전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의

서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

Phototrichogram findings in alopecia areata and their relation to disease activity and severity

( Chung Hyeok Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Won-soo Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Phototrichogram is a non-invasive method, which provides an accurate qualitative as well as quantitative assessment of the hair. Furthermore, taking a close-up photograph of a well-defined scalp area can provide sophisticated high-resolution image about scalp, hair shafts and hair follicles. Objectives: Investigate whether hair findings observed in the phototrichogram is related to the activity and severity of alopecia areata. Methods: We retrospectively analyzed 126 patients and 220 AA patches which is taken with a phototrichogram. The magnification of the phototrichogram was 50x to 100x. Using the one-way anova test, correlations between the incidence of each hair findings on phototrichogram and the severity of disease and disease activity were examined Results: A total of 220 AA patches were analyzed. The association between disease severity of AA and clustered white dots (p-value < 0.01, 95% CI: 0.11-0.88) and black dots (p-value < 0.05, 95% CI: 1.13-6.57) showed statistical significance. The association between disease activity of AA and brown dots (p-value< 0.01, 95% CI: 1.10-5.68), exclamation marks hair (p-value <0.05, 95% CI: 1.13-18.27), short vellus hair (p-value < 0.05, 95% CI: 2.11-4.65) and upright regrowth hair (p-value <0.05, 95% CI: 0.35-0.85) showed statistical significance. Conclusion: Phototrichogram findings are related to the activity and severity of alopecia areata.

Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory multiple myeloma: analysis of efficacy and safety

Lee, Sung Sook,Suh, Cheolwon,Kim, Bong-Seog,Chung, Jooseop,Joo, Young-Don,Ryoo, Hun-Mo,Do, Young Rok,Jin, Jong-Youl,Kang, Hye Jin,Lee, Gyeong-Won,Lee, Moon Hee,Shim, Hyeok,Kim, Kihyun,Yoon, Sung-Soo,B Springer-Verlag 2010 Annals of hematology Vol.89 No.9

Radiofrequency Thermal Ablation of Primary Pleural Synovial Sarcoma

Lee, Ho Kyung,Kwon, Hyeok Jin,Lee, Heung Bum,Jin, Gong Yong,Chung, Myoung Ja,Lee, Yong Chul S. Karger AG 2006 Respiration Vol.73 No.2

<P>Percutaneous radiofrequency (RF) thermal ablation has received attention as an effective minimally invasive approach for the treatment of a variety of neoplasms. However, the therapeutic efficacy of RF thermal ablation on primary pleural synovial sarcoma has not yet been reported. A 76-year-old man with a primary pleural synovial sarcoma who was medically inoperable received RF thermal ablation to achieve local control. Therefore, an RF electrode was inserted into the lesion and connected to an RF generator. In this report, a case of successful treatment of a primary pleural synovial sarcoma using RF ablation without complication is presented.</P><P>Copyright © 2006 S. Karger AG, Basel</P>

Protein Patterns on a Vaginal Mucus during Spontaneous and Estrus Synchronization using CIDR in Korean Native Cattle (Hanwoo)

Chung, Hak-Jae,Kim, Nam-Kuk,Lee, Hwi-Cheul,Yoon, Hyun-Il,Lee, Suk-Dong,Ko, Jin-Sung,Kwon, Hyeok-Jin,Oh, Hae-Ryong,Choy, Yun-Ho,Choi, Seong-Bok,Im, Seok-Ki,Lee, Myeung-Sik 韓國受精卵移植學會 2008 한국동물생명공학회지 Vol.23 No.4

The aim of the present recent study was to compare the protein patterns in the vaginal mucus of Hanwoo cattles during spontaneous and CIDR induced-estrus. Ten cattles, who had been observed in estrus, received no treatment and served as the group of cattles with normal spontaneous estrus. Thirteen cattles in the CIDR received an CIDR insert on day 14 were removed and cattles were injected GnRH on day 15. Vaginal mucus samples were collected from all cattles at the same time the single AI in cattles with spontaneous estrus and the AI in cattles with induced estrus. Spontaneous and CIDR-induced estrus vaginal mucus samples were analyzed on two different array surfaces: cation-exchange (CM10), anion-exchange (Q10). In addition, using the NaCl solution by which the proteins combined after washing are 0.5, 1 and 2 M, it was fractionated and a protein was collected successively. The results are summarized as follows: 1) Ionic surfaces chemistries (Q10 and CM10) gave the best results in terms of detectable protein peaks, with more than 100 protein peaks in the two fractions and under each condition. 2) Protein mass spectrometer using 11 different proteins in protein identification of 7 were able to determine the protein. List of identified proteins as follows; Ribosome-binding protein 1, GRIP 1-associated protein 1, Katanin p60 ATPase-containing subunit A-like 1, Protein FAM44A, DUF729 domain-containing protein 1, Prolactin precursor, Dihydrofolate erductase. Conclusively, on the basis of this study, protein expression in the vaginal mucus could be used as an indicator for time of estrus manifestation in order to increase conception rates by applying AI at an optional time.

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis

( Chung Hyeok Lee ),( Noo Ri Lee ),( Beom Jun Kim ),( Eung Ho Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Glucocorticoids (GCs) are potent anti-inflammatory drugs whose secretion is mediated and controlled by the hypothalamic-pituitary-adrenal axis. However, they are also secreted de novo by peripheral tissues for local use. Several tissues express 11β-hydroxysteroid dehydrogenase 1 (11β -HSD1), including the skin. The inactive GC cortisone is converted by 11β-HSD1 to the active GC cortisol, which is responsible for delayed wound healing during systemic excess of GC. However, the role of 11β-HSD1 in inflammation is unclear. Objectives: We assessed whether 11β-HSD1 affects the development of atopic dermatitis (AD). Methods: Normal human epidermal keratinocytes (NHEKs) transfected with 11β-HSD1 small interfering RNA were used for in vitro study. Oxazolone-induced AD (Ox-AD) mice and HSD11B1 knockout mice were used for in vivo study. Results: In Ox-AD mice, localized inhibition of 11β-HSD1 aggravated the development of AD and increased serum cytokine levels associated with AD. Mice with whole-body knockout (KO) of 11β-HSD1 developed significantly worse AD upon induction with oxazolone. The immunohistochemical staining intensity of 11β-HSD1 was significantly increased in the skin of OxAD mice compared to that in control mice. Conclusion: We propose that 11β-HSD1 is a major factor that affects the pathophysiology of AD via suppression of atopic inflammation due to the modulation of active GC in the skin.

Efficacy and Safety of Treatment with Fractional 1,064-nm Picosecond Laser with Diffractive Optic Element for Wrinkles and Acne Scars: A Clinical Study

( Chung Hyeok Lee ),( Eun Mi Jin ),( Hee Seok Seo ),( Tae-ui Ryu ),( Seung Phil Hong ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.3

Background: Fractional picosecond lasers is effective for the treatment of wrinkles or acne scars. Objective: To investigate the safety and efficacy of treatment with a fractional 1,064-nm picosecond laser with a diffractive optic element for facial wrinkles and acne scars. Methods: This prospective open-labeled trial comprised 22 subjects with facial wrinkles or acne scars. Subjects received three laser treatments with a fractional 1,064-nm picosecond laser at 3-week intervals. The efficacy and safety were evaluated at every visit and 2 months after the final treatment (14 weeks from the first treatment session). Global photographic assessments were performed by three blinded dermatologists and the subjects. Skin profilometry was performed using three-dimensional digital photographs; viscoelasticity was measured. Results: The overall mean global improvement scores assessed by the dermatologists at weeks 3, 6, and 14, were 1.8±1.46, 2.5±1.88, and 3.5±1.84, respectively, and those assessed by the subjects were 2.7±2.08, 4.1±2.24, and 5.0±2.52, respectively. Skin profilometry showed significant improvements in the skin wrinkles, texture, depressions, and pores. The gross elasticity and skin firmness significantly improved by 10.96% and 9.04%, respectively. The major adverse reactions were erythema, pruritus, and petechiae, which disappeared within 2∼3 days. Conclusion: The fractional 1,064-nm picosecond laser is an effective and safe therapeutic modality for skin rejuvenation. (Ann Dermatol 33(3) 254∼262, 2021)

Pigmented allergic contact dermatitis due to henna

( Chung Hyeok Lee ),( Eung Ho Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Henna is a dye prepared from the plant Lawsonia inermis. Henna dyes are made by drying the leaves of this plant. Nowadays, it is a widely used alternative to conventional chemical dyes. It is used alone or in combination with other additives such as para-phenylenediamine (PPD) to hasten the drying process and enhance darkness. Since PPD is widely recognized as a sensitizer, the risk of allergic contact dermatitis (ACD) from henna tattoo mixtures is increasing. A 56-year-old woman had dark brown patches on her face and neck for 6 months. The patches initially developed on the neck and gradually spread throughout the whole neck and face. She had dyed her hair black with henna for 6 months. Every time after dyeing, itching and irritation were occurred in her face and neck, but she continued to dye her hair at intervals of about 10 days. The histopathological findings were consistent with post-inflammatory hyperpigmentation (PIH). Patch test was performed to diagnose ACD due to henna dyes as the cause of PIH. Two kinds of henna mixtures she used were diluted into 5%, 10%, 20%, 30%, and 40%, and then the patch test was performed respectively. As a result, one mixture showed 1+ reaction in 10%, 20%, 30% and 40% and the other mixture showed 1+ reaction in 20%, 30% and 40%. Collectively, she was diagnosed as PIH caused by ACD due to henna dyes.

인슐린 비으존형 당뇨병 환자에서 Angiotensin 전환효서 억제�┛�단백뇨와 Lipoprotein(a) 농동에 미치는 영향

이태희,김용주,정민영,이대호,정동진,신현호,이연상,이대배,김정민,조동혁 대한내과학회 1999 대한내과학회지 Vol.57 No.2

Background: We determined the serum Lipoprotein(a) [Lp(a)] level in patients with NIDDM and evaluated the relationship between serum Lp(a) level and proteinuria, and the efficacy of angiotensin converting enzyme inhibitor(ACEI) in reducing serum Lp(a) level in NlDDM patients. Method: A total of 86 patients with NlDDM(age : 61.2 ±1.2 years) was divided into ACEI treatment group (n=45) and control group(n=41). The changes of the amount of proteinuria and serum Lp(a) were analyzed in both groups. Mean duration of follow-up in control group or ACEI administration in ACEI group was 8.4 months. Results : 1) Befare ACEI treatment, the positive correlation between serum Lp(a) level and amount of proteinuria was present in ACEI group, but not in total subjects and control group. ACEI treatment was associated with decrease in serum Lp(a) level, but not with change in the amounts of proteinuria. 2) Serum Lp(a) levels decreased significantly by ACEI treatment, not only in patients whose diastolic blood pressure(DBP) decreased by more than 10mmHg, but also in patients whose DBP did not response to ACEI administration. 3) Patients with overt proteinuria($gt; 500rng/day) had higher serum Lp(a) level than patients without overt proteinuria before ACEI treatment. After ACEI treatment, serum Lp(a) levels and amount of proteinuria decreased significantly in patients with overt proteinuria, but not in patients without overt proteinuria. 4) In both subgroups of patients with serum Lp(a) level ≤30mg/dl and patients with serum Lp(a) level $lt;30mg/dl, serum Lp(a) levels decreased significantly after ACEI treatment, but the amount of proteinuria did not change in both subgroups. 5) In the analyses of subgroups of patients whose amounts of proteinuria definitively decreased (responder group) or increased (non-responder group) after ACEI, serum Lp(a) levels decreased even in the non-responder group. Conclusion : NIDDM patients with overt proteinuria have higher level of serum Lp(a) than patients without overt proteinuria, and ACEI treatment could reduce serum Lp(a) level as well as proteinuria. Although decrease in Lp(a) is thought to be associated with decreased proteinuria, there may be another effect of ACEI that should be clarified further.