High pressure NMR of ubiquitin

Schick, Martin Christopher Eidgeno@ssische Technische Hochschule Zu@rich 1998 국내박사

Meaning, truth, and belief : an inquiry into the natures of propositions and states of affairs

Schick, Theodore William University Microfilms International A Bell & Howel 1981 국내박사

Lessons for the future? Prophecy and policy in speculative bioethics

Schick, Ari Michigan State University 2014 해외박사(DDOD)

For more than a decade, the field of bioethics has increasingly turned its attention to wide-ranging discussions of possible future biotechnologies, such as those that might be used to determine the genetic endowments of future offspring or to enhance existing people. Yet while the literature on human biomedical enhancement has become a focal point of bioethical debate, few of the technologies that stimulate this discourse have reached the point where they actually generate the ethical questions that the literature addresses. This study offers a comprehensive analysis and critique of speculative bioethics that builds on existing conceptualizations of two parallel modes of bioethical discourse (prophetic and regulatory), and draws from literature outside of bioethics that examines the social function of expectations regarding future technologies. I begin by tracing various developments in bioethics that have given rise to the enhancement discourse in its present form and survey some of the existing criticism that it has drawn. I demonstrate the ways in which speculative bioethics goes wrong when exploring potential future technologies and scenarios, and evaluate the utility of anticipatory bioethics research that attempts to get ahead of expected future technological developments. In the course of developing a robust theory of the nature and function of the prophetic and regulatory aspects of bioethics, I establish that speculative explorations belong within the domain of the prophetic, not regulatory, mode of bioethics. I expand the critique by examining the roles that technological expectations play in driving both biomedical research as well as public engagement with ethical issues in biomedicine. I argue that many existing ethical explorations of possible future technological scenarios mistakenly identify the object of ethical analysis as the actual possible future. Instead, it is the expectations that drive public discussion and research agendas that are the proper object of scrutiny and analysis. After probing the nature of this shortcoming and its consequences, I enlist alternative approaches that are capable of critically assessing the moral implications of technological expectations themselves. Finally, I develop an integrated approach for exploring the possible future technological scenarios found in speculative bioethics. Drawing on work in narrative ethics and the interface between literature and bioethics, I offer a multifaceted model of `narrative competence,' appropriate for analyzing the existing literature on human enhancement, as well as for pursuing alternatives that could better advance useful modes of bioethical discourse and public deliberation.

Strategies for Reducing Voluntary Employee Turnover in Call Centers

Schick, Holly R Walden University ProQuest Dissertations & Theses 2020 해외박사(DDOD)

Call center business leaders who experience voluntary employee turnover are affected by low productivity and high attrition. Call center business leaders are concerned about voluntary employee turnover, as 35 of every 100 call center employees leave the company within the first 6 months of their start date. The purpose of this qualitative multiple case study was to explore strategies call center business leaders use to reduce voluntary employee turnover among several call center managers located in Southeastern New Mexico. The conceptual framework supporting this study was Burns’ transformational leadership theory. The participants included 3 call center business leaders who successfully implemented strategies reducing voluntary employee turnover. Data collection included face-to-face interviews, open-ended questions, and audio recordings. Data were analyzed using Yin’s 5-stage method of qualitative data analysis. Five themes that emerged from this study were: employee turnover, job satisfaction, training and development, employee compensation, and reward and recognition. Business leaders in call center organizations who positively reduce voluntary employee turnover may influence productivity, improve organizational growth, and increase job satisfaction. Business leaders can use the findings from this study to create a positive social change in call center business leaders’ awareness of retention strategies by focusing on the organizations’ performance. Organization leaders who reduce voluntary employee turnover could potentially lead employees to long-term growth and development career opportunities that can affect social change to benefit the behaviors of the company’s employees and families in the community.

On becoming a "better person": Language socialization from modality to morality in middle school dance classes

Schick, Laurie Susan University of California, Los Angeles 2005 해외박사(DDOD)

The basic question being asked in this dissertation is: How are linguistic, embodied and interactional practices being used in these dance classes to socialize students not only into becoming 'good dancers' but also into becoming 'good people'? In addition this dissertation is asking whether the data analyzed here supports the hypothesis that: modal and indexical is particularly suited to socializing social-moral values and practices especially among older children and adolescents. Data collection involved the observation and videotaping of approximately 65 hours of dance class interaction. In addition data collection included informal interviewing of participants and the collection of artifacts such as copies of student journals, assignments, etc. Data analysis is qualitative and focuses primarily on the micro-analysis of videotaped interactions using primarily techniques associated not only with language socialization studies but also with: (a) linguistic analysis; (b) discourse and conversation analysis; (c) the multi-modal analysis of embodied actions; and (d) the analysis of specific classroom interactions. In addition macro-analytic techniques were used to (a) identify those cultural values and practices commonly expressed and enacted by members of the communities in which these interactions take place and (b) examine whether and how the specific sequences examined here may be socializing moral values, decision making and action taking among the students in Mr. B's classrooms. The language socialization practices analyzed provide evidence that modal and indexical language is being used in conjunction with embodied and classroom interaction to socialize social-moral values. The interactions analyzed in this dissertation suggest: (a) that the meanings of moral domain words such as 'good,' 'lying,' 'cheating,' and 'blame' are intersubjectively constructed through language socialization practices; (b) that modal verbs such as 'want' can be used to socialize imitative learning, empathy and responsibility; and (c) that language can be used not only to verbally bully but also to intervene by reframing social identities and relationships during the course of social interaction.

Examining the vulva: The relationship between female genital aesthetic perceptions and gynecological care

Schick, Vanessa R The George Washington University 2010 해외공개박사

Despite the known benefits of gynecological exams, women's concerns about displaying their genitalia may function as a deterrent to care. While little is known about women's genital perceptions, the current rise of female genital cosmetic surgeries suggests that women may be dissatisfied with the deviation of their vulva from a uniform appearance ideal. Thus, the current study investigated the construction of this ideal and the relationship to gynecological care. Specifically, the current study tested a path through which exposure to either a constrained or varied vulva picture set would differentially activate a concatenation of cognitions and emotions that would, in turn, predict gynecological care perceptions and intentions. Young, undergraduate women (N=485) completed the on-line survey at a computer of their choosing. Contrary to the hypothesis, picture set exposure was unrelated to vulva perceptions. However, as predicted, young women's genital perceptions were significantly related to their gynecological care perceptions and intentions.

Loss of the beta(1) integrin subunit in F9 teratocarcinoma cells reveals modulation of alpha(v) family integrin receptor affinity by beta(1), diminished metastatic capacity, and defects in random migration

Schick, Suzaynn Francine University of California, San Francisco 2001 해외박사(DDOD)

Integrin heterodimers mediate cell interactions with extracellular matrix and other cells. Two major integrin families: α_v and β₁, have been identified on the basis of their ability to partner with several β subunits or several α subunits, respectively. To distinguish the roles of these families, the β₁ subunit was mutated by gene targeting in F9 teratocarcinoma stem cells, thereby eliminating the function of all β₁ associated heterodimers in these cells and their parietal endoderm (PE) differentiated counterparts. The function of α_v family integrins was preserved in these cells (named TKO). Deletion of β₁ integrins eliminated adhesion of TKO and TKO-PE cells to, and migration on, collagens, laminin and fibronectin. Furthermore, TKO-PE cells, were unable to organize a fibrillar fibronectin matrix. In contrast, adhesion of TKO and TKO-PE to vitronectin was not only preserved, but substantially enhanced. Surprisingly, however, migration by TKO cells on vitronectin was suppressed. The altered adhesion and migration properties of TKO translated to reduced ability of TKO to metastasize from the spleen to the liver in vivo. Several possible mechanisms were tested that might explain how loss of β₁ integrins, which do not recognize vitronectin in these cells, leads to enhanced adhesion of TKO and TKO-PE to vitronectin. No differences were found in the levels of α_v family integrins on control F9, F9-PE, TKO or TKO-PE. In addition, each α_v family member expressed on F9 made the same percentage contribution to the overall adhesion to vitronectin as it did in TKO cells. To determine whether the intrinsic affinity of the α_v integrins for vitronectin was altered in TKO cells, adhesion assays were conducted at 4°C so as to compare initial binding strength independently of post-attachment strengthening. In this assay, TKO and TKO-PE still showed enhanced binding to vitronectin. Thus, loss of β₁ integrins results in an increased affinity of α_v family integrins for their major substrate, vitronectin. This is a novel example of transdominant inhibition of one integrin by another. Such integrin cross-talk may be regulated by cytoplasmic proteins that bind to the β₁ subunit specifically. In the absence of β₁, this signaling mechanism would be eliminated.

A Critical Writing Pedagogy Toward Mental Health: Novice Teachers and Collective Memory Work

Schick, Anna University of Minnesota ProQuest Dissertations & T 2023 해외박사(DDOD)

Trauma studies in education (Dutro & Bien, 2015) emphasize that while teachers and students may experience acute traumatic events, they are also subjected to the ongoing trauma of institutional spaces that attempt to bracket the emotional from the cognitive. This study engages novice teachers in critical writing pedagogy to examine what teaching is doing to teachers. To engage in critical writing pedagogy, novice teachers participated in collective memory work (Haug, 1999) to write and analyze memories from teaching.Critical writing pedagogy is an urgent area of study. Defined as an approach to teaching writing that engages cognitive, sociocultural, and critical orientations (Kline & Kang, 2022), critical writing pedagogy is necessarily evolving and contextualized (Kamler, 2001; Anzaldua, 1987). This interpretative study (Erickson, 1986) analyzes novice teachers' engagement with artifacts, collective analysis, and "rewrite questions" to theorize what is possible in a critical writing pedagogy toward mental health.This study is significant because of the way critical writing pedagogy revealed the mental health of the novice teachers to them. Findings demonstrate how artifacts interrupted self-gaslighting, the tendency to minimize or suppress the trauma, pain, or uncertainty (Bendt, 2020). Collective analysis invited introspection, generated consensus, and called out the unreasonable. The outcome of "rewrite questions" is interpreted as a space for addressing discomfort (Kumashiro, 2002) and unsettling emotions such as resentment. Informed by a framework of critical writing pedagogy according to Kamler (2001) and Anzaldua (1987), this study highlights how relocating the personal and sustaining contradictions with a collective can increase the visibility and accessibility of mental health. .

The subversion of neo-stoicism and skepticism in "Part I" of "Don Quijote"

Lorca, Daniel Schick The University of Chicago 2010 해외박사(DDOD)

According to the overwhelming majority of critics don Quijote was read as a fool during the Golden Age. At the same time, many critics have shown that Cervantes was very familiar with neo-stoicism and skepticism; therefore, it is a worthy enterprise to discover the extent to which Cervantes subverted both doctrines when he gave life to the knight. This is a worthy goal because if we know how Cervantes subverted both philosophical systems, then we obtain a reading of the text that approximates the kind of reading that would have been popular during the Golden Age. In short, in this work I explain how the text was read during the Golden Age in relation to two very popular systems of the time: skepticism and neo-stoicism. In today's critical opinions it is common to conceive don Quijote as someone who is a good Christian to at least some extent, and/or a good stoic, also to at least some extent. But this is not the way in which he was conceived by the readers of the Golden Age: During that period the knight was a nothing but a fool, and given that it is absurd to maintain that good Christians and/or good stoics were fools during the Golden Age, it follows that at that time don Quijote could not have been either; Therefore, there must have been a powerful change after the Golden Age that explains the current positive conceptions of Don Quijote. I will show that this change took place during the Enlightenment (and not during the Romantic period, as it is now currently maintained). I will show as well that the Enlightened approach to don Quijote is still viable because the influence of the Enlightenment continues to be very strong to this day. To sum up, this work explains in detail two possible ways of approaching Part I of Don Quijote: According to the Golden Age the knight is nothing but a fool because he violates the dictates of neo-stoic and skeptical doctrines, and after the Enlightenment it became possible and even reasonable to perceive the knight as morally admirable to at least some extent.