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Ding Sheng-Long,Zhang Tai-Wei,Zhang Qi-Chen,Ding Wang,Li Ze-Fang,Han Guan-Jie,Bai Jin-Song,Li Xi-Lei,Dong Jian,Wang Hui-Ren,Jiang Li-Bo 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical strain disrupted the CR and inhibited the expression of core clock proteins. The inhibitory effect of mechanical loading on the expression of extracellular matrix genes could be reversed by BMAL1 overexpression in NP cells. The Rho/ROCK pathway was demonstrated to mediate the effect of mechanical stimulation on CR. Prolonged mechanical loading for 12 months affected intrinsic CR genes and induced IDD in a model of upright posture in a normal environment. Unexpectedly, mechanical loading further accelerated the IDD in an Light-Dark (LD) cycle-disrupted environment. These results indicated that intrinsic CR disruption might be a mechanism involved in overloading-induced IDD and a potential drug target for night shift workers.
Emerging Roles of Krüppel-Like Factor 4 in Cancer and Cancer Stem Cells
Ding, Bo,Liu, Ping,Liu, Wen,Sun, Ping,Wang, Chun-Ling Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Cancer stem cells (CSCs) are rare subpopulations within tumors which are recognized as culprits in cancer recurrence, drug resistance and metastasis. However, the molecular mechanisms of how CSCs are regulated remain elusive. Kr$\ddot{u}$ppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse functions in cell differentiation, proliferation, embryogenesis and pluripotency. Recent progress has highlighted the significance of KLFs, especially KLF4, in cancer and CSCs. Therefore, for better therapeutics of cancer disease, it is crucial to develop a deeper understanding of the mechanisms of how KLF4 regulate CSC functions. Herein we summarized the current understanding of the transcriptional regulation of K LF4 in CSCs, and discussed the functional implications of targeting CSCs for potential cancer therapeutics.
딩즈보(Zhi-Bo Ding),송승근(Seung-Keun Song) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.11
본 연구는 해외 관광객들의 문화욕구를 분석하고 감천문화마을에서 제공할 수 있는 문화 서비스 요소를 조사하여 문화 서비스를 개선하는 구체적인 방책을 제시하고 궁극적으로 감천문화마을을 우수한 국제 관광 문화 브랜드를 육성하는 것을 목적으로 한다. 외국관광객들의 문화욕구가 무엇인지 알아보기 위해 도시 재생이 진행된 곳 가운데 감천문화마을을 대상으로 사례 연구를 수행하였다. 연구수행 기간은 4개월이었으며 6개국 외국관광객을 대상으로 문헌조사, 인터뷰, 참여관찰을 통해 기초자료를 수집하였다. 자료 분석은 도시재생, 문화욕구, 서비스 디자인 이론을 토대로 내용분석을 실시하였다. 본 연구는 감천문화마을의 5가지 문화 서비스 목표를 제시하였다. 첫째, 현지 특색문화의 전시 및 홍보, 둘째, 문화상품의 개발과 판매, 셋째, 좋은 관광이미지 부각, 넷째, 특이한 먹거리 제공, 다섯째, 문화체험 최적화이다. 본 연구를 통해 감천문화마을에 대한 문화서비스 향상에 도움을 줄 것으로 기대된다. The purpose of this study is to analyze the cultural needs of foreign tourists, to investigate the cultural service elements that can be provided in ‘Gamcheon Culture Village’, to suggest concrete policy to improve cultural services, and ultimately to cultivate excellent international tourism culture brands in ‘Gamcheon Culture Village’. In order to find out the cultural needs of foreign tourists, we conducted a case study on ‘Gamcheon Culture Village’ among the places where the urban regeneration proceeded. The study period was four months, and basic data were collected from foreign tourists from six countries through literature reviews, interviews and participation observation. Analysis of data was based on urban regeneration, cultural desire and service design theory, and we conducted content analysis. This study presented five cultural service goals of ‘Gamcheon Culture Village’. First, it displays and promotes local characteristic culture. Second, it develops and sells cultural products. Third, it brings up a good tourist image. Fourth, it provides an unusual food. Fifth, cultural experience optimization. Through this study, it is expected to help improve the cultural service of ‘Gamcheon Culture Village’.
Theoretical and practical models for shear strength of corroded reinforced concrete columns
Bo Yu,Zihao Ding,Shengbin Liu,Bing Li 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.5
In order to predict the shear strength of corroded reinforced concrete column (CRCC) accurately and efficiently, both theoretical and practical models for shear strength of the CRCC were established through theoretical derivation and experimental validation. The deterioration mechanism for shear strength of the CRCC due to the steel reinforcement corrosion was explored first based on the shear mechanism analysis of the truss-arch model. Then a theoretical model for shear strength of the CRCC was developed by taking into account the influences of steel reinforcement corrosion on the effective yield strength of transverse reinforcement, the effective cross-sectional area of both corroded transverse and longitudinal reinforcements as well as the effective concrete shear area. Meanwhile, three practical models to evaluate the shear strength of the CRCC were proposed based on 54 sets of experimental data by determining the approximate values of three important parameters, including the contribution coefficient of shear strength for concrete, the ratio of shear stiffness between the truss model and the arch model, as well as the tangent value of the critical crack angle. Finally, the accuracy and applicability of both theoretical and practical models for shear strength of the CRCC were validated by comparing with five existing empirical shear strength models.
Ding, Xiangming,Yu, Wenbo,Liu, Ming,Shen, Suqin,Chen, Fang,Wan, Bo,Yu, Long Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
Septins are a family of conserved cytoskeletal GTPase forming heteropolymeric filamentous structure in interphase cells, however, the mechanism of assembly are largely unknown. Here we described the characterization of SEPT12, sharing closest homology to SEPT3 and SEPT9. It was revealed that subcelluar localization of SEPT12 varied at interphase and mitotic phase. While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively. In addition, we found that SEPT12 can interact with SEPT6 in vitro and in vivo, and this interaction was independent of the coiled coil domain of SEPT6. Further, co-expression of SEPT12 altered the filamentous structure of SEPT6 in Hela cells. Therefore, our result showed that the interaction between different septins may affect the septin filament structure.
Mechanical Properties and Microstructure of Polypropylene Fiber Reinforced Cement Mortar Soil
Bo Ruan,Hui Ding,Jidong Teng,Wei Deng,Shilong Zheng,Chenxi Ruan 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.6
A series of unconfined compressive strength tests and flexural strength tests are carried out to evaluate the improved effect of polypropylene fiber on the defects of cement mortar soil. The following factors, including the fiber content, cement content, sand content and curing age, are studied to investigate the influences on the mechanical properties and microstructure of the samples. The results show that the unconfined compressive strength (UCS), residual strength and flexural strength of the fiber reinforced cement mortar soil (FRCMS) substantially increase with increasing fiber content. The peak strain and ratio of the flexural-compression strength (Rfcs) of the FRCMS first increase and then decrease with an increase in fiber content,and the optimal fiber content is 3.5%. The brittleness index of the FRCMS is found to be inversely proportional to fiber content. The results suggest that the addition of an appropriate amount of fibers can substantially improve the plasticity and lateral stress capacity of the FRCMS. The strength of the FRCMS improves with the increase in cement content, sand content and curing age within a certain range. The microstructure of the FRCMS are analyzedby scanning electron microscopy (SEM) tests.
( Bo Xu ),( Fu Ya Yang ),( Cai Yun Xiong ),( Jun Jun Li ),( Xiang Hua Tang ),( Jun Pei Zhou ),( Zhen Rong Xie ),( Jun Mei Ding ),( Yun Juan Yang ),( Zun Xi Huang ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.4
To isolate novel and useful microbial enzymes from uncultured gastrointestinal microorganisms, a fecal microbial metagenomic library of the pygmy loris was constructed. The library was screened for amylolytic activity, and 8 of 50,000 recombinant clones showed amylolytic activity. Subcloning and sequence analysis of a positive clone led to the identification a novel gene (amyPL) coding for α-amylase. AmyPL was expressed in Escherichia coli BL21 (DE3) and the purified AmyPL was enzymatically characterized. This study is the first to report the molecular and biochemical characterization of a novel α-amylase from a gastrointestinal metagenomic library.
( Bo Xu ),( Li Ming Dai ),( Jun Jun Li ),( Meng Deng ),( Hua Biao Miao ),( Jun Pei Zhou ),( Yue Lin Mu ),( Qian Wu ),( Xiang Hua Tang ),( Yun Juan Yang ),( Jun Mei Ding ),( Nan Yu Han ),( Zun Xi Huang 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
Xylanases sourced from different bacteria have significantly different enzymatic properties. Therefore, studying xylanases from different bacteria is important to their applications in different fields. A potential xylanase degradation gene in Massilia was recently discovered through genomic sequencing. However, its xylanase activity remains unexplored. This paper is the first to report a xylanase (XynRBM26) belonging to the glycosyl hydrolase family (GH10) from the genus Massilia. The gene encodes a 383-residue polypeptide (XynRBM26) with the highest identity of 62% with the endoxylanase from uncultured bacterium BLR13. The XynRBM26 expressed in Escherichia coli BL21 is a monomer with a molecular mass of 45.0 kDa. According to enzymatic characteristic analysis, pH 5.5 is the most appropriate for XynRBM26, which could maintain more than 90% activity between pH 5.0 and 8.0. Moreover, XynRBM26 is stable at 37°C and could maintain at least 96% activity after being placed at 37°C for 1 h. This paper is the first to report that GH10 xylanase in an animal gastrointestinal tract (GIT) has salt tolerance, which could maintain 86% activity in 5 M NaCl. Under the optimum conditions, Km, Vmax, and kcat of XynRBM26 to beechwood xylan are 9.49 mg/ml, 65.79 μmol/min/mg, and 47.34 /sec, respectively. Considering that XynRBM26 comes from an animal GIT, this xylanase has potential application in feedstuff. Moreover, XynRBM26 is applicable to high-salt food and seafood processing, as well as other high-salt environmental biotechnological fields, because of its high catalytic activity in high-concentration NaCl.