http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Impact of Aβ_25-35 Fragment on Cytochrome Oxidase in SK-N-SH cells
Han, Bok-Ghee 한림대학교 환경·생명과학연구소 2000 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.3
It has been proposed that neuritic plaques contribute to neurodegeneration in Alzheimer's disease(AD). It is is also proposed that mitochondrial dysfunction is an important cause of neurological disease including AD^2,3. We have tested this hypothesis by searching for evidence of mitochondrial dysfunction after the exposure of SK-N-SH cells to amyloid β-peptide ^25-35(Aβ), which is an important constituent of neuritic plaques. We measured the activities of cytochrome c oxidase(COX), a marker of cellular energy metabolism and mitochondrial function, and found that a significant decrease in COX after Aβ-treatment. We also analyzed levels of mitochondrial DNA-encoded mRNA for subunits of COX by quantitative polymerase chain reaction, and found that levels of COX subunit mRNA were also decreased in Aβ-treated cells compared with the control cells. In a dose-dependent manner, the Aβ induced a significant decrease in all of the mitochondrial COX subunits(Ⅰ,Ⅱ,Ⅲ) within 24hrs following the treatment. In addition, the oxygen free radical scavengers BPN(N-t-butyl-phenylnitrone) reversed the decrease of the COX activity induced by Aβ. Aβ increased cellular oxygen free radical content as shown by the increase of DCF-fluorescence. These results suggest that the oxidative stress induced by Aβ modulates the mitochondrial gene expression, thus consistent with the suggestion that mitochondrial dysfunction may play a key role in AD-pathogenesis.
김한나 ( Han Na Kim ),정경아 ( Kyung Ah Jeong ),정혜원 ( Hye Won Chung ),배근량 ( Geun Ryang Bae ),한복기 ( Bok Ghee Han ),김형래 ( Hyung Lae Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12
Objective: The objective of the study was to estimate socioeconomic burden of polycystic ovary syndrome (PCOS) during the reproductive life span using current definitions and prevalence or incidence data. Methods: Questionnaires were given to 8,588 reproductive women reviewed at Ewha Womans University Mokdong hospital. The PCOS affected approximately 10.4% of reproductive-aged women (11 million women in Korea, prevalence rate according to 1990 National Institutes of Health PCOS diagnosis criteria). We tied general societal cost data for the different health consequences to reproductive-age PCOS costs, using prevalence data. Results: We estimated the mean annual cost of the initial evaluation to be ₩76 hundred million, that of hormonally treating menstrual dysfunction, providing infertility care, diagnosis/treatment of endometrial hyperplasia, GDM, type 2 DM, and hypertension to be ₩280 billion. The total annual socioeconomic cost of evaluating and providing care to reproductive-aged PCOS women in Korea is ₩350 billion. Conclusion: Because the cost of the diagnostic evaluation accounted for a relatively minor part of the total socioeconomic costs, more widespread screening for PCOS appears be a cost-effective strategy, leading to earlier diagnosis and intervention and possibly the amelioration and prevention of serious sequelae.
Jang, Han Byul,Hwang, Joo-Yeon,Park, Ji Eun,Oh, Ji Hee,Ahn, YounJhin,Kang, Jae-Heon,Park, Kyung-Hee,Han, Bok-Ghee,Kim, Bong Jo,Park, Sang Ick,Lee, Hye-Ja BMJ Publishing Group Ltd 2014 Journal of medical genetics Vol.51 No.12
<P><B>Background</B></P><P>A low serum level of high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 5 (<I>PCSK5</I>) modulates HDL-C metabolism through the inactivation of endothelial lipase activity.</P><P><B>Methods</B></P><P>Therefore, we analysed the effects of <I>PCSK5</I> on HDL-C and investigated the association between genetic variation in <I>PCSK5</I> and dietary polyunsaturated fatty acids (PUFAs) intakes in Korean adults and children. This population-based study which was conducted in South Korea included 4205 adults (43% male) aged 40–69 years and 1548 children (48.6% boys) aged 8–13 years. Dietary intake was assessed using a semiquantitative food frequency questionnaire in adults and modified 3-day food records in children.</P><P><B>Results</B></P><P>After adjustments for age and body mass index, we identified a significant association between SNP rs1029035 of the <I>PCSK5</I> gene and HDL-C concentrations specifically for men in both populations (adults, p=0.004; children, p=0.003; meta, p=7×10<SUP>−4</SUP>). Additionally, the interaction between the <I>PCSK5</I> rs1029035 genotype and dietary polyunsaturated fatty acids intake influenced serum HDL-C concentrations in men (adults, p=0.001; children, p=0.008). The deleterious effect of the C allele on serum HDL-C was present only when dietary PUFA intake was less than the dichotomised median level (adults, p=0.011; children, p=0.001). Serum HDL-C concentrations were decreased in men with the C allele genotype and low consumption of dietary PUFA including n-3 and n-6.</P><P><B>Conclusion</B></P><P>According to these results, men carrying of the C allele were associated with low HDL-C concentrations and might exert beneficial effects on HDL-C concentrations following consumption of a high-PUFA diet.</P>
AKAPDB: A-Kinase Anchoring Proteins Database
Kim, In-Sil,Lim, Kyung-Joon,Han, Bok-Ghee,Chung, Myung-Guen,Kim, Kyu-Won Korea Genome Organization 2010 Genomics & informatics Vol.8 No.2
A-kinase-anchoring proteins (AKAPs) are scaffold proteins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular function like cell growth and development etc. Hence, it is important to understand the basic function of AKAPs and their functional domains. However, diverse names, function, cellular localizations and many members of AKAPs increase difficulties when researchers search appropriate AKAPs for their experimental purpose. Nevertheless, there was no previous AKAPs-related database regardless of their important cellular functions and difficulty of finding appropriate AKAPs. So, we developed AKAPs database (AKAPDB), which contains their sequence information, functions and other information derived from prediction programs and other databases. Therefore, we propose that AKAPDB can be an important tool to researchers in the related fields. AKAPDB is available via the internet at http://plaza3.snu.ac.kr/akapdb/.
Freudenberg, Jan,Lee, Hye-Soon,Han, Bok-Ghee,Shin, Hyoung Do,Kang, Young Mo,Sung, Yoon-Kyoung,Shim, Seung-Cheol,Choi, Chan-Bum,Lee, Annette T,Gregersen, Peter K,Bae, Sang-Cheol J.B. Lippincott Co 2011 Vol.63 No.4
<P>To perform a genome-wide association study (GWAS) in Koreans in order to identify susceptibility loci for rheumatoid arthritis (RA).</P>
Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosa
Kim, Kwang Joong,Kim, Cinoo,Bok, Jeong,Kim, Kyung-Seon,Lee, Eun-Ju,Park, Sung Pyo,Chung, Hum,Han, Bok-Ghee,Kim, Hyung-Lae,Kimm, Kuchan,Yu, Hyeong Gon,Lee, Jong-Young Molecular Vision 2011 Molecular vision Vol.17 No.-
<P><B>Purpose</B></P><P>To determine the spectrum and frequency of rhodopsin gene (<I>RHO</I>) mutations in Korean patients with retinitis pigmentosa (RP) and to characterize genotype–phenotype correlations in patients with mutations.</P><P><B>Methods</B></P><P>The <I>RHO</I> mutations were screened by direct sequencing, and mutation prevalence was measured in patients and controls. The impact of missense mutations to RP was predicted by segregation analysis, peptide sequence alignment, and in silico analysis. The severity of disease in patients with the missense mutations was compared by visual acuity, electroretinography, optical coherence tomography, and kinetic visual field testing.</P><P><B>Results</B></P><P>Five heterozygous mutations were identified in six of 302 probands with RP, including a novel mutation (c.893C>A, p.A298D) and four known mutations (c.50C>T, p.T17M; c.533A>G, p.Y178C; c.888G>T, p.K296N; and c.1040C>T, p.P347L). The allele frequency of missense mutations was measured in 114 ethnically matched controls. p.A298D, newly identified in a sporadic patient, had never been found in controls and was predicted to be pathogenic. Among the patients with the missense mutations, we observed the most severe phenotype in patients with p.P347L, less severe phenotypes in patients with p.Y178C or p.A298D, and a relatively moderate phenotype in a patient with p.T17M.</P><P><B>Conclusions</B></P><P>The results reveal the spectrum of <I>RHO</I> mutations in Korean RP patients and clinical features that vary according to mutations. Our findings will be useful for understanding these genetic spectra and the genotype–phenotype correlations and will therefore help with predicting disease prognosis and facilitating the development of gene therapy.</P>