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The role of mitochondrial DNA mutation on neurodegenerative diseases
차문영,묵인희,김동규 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
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태아곤란증으로 제왕절개 분만한 신생아에 대한 임상적 고찰
최훈,이홍균,김복린,조용균,유태환,서정식,김동영,박규희,차문영 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.3
분만중 태아곤란증으로 제왕절개술을 시행한 168예를 대상으로 신생아의 예후를 중심으로 분석한 바는 다음과 같다. 1. 태아곤란증을 적응증으로 시행한 제왕절개분만아의 1분 저 Apgar 점수[<7]의 빈도는 총 59예로 35%, 5분 저Apgar 점수[<7] 출생아의 빈도는 총 19예로 11%였으며, 저 Apgar 점수의 빈도는 조사군에서 통계적으로 의미 있게 높았다. 2. 태아곤란증을 나타낸 임부 168예 중 107예 [64.9%]에서 한 가지 이상의 산과적 합병증을 가지고 있었으며, 태변침착, 조산, 주수에 비해 태아가 작은 경우, 임신성 고혈압, 조기 파막 등의 합병증이 있었으며, 대조군[24.5%]에 비해 산과적 합병증이 유의있게 많았다. 3. 임신주수에 따른 1분과 5분 저 Apgar 점수의 빈도는 37주 이하인 군[64%]이 38 42주와 42주 이상인 군보다 유의있게 많았다. 또 신생아 체중에 따른 1분과 5분 저 Apgar 점수의 빈도는 2,500 gm 미만의 저 체중아군[69%]이 2,500 3,999 gm 군보다 유의있게 많았다. 4. 조사군의 50%에서 호흡기 합병증, 신생아 고빌리루빈혈증, 급성 장염, 황달과 피부 감염같은 한가지 이상의 합병증을 동반하였고, 대조군[10.5%]과는 유의한 차이를 보였다. 5. 주산기 사망은 조사군에서 3.0% 있었으며, 대 조군[0%]과는 유의한 차이를 보였다. 이상에서 저자들이 태아곤란증으로 제왕절개 분만한 신생아의 예후를 관찰한 바 신생아의 합병증과 주산기 사망이 많았으며, 저 Apgar 점수의 빈도도 의미있게 높았다. Over the past 2 decades, the use of fetal heart rate monitoring has been paralleled by the increased Cesarean section rate. And the physician may choose the option of a $quot;safe$quot; Cesarean section over allowing a labor to continue with any sign or possibility of fetal or maternal stress during labor. This study was undertaken to evaluate the outcomes of the neonates delivered by Cesarean section for fetal distress. In this study, we reviewed the clinical records of 168 patients who had had Cesarean section for fetal distress at the department of obstetrics and gynecology in Sanggye Paik Hospital, InJe university from Jan. 1993 to Dec. 1995. The results were as follows : 1. The number of neonates with low Apgar score of 1 minute[< 7] was 59[35%] and that with low Apgar score of 5 minute[< 7] was 19[11%]. 2. About two thirds of cases[64.9%] were associated with one or more obstetric complications and the complications were meconium staining, preterm delivery, small for dates, and premature rupture of membranes,etc. These were significantly increased in the study group. 3. The number of neonates with low Apgar score of 1 minute and 5 minute was significantly increased in a group with gestational age below 37 weeks, and in a group with birth weight below 2,500 gm. 4. Various kinds of neonatal complications such as respiratory problems,neonatal hyperbilirubinemia, acute gastroenteritis, jaundice, and skin infection were significantly increased in the neonates delivered by Cesarean section for fetal distress. 5. Perinatal mortality was significantly increased in the neonates delivered by Cesarean section for fetal distress. From the above results, we concluded that neonatal complications, low Apgar score, and perinatal mortality rates were increased in the neonates delivered by Cesarean section for fetal distress.
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박규희 ( Kyu Hee Park ),김동영 ( Dong Yeung Kim ),차문영 ( Mun Yeung Cha ),서정식 ( Jeong Sik Seo ),유태환 ( Tae Hwan Yoo ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Rin Kim ),이홍균 ( Hong Kyoon Lee ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Objective: The purpose of this study was to determine the risk factors of the neonatal clavicular fracture. Methods: Between January 1993 and December 1996, forty seven cases of neonatal clavicular fractures were studied and analyzed retrospectively to determine the risk factors. Newborns with radiologically proved fractured clavicles were compared with a control group of infants delivered immediately before & after the study patients. Maternal, labor, delivery & newborn factors were analyzed statistically. Results: The incidence of neonatal clavicular fracture was 0.398%(47/11806) in singleton full-term vaginal deliveries. The statistically significant risk factors were shoulder dystocia(p = 0.001), heavier birth weight(p = 0.001), and macrosomia(p = 0.026). No infant with clavicular fracture had an abnormal finding by neurologic examination. Conclusion: Neonatal clavicular fractures occur infrequently during normal vaginal delivery. Shoulder dystocia, heavier birth weight, and macrosomia are associated risk factors, but they are often unpredictable and unavoidable complication.
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