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Kim, Jung-Ryul,Woo, Hye In,Chun, Mi-Ryung,Lim, Shinn-Won,Kim, Hae Deun,Na, Han Sung,Chung, Myeon Woo,Myung, Woojae,Lee, Soo-Youn,Kim, Doh Kwan Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P><B>Purpose</B></P><P>This study investigated population pharmacokinetics of paroxetine, and then performed an integrated analysis of exposure and clinical outcome using population pharmacokinetic parameter estimates in depressed patients treated with paroxetine.</P><P><B>Patients and methods</B></P><P>A total of 271 therapeutic drug monitoring (TDM) data were retrospectively collected from 127 psychiatric outpatients. A population nonlinear mixed-effects modeling approach was used to describe serum concentrations of paroxetine. For 83 patients with major depressive disorder, the treatment response rate and the incidence of adverse drug reaction (ADR) were characterized by logistic regression using daily dose or area under the concentration–time curve (AUC) estimated from the final model as a potential exposure predictor.</P><P><B>Results</B></P><P>One compartment model was developed. The apparent clearance of paroxetine was affected by age as well as daily dose administered at steady-state. Overall treatment response rate was 72%, and the incidence of ADR was 30%. The logistic regression showed that exposure predictors were not associated with treatment response or ADR in the range of dose commonly used in routine practice. However, the incidence of ADR increased with the increase of daily dose or AUC for the patients with multiple concentrations.</P><P><B>Conclusion</B></P><P>In depressed patients treated with paroxetine, TDM may be of limited value for individualization of treatment.</P>
Screening of genetic variations of SLC15A2, SLC22A1, SLC22A2 and SLC22A6 genes.
Cheong, Hyun Sub,Kim, Hae Deun,Na, Han Sung,Kim, Ji On,Kim, Lyoung Hyo,Kim, Seung Hee,Bae, Joon Seol,Chung, Myeon Woo,Shin, Hyoung Doo Springer-Verlag 2011 Journal of human genetics Vol.56 No.9
<P>A growing list of membrane-spanning proteins involved in the transport of a large variety of drugs has been recognized and characterized to include peptide and organic anion/cation transporters. Given such an important role of transporter genes in drug disposition process, the role of single-nucleotide polymorphisms (SNPs) in such transporters as potential determinants of interindividual variability in drug disposition and pharmacological response has been investigated. To define the distribution of transporter gene SNPs across ethnic groups, we screened 450 DNAs in cohorts of 250 Korean, 50 Han Chinese, 50 Japanese, 50 African-American and 50 European-American ancestries for 64 SNPs in four transporter genes encoding proteins of the solute carrier family (SLC15A2, SLC22A1, SLC22A2 and SLC22A6). Of the 64 SNPs, 19 were core pharmacogenetic variants and 45 were HapMap tagging SNPs. Polymorphisms were genotyped using the golden gate genotyping assay. After genetic variability, haplotype structures and ethnic diversity were analyzed, we observed that the distributions of SNPs in a Korean population were similar to other Asian groups (Chinese and Japanese), and significantly different from African-American and European-American cohorts. Findings from this study would be valuable for further researches, including pharmacogenetic studies for drug responses.</P>
Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10
박해든 ( Hae-deun Park ),이용조 ( Yong-jo Lee ),최지희 ( Ji-hee Choi ),김민지 ( Min-ji Kim ),이석기 ( Seok-ki Lee ),노광현 ( Kwang-hyun Ro ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2
모바일 쇼핑의 급속한 성장으로 인해 스마트 쇼핑과 같은 쇼핑시장의 새로운 패러다임이 발생하였다. 본 연구에서는 모바일 쇼핑시장을 이루고 있는 주된 의류분야에서 오프라인과의 통합된 시스템을 개발하여 새로운 의류 IT의 출현을 도모하고,이를 통해 고객 만족도와 서비스를 높일 수 있는 방안을 연구하였다. 오프라인 매장에 스캐너를 개발하여 오프라인 쇼핑의 활용도를 높이고 고객에게 브랜드의 새로운 차별성을 제시할 수 있는 방안을 모색하였다. 스캐너에 키넥트를 이용하여 인체 골격구조에 따라 신체를 측정하고 신체 측정 시 발생하는 사용자 인식률 및 스캐너와의 거리에 따라 변하는 오차 범위를 연구하였다. 스캐너는 의류 매장 안에서 신체치수를 측정할 뿐 아니라 의류 RFID 태그를 이용하여 직접 입어보지 않고 가상 Fitting할 수 있는 기능을 가진다. 또한 측정된 치수를 스마트 폰과 블루투스로 연결하여 가상 아바타를 생성 할 수 있고 이는 또한 스마트폰에서 가상 Fitting이 가능하여 오프라인과 모바일 쇼핑의 통합성을 추구했다.