http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이창수 (검색결과 1,793 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
-
이창수 한국경영과학회 2010 한국경영과학회 학술대회논문집 Vol.2010 No.6
GoBizKorea(인터넷중소기업관, www.gobizkorea.com)는 1996년부터 e마켓 플레이스를 운영하여 2008년 278만불의 수출실적을 실현하는 등 누적 수출액 15억불을 달성하고 있다. 본 연구는 GoBizKorea에 참여한 중소기업의 해외수출실적 증가추이 및 만족도 등에 대한 객관적 지표평가를 통하여 동 사업의 실행성과를 점검해 보고, 대내외적인 경영 및 경제 환경 변화에 대응하여 현재의 대상기업에 대한 기존 평가지표를 보다 합리적으로 개선할 수 있는 방안이 무엇인지를 검토한다. 세부적으로 GoBizKorea 사업성과 측정지표를 개발하고 평가하며 사업계획 수립에서 성과창출까지 사업진행 과정을 파악하여 성공적인 사업수행 요소를 추출하고 성과제고방안을 제시한다.
-
이창수 한국도서관·정보학회 2005 한국도서관정보학회지 Vol.36 No.3
In this paper we outline the evolving process of the cataloguing rules in Korea focused on the standardization. We analyzed the new and updated rules under the KCR4(Korean Cataloguing Rules, 4th edition) in terms of usability of the catalogue. Our findings can be summarized as follows: ① Since there are the rules of the unlimited number of the statement of responsibility, the access point is expanded and may bring the high searchability as a result, ② Since the rules of the general material designations are added, the catalogue users may easily identify the material, ③ Since the rules of the material specific details area are added, the catalogue users may easily understand the characteristics and other features of a publication, ④ The KCR4 seems a kind of the integrated cataloguing rules for diverse types of materials including the monographs, ⑤ Since the rules of choice and forms of the access point treated in the authority control, there seem some problems in usability of the catalogue, ⑥ The concept of the uniform heading is eliminated which seems considered only for the convenience of the cataloguers not for usability of the catalogue. 이 연구는 한국에서의 목록규칙의 발전과정을 개관하면서 표준화의 과정을 살펴 본 후 가장 최근에 개정하여 출판된 한국목록규칙 4판을 중심으로 이 규칙에 반영되어 있는 중요한 몇 가지 목록의 유용성 문제를 분석하였다. 목록의 유용성 고려라는 측면에서 KCR4는 저록에 포함되는 책임표시의 수에 원칙적으로 제한을 가하지 않은 점, 기술 대상자료의 유형을 제시한 점, 자료의 서지적 특성을 제시하는 기술사항을 추가한 점, 단행본뿐만 아니라 다양한 유형의 자료를 대상으로 하는 통합 목록규칙이라는 점 등은 긍정적인 반면, 접근점의 선정과 형식을 전거에서 처리하도록 미룬 점, 통일표목의 개념을 배제한 점 등은 부정적인 면으로 분석되었다.
-
모르핀이 산화적 손상에 의한 신경아종 세포주 SH-SY5Y 의 세포고사에 미치는 영향
이창수,손용,윤재승,김태요,송윤강,정영표,하정량,최덕화,김정훈 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.2
Background: The effect of opioids on nitric oxide (NO)- and peroxynitrite-induced neuronal cell death is largely unknown. In the present study, we examined the effect of morphine on NO- and per- oxynitrite-induced cell death using a human neuroblastoma SH-SY5Y cell line, which abundantly expre- sses μ, 8, κ-opioid receptors. Methods: The cultured cells were pretreated with morphine and exposed to 3-morpholinosydnonimine (SIN-1) that simultaneously generates NO and superoxide, thus possibly forming peroxynitrite. The cell damage was assessed by using MTT assay and crystal violet staining. Morphological nuclear changes and enzymatic evidences of apoptosis of the cells after exposure to SIN-1 for 24 hours were evaluated by using 4', 6-diamidino-2-phenylindole (DAPI) staining and the measurement of pro-apoptotic protease (caspase-3) activity, respectively. Levels of reduced glutathion (GSH) were measured by monochlo- ronimane (MCB) assay. Results: Pretreatrnent of SH-SY5Y with morphine significantly inhited the apoptotic cell death. Morphine also inhibited SIN-1-induced caspase-3 (pro-apoptotic protease) activity in a dose-dependent ma1nner. However, naloxone (20 μM) could not antagonize completely the effect of morphine in SIN- 1-induced cell death. Pre-administered GSH and N-acetylcysteine (NAC) have been found to protect SIN-induced apoptosis, and the neuroblastoma cells treated with morphine had significantly elevated the levels of GSH. Conclusions: The present study shows that morphine protects the human neuroblastoma cell line SH- SY5Y frorn peroxynitrite-induced apoptotic cell death through elevated GSH levels.The protective action of morphine seems to be associated with inhibition of the apoptotic pathway. However, it is suggested that morphine protects the cells possibly via other unknown mechanisms in addition to the activation of opioid receptors. ( Korean J Anesthesion 2000; 38: 356~364 )
-
모르핀이 백서 뇌 별아교 세포의 세포죽음에 미치는 영향
이창수,손용,김귀순,이강창,김태요,정영표,김명선,최덕화,정대관 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.2
Background : Astrocytes, representing a major non-neuronal cell population in the central nervous system (CNS), contain opioid receptors and are actively involved in several brain functions. This study is designed to evaluate the effects by which morphine contributes to cytotoxicity of nitric oxide (NO) species including NO and peroxynitrite (ONOO) in primary astrocytes isolated from the cerebral cortexes of 1-2 day sprague-Dawley rats. Methods : The cultured cells were pretreated with morphine and exposed to 3-morpholinosydnonimine (SIN-1) which simultaneously gene,rates NO and superoxide, thus possibly forming peroxynitrite. The cell damage was assessed by using an MTT (methylthizol-2-y1-2, 5-diphenyl, tetrazolium bromide) assay. Morphological nuclear changes of the cells after exposure to SIN-I for 24 hours was evaluated by using 4, 6-diamidino-2-phenylindole (DAPI) staining. Results : Morphine significantly protected primary rat astrocytes in a dose-dependent manner from the death mediated by sodum nitroprusside (SNP), a donor of nitric oxide, and SIN-1. Moreover, it was found that naloxone antagonized the protective effect of morphine on SIN-1-induced cell death, revealed as apoptosis by the occurrence of morphological nuclear changes characteristic of apoptosis. Morphine also inhibited the nuclear condensation of SIN-1-treated cells, however the action of morphine was antagonized by pretreatment of naloxone. The protective role of morphine on SIN-1-induced cyto- toxicity was inhibited by DL-Buthionine-[S, R]-sulfoximine (BSO). Furthermore, the effects of morphine on SIN-1-induced cytotoxicity were blocked by pretreatment of Gi protein inhibitor, pertussis toxin, and phosphoinositide 3-kinase (PI3 kinase) inhibitors, Wortmannin and LY294002. Conclusions : These results suggest that morphine may protect primary rat astrocytes from NO species via the signaling cascades involving G-protein and PI3-kinase, and possibly regulates the anti-oxidant, glutathione (GSH). (Korean J Anesthesiol 2000; 38: 348-355)
-
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
