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졸-겔법으로 제조한 ZrO_2·SiO_2계 결정화 유리의 결정화 및 파괴인성에 관한 연구
신대용,한상목,강위수 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A
Precursor gels with the composition of xZrO_2·(100-x)SiO_2 systems (x=10,20 and 30mol%) were prepared by the sol-gel method. Kinetic parameter, such as activation energy, Avrami's exponent, n, and dimensionality crystal growth value, m, have been simultaneously calculated from the DTA data using Kissinger and Matusita equations. The crystallite size dependence on tetragonal to monoclinic transformation of ZrO_2 was investigated using XRD, in relation to the fracture toughness. The crystallization of tetragonal ZrO_2 occurred through 3-dimensional diffusion controlled growth(n=m=2) and the activation energy for crystallization was calculated using Kissinger and Matusita equations, as about 310∼325±10kJ/mol. The growth of t-ZrO_2, in proportion to the cube of radius, increased with increasing heating temperature and heat-treatment time. It was suggested that the diffusion of Zr4+ions by Ostwald ripening was rate-limiting process for the growth of t-ZrO_2 crystallite size. The fracture toughness of xZrO_2·(100-x)SiO_2 systems glass ceramics increased with increasing crystallite size of t-ZrO_2. The fracture toughness of 30ZrO_2·70SiO_2 system glass ceramics heated at 1,100℃ for 5h was 4.84 MPam^1/2 at a critical crystaliite size of 40 nm.
박지은,정연재,박준범,김혜영,유영현,이광식,양원태,김도훈,김종민 한국발생생물학회 2019 발생과 생식 Vol.23 No.3
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic BKS.Cg-m+/+Leprdb mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPFfed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.
Wie Sung Hwan Military Operations Research Society of Korea 1984 한국국방경영분석학회지 Vol.10 No.2
Consider an m machine flow shop with blocking. The processing time of job j,j=1,..., n on each one of the m machines is equal to the same random variable $X_j$ and is distributed according to $F_i$. We assume that the processing times are stochastically ordered, i.e., $F_{1_{-st}}{<}F_{2_{st}}{<}cdots_{-st}{<}F_n$. We show that the sequence 1,3,5,...,n-1,n,n-2,...,6,4,2 when n is even and sequence 1,3,5,...,n-2,n,n-1 ... 6,4,2 when n is odd minimizes the expected makespan and that the sequence 1,...,n minimizes the expected flow time.
Wie, Jinhong,Kim, Byung Joo,Myeong, Jongyun,Ha, Kotdaji,Jeong, Seung Joo,Yang, Dongki,Kim, Euiyong,Jeon, Ju-Hong,So, Insuk TaylorFrancis 2015 Channels Vol.9 No.4
<P>TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα<SUB>i/o</SUB> and Gα<SUB>q</SUB> protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.</P>
Wie, Gyung-Ah,Cho, Yeong-Ah,Kang, Hyun-hee,Ryu, Kyoung-A,Yoo, Min-Kyoung,Kim, Young-A,Jung, Kyu-Won,Kim, Jeongseon,Lee, Joo-Hyuk,Joung, Hyojee Cambridge University Press 2014 The British journal of nutrition Vol.112 No.2
<P>Cancer is a leading cause of death, and the dietary pattern in Korea is changing rapidly from a traditional Korean diet to a Westernised diet. In the present study, we investigated the effects of dietary factors on cancer risk with a prospective cohort study. Among 26 815 individuals who participated in cancer screening examinations from September 2004 to December 2008, 8024 subjects who completed a self-administered questionnaire concerning demographic and lifestyle factors, and a 3 d food record were selected. As of September 2013, 387 cancer cases were identified from the National Cancer Registry System, and the remaining individuals were included in the control group. The hazard ratio (HR) of cancer for the subjects older than or equal to 50 years of age was higher (HR 1·80, 95 % CI 1·41, 2·31; <I>P</I>< 0·0001) than that for the other subjects. Red meat consumption, Na intake and obesity (BMI ≥ 25 kg/m<SUP>2</SUP>) were positively associated with overall cancer incidence in men (HR 1·41, 95 % CI 1·02, 1·94; <I>P</I>= 0·0382), gastric cancer (HR 2·34, 95 % CI 1·06, 5·19; <I>P</I>= 0·0365) and thyroid cancer (HR 1·56, 95 % CI 1·05, 2·31; <I>P</I>= 0·0270), respectively. Participants who had at least three dietary risk factors among the high intakes of red meat and Na, low intakes of vegetables and fruits, and obesity suggested by the World Cancer Research Fund/American Institute for Cancer Research at baseline tended to have a higher risk of cancer than the others (HR 1·26, 95 % CI 0·99, 1·60; <I>P</I>= 0·0653). In summary, high intakes of red meat and Na were significant risk factors of cancer among Koreans.</P>
ENSO-related PM10 variability on the Korean Peninsula
Wie, Jieun,Moon, Byung-Kwon Elsevier 2017 Atmospheric environment Vol.167 No.-
<P>Particulate matter, defined as particles of less than 10 mu m in diameter (PM10), was analyzed over the Korean Peninsula from 2001 to 2015 to examine the influence of the El Nino-Southern Oscillation (ENSO) on subseasonal PM10 variability. The PM10 data were obtained from 151 air quality monitoring stations provided by the Korea Environment Corporation (KECO). Lead-lag correlation analysis, which was performed to investigate the connection between NDJF (November-February) NINO3 index and seasonal mean PM10 data, did not yield any statistically significant correlations. However, using five-pentad moving-averaged PM10 data, statistically significant correlations between NDJF NINO3 index and PM10 variability were found in four subseasonal periods, with alternating positive and negative correlations. In the periods during which PM10 levels on the Korean Peninsula were positively (negatively) correlated with the ENSO index, the positive PM10 anomalies are associated with El Nino (La Nina) years, which implies that the occurrence of high-PM10 events could be modulated by the ENSO phase. In addition, this ENSO-related PM10 variation is negatively correlated with ENSO-related precipitation in the Korean Peninsula, indicating that more (less) wet deposition leads to lower (higher) PM10 level. Therefore, we conclude that the ENSO-induced precipitation anomalies over the Korean Peninsula are mainly responsible for ENSO-related PM10 variations. This study will be helpful for further identifying detailed chemistry-climate processes that control PM10 concentrations. (C) 2017 The Author(s). Published by Elsevier Ltd.</P>
Tunnel-Free Scheme Using a Routing Table in a PMIPv6-Based Nested NEMO Environment
Wie, Sunghong,Jang, Jaeshin The Korea Institute of Information and Commucation 2013 Journal of information and communication convergen Vol.11 No.2
In this paper, we propose a novel tunnel-free scheme in a proxy mobile IPv6 (PMIPv6)-based nested network mobility environment; several mobile nodes (MNs) and mobile routers (MRs) compose a hierarchical wireless network topology. Because tunnels created by several MRs overlap and data packets travel along several local mobility anchors (LMAs), the utilization of the wireless section is reduced and the packet forwarding path of the wire-line section is not optimal. In our tunnel-free scheme, the mobile access gateway (MAG) plays an important role in both the wireless and wire-line sections. Using a local binding update, this tunnel-free scheme forwards data packets with a host-based routing table without any tunnel. Establishing a direct tunnel between the MAG and the last LMA, this scheme removes nested tunnels between intermediate LMAs and MRs, and optimizes the forwarding path to the MN in the wire-line section.