http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Changes in T Cells in Peripheral Blood after Adult Liver Transplantation
( Jong Man Kim ),( Jisoo Lee ),( Kyung-sik Kim ),( Nuri Lee ),( Chan-woo Cho ),( Gyu-seong Choi ),( Choonhyuck David Kwon ),( Jae-won Joh ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Backgrounds: T lymphocytes are an essential component of allograft rejection and tolerance. The aims of the present study are to analyze the characteristics of T cell subsets between deceased donor liver transplantation (DDLT) patients and living donor liver transplantation (LDLT) patients and to investigate the potential role of T cell subsets in cytomegalovirus (CMV) infection, acute rejection, and graft failure. Methods: Between April 2013 and June 2014, 64 patients underwent adult LT. All patients received basiliximab as induction therapy and tacrolimus as maintenance therapy. The distribution of peripheral blood T lymphocyte subsets pretransplant and 4, 8, 12, and 24 weeks post-transplant were serially monitored. Results: Patient characteristics did not vary between DDLT and LDLT groups except for Child-Pugh class, model for end-stage liver disease score, and cold ischemic time. However, the Vδ1/Vδ2 ratio in the DDLT group was higher than in the LDLT group (P=0.045). Comparison between LDLT and DDLT groups revealed that CD4+ T cells, CD8+ T cells, CD4/CD8, Vδ1 cells, Vδ2 cells, and γδ T cells did not change significantly over time. The Vδ1/Vδ2 ratio in patients with CMV infection was higher than in patients without CMV infection. The absolute CD3+ and CD8 T cell counts in patients with biopsy-proven acute rejection (BPAR) were higher than in patients without BPAR. The absolute lymphocyte counts, CD4+ T cell, γδ T cell, and Vδ2 γδ T cell counts in patients with graft failure were lower than in patients without graft failure. Conclusion: CD3+ T cells are different between DDLT and LDLT groups. Patients with BPAR showed elevated CD3+ and CD8+ T cells. The present study suggests that LDLT patients receive high doses of immunosuppression compared with DDLT patients. Vδ2γδ T cells are closely associated with CMV infection and graft failure.
( Jong Man Kim ),( Kwang-woong Lee ),( Gi-won Song ),( Bo-hyun Jung ),( Hae Won Lee ),( Nam-joon Yi ),( Choonhyuck David Kwon ),( Shin Hwang ),( Kyung-suk Suh ),( Jae-won Joh ),( Suk-koo Lee ),( Sung- 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.3
Background/Aims: The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR. Methods: We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers. Results: BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive. Conclusions: The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival. (Clin Mol Hepatol 2016;22:366-371)
Intraoperative abortion of adult living donor liver transplantation
Jungchan Park,Gyu-Seong Choi,Mi Sook Gwak,Justin Sangwook Ko,Sangbin Han,Bobae Han,Jae Won Joh,Sung Joo Kim,Suk-Koo Lee,Choonhyuck David Kwon,Jongman Kim,Chan Woo Cho,Gaab Soo Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.4
Purpose: This study aimed to report intraoperative abortion of adult living donor liver transplantation (LDLT). Methods: From June 1997 to December 2016, 1,179 adult LDLT cases were performed. 15 cases (1.3%) of intraoperative abortions in LDLT were described. Results: Among 15 cases, 5 intraoperative abortions were donor-related, and remaining 10 cases were recipient-related. All donor-related abortions were due to unexpected steatohepatitis. Among remaining 10 recipient-related intraoperative abortions, unexpected extension of hepatocellular carcinoma was related in 5 cases. Two cases of intraoperative abortions were related to bowel inflammation, and 2 cases were associated with severe adhesion related to previous treatment. One recipient with severe pulmonary hypertension was also aborted. Conclusion: Complete prevention of aborted LDLT is still not feasible. In this regard, further efforts to minimize intraoperative abortion are required.