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Pregnane Glycoside Multidrug-Resistance Modulators from Cynanchum wilfordii
Hwang, Bang Yeon,Kim, Se Eun,Kim, Young Ho,Kim, Hang Sub,Hong, Young-Soo,Ro, Jai Seup,Lee, Kyong Soon,Lee, Jung Joon 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-0-β-D-cymaropyranoside (1), wilfoside KlN (2), wilfoside ClN (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1μM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.
Insecticidal Limonoids from Melia toosendan
Bang Yeon Hwang,Se Ryang Oh,Young Ho Kim,Hyeong Kyu Lee,Jung Joon Lee 한국응용생명화학회(구 한국농화학회) 1993 한국응용생명화학회 학술발표회 Vol.1993 No.-
The fruits of Melia species in Asia are somewhat poisonous, but regarded as anthelmintic, antifeedant, antifebrile and diuretic. They are employed to treat fever, delirium, hernia and uterine illness. Recently we isolated a potent insecticidal compound against larvae of Bombyx mori from the fruits of Melia toosendan, The active principle was isolated by repeated column chromatography and recrystallization as a needle crystal. The structure was elucidated by ¹H-NMR , ^(13)C-NMR , MS and other spectroscopic data of acetylated compounds. This presentation describes isolation, purification, structure elucidation and insecticidal activity of this compound.
Acetophenones from the Roots of Cynanchum wilfordii HEMSLEY
Hwang, Bang-Yeon,Kim, Young-Ho,Ro, Jai-Seup,Lee, Kyong-Soon,Lee, Jung-Joon The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.1
Two acetophenones, cynandione A (1) and cynanchone A (2), were isolated from the roots of Cynanchum wilfordii. Their structures were identified by comparison of their physicochemical and spectral data with reported values.
Effect of Yacon on Platelet Function in Hypercholesterolemic Rabbits
( Seock Yeon Hwang ),( Yong Lim ),( Dong Ju Son ),( Yun Bae Kim ),( Bang Yeon Hwang ),( Yeo Pyo Yun ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
Hypercholesterolemia indirectly increases the risk of arterial and venous thrombosis by enhancing the ability of platelets to aggregate. Yacon (Smallanthus sonchifolius) is composed of fructooligosaccharides, proteins, minerals and phenolic compounds, and has potential benefi ts for the management of diabetes. This study investigated whether the consumption of yacon in the diet inhibits platelet aggregation under hypercholesterolemic conditions. Male New Zealand white rabbits were fed one of fi ve dietary interventions: a normal control diet, 0.5% cholesterol diet, 0.5% cholesterol diet+a low dose of yacon (0.5 g/kg body weight given orally each day), 0.5% cholesterol diet+a high dose of yacon (2.5 g/kg body weight given orally each day), or a 0.5% cholesterol diet+lovastatin (2 mg/kg body weight given orally each day). After 8 weeks, blood was collected to measure the amount of collagen- and thrombin-induced platelets present. Yacon inhibited the platelet aggregation induced by low doses of agonists (0.5 μg/ml collagen and 0.02 units/ml thrombin) in a concentration-dependent manner. In addition, yacon concentration-dependently inhibited collagen-induced arachidonic acid liberation. Moreover, n-hexane, chloroform and ethyl acetate fractions showed a marked and selective inhibition of the platelet aggregation induced by collagen, again in a dose-dependent manner. These fractions, especially that of chloroform, signifi cantly suppressed platelet aggregation. The results of this study demonstrate that when yacon is added to a cholesterol-enriched diet, cholesterol-induced platelet aggregation returns to control levels. This may also be benefi cial in preventing atherosclerosis and reducing risk factors for coronary artery disease and stroke.
Jae-Sam Hwang,Yeon-Ju Kim,Hea-Son Bang,Eun-Young Yun,Seong-Ryul Kim,Kwan-Ho Park,Hwa Jin Suh,Bo-Ram Kang,Iksoo Kim 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
To find some antibacterial peptides responsible for bacterial resistance, we performed differential hybridization with total cDNA probes which synthesized from normal and immunized larvae. Thirteen individual cDNA transcripts were expressed differentially in a total 1,862 random cDNA clones. One of upregulated genes is a novel member of the insect defensin-like peptide(Coprisin), a family of antibacterial peptide. Northern blot analysis showed that Coprisin was up-regulated at 4h and reached the highest point level at 16h after injection of E.coli. The deduced amino acid sequence of Coprisin was composed of 80 amino acids with predicted molecular weight of 8.6 kDa and PI of 8.72. Comparison of the deduced amino acid mature portion of Coprisin with defensin-like peptide of other insect indicated that it has 79.1% and 67.4% identity with Anomala cuprea and Allomyrina dichotoma, respectively. To find antibacterial active region of Coprisin, we synthesized four peptides corresponding to amino acid residues 1V-43N-NH2(CopN1), 5-16(CopN2), 19-30(CopN3) and 31-43(CopN4) of coprisin having amidated amino acid residues at their Cterminal. A 12-mer amidated at its C-terminus, ACALHCIALRKK-NH2 (Ala19-Lys30-NH2) was synthesized based on the deduced amino acid sequence, assumed to be an active site sequence. This peptides showed antibacterial activity against E.coli, Staphylococcus aureus, MRSA, Psedomonas syringae, and Pectobacterium carotovorium. Modified 9-mer peptide, LRCIALRKK-NH2, showed strong antibacterial activity than mellitin peptide used as a positive control against gram-negative and gram-positive bacteria. This peptide showed no haemolytic activity and quite stable at 100℃ for several hours of incubation and in a wide pH range(pH2-12). Therefore, this peptide may be a good candidate for the development of new drug with potent antibacterial activity without cytotoxicity.