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( Hyejung Kim ),( Sun-hee Kim ),( Mi Seon Kang ),( Park Seok Ju ),( Min Sung An ),( Ki Beom Bae ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury with high morbidity and mortality due to limited therapy. AKI emerges in various clinical settings and is complex with outcome linking oxidative stress, inflammation, and cell death. Therefore protection of AKI is still an unsolved problem. Indomethacin is generally known that it inhibits the production of prostaglandins through the inhibition both cyclooxygenase (COX) 1 and 2. Prostaglandins have a wide variety of effect such as regulation of vasodilation, inflammation, regeneration, pain, fever. Therefore effect of indomethacin in AKI is different according to injury model. We investigated whether indomethacin which inhibits the production of prostaglandins aggravate the renal injury in AKI mouse model. Methods: Male C57/BL6 mice (8-10 weeks old, weight 20~25 g) were used. Acute kidney injury is induced by bilateral kidneys pedicle clamping which were subjected to 20 min or 30 min at both kidneys. Mice were treated with indomethacin at before and after injury. Blood and kidney samples were collected at 24 hr after IRI. The expression level of creatinine, N-gal & Kim-1 were detected in serum. And the expression level of PGE2, cAMP and adenosine were detected in kidney. Kidney Injury score were measured by HE staining and TUNEL. Results: In bilateral AKI model, Serum NGAL level and creatinine level were significantly highest in indomethacin treated group compared to non-treated group (NGAL, p<0.05; creatinine, p<0.01). Indomethacin treated group showed significantly more necrosis and apoptosis compared to non-treated group. Furthermore, Indomethacine inhibited the production of prostaglandins, cAMP and adenosine. Conclusions: Indomethacin inhibits adenosine-mediated renal protection by inhibition of prostaglandin production in AKI. Therefore Indomethacin worsened renal injury by inhibition of prostaglandin production in AKI. * This research was supported by a grant of the Korea Health Technology R&D Project through the KHIDI, funded by the Ministry of Health & Welfare, Republic of Korea (grant number :H15C2212)
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Effects of Exercise Types on BNDF and Cognitive Functions in Middle Aged Women
김유범(Yu-Beom Kim1),김경래(Kyeong-Lae Kim),박성태(Sung-Tae Park) 한국교원대학교 뇌기반교육연구소 2020 Brain, Digital, & Learning Vol.10 No.2
This study is to analyse the impact of two types of exercise on BDNF and cognitive functions in middle aged women. Thirty nine healthy women, aged 50~64 years followed by randomly assigned to a task learning exercise group(n=13), non-task learning exercise group(n=13) and control group(n=13). The TEG performed a dance sports and cognitive band resistance exercise and the NTEG performed a walking and band resistance exercise. Blood sampling and auditory verbal learning test(AVLT) were performed at before exercise, after one bout exercise, and 4 weeks after. As a result, an one bout exercise of moderate intensity on middle aged women was not affected transient change of BDNF significantly regardless of exercise types, but a task-learning exercise was affected positive effect on AVLT. A chronic exercise of moderate intensity for 4 weeks on healthy middle aged women was not affected increasing of basal BDNF levels and memory performance significantly.
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Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats
Jeong, Mi-Hye,Kim, Young-Won,Min, Jeong-Ran,Kwon, Min,Han, Beom-Suk,Kim, Jeong-Gyu,Jeong, Sang-Hee Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.3
Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (${\beta}2m$), glutathione S-transferase alpha (GST-${\alpha}$), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.
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Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats
Mihye Jeong,Young-Won Kim,Jeong-Ran Min,Min Kwon,Beom-Suk Han,Jeong-Gyu Kim,Sang-Hee Jeong 한국독성학회 2012 Toxicological Research Vol.28 No.3
Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-α), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.
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Outcome of Multipair Donor Kidney Exchange by a Web-Based Algorithm
Kim, Beom Seok,Kim, Yu Seun,Kim, Soon Il,Kim, Myoung Soo,Lee, Ho Yung,Kim, Yong-Lim,Kim, Chan Duck,Yang, Chul Woo,Choi, Bum Soon,Han, Duck Jong,Kim, Yon Su,Kim, Sung Joo,Oh, Ha-Young,Kim, Dae Joong American Society of Nephrology 2007 Journal of the American Society of Nephrology Vol.18 No.3
<P>Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.</P>
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( Sang Youn Lim ),( Jong Jae Park ),( Beom Jae Lee ),( Jae Seon Kim ),( Young Tae Bak ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by the downward growth of hyperplastic mucosa into the submucosal layer, usually resembling a submucosal tumor macroscopically. Gastric IHP is diffi cult to diagnose accurately because of its inversion into the submucosal layer, so diagnosed by the pathological characteristics of the tumor. The pathogenesis of gastric IHP remains unclear because reported cases are extremely rare. Here, we present the case of Gastric inverted hyperplastic polyp. Case Report: A 37-year-old male was admitted to our hospital for gastric endoscopic submucosal dissection(ESD). He presented with two-months history of sore throat & heartburn. Physical examination and laboratory data were not remarkable abnormal fi ndings. Endoscopic examination showed a 1. 5cm-sized submucosal mass with central ulceration on greater curve of high body. Endoscopic ultrasonography showed a 1. 5cm-sized, heterogenous echogenic mass originated from submucosal layer. Computed tomography demonstrated a 1. 9cm-sized polypoid lesion on posterior wall of high body in stomach that is suggestive of submucosal tumor such as GIST. On purpose of a diagnosis of gastric submucosal tumor, “En bloc” resection using ESD techniques was performed and the patient was discharged without any complications. The resected specimen, measuring 2. 2*1. 3cm, was a well-circumscribed, protruding mass covered with normal gastric mucosa. Histologically, the lesion consisted of mainly cystic dilated foveloar epithelium and proliferation of smooth muscle. Discussion: Gastric IHP is pathologically defi ned by cystic dilated hypertrophic pseudo- pylorus gland proliferation and smooth muscle located in the submucosal layer. The pathogenesis of Gastric IHP remains unclear because reported cases are extremely rare. Although Gastric IHP is a benign tumor, approximately 20% of it coexist with precancerous or cancerous areas. Therefore, it is important to diagnose these polyps and we suggest En bloc resection using ESD techniques is recommended.
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Kim, Ho-Hyun,Chang, Kyu-Young,Lee, Hee-Joo,Han, Sang-Beom Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.1
A sensitive method for quantitation of glimepiride in human plasma has been established using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS). Glipizide was used as an internal standard. Glimepiride and internal standard in plasma sample was extracted using diethyl etherethyl acetate (1 : 1). A centrifuged upper layer was then evaporated and reconstituted with the mobile phase of acetonitrile-5 mM ammonium acetate (60:40, pH 3.0). The reconstituted samples were injected into a $C_{18}$ reversed-phase column. Using MS/MS in the multiple reaction monitoring (MRM) mode, glimepiride and glipizide were detected without severe interference from human plasma matrix. Glimepiride produced a protonated precursor ion ([M+H]$^+$) at m/z 491 and a corresponding product ion at m/z 352. And the internal standard produced a protonated precursor ion ([M+H]]$^+$) at m/z 446 and a corresponding product ion at m/z 321. Detection of glimepiride in human plasma by the LC-ESI/MS/MS method was accurate and precise with a quantitation limit of 0.1 ng/mL. The validation, reproducibility, stability, and recovery of the method were evaluated. The method has been successfully applied to pharmacokinetic studies of glimepiride in human plasma.
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( Sang Yoon Chung ),( Ja Seol Koo ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Bora Keum ),( Beom Jae Lee ),( Yoon Tae Jeen ),( Sang Woo Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Aims: In Korea, the surveillance colonoscopy after initial negative colonoscopy is recommended 5 years after negative colonoscopy. We evaluated the risk factors for colorectal neoplasia after negative screening colonoscopy. Methods: Among the patients underwent screening colonoscopy at Korea University Ansan Hospital from Jan. 2002 to Dec. 2009, the subjects without adenomas wereenrolled in the study retrospectively. Baseline characteristics on index colonoscopy and surveillance colonoscopic fi ndings were reviewed. Advanced adenoma was de-fi ned as an adenoma that met more than one of the following criterias: a size =10 mm, the presence of a substantial villous component, the presence of high-grade dysplasia. The prevalence of any adenoma and advanced adenoma were identifi ed and the risk factors on surveillance colonoscopy after negative screening colonoscopy were evaluated by using Cox regression model. Results: Among total 3,516 patients with screening colonoscopy, 1,506 without any adenomas were enrolled. The median of follow up interval after screening colonoscopy was 47.3 months(range,12.0 ~ 124.8). The incidence of any adenoma within 5years after negative colonoscopy was 293(29.0%) and those of any adenoma from 5 to 10 years was 135(27.2%). The prevalences of same terms in advanced adenoma were23(2.5%) and 8(1.4%). In cox regression analysis, the prevalence of any adenoma on surveillance colonoscopy were significantly increased in male(P<0.001) and old age(P<0.001). However, male gender and age were not associated with risk of advanced adenoma. Conclusions: Among the subjects with no colorectal adenoma on initial screening colonoscopy, the incidence of advanced adenomas was 2.1% on 10 year follow up surveillance. Although gender and age is associated with metachronous colorectal adenoma on surveillance colonoscopy, those are not associated with advanced adenoma. Therefore, surveillance interval of colonoscopy can be prolonged to 10 years.
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