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RISS 인기검색어
- 검색키워드
- 저자 : ( Ashot Mkrtumyan ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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( Ashot Mkrtumyan ),( Tatiana Markova ),( Vadim Kichigin ),( Dmitry Mapkov ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: the frequency of obesity in the general population ranges from 2.9% to 42%, depending on gender and ethnicity. Objective: to study the prevalence of obesity and metabolic syndrome (MS) in ethnic groups (Russian, Chuvash) population inhabitants of the Chuvash Republic (Russia). Methods: obesity is associated with formation of MS, and cardiovascular diseases. The frequency of obesity in the general population ranges from 2.9% to 42%, depending on gender and ethnicity. Objective: to study the prevalence of obesity and MS in ethnic groups (Russian, Chuvash) population inhabitants of the Chuvash Republic (Russia). Results: the prevalence of obesity in the Chuvash Republic was 14.6%. Among Russianprevalence of obesity was higher than among the Chuvash: 17.2% vs. 9.1%, pχ 2 <0.001. Obesity was recorded more often in women - 15.8%, than men - 8.1% pχ 2 <0.001. Obesity is diagnosed in 23.0% of Russian women and 7.7% of Russian men (pχ2 <0.001), in 11.2% of the Chuvash women and 6.1% men Chuvash (pχ2 <0.001). Frequency of MS was 19.5%. Laws of MS prevalence with gender and ethnic components were similar laws prevalence of obesity: in Russian MS was recorded twice as likely than the Chuvash: 27.8% versus 12.8%, pχ2 <0.001, and women more often than men: 23.3% vs. 12.0%, pχ2 <0.001. Frequency of MS in Russian women (34.9%) was signifi cantly higher compared to Russian men (14.3%, pχ2 = 0.001), while the Chuvash women (16.0%) higher than the Chuvash men (8.0 %, pχ2 <0.001). Conclusions: the prevalence of obesity and MS in the Chuvash Republic is dependent on gender (women more than men) and nationality (in Russian more than the Chuvash). Low incidence of obesity in the Chuvash causes and lesser prevalence of MS in the Chuvash compared to Russian.
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( Ivanovna Maria Sviridova ),( Ashot Mkrtumyan ),( Svetlana Podzchina ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To study the effects of GLP-1 mimetic exenatide on diastolic and endothelial function, markers of cardiovascular risk in patients with type 2 diabetes. Methods: In 70 patients with type 2 diabetes were studied echocardiography, parameters of diastolic function (E and A), endothelial function by test with postocclusive reactive hyperemia, the level of HbA1c, lipid profi le, markers of cardiovascular risk: C-reactive protein (CRP), tumor necrosis factor - alpha (TNF), N-terminal propeptide natriuretic hormone (NT-ProBNP), anthropometric indices. Patients were divided randomly randomization into 2 groups: the main - 50 people to oral hypoglycemic drugs was added GLP-1 mimetic exenatide, comparison group - 20 people continued to receive prior glucose-lowering therapy. The study lasted 26 weeks. Results: Indicators of diastolic and endothelial function improved in the main group receiving exenatide. Indicator E / A increased from 0,8 ± 0,2 to 0,9 ± 0,2 (P = 0,01). There is a tendency to increase brachial artery diameters after occlusion of 3.6% to 4.8% (P = 0.3). Only in the main group received reducing markers of cardiovascular risk: CRP 0.5 mg / dL to 0.3 mg / dL (P = 0.0002), there is a tendency to reduce TNF-alpha from 9.4 pg / ml to 8.6 pg / ml (P = 0.2). Level of NT-ProBNP unchanged in both groups. In the main group achieved signifi cant improvement in carbohydrate metabolism, lipid parameters, weight loss patients at 6 kg. Conclusions: GLP-1 mimetic (exenatide) has a benefi cial effect on the condition of markers of cardiovascular risk, improves endothelial and diastolic function that allows the use of the drug for the correction of cardiovascular disorders, that observed in the majority of patients with type 2 diabetes.
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