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오늘 본 자료
Sang-Ik Oh,Ha-Young Kim,Jae-Won Byun,Myungju Chae,Jong Ho Kim,Yu-Ran Lee,Bun Seung Jo,Ji-Sun Yoon,Jong Wan Kim 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.1
The seroprevalence of major infectious abortion agents was investigated in native Korean goats from Jeonnam province using ELISA. A total of 98 blood samples were collected from goats. Overall, 48 (49.0%), 11 (11.2%), and 1 (1.0%) serum samples tested positive for C. burnetii, T. gondii, and C. abortus, respectively, while none of the samples were positive for B. abortus or N. caninum. Moreover, a PCR assay conducted to detect C. burnetii antigens in goats with a history of abortion revealed 18 (38.3%) of 47 goats were C. burnetii positive by both the ELISA and PCR assay.
( Sung Bum Cho ),( Jong Sun Rew ),( Sung Young Park ),( Hyeng Chen Park ),( Kyeong Won Yoon ),( Seok Cho ),( Wan Sik Lee ),( Chang Hwan Park ),( Hyen Soo Kim ),( Sung Kyu Choi ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: Rectal carcinoid has been increasingly detected due to the recent wide use of colonoscopy for routine health examination. Although endoscopic resection should be considered as the treatment for rectal carcinoid, the scar formation after colonoscopic biopsy can lead to unpredicted difficulty in this procedure. This study evaluates the per-procedure findings and treatment results in an attempt to elucidate the effect of scar formation after colonoscopic biopsy in endoscopic resection for rectal carcinoid. Methods: Twelve cases of rectal careinoid with scar formation were compared with 18 non-scar cases, which were treated using the endoscopic resection from January 2002 to August 2007, in terms of the endoscopic findings, resection methods and treatment results. Results: The differences in the clinical findings and tumor size between the scar group and the non-scar group were nonspecific. The average waiting-time between biopsy and resection was shorter (13±16 vs 42±26 ds; p=0.11) in the scar group. During endoscopic resection, small active ulcer was found in 4 scar cases with lesser than 7 days of waiting-time. The risk of limited elevation after submucosal injection was higher (83% vs 44%, p=0.03) in the scar group. In resection methods, ESD was frequently adopted in the scar group (4 cases vs 1 case). The difference in the result of pathologic complete resection between two group were nonspecific. Four patients in the scar group should be admitted (vs 1 case in the non-scar group). Conclusions: ESD technique should be considered in selected cases, because of the postbiopsic scar can block the submucosal elevation in endoscopic resection for rectal carcinoid.
Wan Seok Song,Sung-il Yoon 한국구조생물학회 2016 Biodesign Vol.4 No.4
Flagellin constitutes the flagellar filament that provides bacteria with locomotion and allows pathogens to invade the host tissue as a virulence factor. The N-terminal and C-terminal domains of flagellin are functionally important in filament formation and are highly conserved across diverse bacterial species. In the host, the conserved flagellin of pathogenic bacteria activates the innate immune receptors, including Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4), and functions as a pathogen-associated molecular pattern that alarms the host immune system. Recently, an array of structural studies has revealed flagellin-mediated immune receptor activation mechanisms, which can provide deep insights into the development of immune-modulating vaccines and therapeutics. In this review, we explain the biological functions and structural properties of flagellin in filament formation and immune activation and describe the application of flagellin to vaccine and drug development.
SUNG SOON JANG,SUNG-WOO KWAK,HOSIK YOO,JUNG-SOO KIM,WAN KI YOON 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.5
A vulnerability assessment is essential for the efficient operation of a physical protection system (PPS). Previous assessment codes have used a simple model called an adversary sequence diagram. In this study, the use of a twodimensional (2D) map of a facility as a model for a PPS is suggested as an alternative approach. The analysis of a 2D model, however, consumes a lot of time. Accordingly, a generalized heuristic algorithm has been applied to address this issue. The proposed assessment method was implemented to a computer code; Systematic Analysis of physical Protection Effectiveness (SAPE). This code was applied to a variety of facilities and evaluated for feasibility by applying it to various facilities. To help upgrade a PPS, a sensitivity analysis of all protection elements along a chosen path is proposed. SAPE will help to accurately and intuitively assess a PPS.
Yoon, Wan-Hee,Song, In-Sang,Lee, Byung-Hak,Jung, Yeon-Ju,Kim, Tae-Dong,Li, Ge,Lee, Taek-Gu,Park, Hae-Duck,Lim, Kyu,Hwang, Byung-Doo 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-
Vimentin is a growth-related gene and often expressed when epithelial cells are stimulated to proliferate by growth factors. In cancer, vimentin expression is associated with a dedifferentiated malignant phenotype, increased motility, invasive ability and poor prognosis. We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells. TPA showed marked induction of vimentin mRNA, while RA decreased the mRNA level. TPA or RA did not affect cell proliferation, cell-matrix prolein adhesion, and matrix metalloproteinases and urokinase plasminogen activator activities. In vitro invasion ability was significantly increased or decreased with TPA or RA treatment, paralleled to the in vitro motile activity, respectively. These findings suggest that TPA and RA could modulate the invasive potential of Hep 3B cells by altering cellular motility related to differential regulation of vimentin mRNA.
Physical Health Literacy and Health-related Behaviors in Patients with Psychosis
Sung-Wan Kim,Woo-Young Park,Min Jhon,Mina Kim,Ju-Yeon Lee,Seon-Young Kim,Jae-Min Kim,Il-Seon Shin,Jin Sang Yoon 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: This study compared the levels of knowledge of physical illnesses and patterns of health behaviors between patients with psychosis and the general population. Methods: A total of 712 participants were included in the study; 292 patients with a schizophrenia spectrum disorder and 420 healthy controls matched for age and gender. Questionnaires were administered to study participants to determine the level of knowledge of chronic physical illnesses such as cancer, hypertension, and diabetes mellitus and health-related behavior. Results from the two study groups were compared to identify differences in knowledge of physical illness and health-related behaviors. Results: Compared with healthy controls, patients with psychosis were less likely to undergo regular medical check-ups and engage in exercise. Patients with psychosis had poorer knowledge of physical illnesses, and were more likely to smoke, be overweight, or have diabetes. Patients with psychosis were significantly less likely to acknowledge the importance of early detection of cancer and controlling hypertension and diabetes, independent of education and type of medical insurance. Patients who smoked were significantly less likely to agree with the statement on the relationship between smoking and physical illnesses. Patients not undergoing regular medical check-ups were significantly less likely to agree with statements concerning the need for cancer screening. Conclusion: Patients with psychosis demonstrated lower levels of knowledge of physical illnesses and a lack of understanding of preventive behaviors. Low levels of knowledge were associated with poor health-related behaviors. Education of physical health should be provided to patients with psychosis.
Yoon, Wan-Hee,Jung, Yeon-Joo,Kim, Tae-Dong,Li, Ge,Park, Byoung-Jeon,Kim, Ji-Yeon,Lee, Young-Chul,Kim, Jim-Man,Park, Jong-Il,Park, Hae-Duck,No, Zae-Sung,Lim, Kyu,Hwang, Byung-Doo,Kim, Young-S 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-
Gabexate mesilate (GM), a synthetic protease inhibitor, has an antiproteinase activity on various types of plasma serine proteases. However, its role on matrix metalloproteinases (MMPs) has not been identified. In this study, we investigated the effect of GM on MMPs and on the invasion and metastasis of human colon cancer cell lines and neoangiogenesis. The activities of MMPs secreted from these cells were significantly reduced by GM but unaffected by the serine protease inhibitor aprotinin. GM directly inhibited purified progelatinase A derived from T98G human glioblastoma cells. In vitro, GM significantly reduced the invasive ability of colon cancer cells but not cellular motility, whereas aprotinin affected neither. Liver metastatic ability and tumorigenic potential in nude mice were remarkably reduced on treatment with GM. Immunohistochemical analysis of GM-treated tumors in mice showed a marked increase in apoptosis and a significant reduction in tumor angiogenesis. Human umbilical vein endothelial cell proliferation, tube formation, and neoangiogenesis in the rabbit cornea and Matrigel implanted in mice were significantly inhibited by GM. These results suggest that GM is a novel inhibitor of MMPs and that it may inhibit the invasion and metastasis of human colon cancer cells by blocking MMPs and neoangiogenesis.