (r=0.52, p<0.01, r=0.41, p<0.05) post BMT. A significant correlation was found between the IGF-I and osteocalcin levels pre-BMT, and 3 weeks after the BMT. Another positive correlation was found between the M-CSF and the ICTP levels at 3 weeks post BMT (r=0.54, p<0.05). Conclusion: In conclusion, there were significant changes in the serum IGF-I, FGF-2 and M-CSF levels in the immediate post-BMT period, which were related to a decrease in bone formation and loss in the proximal femoral BMD during the year following the BMT (J Kor Soc Endocrinol 17:664∼674, 2002).

Seismic reflection imaging of Quaternary faulting offshore the southeastern Korean Peninsula

Han-Joon Kim,YoungSook Baek,Hyeong-Tae Jou,Sang Hoon Lee,Seonghoon Moon,Jin Soo Kim,Su-hwan Lee,Gwang Hoon Lee,Seung-Goo Kang,Woo-Hyun Son,Ryeongsim Seok 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.3

The Yangsan Fault System (YFS) is a dominating tectonic structure in the southeastern part of the Korean Peninsula. The YFS consists of NNE-striking dextral strike-slip faults that are traced to the southeastern coast of the Korean Peninsula. We acquired high-resolution seismic profiles offshore the southeastern Korean Peninsula to investigate how the YFS extends offshore and constrain the age of fault activity using stratigraphic interpretation. The seismic profiles image near-vertical faults trending NE to NNE that constitute a fault zone similar to a duplex structure at a releasing bend of a right-lateral strike-slip fault. The faults are interpreted as an offshore extension of the Ilgwang fault that is a member of the YFS. Stratigraphic interpretation of seismic profiles indicates that the offshore faults were activated repeatedly in the Pliocene and Quaternary. The right-lateral activity of the Ilgwang fault is consistent with the current stress regime in and around the southeastern Korean Peninsula that dictates the P-axis direction in the E-W or ENE-WSW since the Pliocene.

INTRACELLULAR Ca^2+ RELEASE MEDIATES URSOLIC ACID-INDUCED APOPTOSIS IN HUMAN LEUKEMIC HL-60 CELLS

BAEK, Jin Hyen,LEE, Yong Soo,KANG, Chang Mo,KIM, Jung-Ae,KWON, Kyung Sool,SON, Han Chul,KIM, Kyu-Won 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

The effect of ursolic acid(UA)on tumor cell apoptosis was investigated using HL-60 human promyelocytic leukemia cells as a model cellular system. Treatment with UA resulted in a concemtration-dependent decreased cell viability assessed by MTT assay. UA also induced genomic DNA fragmentation, a hallmark of apoptosis, indicating that the mechanism by which UA induced celldeath was through apotosis. The intracellular Ca^2+ level was increased by treatment with UA. Intracellular Ca^2+ inhibitors, such as intracellular Ca^2+, release blockers(dantrolene, TMB-8 and ruthenium red) and an intracellular Ca^2+ chelator(BAPTA/AM),significantly blocked the UA-induced increased intracellular Ca^2+ concentration. These inhibitors also blocked the effect of UA on cell viability and apoptosis. These results suggest that enhanced intracellular Ca^2+ signals may be involved in UA-induced apoptosis in HL-60 cells.lnt.J.Cancer 73:725-728,1997.

식중독균 항원(Salmonella typhimurium)에 의한 계란항체(IgY) 생산성과 항체특성 및 항균효과

백경연,손규목,배만종,백반석,한준표 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-

본 연구는 식중독균을 항원으로 하여 산란계에 면역시킨 후 계란 항체(IgY)의 생산 가능성을 검토하고, 그 항체의 특성과 항균성을 조사하고자 실시하였다. 그 방법으로는 항원으로 사용된 Salmonella typhimurium(ATCC 14028) 등을 incomplete Freund's adjuvant와 동량으로 혼합하여 면역시킨 후 10주간 생산된 계란을 수집하여, 계란항체(IgY)의 분리 및 식중독균 항원에 대한 항체의 특성, 항균성, 생화학적 특성을 측정하였다. S. typhimurium 항원에 면역된 산란계의 계란항체(IgY)생산 및 증가를 측정한 결과, 산란계가 이들 항원에 면역반응을 일으켜 2주 후 혈청과 난황에서 각각 normal군에 비하여 뚜렷한 항체가 생성능을 보였으며, 혈청내의 IgG생성에 비하여 계란항체(IgY)의 생성이 다소 낮은 것으로 나타났다. 혈청 및 난황내의 단백질 함량은 normol군에 비하여 약간 높은 경향을 나타내어 산란계의 혈청 및 난황내의 단백질이 이들 항원에 의하여 증가하는 것으로 나타났다. DEAE-Sephacel column을 통과한 fraction은 두 개의 peak를 나타내었다. 각 fraction의 IgY농도를 ELISA법으로 확인한 결과 두 번째 peak에서 대부분 측정되었다. 분리 정제된 IgY의 분자량을 SDS-polyacrylamide 전기영동법으로 측정한 결과, heavy chain 72∼75KD, light chain 30∼40KD정도였다. Anti-S. typhimurium 항체의 온도에 대한 활성은 60℃에서 30분 가열시 91.5%, 65℃에서 15분 가열시 각각 73.2%의 활성도를 나타내었으며, 80℃에서 15분간 가열시는 거의 활성이 없는 것으로 나타났다. pH에 대한 안정성은 pH 7부터 pH 4까지는각각 98.7%의 활성도를 유지하다가 pH 3부터 급격히 감소하여, pH 2에서는 9.6%로 거의 활성도를 나타내지 않았다. 항균활성을 응집가, 생균수, disc diffusion susceptibility test 등으로 측정한 결과 anti-S. typhimurium 항체의 항균활성도는 매우 미약하게 나타났다. 이상의 결과에서, 본 실험에서 사용된 IgY는 항원에 대한 특이성 및 생화학적 특성 등을 고려해 볼 때 앞으로 식중독균 제거 및 예방 치료뿐만 아니라 식품산업 소재, 각종 질병예방을 위한 의약품 소재, 연구용 kit와 진단용 kit 및 축산분야 등 여러 분야에 응용될 수 있으리라 기대된다. This study was carried out to investigated to get a industrial information from discussion about productive a possibility if IgY antibody, antimicrobial activity and properties of IgY antibody in egg yolk. Immunoglobulin Y in egg yolk and immunoglobulin G in serum were obtained from gens which were immunized with Salmonella typhimurium(ATCC14028). These antibody titers were evaluated in serum and egg yolk by ELISA. After the initial immunization the anti-Salmonella typhimurium IgY antibody level gradually were decreased from firth week to tenth week. On the other hand, the antibody level in the serum were increased from the first week, reaching its peak in the sixth week. The residual antibody activities of IgY were 91.5% after heating for 30min at 60℃. At the same time, were 73.2% after heating 15min at 65℃ and decreased vapidly at 70℃ and little antibody activity was left after heating for 15min at 80℃. When the prepared IgY was stable from pH 7 to 4 and remained to 69.8% at pH 3, respectively.

Role of salivary function in patients with globus pharyngeus

Baek, Chung-Hwan,Chung, Man Ki,Choi, Joon Young,So, Yoon Kyoung,Son, Young-Ik,Jeong, Han-Sin Wiley Subscription Services, Inc., A Wiley Company 2010 Head & neck Vol.32 No.2

<B>Background.</B><P>Our aim was to investigate the prevalence and the clinical role of salivary hypofunction in patients with globus sensation.</P><B>Methods.</B><P>We conducted a prospective observational study in 340 patients with globus pharyngeus. A standard questionnaire and <SUP>99m</SUP>Tc-pertechnate salivary scintigraphy were used to evaluate salivary hypofunction, with a full examination from the nasal cavity to the larynx (N = 303). We also investigated the effect of xerostomia management on globus symptoms (N = 252).</P><B>Results.</B><P>The symptom scores for xerostomia were higher in patients with severe globus (p < .05). Objective salivary hypofunction was noted in 57.4% of the patients, based on the reference values from control groups. Globus symptoms were more severe in the subgroup with salivary hypofunction (p = .0447). Conservative management of xerostomia significantly reduced the severity of globus at 1 and 3 months (p = .0002) regardless of salivary function.</P><B>Conclusions.</B><P>Salivary hypofunction seems to be an aggravating factor in globus pharyngeus, but not a direct cause. Conservative management of xerostomia improves globus symptoms. © 2009 Wiley Periodicals, Inc. Head Neck, 2010</P>

이중박동펌프를 이용한 체외생명구조장치의 효과

백광제,김준식,선경,손호성,기웅,한승백,민병구 대한응급의학회 2002 대한응급의학회지 Vol.13 No.4

Purpose: The purpose of this study was to observe and compare the changes in the patterns of hemodynamic and blood profiles on the circuit of Extra-corporeal life support system (ECLS) by using a dual pulsatile pump (T-PLS). Methods: An acute heart failure model using partial pulmonary artery banding was constructed in 12 piglets (20-25 ㎏). The animals were divided into centrifugal (n=6) and dual pulsatile pump (n=6) group. Each animal was placed on an ECLS system with a membrane oxygenator bypassing the right atrium and the aorta for 2 hours under general anesthesia. The parameters mainly observed were intra-circuit pressure changes, arterial pulsatility (pulse pressure), plasma free hemoglobin, hemodynamic changes, and other blood profiles. The parameters obtained just prior to the bypass wee compared with the corresponding parameters obtained two hours after the bypass. Results: Before bypass, the parameters were statistically the same between the groups. Two hours after the bypass, no significant differences were observed between the groups in ABGA, VBGA,, AST/ALT, BUN/Cr, and electrolytes; the plasma free hemoglobin was 14.8±4.7 g/dl in the dual pulsatile group and 19.1±9.1 g/dl in the centrifugal group (p=NS). The pulse pressure was higher in the dual pulsatile pump than in the centrifugal pump group (35±8 vs. 11±7 mmHg, p=0.0253 mmHg). The highest circuit pressure was generated at the inlet of the membrane oxygenator and was higher in the dual pulsatile group than in the centrifugal group (173±12 mmHg vs. 222±8 mmHg, p=0.0000). Conclusion: The results demonstrate that a dual pulsating mechanism lessens blood cell trauma while providing physiologic pulsatile blood flow. The ECLS system using a dual pulsatile pump (T-PLS) can be useed as an effective and safe driving motor for an ECLS.