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충주 지역에서 10년간 급성심근경색의 임상관찰에 대한 연구
박봉안,류하근,이종혁,김인숙,류주성,유재등,이용구,문언수,김형수 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-
Background: The current treatments of acute myocardial infarct(AMI) Include noninvasive method using thrombolytics and invasive methods such as primary percutaneous transluminal coronary angioplasty(PTCA) and coronary artery bypass graft(CABG)surgery. Although there are many studies comparing the effectiveness of noninvasive and invasive methods, when large clinical centers, 20% of totar hospitals, were excluded, most middle-sized hospitals lacked personnels and facilities for the invasive methods. Thus they opted for the noninvasive methods. Therefore, in this study, the clinical characteristics of AMI patients and the results of thrombolytic & conservative treatment were observed. Method: 137 patients with acute myocardial infarct, who visited KonKuk University Medical Center, ChoongJu Hospital during Sept. 1990 to Sept. 1999 were analysed retrospectively using medical records. Result: The sexual compositions of patients were 63.5% male, and 36.5% female. The mean age for male patients were 56±12.9, and for female patients 68.7±9.6 (p<0.05). The mean age for female patients was significantly older than male patients. The patients in the thrombolytic treatment group had mortality rate of 6.25% which is lower than that of the conservative treatment group at 12% (p>0.05). Conclusion: Although in our study, small number of acute myocardial infarct patients caused the statistical insignificance, rapid revascularization by thrombolytic therapy within 6 hours of onset of symptoms improved mortality rate and early ambulation. And we had good results on AMI with thrombolytic agent in ChungJu including near rural area as primary emergency hospital. Therefore a prospective research with greater number of subjects is needed to develop better treatments for AMI.
Eradication of <i>Helicobacter pylori</i> Increases Ghrelin mRNA Expression in the Gastric Mucosa
Lee, Eon Sook,Yoon, Yeong Sook,Park, Cheol-Young,Kim, Han-Seong,Um, Tae Hyun,Baik, Hyun Wook,Jang, Eun Jeong,Lee, Sangyeoup,Park, Hee Soon,Oh, Sang Woo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.2
<P>It has been suggested that <I>Helicobacter pylori</I> eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we conducted this randomized controlled trial using <I>H. pylori</I> infected subjects without any gastrointestinal symptoms. The treatment group received triple <I>H. pylori</I> eradication therapy for 7 days and the control group received no medication. We measured ghrelin, obestatin and the tumor necrosis factor-α (TNF-α) mRNA levels in endoscopic biopsy specimens and the changes from baseline to follow-up. The plasma active <I>n</I>-octanoyl ghrelin and obestatin levels were measured in both groups. The ghrelin/obestatin ratios in plasma and gastric mRNA expression were calculated at baseline and follow-up. Ghrelin mRNA expression in the fundic mucosa after <I>H. pylori</I> eradication increased significantly compared to the control group (4.47±2.14 vs. 1.79±0.96, <I>P</I>=0.009), independent of inflammatory changes. However, obestatin mRNA expression decreased in the antral mucosa (-0.57±1.06 vs. 0.41±0.72, <I>P</I>=0.028). The treatment group showed a marginal increase (<I>P</I>=0.060) in plasma ghrelin/obestatin ratio. The TNF-α mRNA expression also decreased significantly with treatment. This randomized controlled trial demonstrates that <I>H. pylori</I> eradication increases ghrelin mRNA expression, independent of inflammatory cell changes.</P>
Lee, Moo Hyun,Han, Wonshik,Lee, Jeong Eon,Kim, Ku Sang,Park, Heeseung,Kim, Jongjin,Bae, Soo Youn,Shin, Hyun Joo,Lee, Jong Won,Lee, Eun Sook Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.2
<P><B>Purpose</B></P><P>The 21-gene (Oncotype DX) recurrence score (RS) assay is useful in predicting the benefits of adjuvant chemotherapy for early breast cancer patients and is widely used in Western countries. However, to date, it has not gained much popularity in East Asia. We analyzed the results from five institutions’ experience from using the 21-gene assay and examined the impact of assay results on decision making of chemotherapy in Korean breast cancer patients and the associations between RS and clinicopathologic characteristics.</P><P><B>Materials and Methods</B></P><P>The 21-gene assay was performed on 212 patients with estrogen receptor-positive early breast cancer in five institutions. Each center made systemic treatment decisions both before and after the knowledge of assay results.</P><P><B>Results</B></P><P>Among the 212 patients, 132 (62.3%) had a low RS of < 18, 60 (28.3%) had an intermediate RS of 18-30, and 20 (9.4%) had a high RS of ≥ 31. Histologic grade, presence of micrometastases, Ki-67, and presence of lymphatic invasion were statistically associated with the RS results. Treatment decisions were changed in 115 of 212 patients (54.2%) in 109 of 212 (51.4%) from chemotherapy plus hormone therapy to hormone therapy, and in six of 212 (2.8%) from hormone therapy to chemotherapy plus hormone therapy.</P><P><B>Conclusion</B></P><P>The 21-gene breast cancer assay proved to have a significant impact on treatment decision- making. The test reduces chemotherapy use in more than 50% of Korean estrogen receptor-positive, early breast cancer patients.</P>
Lee, Eon Sook,Yang, Yun Jun,Lee, Jun Hyung,Yoon, Yeong Sook The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.2
Background: Ginseng has been used as an ergogenic agent, although evidence for its effectiveness is weak. A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of a ginsenoside complex (UG0712) on changes in exercise performance. Methods: Sedentary individuals (n = 117) were randomly assigned into one of three groups: low-dose ginsenoside supplementation (100 mg/d, n = 39), high-dose ginsenoside supplementation (500 mg/d, n = 39), or a placebo group (500 mg/d, n = 39). All participants underwent a supervised 12-wk aerobic and resistance exercise training course. To assess the effects of supplementation on physical performance, maximal oxygen consumption ($VO_2max$), anaerobic threshold (AT), lactic acid, and muscle strength of the dominant knee were measured at baseline, every visit, and after the training program. Results: Both ginsenoside groups showed significant increases in $VO_2max$ and muscular strength during exercise training. There were no definite changes in AT and lactic acid levels over time. After exercise training, there were definite differences in the $VO_2max$ (28.64.9 to $33.7{\pm}4.9ml/kg/min$ in high-dose group vs. $30.4{\pm}6.7$ to $32.8{\pm}6.6ml/kg/min$ in placebo, p = 0.029) and AT ($19.3{\pm}4.2$ to $20.9{\pm}3.5ml/kg/min$ in high-dose group vs. $20.0{\pm}5.1$ to $20.0{\pm}4.9ml/kg/min$ in placebo, p = 0.038) between the high-dose ginsenoside and placebo groups. However, there was no difference in $VO_2max$ between the low-dose ginsenoside and placebo groups (p = 0.254). There were no differences in muscular strength during exercise training among the three groups. Conclusion: High-dose ginsenoside supplementation (UG0712) augmented the improvement of aerobic capacity by exercise training.
Hepatic Iron, Serum Ferritin, <i>HFE</i> Mutation, and Hepatic Fibrosis in Chronic Hepatitis C
Won, Ji-Eon,Jeong, Sook-Hyang,Chung, Jae Il,Lee, Ji Hye,Hwang, Sung Ho,Kim, Jin-Wook,Lee, Sang Hyub,Kim, Nayoung,Park, Young Soo,Lee, Dong Ho,Kim, Haeryoung S. Karger AG 2009 Intervirology Vol.52 No.5
<P><I>Objectives:</I> We studied the status of hepatic iron deposition and its relationship with blood iron indices, liver histology, and <I>HFE </I>gene mutations in Korean patients with chronic hepatitis C (CH-C). <I>Methods:</I> 105 patients with CH-C who underwent pretreatment liver biopsy were consecutively enrolled. The hepatic iron deposition, histological activity and fibrosis were assessed by appropriate pathological scoring systems, clinical data including serum iron indices, and <I>HFE</I> gene mutation. <I>Results:</I> Hepatic iron deposition was found in 37 patients (35%), which was not significantly associated with degree of hepatic fibrosis or steatosis. The serum ferritin level was elevated in 27% of the patients and was an independent factor associated with hepatic iron deposition by logistic regression; however, it was not significantly associated with hepatic fibrosis either. Only H63D heterozygote was found in 6 out of 48 patients (12.5%), which was not different from the prevalence of H63D mutation in the Korean population (8.5%). <I>Conclusions:</I> Hepatic iron deposition was uncommon and mild in Korean CH-C. Neither hepatic iron deposition nor serum ferritin were significantly related to the severity of hepatic fibrosis, which does not support the significant role of iron in the progression of hepatic fibrosis.</P><P>Copyright © 2009 S. Karger AG, Basel</P>
울증(鬱證)환자에게 용서프로그램을 활용한 오지상승요법(五志相勝療法)을 시행하여 호전된 1례
이상언 ( Sang Eon Lee ),노동진 ( Dong Jin No ),박장호 ( Jang Ho Park ),이고은 ( Go Eun Lee ),박인숙 ( In Sook Park ),류영수 ( Yeong Su Lyu ),안민섭 ( Min Seob Ahn ),정지호 ( Ji Ho Jung ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.2
Yuzheng(鬱證) comes from obstruction of qi by stress. The patient has depressed mood, irritable sign, chest discomfort, costal pain, angry state or some strange feeling on the throat. Oh-Ji-Sang-Seung(五志相勝) therapy is base on the theory of interrelation in five elements in oriental medicine. The contents of Oh-Ji-Sang-Seung(五志相勝) therapy include five subjugations of five emotions. Anxiety subjugates fear(思勝恐), fear subjugates joy(恐勝喜), joy subjugates pity(喜勝悲), pity subjugates anger(悲勝怒), and anger subjugates anxiety(怒勝思). Forgiveness program is a kind of psychological therapies to decrease the degree of anger and it is included in Oh-Ji-Sang-Seung(五志相勝) therapy. In this case, a female patient, 50 years old, who suffered from Yuzheng(鬱證) with chest discomfort, irritable sign, easily angry state, depressed mood, hot flush, insomnia. We used Oh-Ji-Sang-Seung(五志相勝) therapy besides herbal medication, acupuncture to her condition got improved. Therefore we reported it for the treatment.
Risk factors and Clinical symptoms of Gastroesophageal reflux disease (초)
( Eun Sil Lee ),( Na Young Kim ),( Jong Chon Nah ),( Youn Mu Jung ),( Ji Eon Won ),( Min Sik Uhm ),( Kwang Ho Lee ),( Sang Hyub Lee ),( Young Soo Park ),( Jin Wook Kim ),( Sook Hyang Jeong ),( Dong Ho 대한내과학회 2008 대한내과학회지 Vol.75 No.1S
Risk factors and clinical symptoms of gastroesophageal reflux disease (초)
( Eun Sil Lee ),( Na Young Kim ),( Jong Chon Nah ),( Youn Mu Jung ),( Ji Eon Won ),( Min Sik Uhm ),( Kwang Ho Lee ),( Sang Hyub Lee ),( Young Soo Park ),( Jin Wook Kim ),( Sook Hyang Jeong ),( Dong Ho 대한내과학회 2008 대한내과학회 추계학술발표논문집 Vol.2008 No.-