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      • Dynamic Interaction System Design of Urban Landscape Information Based on PHP Technology

        Wang Shun-Hui,Zou Jie 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.6

        In the transitional period of Urbanization, the urban landscape and its aesthetical experience became one of research priorities. Design and develop professional interactive information system is one of the most important thing for urban landscape design. The research uses PHP as core technology, uses DW which is the integration of MySQL-related technologies as developing tools, to set up a integrated system platform based on Apache, MySQL and PHP. It is a dynamic interactive information system of urban landscape based on Web technologies. This article described the structure and functions of the system, explained design methods of the database and application. The construction and application of the system can integrate landscape information of the transitional period of Urbanization, such as item information, engineering information, education information and artistic information, offer a human-machine interactive communication platform based on P2P mode (point-to-point). It will become innovative power for the development of urban landscape industry.

      • Development and Design of Ice and Snow Landscape System Based on Network and Information Technology

        Wang Shun-hui,Lin Xue-wei 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.1

        Ice and Snow Art Landscape is unique urban landscape form in cold region. It is also artistic form reflecting the regional characteristics and cultural connotations as the symbol of the city. It has the important meaning for urban tourism industry and related industries. The construction of Urban Ice and Snow Art Landscape Information Database is an important channel promoting the development of Urban Ice and Snow Art. The research is based on modern network information technology, taking Urban Ice and Snow Art Landscape as research object. It puts forward on idea constructing Urban Ice and Snow Art Landscape Information Database, and design system architecture in the background using the technology of database, front design using DW, including Data Dictionary, E-R model, SQL, PHP and WEB publish. The development and Application of Urban Ice and Snow Art Landscape Information Database, is very necessary for the great-leap-forward development of Urban Ice and Snow Art Landscape.

      • Design and Implementation of Online Mobile Game based on J2ME

        WANG Shun-hui,ZOU Jie 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.7

        Online mobile game is a hot industry. It is a comprehensive industry including program design, planning and art design. This paper analyzed JAVA program and mainstream game development environment, then developed a mobile game based on J2ME, including modeling design,architecture design, class.

      • KCI등재

        MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort

        Hui Han,Chenghua Han,Yu-Hong Wang,Ting-Ting Sun,Feng-Qing Li,Junxiao Wang,Shan-Shun Luo,Guang-Jin Qu 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-

        The aim of this study was to investigate the expression of circulating microRNAs (miRNAs) in apolipoprotein E (apoE) knockout mice (apoE− / −) and to validate the role of these miRNAs in human coronary artery disease (CAD). Pooled plasma from10 apoE− / − mice and 10 healthy C57BL/6 (B6) mice was used to perform the microarray analysis. The results showed that miR-34a, miR-21, miR-23a, miR-30a and miR-106b were differentially expressed in apoE− / − mice, and these expression changes were confirmed by real-time quantitative reverse-transcription PCR. Then, miR-34a, miR-21, miR-23a, miR-30a and miR-106b were detected in the plasma of 32 patients with CAD and of 20 healthy controls. Only miR-34a, miR-21 and miR-23a were significantly differentially expressed in the plasma of CAD patients (all Po0.01). In conclusion, miR-34a, miR-21 and miR-23a were elevated in CAD patients, which means that these miRNAs might serve as biomarkers of CAD development and progression.

      • KCI등재

        Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform

        Hui Han,Wei Jiang,Yu-Hong Wang,Guang-Jin Qu,Ting-Ting Sun,Feng-Qing Li,Shan-Shun Luo 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.3

        The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary microarray platforms applying cross-verification methodology. A screening platform was established using both miRNA and genomic microarrays. Microarray analysis was then simultaneously performed on pooled atherosclerotic aortic tissues from 10 Apolipoprotein E (apoE) knockout mice (apoE/) and 10 healthy C57BL/6 (B6) mice. Differentiated miRNAs were screened and cross-verified against an mRNA screen database to explore integrative mRNA–miRNA regulation. Gene set enrichment analysis was conducted to describe the potential pathways regulated by these mRNA–miRNA interactions. High-throughput data analysis of miRNA and genomic microarrays of knockout and healthy control mice revealed 75differentially expressed miRNAs in apoE/ mice at a threshold value of 2. The six miRNAs with the greatest differentiation expression were confirmed by real-time quantitative reverse-transcription PCR (qRT–PCR) in atherosclerotic tissues. Significantly enriched pathways, such as the type 2 diabetes mellitus pathway, were observed by a gene-set enrichment analysis. The enriched molecular pathways were confirmed through qRT–PCR evaluation by observing the presence of suppressor of cytokine signaling 3 (SOCS3) and SOCS3-related miRNAs, miR-30a, miR-30e and miR-19b. Cross-verified highthroughput microarrays are optimally accurate and effective screening methods for miRNA regulation profiles associated with atherosclerosis. The identified SOCS3 pathway is a potentially valuable target for future development of targeted miRNA therapies to control atherosclerosis development and progression.

      • KCI등재

        Gonadotropins Improve Porcine Oocyte Maturation and Embryo Development through Regulation of Maternal Gene Expression

        Wang, Qing-Ling,Zhao, Ming-Hui,Jin, Yong-Xun,Kim, Nam-Hyung,Cui, Xiang-Shun The Korean Society of Embryo Transfer 2013 한국동물생명공학회지 Vol.28 No.4

        The present study assessed the effect of FSH and LH on oocyte meiotic, cytoplasmic maturation and on the expression level and polyadenylation status of several maternal genes. Cumulus-oocyte complexes were cultured in the presence of FSH, LH, or the combination of FSH and LH. Significant cumulus expansion and nuclear maturation was observed upon exposure to FSH alone and to the combination of FSH and LH. The combination of FSH and LH during entire IVM increased the mRNA level of four maternal genes, C-mos, Cyclin B1, Gdf9 and Bmp15, at 28 h. Supplemented with FSH or LH significantly enhanced the polyadenylation of Gdf9 and Bmp15; and altered the expression level of Gdf9 and Bmp15. Following parthenogenesis, the exposure of oocytes to combination of FSH and LH during IVM significantly increased cleavage rate, blastocyst formation rate and total cell number, and decreased apoptosis. In addition, FSH and LH down-regulated the autophagy gene Atg6 and upregulated the apoptosis gene Bcl-xL at the mRNA level in blastocysts. These data suggest that the FSH and LH enhance meiotic and cytoplasmic maturation, possibly through the regulation of maternal gene expression and polyadenylation. Overall, we show here that FSH and LH inhibit apoptosis and autophagy and improve parthenogenetic embryo competence and development.

      • Study on Individualized Network Teaching Model Based on Intelligent Agent Technology

        ZOU-Jie,WANG Shun-hui 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.1

        From the perspective of modern cognitive science, firstly the theoretical model of network teaching is analyzed, and then an individualized network teaching model based on intelligent agent technology. Finally, implementation strategies of individualized network teaching will be discussed.

      • KCI등재

        Vibration control of a stay cable with a rotary electromagnetic inertial mass damper

        Zhi Hao Wang,Yan Wei Xu,Hui Gao,Zheng Qing Chen,Kai Xu,Shun Bo Zhao 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6

        Passive control may not provide enough damping for a stay cable since the control devices are often restricted to a low location level. In order to enhance control performance of conventional passive dampers, a new type of damper integrated with a rotary electromagnetic damper providing variable damping force and a flywheel serving as an inertial mass, called the rotary electromagnetic inertial mass damper (REIMD), is presented for suppressing the cable vibrations in this paper. The mechanical model of the REIMD is theoretically derived according to generation mechanisms of the damping force and the inertial force, and further validated by performance tests. General dynamic characteristics of an idealized taut cable with a REIMD installed close to the cable end are theoretically investigated, and parametric analysis are then conducted to investigate the effects of inertial mass and damping coefficient on vibration control performance. Finally, vibration control tests on a scaled cable model with a REIMD are performed to further verify mitigation performance through the first two modal additional damping ratios of the cable. Both the theoretical and experimental results show that control performance of the cable with the REIMD are much better than those of conventional passive viscous dampers, which mainly attributes to the increment of the damper displacement due to the inertial mass induced negative stiffness effects of the REIMD. Moreover, it is concluded that both inertial mass and damping coefficient of an optimum REIMD will decrease with the increase of the mode order of the cable, and oversize inertial mass may lead to negative effect on the control performance.

      • KCI등재

        Gonadotropins Improve Porcine Oocyte Maturation and Embryo Development through Regulation of Maternal Gene Expression

        Qing-Ling Wang,Ming-Hui Zhao,Yong-Xun Jin,Nam-Hyung Kim,Xiang-Shun Cui 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.4

        The present study assessed the effect of FSH and LH on oocyte meiotic, cytoplasmic maturation and on the expression level and polyadenylation status of several maternal genes. Cumulus-oocyte complexes were cultured in the presence of FSH, LH, or the combination of FSH and LH. Significant cumulus expansion and nuclear maturation was observed upon exposure to FSH alone and to the combination of FSH and LH. The combination of FSH and LH during entire IVM increased the mRNA level of four maternal genes, C-mos, Cyclin B1, Gdf9 and Bmp15, at 28 h. Supplemented with FSH or LH significantly enhanced the polyadenylation of Gdf9 and Bmp15; and altered the expression level of Gdf9 and Bmp15. Following parthenogenesis, the exposure of oocytes to combination of FSH and LH during IVM significantly increased cleavage rate, blastocyst formation rate and total cell number, and decreased apoptosis. In addition, FSH and LH down-regulated the autophagy gene Atg6 and upregulated the apoptosis gene Bcl-xL at the mRNA level in blastocysts. These data suggest that the FSH and LH enhance meiotic and cytoplasmic maturation, possibly through the regulation of maternal gene expression and polyadenylation. Overall, we show here that FSH and LH inhibit apoptosis and autophagy and improve parthenogenetic embryo competence and development.

      • KCI등재

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