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정치량 ( Chi Ryang Chung ),홍윤경 ( Yun Kyung Hong ),김소영 ( So Young Kim ),최영훈 ( Yung Hun Choi ),나영균 ( Young Gyun Na ),박승용 ( Seung Yong Park ),황정환 ( Heong Hwan Hwang ),문희 ( Hee Moon ),오호준 ( Ho Jun Oh ),이석 ( 전북대학교 의과학연구소 2005 全北醫大論文集 Vol.29 No.2
Background: An alteration in the balance between a T-helper type 2 cell (Th2) response and a T-helper type 1 cell (Th1) response may predispose to the development of bronchial asthma. IL-18 has an ability to promote both Th1 and Th2 responses depending on the surrounding cytokine environment. Reactive oxygen species (ROS) play a crucial role in the pathogenesis of airway inflammation and hyperresponsiveness. Objective: An aim of the present study was to determine the effect of ROS on the regulation of IL-18 expression. Methods: We used a C57BL/6 mouse model of allergic asthma to examine effects of antioxidants on the regulation of IL-18 expression. Our present study with ovalbumin (OVA)- induced murine model of asthma revealed that ROS production in cells from bronchoalveolar lavage (BAL) fluids was increased, and that administration of L-2-oxothiazolidine-4-carboxylic acid (OTC) or α-lipoic acid reduced the increased levels of ROS, the increased expression of IL-18 protein and mRNA, airway inflammation, and bronchial hyperresponsiveness. Our results also showed that antioxidants down-regulated a transcription factor, nuclear factor-kB (NF-kB) activity. Conclusion: These results indicate that antioxidants may inhibit LL-18 expression in asthma by inhibiting activity of NF-kB, and suggest that ROS regulate the LL-18 expression.
임성윤 ( Chi Ryang Chung ),( Kyeongman Jeon ),( Sang-bum Hong ),( You Na Oh ),( Sang-min Lee ),( Woo Hyun Cho ),( Sunghoon Park ),( Yeon Joo Lee ),( Young-jae Cho ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Introduction: The recirculation during veno-venous extracorporeal membrane oxygenation (VV ECMO) had been a drawback, which could limit sufficient oxygenation. Purpose of this study is to compare the short-term oxygenation and long-term mortality in acute respiratory distress syndrome (ARDS) patients under VV ECMO according to their cannula configurations, especially in the national environment of the absence of newly developed double-lumen, single cannula. Methods: Data were retrospectively analyzed from the severe ARDS patients receiving VV ECMO from 2012 to 2015 at six hospitals. Primary outcomes were PaO2 at 1, 4, and 12 hours after initiation of ECMO and 180-day their mortality. Results: We included 354 patients and divided them into two groups according to the sites of return cannula; 193 patients were cannulated to femoral vein, and 161 patients to internal jugular vein. Baseline characteristics at admission including PaO2 were similar between two groups. PaO2 in 1 hour of the femoral group was higher than the jugular group (190.3 vs. 160.0, P=0.108), however, there was no significant difference in the increments of PaO2 including 4 and 12 hours after initiation of ECMO between two groups. Mortality rate at 180 days after ECMO was not significantly different by the site of cannulation. Mechanical or infectious complications in terms of cannulation also did not show significant difference. Conclusion: Regardless of cannula configurations, ARDS patients under VV ECMO showed comparable clinical outcomes. Further randomized control trials should be warranted.
Jeeyoun Lim,Chi Ryang Chung,유정암,길은미 대한외상중환자외과학회 2021 Journal of Acute Care Surgery Vol.11 No.1
Purpose: In the intensive care unit, a peripherally inserted central catheter (PICC) may be analternative option to standard central venous catheters, particularly in patients with coagulopathiesor at high risk of infection. The purpose of this research was to assess the feasibility of bedsideultrasound (US)-guided PICC placement by critical care fellows on intensive care units. Methods: All bedside US-PICCs inserted by critical care fellows from July 2013 to September2015 were retrospectively reviewed focusing on the rate of successful insertion, complications ofinsertion, or during maintenance. Results: A total of 177 US-guided PICCs were inserted in 163 patients and included in the analysis. The median age was 62 years (IQR 50-70 years) and 104 cases (58.8%) were male. There were172 cases (90.4%) of PICCs inserted in the upper arm. Anticoagulant therapy was used in 26patients (14.7%) and 8 patients (5.2%) had severe coagulopathies. The median procedural timewas 30 minutes (IQR 19-45 minutes). Insertion success rate was 93.2%, and there were no majorcomplications during insertions except for malposition (12.1%). Catheters remained in place for atotal of 3,878 days (median 16 days: IQR 8-31 days). There was only 1 case (0.6%) of catheter-relatedbloodstream infection, and 2 cases (1.2%) of symptomatic venous thromboembolism. Conclusion: Bedside US-guided placement of PICCs by critical care fellows is safe and feasible. Thesuccess rate of the procedure was “acceptable,” and was not associated with significant risks ofinfectious and non-infectious complications, even in patients with coagulopathies.
유정암,양정훈,Chi Ryang Chung,서지영,홍승철 대한의학회 2017 Journal of Korean medical science Vol.32 No.6
Limited data are available on improved outcomes after initiation of neurointensivist co-management in neurosurgical intensive care units (NSICUs) in Korea. We evaluated the impact of a newly appointed neurointensivist on the outcomes of neurosurgical patients admitted to an intensive care unit (ICU). This retrospective observational study involved neurosurgical patients admitted to the NSICU at Samsung Medical Center between March 2013 and May 2016. Neurointensivist co-management was initiated in October 1 2014. We compared the outcomes of neurosurgical patients before and after neurointensivist co-management. The primary outcome was ICU mortality. A total of 571 patients were admitted to the NSICU during the study period, 291 prior to the initiation of neurointensivist co-management and 280 thereafter. Intracranial hemorrhage (29.6%) and traumatic brain injury (TBI) (26.6%) were the most frequent reasons for ICU admission. TBI was the most common cause of death (39.0%). There were no significant differences in mortality rates and length of ICU stay before and after co-management. However, the rates of ICU and 30-day mortality among the TBI patients were significantly lower after compared to before initiation of neurointensivist co-management (8.5% vs. 22.9%; P = 0.014 and 11.0% vs. 27.1%; P = 0.010, respectively). Although overall outcomes were not different after neurointensivist co-management, initiation of a strategy of routine involvement of a neurointensivist significantly reduced the ICU and 30-day mortality rates of TBI patients.
Baek, Moon Seong,Chung, Chi Ryang,Kim, Hwa Jung,Cho, Woo Hyun,Cho, Young-Jae,Park, Sunghoon,Park, Seung Yong,Kang, Byung Ju,Kim, Jung-Hyun,Park, So Hee,Oh, Jin Young,Sim, Yun Su,Hong, Sang-Bum AME Publishing Company 2018 Journal of thoracic disease Vol.10 No.3
<P>Conclusions: The RESP score is significant model for predicting outcomes in a Korean ECMO population. Elderly patients had higher mortality, and age alone showed similar discrimination ability for prediction of mortality compared to the RESP score.</P>
박성주,Mi Seon Park,Chi Ryang Chung,Ju Sin Kim,Seoung Ju Park,이흥범 대한중환자의학회 2016 Acute and Critical Care Vol.31 No.3
Background: Colistin (polymyxin E) is active against multidrug-resistant Gram-negative bacteria (MDR-GNB). However, the effectiveness of inhaled colistin is unclear. This study was designed to assess the effectiveness and safety of aerosolized colistin for the treatment of ventilator-associated pneumonia (VAP) caused by MDR-GNB. Methods: In this retrospective longitudinal study, we evaluated the medical records of 63 patients who received aerosolized colistin treatment for VAP caused by MDR-GNB in the medical intensive care unit (MICU) from February 2012 to March 2014. Results: A total of 25 patients with VAP caused by MDR-GNB were included in this study. The negative conversion rate was 84.6% after treatment, and acute kidney injury (AKI) occurred in 11 patients (44%, AKI group). The average length of MICU stay and colistin treatment- related factors, such as daily and total cumulative doses and administration period, were not significantly different between groups. In-hospital mortality tended to be higher in the AKI group (p = 0.07). Multivariate analysis showed that a body mass index less than 18 was an independent risk factor of mortality (odds ratio [OR] = 21.95, 95% confidence interval [CI] 1.59-302.23; p = 0.02). Notably, AKI occurrence was closely related to the administration of more than two nephrotoxic drugs combined with aerosolized colistin (OR = 15.03, 95% CI 1.40-161.76; p = 0.025) and septic shock (OR = 8.10, 95% CI 1.40-161.76; p = 0.04). Conclusions: The use of adjunctive aerosolized colistin treatment appears to be a relatively safe and effective option for the treatment of VAP caused by MDR-GNB. However, more research on the concomitant use of nephrotoxic drugs with aerosolized colistin will be necessary, as this can be an important risk factor of development of AKI.