Effect of Highly Pressurized Hydrogen Gas Charging on the Hydrogen Embrittlement of API X70 Steel

Dong-Su Bae,Chi-Eun Sung1,Hyun-Ju Bang,Sang-Pill Lee,Jin-Kyung Lee,In-Soo Son,조영래,Un-Bong Baek,Seung-HoonNahm 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.4

During the use of API X70 steel as a pipeline structural material for the transportation of natural gas,hydrogen embrittlement can occur due to the hydrogen contained in natural gas. The aim of this study is toinvestigate the effects of the hydrogen content under high-pressure hydrogen gas conditions on the hydrogenembrittlement of air-cooled API X70 steel. The air-cooled API X70 steel was manufactured by hot rollingand was then air-cooled to room temperature. Tensile test specimens were held for 0 h, 1000 h, and 2000 hwithin a pressure vessel filled with 100% hydrogen gas at a gas pressure of 10 MPa, with the tensile teststhen performed at room temperature. The microstructure of the API X70 steel consists of coarse polygonalferrite, coarse pearlite, and fine acicular ferrite. The yield and tensile strength increased and elongationdecreased considerably after a holding time of 2000 h compared to those of 0 h and 1000 h within the pressurevessel. The morphology of the fracture surface changed from ductile to brittle upon hydrogen gas charging. Secondary cracks were observed in both of the hydrogen-gas-charged specimens. No external cracks wereformed on the surface of the tensile-tested specimen with a 0 h holding time; however, many external crackswere observed on the specimen surface subjected to hydrogen gas charging.

Dietary Nutrient Intakes and Plasma Oxidative Stress Markers of Patients with Rheumatoid Arthritis

( Sang Cheol Bae ),( Suk Kyu Park ),( Soo Jin Kim ),( Mi Kyung Sung ) 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-

Chronic Cholecystitis

( Soo Hyeon Lee ),( Hae Il Jung ),( Sang Ho Bae ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Although hepatobiliary scintigraphy has been widely used in patients with biliary pain, the histopathological factors of gallbladder that affect the findings of hepatobiliary scintigraphy is not fully known. The aim of the present study is to investigate the relationship between hepatobiliary scintigraphy findings and histopathological results in patients with recurrent biliary colic. Methods: A total of 107 patients who underwent hepatobiliary scintigraphy for recurrent biliary colic and subsequent cholecystectomy were retrospectively enrolled. According to the hepatobiliary scintigraphy findings, patients were categorized into three groups; patients with non-visualization of gallbladder activity (non-visualized GB group), gallbladder ejection fraction (GBEF) of <35% (low GBEF group), and GBEF of = 35% (normal GBEF group). Differences of histopathologic factors between three patient groups were evaluated and multivariate logistic regression analyses were performed to identify histopathological predictors for non-visualization of gallbladder activity and low GBEF. Results: Of all patients, 31 patients were classified as non-visualized GB group, 33 were low GBEF group, and 43 were normal GBEF group. Non-visualized group showed higher rates of patients with severe neutrophil, lymphoplasma cell, and eosinophil infiltrations and empyema and showed more increased cystic duct wall thickness than other groups (P<0.05). Low GBEF group showed higher muscle-to-total wall thickness ratio and muscle-to-fibrosis thickness ratio than those with normal GBEF group (P<0.05). On multivariate logistic regression analysis, Severe degrees of lymphoplasma cell infiltration (P=0.027) and eosinophil infiltration (P<0.001) were independent predictors for non-visualization gallbladder activity, and muscle-to-fibrosis thickness ratio (P=0.030) was an independent predictor for low GBEF. Conclusions: In patients with recurrent biliary colic, non-visualization of gallbladder activity on hepatobiliary scintigraphy was related with the degree of inflammation in the gallbladder, while GBEF was related with muscular hypertrophy of the gallbladder.

General Surgery

( Soo Hyun Lee ),( Hae Il Jung ),( Sang Ho Bae ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Although hepatobiliary scintigraphy has been widely used in patients with biliary pain, the histopathological factors of gallbladder that affect the findings of hepatobiliary scintigraphy is not fully known. The aim of the present study is to investigate the relationship between hepatobiliary scintigraphy findings and histopathological results in patients with recurrent biliary colic. Methods: A total of 107 patients who underwent hepatobiliary scintigraphy for recurrent biliary colic and subsequent cholecystectomy were retrospectively enrolled. According to the hepatobiliary scintigraphy findings, patients were categorized into three groups; patients with non-visualization of gallbladder activity (non-visualized GB group), gallbladder ejection fraction (GBEF) of <35% (low GBEF group), and GBEF of ≥ 35% (normal GBEF group). Differences of histopathologic factors between three patient groups were evaluated and multivariate logistic regression analyses were performed to identify histopathological predictors for non-visualization of gallbladder activity and low GBEF. Results: Of all patients, 31 patients were classified as non-visualized GB group, 33 were low GBEF group, and 43 were normal GBEF group. Non-visualized group showed higher rates of patients with severe neutrophil, lymphoplasma cell, and eosinophil infiltrations and empyema and showed more increased cystic duct wall thickness than other groups (P<0.05). Low GBEF group showed higher muscle-to-total wall thickness ratio and muscle-to-fibrosis thickness ratio than those with normal GBEF group (P<0.05). On multivariate logistic regression analysis, Severe degrees of lymphoplasma cell infiltration (P=0.027) and eosinophil infiltration (P<0.001) were independent predictors for non-visualization gallbladder activity, and muscle-to-fibrosis thickness ratio (P=0.030) was an independent predictor for low GBEF. Conclusions: In patients with recurrent biliary colic, non-visualization of gallbladder activity on hepatobiliary scintigraphy was related with the degree of inflammation in the gallbladder, while GBEF was related with muscular hypertrophy of the gallbladder.

MiR-22-3p Alleviated Hepatic Lipogenesis via Inhibiting the SIRT1-PPAR Gamma Signal Pathway in Non-Alcoholic Fatty Liver Disease

( Sung Woo Cho ),( Jung Hoon Cha ),( Na Ri Park ),( Won Hee Hur ),( Pill Soo Sung ),( Jong Young Choi ),( Seung Kew Yoon ),( Si Hyun Bae ),( Hee Chul Nam ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Non-alcoholic fatty liver disease (NAFLD) is a metabolic- related disorder ranging from simple steatosis to more severe forms, but the exact mechanism of progression remains unknown. MicroRNAs(miR), a class of small noncoding RNAs, are implicated in controlling a variety of biological processes. The aim of this study is to investigate the regulatory and protective role of miR-22-3p in NAFLD progression. Methods: Both in vitro and in vivo models of NAFLD were generated by treating HepG2 and Huh-7 cells with palmitic acid (PA) and by feeding mice a high-fat diet (HFD), respectively. HE and Oil Red O staining were used to examine liver tissue morphology and lipid deposition, respectively. qRT-PCR (quantitative real time polymerase chain reaction) was used for investigate expression of miR, SIRT1, and proteins involved in lipogenesis Results: HFD-mice hepatic tissues and PA-treated HepG2 and Huh-7 cells presented excess lipid production. Both in vitro and in vivo NAFLD model displayed decreased miR-22-3p and SIRT1 expression as evidenced by qRT-PCR. Overexpression of miR-22-3p induced downregulation of FAS, PPAR gamma and SREBP-1c via upregulation of SIRT1 expression. Reduction of hepatic lipid accumulation was observed by Oil red O staining. Conclusions: In this study, miR-22-3p had a role in ameliorating hepatic lipogenesis by regulation of SIRT1 signal pathway in NAFLD model. The overexpressed miR-22-3p protects hepatocytes from lipid metabolism and suppresses hepatic lipogenesis, suggesting as a potential target for the therapeutic strategy of NAFLD.

Chemisorption of Ethanol on Ge(100) Surface

Bae, Sung-Soo,Lee, A-Reum,Kim, Sehun,Kim, Do Hwan American Chemical Society 2018 The Journal of Physical Chemistry Part C Vol.122 No.27

<P>Chemical reaction of ethanol (CH<SUB>3</SUB>CH<SUB>2</SUB>OH) with Ge(100) surface has been investigated using scanning tunneling microscopy (STM) observation and density functional theory (DFT) calculations. At low coverage, high-resolution STM images showed that ethanol dissociatively adsorbed on a single Ge dimer. The adsorption features included bright protrusions assigned to Ge-OCH<SUB>2</SUB>CH<SUB>3</SUB> structure formed via O-H dissociation of ethanol. Real-time STM observations revealed that the molecular chain of ethanol increased gradually via successive adsorption along the dimer row direction following increased exposure to ethanol. DFT calculation results showed that the adsorption of ethanol on Ge(100) was dominated by kinetic control at room temperature. Thus, an integrated study of experimental and theoretical approaches coherently confirmed that ethanol reacts with Ge(100) via O-H dissociative adsorption and the final structure has the H-Ge-Ge-OCH<SUB>2</SUB>CH<SUB>3</SUB> geometry on a single dimer of Ge(100).</P> [FIG OMISSION]</BR>

Monolayer Assembly of Co - nanoparticle on Si by Covalent Linkage

Sung-Soo Bae,Do Kyung Lim,Jong-Il Park,Jinwoo Cheon,Sehun Kim 한국진공학회 2002 한국진공학회 학술발표회초록집 Vol.- No.-

Long-Term Outcome of Liver Resection Versus Transplantation for Hepatocellular Carcinoma in a Region Where Living Donation is a Main Source

Sung, Pil Soo,Yang, Hyun,Na, Gun Hyung,Hwang, Seawon,Kang, Donghoon,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Kim, Dong Goo,Yoon, Seung Kew,You, Young Kyoung 'International Scientific Information, Inc.' 2017 Annals of transplantation Vol.22 No.-

Bilateral Bipartite Carpal Scaphoid

Sang-Bum Kim(김상범),Woo-Sik Kim(김우식),Whan-Yong Chung(정환용),Taek-Soo Jeon(전택수),In-Tak Bae(배인탁) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.5

이분 주상골은 드문 기형이며 아직도 그 선천성 혹은 외상성의 논란의 여지는 있으나 대부분의 보고가 선천성의 가능성을 시사 하고 있다. 현재 까지 이분 주상골에 대한 국내 증례보고는 없었으며 이에 저자들은 38세 남자의 이분 주상골의 증례를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. Bipartite scaphoid is a rare anomaly and it has been questioned as whether it is of congenital origin or traumatic. However, many authors have reported that congenital origin is more probable. There was no case report in Korea about bipartite scaphoid, but this article reports a case of a 38-year-old male with bilateral bipartite scaphoid.

Saponin-enriched extract of <i>Asparagus cochinchinensis</i> alleviates airway inflammation and remodeling in ovalbumin-induced asthma model

Sung, Ji-Eun,Lee, Hyun-Ah,Kim, Ji-Eun,Yun, Woo-Bin,An, Beum-Soo,Yang, Seung-Yun,Kim, Dong-Seob,Lee, Chung-Yeoul,Lee, Hee-Seob,Bae, Chang-Joon,Hwang, Dae-Youn UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.40 No.5

<P>Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction and airway hyper-responsiveness. The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of <I>Asparagus cochinchinensis</I> (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. To accomplish this, alterations of the nitric oxide (NO) level, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, as well as variations in immune cell numbers, immunoglobulin E (IgE) concentration, histopathological structure and inflammatory cytokine levels were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells or an OVA-induced mouse model of asthma treated with SEAC. The concentration of NO and mRNA levels of COX-2 and iNOS were significantly decreased in the SEAC + LPS-treated RAW264.7 cells compared with the vehicle + LPS-treated RAW264.7 cells. Additionally, in the OVA-induced asthma model, the number of immune cells in the bronchoalveolar lavage fluid, the concentration of OVA-specific IgE, the infiltration of inflammatory cells, the bronchial thickness and the levels of the inflammatory mediators interleukin-4 (IL-4), IL-13 and COX-2 were significantly lower in the OVA + SEAC-treated group compared with the OVA + vehicle-treated group. In addition, a significant reduction in goblet cell hyperplasia, peribronchiolar collagen layer thickness and VEGF expression for airway remodeling was detected in the OVA + SEAC-treated group compared with the OVA + vehicle-treated group. These findings indicate that SEAC is a suppressor of airway inflammation and remodeling, and may therefore be useful as an anti-inflammatory drug for the treatment of asthma.</P>