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임이석(Ee Seok Lim),박용욱(Yong Wook Park),홍창권(Chang Kwun Hong),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.2
We report a case of mycosis fungoides in a 37 year-old male patient who had relatively well defined, irregular, erythematous plaques covered with acales on the buttock, lower extremities, anterior chest and back. Histopathological findings showed epidermotropism and Pautrier microabscesses in the epidermis and infiltration of atypical lymphocytes in the upper dermis. Electron microscopic findings showed mycosis cells with convoluted nuclei and prominent nucleolei He had been received PUVA therapy combined with topical and systemic corticosteroid for 4 months. Skin lesions were improved markedly after treatment with total 262 joules/crn2 and then maintained with 14 joules/cm2 in every week.
정상 피부에서의 Superoxide Dismutase 활성도에 관한 연구
임이석,김명남,노병인 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.2
Superoxide dixmutase(SOD) provides a protective defense mechanism against potential cytotoxicity of superoxide radical in the aerobic organism. Although human skin is constantly at risk for developing acute and chronic changes by ultraviolet radiation and phototoxic reactions with exogenous and endogenously produced photosensitizing molecules, studies on SOD in the human skin are rare. Author assayed the level of SOD activities in 40 normal human skin specimens, which were obtained from face/neck(11 specimens), forearm(8 specimens), trunk(11 specimens), and lower extremity(10 specimens). This study was to investigate changes of SOD activity by age, and sexual and regional differences of SOD activities in the normal skin. The results were as follows; 1. Activities of total SOD, Cu,Zn-SOD and Mn-SOD were 29.83±11.90units/mg protein, 20.53±8.82 units/mg protein and 9.21±4.21 units/mg protein respectively in the normal skin. 2. The changes of total SOD, Cu,Zn-SOD and Mn-SOD activities by age were similar each other, and highest in the third decade. But there were no significant differences between age groups in total, Cu,Zn-and Mn-SOD activities. 3. In sun exposed area, there were no significant differences between face/neck and forearm in SOD activities. In unexposed area, there were also no significant differences between trunk and lower extremity in SOD activities. But SOD activities(total, Cu,Zn-, and Mn-SOD) in face/neck were higher significant than those in trunk and lower extremity(P<0.05). 4. SOD activities in exposed area were higher significantly than those in unexposed area (P<0.01). 5. There were no significant differences between male and female in SOD activities. 6. In male, exposed area were significantly higher than unexposed area in SOD activities(P<0.05). But in female, there were no significant differences between exposed area and unexposed area in SOD activities. These finding suggest that there are no differences in the intrinsic SOD activities by age and sex in the normal huma skin, and the differences between exposed and unexposed area are due to the induction of exogenous SOD activity by sun-light(UVR), and author supposes this study is useful to investigate the protective role of SOD in the clinically relevant skin condition.
Lim, Joon Seok,Kim, Daehong,Baek, Song-Ee,Myoung, Sungmin,Choi, Junjeong,Shin, Sang Joon,Kim, Myeong-Jin,Kim, Nam Kyu,Suh, Jinsuk,Kim, Ki Whang,Keum, Ki Chang Springer International 2012 EUROPEAN RADIOLOGY Vol.22 No.8
<P>To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.</P>
Preoperative CT Navigation of Perigastric Vessel Anatomy for Gastrectomy
Baek, Song-Ee,Hyung, Woo Jin,Lim, Joon Seok International Society for Simulation Surgery 2014 Journal of International Society for Simulation Su Vol.1 No.1
The aim of this report is showing the case that we could give exact navigation of perigastric vessels for gastrectomy with 3D CTA. A 74-year-old male patient visited hospital with gastric cancer. Early gastric cancer, type IIb was found at stomach antrum great curvature side. Before surgery, he underwent 3D CT angiography. 3D volume rendering images and MIP images were made by post processing. He had replaced Lt. hepatic artery arising from Lt. gastric artery. Surgeon could get patient's specific vascular anatomy before surgery including surgically relevant anatomical distance and direction and could finish gastrectomy within 4 hours and just 53ml blood loss.
Min, Yeong-Ki,Chung, Seok-Hee,Lee, Jong-Soo,Kim, Sung-Soo,Shin, Hyun-Dae,Lim, Baek-Vin,Shin, Min-Chul,Jang, Mi-Hyeon,Kim, Ee-Hwa,Kim, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Red ginseng has been used as an ergogenic aid for endurance exorcise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exorcise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running. and Red ginseng treatment inhibited exorcise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.