저체중 출생이 학동기 및 청소년기 소아 천식의 중증도에 미치는 영향에 대한 고찰

정훈 ( Hoon Jeung ),김형대 ( Heung Dae Kim ),이윤진 ( Yun Jin Lee ),이균우 ( Kyun Woo Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2006 소아알레르기 및 호흡기학회지 Vol.16 No.1

목 적 : 본 연구는 저출생 체중아로 출생한 소아에 있어서 학동기 및 청소년기 소아 천식의 중증도에 미치는 영향에 관해서 후향적으로 검토하였다. 방 법 : 대동병원 소아과와 호흡기내과에 통원 중에 있거나 부산 동래구 및 연제구 소재 개인의원에서 대동병원으로 전원 된 천식 환자 중에서 8세 이상 18세 이하의 소아 및 청소년을 대상으로 출생체중을 기준으로 1,500 g 이상 2,500 g 미만인 15명을 추출하여 연구군으로 하고 출생체중 2,500 g 이상이며 연구군의 나이에 일치하는 순서대로 2명씩 추출하여 이 30명을 대조군으로 하였다. 결 과 : 양군을 비교한 결과 천식 중증도는 연구군에서 유의하게 높았다.(P=0.015) 또 흡입 스테로이드 약의 사용 빈도(증례군 13명/15명, 대조군 4명/30명 : P=0.0001)와 사용 기간에 있어서도 연구군에서 유의하게 높게 나왔다.(P= 0.009) 혈중 총 IgE치와 아토피피부염의 유병률은 대조군에서 높았다.(각각 P=0.007, P=0.0001) 폐기능 검사와 PC(20), 특이 IgE 항체는 두 군 사이에 유의한 결과를 볼 수가 없었다.(P>0.05) 결 론 : 천식의 중증도와 흡입 스테로이드 사용의 빈도와 기간 등으로 미루어 볼 때 저출생 체중은 소아 천식의 중증도를 증가시키는 요인 일 수 있음을 시사한다. Purpose : Over the past several decades, the survival rates of low birth weight(LBW; birth weight <2,500 g) infants have been improving. Many of these infants have had bronchial asthma(BA) at childhood and aldolescence. The aim of this study is to investigate whether LBW influenced the severity of BA in prealdolescent children and aldolescence by a retrospective case control study. Methods : 15 LBW children(1,500 g<birth weight<2,500 g) between 8 year-old and 18 year-old with BA visiting Dae-dong hospital as the case group were compared with 2 BA children to each case as the control group(total 30 children) on the basis of following criteria : the same age, he/she attended Dae-Dong hospital or local medical center after 8 years old, birth weight was more than 2,500 g. Asthma severity was modified from 2003 Guideline for management of childhood asthma at The Korean Academy of Pediatric Allergy and Respiratory Disease. PFT(Pulmonary function test) were measured using a portable spirometer. The value are expressed as percentage predicted using standard reference values. Total IgE and specific IgE Ab. were assessed by the PRIST method and MAST Allergy Test. Methacholine challenge test and PC20 was assessed by the Masterlab. Results : LBW group had : a significantly more severe symptoms between 8 year-old and 18 year-old than control group.(P=0.015) A significantly more used to ICSs(Inhaled corticosteroids) and add-on therapy than control group.(P=0.009)(P=0.0001) There were no significant differences in the PFT and PC(20) and specific IgE Ab. between LBW group and control group. But, total IgE level is higher in the control group than in the LBW group. Conclusion : These results suggest that LBW is a risk factor for the severity of BA. We suggest that infants with birth weight of less than 2,500 g have a more severe risk of asthma during prealdolescent children and aldolescence than who were birth weight of more than 2,500 g. [Pediatr Allergy Respir Dis(Korea) 2006;16:38-46]

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Photo-Etching 方法으로 生産된 AT-Strip 水晶振動子에 關한 硏究

李大勳 충주대학교 1997 한국교통대학교 논문집 Vol.32 No.2

The purpose of this paper is to present the works taat have been done and statek in the past few years in this frequency range. The works include design,Process, Pakage consideration on Fandamental 3rd Overtone and 5th Overtone resonators.

Strip-cast Nd-Fe-B 합금의 미세조직에 미치는 Dy의 영향

이대훈,장태석 선문대학교 ·중소기업기술지원연구소 2002 선문공대 연구/기술 논문집 Vol.7 No.1

고특성 소결자석용 strip 합금을 개발하기 위한 연구의 일환으로 Dy 첨가가 strip 합금의 상형성 및 분포, 자기특성 등에 미치는 영향을 조사하였다. Dy 첨가량이 증가할수록 strip의 수지상정이 개선되는 경향을 나타냈으며, 특히 Dy를 Nd_l4-xDy_xFe_80B_6 (x = 0.3 ~ 1.0)의 조성에서 0.7 at% 이상 투입하였을 때, 가장 우수한 결과를 나타냈다. 또한 이 조성에서는 초정 Fe도 발견되지 않았으며, 수지상정간 거리는 약 4 ㎛로, 고특성 소결자석을 제조하기 위한 요건에 잘 부합되었다. 제조된 strip은 모두 strip 표면에 수직한 방향으로 <001> perforred orientation을 일으키고 있었으며, Dy 첨가량이 증가함에 따라 그 경향이 증가하였다. 이것은 소결자석의 제조시 결정립 배향성에 기여하여 자석의 성능 향상에 도움을 줄 것으로 기대가 된다. 한편 Dy를 첨가함에 따라 보자력은 증가하였으나, Fe와의 antiferromagnetic coupling의 영향으로 인해 포화자화값은 감소하였다. In order to develop a percursor for hight performance sintered magnets, we investigated the effect of dysprosium additions on the phase formation, distribution, and magnetic properties of the strip cast Nd-Fe-B alloys. As Dy addition increased, formation of the dendrites of Nd_2Fe_14B in the strip cast alloy was improved. Especially, in the alloys of Nd_l4-xDy_xFe_80B_6 (x = 0.3 ~ 1.0), the formation of the dendrites was appeared to be optimized when x was more than 0.7. In these compositions, furthermore, the primary α-Fe was not found any more and the arm spacing of the dendrites was about 4 ㎛, adequate for producing a high energy sintered magnet. It was found that <001> preferred orientation took place along the direction normal to the strip surface in all alloys, and the preferred orientation was more clear as Dy addition increased. It is expected that such preferred orientation will improve the particle alignment of the green compact for sintered magnets. While the coercivity of the strip cast alloys increased as Dy addition increased, the saturation magnetization decreased due to the antiferromagnetic coupling between Fe and Dy atoms.

U-Computing 환경 하에서의 e-Learning에 관한 연구

이대훈 忠州大學校 2004 한국교통대학교 논문집 Vol.39 No.1

This paper aims to study Ubiquitous and U-computing in terms of thier use and application. In conclution, I found out that this study can contribute on Cyber-education.

RT-LAMP를 이용한 콩황화일반모자이크바이러스의 진단

배대현, 이영훈, 김봉섭, 윤영남, 강범규, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

Soybean yellow common mosaic virus (SYCMV) has been recently reported, it has been occurred a lot with Soybean mosaic virus (SMV) and Soybean yellow mottle mosaic virus (SYMMV) in soybean field. SYCMV belongs to genus of Sobemovirus and induced viral symptoms with yellowing, mottle and mosaic. A reverse transcription loop-mediated isothermal amplification (RT-LAMP) method allowed one-step detection of gene amplification by simple procedure and needed only a simple incubator for isothermal template. This RT-LAMP method allowed direct detection of RNA from virus-infected plants without thermal cycling and gel electrophoresis. In this study, we designed RT-LAMP primers named SYCML-F3/B3/FIP/BIP from coat protein gene sequence of SYCMV. After the reaction of RTLAMP, products were identified by electrophoresis and with the detective fluorescent dye, SYBR Green I. under daylight and UV light. Optimal reaction condition was at 63 for 60min and the primers of RTLAMP showed the specificity for only SYCMV tested in this study.

水晶發振器의 溫度補償에 對한 硏究

李大勳 忠州大學校 1987 한국교통대학교 논문집 Vol.21 No.-

In this paper I studed on the temperature compensation circuit and compensation way of crystal oscillator. And I described how to compute device of temperture Compensation circuit I pursued the characteristics of temperature compensation in range of -30℃~70℃ by Colpitts type oscillation circuit consisted of TTL-IC, and conformed that its variation is 2ppm. From the results I presented that the compensation circuit consisted of 3 thermistors is more effective in stability of general oscillation circuit.

Program 可能한 SC Filter의 設計에 對한 硏究

이대영,이영훈 慶熙大學校 1983 論文集 Vol.12 No.-

In this paper, it is implemented of the programmable switched capacitor filter that the center frequency can be varied with the clock frequency, and that the gain and bandwidth of the filter can be controlled with the capacitor-array. As a result this filter has a good programmability and linearity and temperature charactrics. In addition, this filter can be applied to the speech and music syntheisiser etc. so, I will study to the application of speech with this SC filter.

아연 전처치가 카드뮴 급성 중독에 미치는 영향에 대한 실험적 연구

이정훈,최정목,강대영 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

In an attempt to elucidate the effects of zinc on rat tissue changes induced by cadmium, the present study was undertaken in male Sprague-Dawley rats. Rats were intraperitoneally pretreated with zinc chloride(15.0mg/kg) for 3 days, and then were intraperitoneally given CdCl_2(3.0mg/kg). The body and organ weights of the experimental rats were weighed on the 1st, 3rd, 7th, 15th, 30th and 60th day after CdC_12 injection. The lungs, livers, kidneys and testes were microscopically illuminated and examined under the electron microscope. The results were as follows: 1. The cadmium induced toxicity were most prominent in the testes. The testes showed diffuse hemorrhage, followed by massive hemorrhagic necrosis, calcification and complete disappearance of normal parenchymal tissue(severe atrophy). 2. In the zinc treated group, there were no specific light microscopic changes in the organs. Marked ultrastructural changes were not observed, however the number of glycogen particles increased. 3. The cadmium toxicity to the lung was proportional to the number of days. The lung changes showed chronic bronchitis and progressive interstitial fibrosis of the alveoli. 4. In the cadmium treated group, the liver showed ultrastructural changes such as mitochondrial swelling, dilatation of rough endoplasmic reticulum, myelin figure formation, and decreased number of glycogen particles. The degree of ultrastructural changes slightly decreased in the zinc pretreated group. Also nuclear membrane irregularity was noted after experimental 30th day. 5. After 30th experimental day in the cadmium treated group, ultrastructural appearence of the proximal convoluted tubules of the kidneys showed detachment of microvilli, absence of basal cytoplasmic membrane invagination and irregular mitochondrial shape. In the zinc pretreated group, the degree of ultrastructural changes were mild compared to those of the cadmium only treated group. In conclusion, these experimental results suggest that cadmium toxicity was most prominent in the testes and can be the cause of infertility, and that zinc reduces ultrastructural cellular damage induced by cadmium in the rat tissues.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.