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- 저자 : ( Berrin Inal ) (검색결과 2 건)
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( Feray Akbas ),( Hanife Usta Atmaca ),( Berrin Inal ),( Yasin Yuksel ),( Emin Piskinpasa ),( Mustafa Boz ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Recent studies have shown that microalbuminuria (MAU) refl ected in a higher probability of cardiovascular disease for cardiovascular risk assessment. We aimed to question the availability of microalbuminuria in metabolically healthy obese patients as a predictor of diastolic dysfunction to assess the cardiovascular risk. Methods: 100 obese patients without accompanying diseases were included in the study. They were screened for any signs of acute/chronic inflammation and those having any were excluded. None of the patients were on any medications infl uencing diastolic dysfunction. Blood glucose, HbA1c, urea, creatinine, total cholesterol, LDL, HDL, triglyceride and 24-hour-urine microalbuminuria and creatinine clearance (GFR) levels were studied. Two-dimensional doppler echocardiography was performed. Data was statistically analyzed using SPSS Windows 11.5. Results: Statistical analysis showed that there was no signifi cant difference between patients with diastolic dysfunction and normal echocardiograpghy fi ndings when compared for MAU and also for BMI. In all groups, there was no relation between MAU and BMI according to correlation analysis. There was statistically significant difference for age (p<0,0001), glucose (p=0,019), total cholesterol (p=0,009) and LDL (p=0,019) and no difference for gender, smoking, HbA1c, HDL, systolic and diastolic blood pressure, creatinine, GFR and triglyceride (p>0,05) between groups. Conclusions: Microalbuminuria found in obese patients can be related with diastolic dysfunction which might refl ect subclinical cardiac damage with a simple method and in advance. The lack of demonstration of this relationship in our study might be due to limited number of patients included and especially low percentage of patients with microalbuminuria. But the relationship found for blood glucose and lipid parameters still can show metabolic tendency. If an approval of this relationship can be achieved by studies with a higher number of patients, an easy and non-invasive method to predict obesity cardiomyopathy might be possible.
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( Hanife Usta Atmaca ),( Feray Akbas ),( Ilker Nihat Okten ),( Eda Nuhoglu Kantarci ),( Berrin Belcik Inal ),( Mustafa Boz ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Obesity is a disease known to stimulate low grade infl ammation. N/L ratio has been started to be used as an indicator of systemic infl ammation. This study aims to examine the relationship between obesity and N/L ratio over anthropometric measurements, obesity grade, and some biochemical parameters. Methods: 96 obese patients (mild-moderate and severe) who are being monitored in obesity outpatient clinic, who have no concomitant disease, and who do not have a history of smoking and drug use, and as the control group, 20 patients of normal weight with the same characteristics were included in the study. Anthropometric measurements were recorded, and BMI was calculated. Biochemical tests and total blood counts were performed. N/L ratio was obtained by dividing neutrophil count by lymphocyte count. The results were evaluated using SPSS statistical analysis program. Results: A signifi cant increase was present in neutrophils and lymphocyte counts of morbid obese group compared to control groups. Due to both increased neutrophil and lymphocyte counts, even though L/N ratio increased, it was not found statistically signifi cant. The increase in total leucocyte count of morbid obese was statistically signifi cant compared to mild obese. While N/L ratio demonstrated a strongly positive correlation with total leucocyte count and neutrophil count, it demonstrated a weakly positive correlation with waist circumference and with hip circumference. Conclusions: N/L ratio increases by obesity grade and reveals that concomitant infl ammatory response increases. High count of circulating neutrophil in obese patients might be considered as an acute infl ammatory response to a chronic infl ammatory state. Therefore, N/L ratio might be used as an infl ammatory marker in obese patients, and might be helpful in the prediction of cardiovascular and metabolic risks for the patient.
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