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조기현,비제이,Sushila Maharjan,장윤정,최윤재,조종수 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.14 No.3
Healing process in scarring inevitably produces a considerable amount of non-organized dense collagen-rich matrix called scar thus impairing the native structure of skin. Connective tissue growth factor (CTGF) overexpression within healing tissues is known to play an imperative role in collagen production stimulated by transforming growth factor-beta in cutaneous wound healing. Undoubtedly, the knockdown of CTGF expression through siRNA-mediated gene silencing could simply impede the scarring process. However, the less stability and low transfection of siRNAs themselves urge a safe carrier to protect and transfect them into cells at a high rate avoiding toxicities. Here, we developed a degradable poly(sorbitol-co- PEI) (PSPEI), prepared by polymerization of sorbitol diacrylate with low molecular weight polyethylenimine, which has high transfection efficiency but low cytotoxicity, and utilized it in siCTGF delivery to silence the expression of CTGF in an animal model of cutaneous wound healing. Unlike contracted scar in normal healing, there was no or less contraction in the healed skin of mice treated with siCTGF using PSPEI. Histologically, the healed tissues also had distinct papillary structures and dense irregular connective tissues that were lacking in the control scar tissues. This study exemplifies a successful treatment of cutaneous wound healing using a polymer system coupled with RNA interference. Hence, the approach holds a great promise for developing new treatments with novel targets in regenerative medicines.
조기현 한국현대영어영문학회 2012 현대영어영문학 Vol.56 No.3
This paper aims to examine syntactic characteristics of English possessive gerund in Present-Day English from the diachronic point of view. In Old English and Early Middle English, English gerunds were used only for abstract nouns expressing actions. From Late ME and Early Modern English so-called mixed gerunds, such as determiner(the, his, etc) + gerund(-ing) + object structures, occurred. it is argued that his in his + gerund + object differs in function from that of a nominal gerund such as his + gerund + of-object. Based on Fanego(2004)'s claim, it is assumed that his in his + gerund + object might have functioned temporarily as a complementizer or a subordinator like the in the + gerund + object structure. The data shows that the frequency of the mixed gerunds has gradually decreased, which means that in Present-Day English gerunds are used splitting into two independent categories-nominal gerunds and verbal(clausal) gerunds. It is assumed that his + gerund + object structures have been replaced by him + gerund + object structures which began to appear from the late ME, and eventually will be lost in English due to the definiteness between categories. It can be said that possessive gerunds in English are still being verbalized toward clausal gerunds such as PRO/Him gerunds.
e-Science Paradigm for Astroparticle Physics at KISTI
조기현 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.1
The Korea Institute of Science and Technology Information (KISTI) has been studying the e-Science paradigm. With its successful application to particle physics, we consider the application of the paradigm to astroparticle physics. The Standard Model of particle physics is still not considered perfect even though the Higgs boson has recently been discovered. Astrophysical evidence shows that dark matter exists in the universe, hinting at new physics beyond the Standard Model. Therefore, there are efforts to search for dark matter candidates using direct detection, indirect detection, and collider detection. There are also efforts to build theoretical models for dark matter. Current astroparticle physics involves big investments in theories and computing along with experiments. The complexity of such an area of research is explained within the framework of the e-Science paradigm. The idea of the e-Science paradigm is to unify experiment, theory, and computing. The purpose is to study astroparticle physics anytime and anywhere. In this paper, an example of the application of the paradigm to astrophysics is presented.