선천눈꺼풀처짐 교정술 후 발생한 난시변화

이동섭,김준모,우경인,장혜란,Dong Sub Lee,Joon Mo Kim,Kyung In Woo,Hae Ran Chang 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To determine postoperative astigmatic changes after surgery for congenital ptosis and the astigmatic changes depending on surgical method and to discern cases of postoperatively developed anisometropia or amblyopia. Methods: Fifty-one patients who underwent surgery due to congenital ptosis were reviewed. Refraction or cycloplegic refraction was conducted preoperatively and 3 to 6 months after surgery to measure astigmatic changes. Astigmatic changes in operated eyes were compared to control eyes. Astigmatic changes were compared depending on surgical method. Results: The mean astigmatism was 1.33±1.29D preoperatively and 1.48±1.13D postoperatively (P=0.10) and the mean astigmatic change in the ptotic and control eye was an increase in cylinder +0.56±0.55D and +0.68±0.72D (P=0.37). The mean astigmatic change of patients receiving frontalis sling was +0.57±0.67D which was similar to those who received levator resection (+0.56±0.50D). Newly developed anisometropia was found in three patients postoperatively due to an increase in astigmatism, but newly developed amblyopia was not found. Conclusions: The increase of astigmatism by ptosis surgery was not statistically significant and there was no statistically significant difference when accounting for surgical method. However, it is necessary to monitor refractive error carefully in younger patients to prevent amblyopia because postoperative increase of astigmatism can cause anisometropia.

Latobacillus plantarum AF1이 생성한 조항진균 물질의 흰쥐에 대한 반복투여독성

이환 ( Hwan Lee Myung ),이명렬 ( Yul Lee Hae ),장해춘 ( Choon Chang Jae ),이재준 ( Joon Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.3

본 연구는 김치산막효모억제 유산균인 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물을 SD계통의 흰쥐에게 4주간 반복 경구투여를 통하여 장기투여에 의한 안전성을 확인하였다. 암·수 흰쥐에 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물을 0, 500, 1,000 및 2,000mg/kg/day의 용량으로 4주간 반복 경구투여한 후 사망률, 일반증상, 체중변화, 사료섭취량, 수분섭취량, 부검소견, 장기무게 변화, 혈액학적, 혈액생화학적 및 병리조직학적 검사를 실시하였다. 모든 시험군에서 전 시험기간 시험물질로 인한 임상증상 및 사망동물이 관찰되지 않았다. Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물의 경구투여 결과 체중이 4주간 지속적으로 증가되었지만 대조군과 유의성 있는 변화가 없었다. 또한 장기의 육안적 관찰, 장기 중량변화,혈액학적, 혈액생화학적 및 병리조직학적 검사에서도 모든 시험물질 투여군이 대조군과 유의성이 있는 차이를 보이지 않았으며, 모두 정상 범위의 수치로 시험물질에 기인하는 이상 소견을 발견할 수 없었다. 이상의 결과 4주 반복투여 독성시험 결과 Lb. plantarum AF1이 생산한 조항진균 물질 부분 정제물은 저독성의 안전한 물질로 판정되었다. This study was performed to investigate the four-week repeated-dose toxicity of the crude antifungal compounds produced by Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacterium isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 500, 1,000, and 2,000 mg/kg/day for four weeks. There were no test-article-related deaths or abnormal clinical signs in both the male and female rats during the observation period. Furthermore, no differences in the body weight changes, food intake and water consumption levels of the control and treatment groups were found. The hematological parameters, serum biochemical analysis results, histopathological examination results and all other findings also showed no significant or dose-dependent changes. There were also no changes in the organ weights upon the administration of the crude antifungal compounds produced by Lb. plantarum AF1. These results suggest that the oral administration of the crude antifungal compounds produced by Lb. plantarum AF1 had no adverse effects up to a dosage level of 2,000 mg/kg in both male and female rats.

Contributions of intramolecular and intermolecular energy changes to strain-induced enthalpy relaxation in uniaxially drawn poly(lactic acid) films

Kim, Min Sung,Chang, Jin-Hae,Lee, Sang Cheol Elsevier 2015 Polymer Vol.64 No.-

<P><B>Abstract</B></P> <P>Blends of poly(lactic acid)s (PLAs) containing three different concentrations of <SMALL>D</SMALL>-isomer (i.e., 1, 4, and 10 mol%; referred to as PLA1, PLA4, and PLA10, respectively) with poly(<SMALL>DL</SMALL>-lactic acid) (PDLLA) were prepared via solution blending. The three PLAs were miscible with PDLLA, as determined by dynamic mechanical analysis. Drawn films of PLA1/PDLLA, PLA4/PDLLA, and PLA10/PDLLA blends exhibited endothermic peaks just above the glass transition temperature, which is evidence of strain-induced enthalpy relaxation. A thermodynamic model for the miscible blend system was applied to determine contributions of intramolecular and intermolecular energy changes to strain-induced enthalpy relaxation for PLA1, PLA4, and PLA10; the resultant values suggested that intramolecular energy changes are mainly responsible for strain-induced enthalpy relaxation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Drawn films of PLA blends exhibit endothermic peaks just above glass transition temperature. </LI> <LI> For PLA containing less than 4 mol% of <SMALL>D</SMALL>-isomer, almost 60% of the endothermic heat originates from intramolecular energy change. </LI> <LI> As the <SMALL>D</SMALL>-isomer content of PLA increases, the contribution of intramolecular energy change to the endothermic heat increases. </LI> <LI> Overall, intramolecular energy change is primarily responsible for strain-induced enthalpy relaxation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Near-Normalized Gene Expression Profiles in Bladder With Detrusor Overactivity in Rats With Bladder Outlet Obstruction After Deobstruction

Lee, Tack,Lim, U-Sung,Kang, Dong Hyuk,Jung, Hae-Do,Kim, Hyunzu,Choi, Bo-Hwa,Kang, Ju-Hee,Yoon, Sang-Min,Park, Chang-Shin Korean Continence Society 2017 International Neurourology Journal Vol.21 No.4

<P><B>Purpose</B></P><P>The pathophysiological role of detrusor overactivity (DO) in the bladder, which is commonly observed in various bladder diseases, is not well understood. DO appears in bladder outlet obstruction (BOO), and may continue even after subsequent deobstruction. DO therefore provides an excellent opportunity to observe molecular biological changes.</P><P><B>Methods</B></P><P>In this study, to understand the molecular effects of persistent DO after BOO induction and deobstruction, we performed awake cystometry on female Sprague-Dawley rats divided into 4 groups: a sham group, a BOO group, a deobstructed group with DO after BOO (DDO), and a deobstructed group without DO after BOO (non-DDO). Total RNA was extracted from the bladder samples, and gene expression profiles were compared between the sham and model groups.</P><P><B>Results</B></P><P>DO was observed in 5 of the 6 rats (83%) in the BOO group, and in 6 of the 13 rats (46%) in the deobstructed group. The non-DDO group showed a significantly greater residual volume than the DDO group. Through a clustering analysis of gene expression profiles, we identified 7,532 common upregulated and downregulated genes, the expression of which changed by more than 2 fold. In the BOO group, 898 upregulated and 2,911 downregulated genes were identified. The non-DDO group showed 3,472 upregulated and 4,025 downregulated genes, whereas in the DDO group, only 145 and 72 genes were upregulated and downregulated, respectively.</P><P><B>Conclusions</B></P><P>Abnormal function and gene expression profiles in bladders after BOO were normalized in the BOO rats with DO after deobstruction, whereas in those without DO, abnormal function persisted and the gene expression profile became more abnormal. DO may play a protective role against the stress to the bladder induced by BOO and deobstruction as a form of adaptive neuroplasticity.</P>

기관내 삽관을 위한 Atracurium 의 적정량에 대한 임상적 고찰

이혜원,신정순,장성호,임혜자,김종욱,정형근 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.6

The usefulness of a nondepolarizing muscle relaxant for endotracheal intubation is limited by its relatively slow onset of neuromuscular block compared to that achieved with succinylcholine. Several attempts have been made to produce a more rapid onset of muscle relaxation for endotracheal intubation. A large dose of nondepoarizing muscle relaxant may produce rapid onset but cauae undesirable side effects and a prolonged duration of neuromuscular block. The authors observed the degree of vocal cord relaxation and intubation condition 2 minutes after administration of atracurium and measured changes in mean arterial blood pressure and heart rate at the time of arrival in the operating room, just before abministration of atracurium, 2minutes after administration, and 5mins after intubation. The 40 of patients in this observation were divided into four groups. Group 1; 10patients, received 0.3 mg/kg of atracurium Group 2; 10patients, received 0.4 mg/kg of atracurium Group 3; 10patients, received 0.5 mg/kg of atracurium Group 4; 10patients, received 0.6 mg/kg of atracurium The results were as follows; 1) There were better intubating conditions in Group 3 and 4 than in Group 1 and 2(p$lt;0.001). 2) Mean arterial blood pressure and heart rate did not change significantly after administration of atracurium in all four groups. From the above results we conclude that 0.5~0.6 mg/kg of atracurium provides satisfactory intubation condition 2 minutes after administration without hemodynamic changes.

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

제왕절개술을 위한 경막외 마취시 술전 투여 수액이 신생아 혈당치에 미치는 영향

이혜원,김선희,신정순,장성호,임혜자,채병국 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.4

It is common for patient undergoing cesarean section under epidural anesthesia to have lower blood pressure because of not only supine hypotension syndrome but vasodilation due to sympathetic blockade. So it is necessary to give large volume of fluid before perfarming epidural anesthesia to prevent hypotension. When we use the dextrose containing fluid for that purpose, newborn baby could have a high blood glucose at delivery and low blood glucose level due to high insulin level after birth. The authors examined the blood glucose level at delivery and two hours after birth following use of 5% dextrose in lactated Ringers solution(HD group, n=24) or lactated Ringers solution (HS group, n=24) for prevention of hypotension during epidural anesthesia for cesarean section. The results were as follows; 1) The total amount of fluid was 789.6±264.2 ml in HD group and 741.1±253.5 ml in HS group. 2) The glucose level of mother at delivery was 300.9±76.3 mg/dl in HD group and 98.7±24.6 mg/dl in HS group and there wastistical significance(p$lt;0.01). 3) In HD group, the glucose level of newborn baby was 212.2±57.2 mg/dl at delivery and 465.±20.3 mg/dl at 2 hours after birth. The change of amount during 2 hours after birth was highly related to the glucose level at birth. Higher level of glucose at birth, larger amount of change during 2 hours after birth. 4) In HS group, the glucose level of newborn baby was 66.8±10.2 mg/dl at birth and 67.0±12.1 mg/dl at 2 hours after birth. There was no significant change.

주민자력의 주택개량을 위한 가구단위 주거모델 선정에 관한 연구

이창호(Lee Chang-Ho),백혜선(Paik Hae-Sun) 대한건축학회 2009 대한건축학회논문집 Vol.25 No.10

Korean Government launched the local improvement project on May, 2007 that was a public-based model project for setting up the base for further renewal in terms of social renewal. This study researched 12 deteriorated residential area case for devicing housing types and a selection system with self-evaluation results that induce the residents to self-environment improvement and provides an easy reference. The study is concluded as follows. First, it proposes four types of block housing models for residents' self-environment improvement, and is evaluated by the evaluation index based on the literature review over the past 15 years. Second, it suggests the selecting system from which residents can judge each housing type by its factors-cost, the number of households and layers, and select their own model, if they improve their housing environment. Third, it suggests the master plan for a test site, designs the site plan with the devised housing types and simulates the changes. It can be used as a guideline for inducing the residents to self-environmental improvement and easy improvement in their own way, and also a manual for government officials and professionals to promote the local improvement project in actuality.

주민자력의 주택개량을 위한 주거모델 선정 시스템 구축 및 시뮬레이션에 관한 연구

이창호(Lee, Chang-Ho),백혜선(Parik, Hae-Sun) 한국도시설계학회 2009 도시설계 : 한국도시설계학회지 Vol.10 No.4

본 연구는 주민들이 자신들의 의지에 따라 손쉽게 주택개량을 추진할 수 있도록 주거모델 선정 시스템을 구축하고, 실제의 대상지에 주거모델을 적용하여 그 변화상을 시뮬레이션 하였다. 연구방법으로서는 첫째, 박스형, 필로티형, 테라스형, 굴곡형, 응용형의 5가지 유형별로 필지단위 주거모델을 제시하였다. 다음으로 과거 15년간의 선행연구로부터 7가지 평가지표를 도출하여 각각의 주거모델에 대한 주거환경을 상대평가 방식으로 평가하였다. 둘째, 주민들이 자력으로 주택개량을 할 때 사업비 및 대지폭, 가구구성으로부터 주거모델의 후보군을 선정한 후, 주거환경을 평가하여 주민들이 자신에게 맞는 최적의 모델을 선정할 수 있는 시스템을 구축하였다. 마지막으로 셋째로는, 충남 서천군사지구의 주민들을 대상으로 설문조사를 실시하여 이를 바탕으로 시뮬레이션의 기본구상을 설정하고, 주거모델을 실제로 적용하여 지구의 변화상을 시뮬레이션 하였다. 도출된 연구성과는 정비지구 주민들이 자신들의 의지에 따라 손쉽게 주택개량을 추진할 수 있도록 해주는 가이드라인의 역할과, 담당공무원 및 사업시행자 등이 주택개량을 원활히 유도할 수 있도록 하는 매뉴얼의 역할을 담당할 수 있다. This study set up a selection system of housing models with self-evaluation results that induce the residents to self-improvement and simulated the changes of the test site with applying the new housing models. The research process and conclusions of this study are as follows. First, it proposes five types of housing models for a lot - Box type, Piloti type, Terrace type, Folded type and Complex type - for residents’ self-improvement, and they are evaluated by the 7 evaluation index based on the literature review over the past 15 years. Second, it suggests the selection system from which residents can judge each housing type with its factors - cost, width of each lot and household feature and select several alternations of housing model, and then select their own housing model with self-evaluation results by the 7 evaluation index, if they improve their housing environment. Third, it suggests the master plan for a test site - Chungnam Seochoen Gunsa area- based on the results of the residents’ survey, designs the site plan with the devised housing types and simulates the changes.