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RISS 인기검색어
- 검색키워드
- 저자 : ( Fidan Canan Celik Yagan ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Poster Session : PS 0010 ; Allergy : Polyhedral Allergy
( Gulcin Gungor Olcum ),( Fidan Canan Celik Yagan ),( Guven Koc ),( Ece Yigit Taskin ),( Hanife Serife Aktas ),( Sati Sena Yildiz ),( Fatih Akdogan ),( Senem Ertilav ),( Sibel Serin ),( Sema Basat ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Drug allergies can be manifested in a wide specturum such as a mild skin rash to life-threatening epidermal necrolysis. Therefore,allergic reactions, needs to be always kept in mind and etiology should be investigated througly. Case: 43 year old female patient was admitted to our department due to high fever, palpitations and sweating. In physical examination the patient was agitated, her skin was humid and fever was above 39.50C. Her pulse: 125/min, arterial pressure: 80/50 mmHg, respiration: 26/min.In the right gluteal region there was fronculosis. Because of her breast cancer, she had taken chemotherapy recently. For the treatment of fronculosis, she was taking moxifl oxacin. Patient was then evaluated by Infectious diseases and due to the current fi ndings intravenous targocid and tazobactam was started. The patient`s vital signs returned to normal and agitation dissappeared after admission to hospital within 8 hours. Maculopapular skin rashes, occurred after 12 hours after the beginning of IV antibiotic treatment therefore they were discontinued and oral ciprofloksasin and amoksisilin with kluvanat was started. Patient showed; per-oral hypoesthesia,agitation,palpitations just after 3 hours of ciprofl oxacin treatment. In the physical examination;the patient was agitated, pulse: 110/min and sinus tachycardia was present, other systems were normal.The patient`s condition was similar as her admission to the hospital. The emergence of the similar complaints suggested hypersensitivity reaction. Antibiotics were stopped and oral Antihistaminic treatment was started. Vital signs returned to normal after antihistaminic treatment.Agitation and peroral hipoesthesia were resolved Discussion and Conclusion: In the literature; the fluoroquinolones caused adverse events, such as hypotension, tachycardia, long QT syndrome, Torsades de pointese and even cardiac death. In our case, the high fever, tachycardia,hypotension, and neurologic fi ndings were present. There was no skin fi ndings when the patient was admitted to the hospital. Complaints after Ciprofl oxacin treatment were similar to the patients complaints at the hospital admission. Thus, our clinical diagnosis confi rmed hypersensitivity reaction due to moxifl oxacin treatment. In particular,as in our case,become drug hyper-sensitivity reactions and infectious diseases findings, can very similar. Therefore drug allergies should always be kept in mind.
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( Gulcin Gungor Olcum ),( Guven Koc ),( Fidan Canan Celik Yagan ),( Ece Yigit Taskin ),( Senem Ertilav ),( Hanife Serife Aktas ),( Sati Sena Yildiz ),( Demet Ataman Tasan ),( Fatih Akdogan ),( Sema Ba 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: RA is a chronic systemic disease manifest with multiple joint infi ammation. Vasculitis, heart, lung disease, extra-articular symptoms can also be present. TNF-a,IL-6 and mediators such as cytokines, have been shown to have an important role in this infi ammatory process. Anti-TNF drugs considered to be effective in preventing; RA,disability and joint destruction. CRP is one of the best indicators of infi ammation though, ESR is an indirect indicator of infi ammation and ESR levels affected by age, sex, status and anemia. ESR and CRP levels in patients with RA, disease activity and has been shown to correlate with radiographic fi ndings In this study, we aim to to show the correlation between ESR, CRP levels with disease activity in patients receiving anti-TNF alpha therapy. Methods: In this Retrospective study between January 2006 to March 2010 patients diagnosed with RA were evaluated in two groups. In the study group patients receiving at least one year of TNF-alpha were included where as in the control group patients only receiving DMARD were include. Only female patients were involved in both groups. There were 46 women in the study and 47 women in the control group. Disease severity and DAS 28 score was used to determine the disease activity. For statistical analysis Number Cruncher Statistical System 2007 & PASS 2008 Statistical Software (Utah,USA) was used. Results: In patients receiving anti-TNF alpha therapy DAS 28 scores showed statisticallysignifi cant correlation with the ESR. A statistically signifi cance between DAS 28 and CRP were not found. In control group with only DMARD treatment, the DAS 28.
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