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RISS 인기검색어
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- 저자 : ( Grace Hyun J. Kim ) (검색결과 6 건)
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( Ju Hyun Oh ),( Grace Hyun J. Kim ),( Jonathan G Goldin ),( Jooae Choe ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Interstitial lung abnormality (ILA) refers to incidental findings of parenchymal abnormalities suggestive of early interstitial lung disease (ILD) affecting >5% of lungs on CT scan. We aimed to determine the prevalence and progression rate of ILA evaluated by automated quantification system (AQS). Methods A total of 2890 subjects (mean age: 49 years, male: 79.4%), who participated in a health screening program, and had serial chest CT images (median interval: 6.5 years), were included. The quantitative lung fibrosis (QLF) and quantitative ILD (QILD, sum of QLF, honeycombing and ground glass opacity) were measured by AQS. ILA was defined as QILD ≥5 and QLF ≥3, and progression as an increase in QLF changes compared to baseline CT images. Results In the baseline scan, ILA was identified in 251 participants (8.6%). Those with ILA showed older age, higher body mass index (BMI), and low-density lipoprotein level than those without. The prevalence of ILA increased from 2.9% to 19.2% with age (Figure 1a). During follow-up, 21.1% (53/251) of participants initially identified with ILA progressed, while improvement or no change was noted in 78.9%. ILA was identified in 13.4% (387/2890) in follow-up CT images. Those who newly developed ILA were 11% (290/2639) of those who didn’t have ILA on initial CT images. Older age (HR: 1.026, 95% CI: 1.011-1.041) and higher BMI (HR: 1.056, 95%CI: 1.008-1.107) were independent risk factors for ILA development. When comparing the degree of QLF increase, the ILA group on the initial CT images showed a larger increase than the no-ILA group (Figure 1b). Conclusions ILA was not uncommon in the Korean population, with an increased prevalence in the group of subjects followed for 6.5-years. Progression was noted in 21.1% of the initially identified ILA cohort. Older age and higher BMI were risk factors for ILA development.
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( Ju Hyun Oh ),( Grace Hyun J. Kim ),( David W Dai ),( S Sam Weigt ),( Jonathan G Goldin ),( Lila Pourzand ),( Jooae Choe ),( Fereidoun Abtin ),( Matthew S. Brown ),( Pangyu Teng ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Interstitial lung disease (ILD) includes a heterogeneous group of disease entities. Idiopathic pulmonary fibrosis (IPF) is ultimately fatal, and accurate diagnosis of IPF is critical to clinical decision making. Visual interpretation of chest high resolution CT (HRCT) is subjective and has limited reproducibility, especially with early disease. So we have previously developed attention-gated deep learning algorithm to diagnosis IPF and machine learning to predict IPF progression. The overall aim of IS-IPF is to collect the data from two centers of excellence and evaluate the robustness of the algorithm. We present the preliminary data of the patients studied following disease classification by the multidisciplinary review committees (MDCs) at UCLA and Asan Medical Center (AMC). Methods The IS-IPF study plans to include 234 IPF and 266 non-IPF cases from two large ILD centers (UCLA and AMC). Eligible patients were evaluated in ILD MDC, were >18 years old, had a HRCT, pulmonary function testing, and a committee diagnosis of IPF or non-IPF. Relevant demographic information was collected from the medical record. Results Total 185 IPF and 266 non-IPF patients’ HRCT images have been collected in the IS-IPF study. By center, 51 IPF and 133 non- IPF patients’ HRCT were collected from UCLA, and 134 IPF and 133 non-IPF patients’ HRCT were collected from AMC. On MDC diagnosis, non-IPF cohorts consisted of 33% hypersensitivity pneumonitis, and 67% other connective tissue disease-ILD. Mean age was 61 years (63 IPF and 58 non-IPF), and 63% were male (82% IPF and 57 % non-IPF). Up to date, the predicted FVC was 74.7% and the predicted DLco was 61.6 % in the IPF cohort. Data collection is on-going. Conclusions These well-characterized cohorts will be used to evaluate HRCT image signatures for distinguishing IPF from other ILD, and predicting patient-specific IPF progression within 2 years of diagnosis.
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( Ju Hyun Oh ),( Grace Hyun J. Kim ),( Gary Cross ),( Joseph Barnett ),( Jacob Joseph ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Interstitial lung disease (ILD) is the most common pulmonary complication with high mortality in patient with rheumatoid arthritis (RA). It is challenging to predict the prognosis of RA-ILD because of variable clinical course. The aim of this study is to determine the prognostic value of automated quantification system (AQS) in patient with RA-ILD. Methods Clinical data and high resolution computed tomography (HRCT) images were retrospectively analyzed in 144 patients with RA-ILD. The quantitative lung fibrosis (QLF, sum of reticulation and traction bronchiectasis) and quantitative ILD (QILD, sum of QLF, honeycombing [HC] and ground glass opacity [GGO]) scores were measured by AQS along with HC, and GGO on HRCT. Results Of total subjects, mean age was 61.2 years and 43.8% were male. The median follow up period was 52.5 months and 5-year mortality was 30.5%. The Results of AQS assessment were significantly correlated with those of visual assessment except GGO. In the unadjusted Cox analysis, all AQS scores were significantly associated with the 5-year mortality. In the multivariable Cox analysis, except GGO, higher QLF (hazard ratio [HR]:1.068, p 0.002), HC (HR:1.090, p 0.010) and QILD scores (HR:1.048, p 0.010) were independent prognostic factors along with older age and higher erythrocyte sedimentation rate. In the receiver operating characteristic analysis QLF scores showed better performance in predicting 5-year mortality (AUC=0.721, p <0.001; cut-off value=12%, sensitivity 65.9%, specificity 71.0%) than HC and GGO scores, but was similar to QILD scores (Figure 1a). Among patients with RA-ILD, those with high QLF scores (≥12%) showed higher 5-year mortality (50% vs 17.4%, p <0.001) than those without (<12%) (Figure 1b). Conclusions Our Results suggest that QLF scores might be useful to predict prognosis in patients with RA-ILD, and high QLF scores differentiate a progressive phenotype with poor survival similar to idiopathic pulmonary fibrosis.
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Seed development and hydroxy fatty acid biosynthesis in <i>Physaria lindheimeri</i>
Chen, Grace Q.,Riiff, Timothy J.,Johnson, Kumiko,Morales, Eva,Kim, Hyun Uk,Lee, Kyeong-Ryeol,Lin, Jiann-Tsyh ELSEVIER 2017 INDUSTRIAL CROPS AND PRODUCTS Vol. No.
<P><B>Abstract</B></P> <P>Hydroxy fatty acids (HFAs) are valuable industrial raw materials used in many industries. <I>Physaria lindheimeri</I> accumulates over 80% HFA, in the form of lesquerolic acid (20:1OH), in its seed oil. Understanding the seed development of <I>Physaria lindheimeri</I> is an important step to utilizing this unique wild species as a genetic source of HFAs biosynthesis. The changes of seed growth, lipid accumulation and fatty acid composition during seed development of <I>P. lindheimeri</I> were examined from 14days after pollination (DAP) to desiccation (56 DAP). The seed development could be divided into three periods. During the early period (14 and 21 DAP), seed rapidly increased in size and fresh weight. In mid-maturation period (28, 35, and 42 DAP), lipids and dry weights accumulated steadily. When seeds developed to late-maturation/desiccation stages (49 and 56 DAP), fresh weight dropped significantly due to water loss, and the dry weight and lipid accumulation reached their maximums. Seed color remained green up to 42 DAP and turned to orange-brown at 49 and 56 DAP. The major fatty acid 20:1OH started accumulation when seeds developed into mid-maturation stage (28 DAP) and the accumulation continued thereafter up to 56 DAP, eventually reaching up to 77% of the total seed oil. The HFA accumulation indicates embryonic storage tissue formation, thus 28 DAP defines a critical time point for seed development entering reserve synthesis and accumulation. The information and knowledge obtained from this study are essential to the success of HFA production using metabolic pathway engineering approaches in commodity oilseed crops.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Three distinct seed developmental periods of <I>Physaria lindheimeri</I> have been established. </LI> <LI> A starting time point of embryo development of <I>P. lindheimeri</I> has been identified. </LI> <LI> This research provides a framework for future seed developmental studies in <I>P. lindheimeri</I>. </LI> </UL> </P>
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Tinsley, Kevin W.,Hong, Changwan,Luckey, Megan A.,Park, Joo-Young,Kim, Grace Y.,Yoon, Hee-won,Keller, Hilary R.,Sacks, Andrew J.,Feigenbaum, Lionel,Park, Jung-Hyun American Society of Hematology 2013 Blood Vol.122 No.14
<P>The zinc-finger protein Ikaros is a key player in T-cell development and a potent tumor suppressor in thymocytes. To understand the molecular basis of its function, we disabled Ikaros activity in vivo using a dominant negative Ikaros transgene (DN-IkTg). In DN-IkTg mice, T-cell development was severely suppressed, and positively selected thymocytes clonally expanded, resulting in a small thymus with a heavily skewed T-cell receptor (TCR) repertoire. Notably, DN-IkTg induced vigorous proliferation concomitant to downregulation of antiapoptotic factor expression such as Bcl2. Ikaros activity was required during positive selection, and specifically at the CD4<SUP>+</SUP>CD8<SUP>lo</SUP> intermediate stage of thymocyte differentiation, where it prevented persistent TCR signals from inducing aberrant proliferation and expansion. In particular, DN-IkTg induced the accumulation of CD4 single-positive (SP) thymocytes with a developmentally transitional phenotype, and it imposed a developmental arrest accompanied by massive apoptosis. Thus, we identified an in vivo requirement for Ikaros function, which is to suppress the proliferative potential of persistent TCR signals and to promote the survival and differentiation of positively selected thymocytes.</P>
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