http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이순복(Soon Bok Lee),이선미(Sun Mee Lee),조태순(Tai Soon Cho),정철(Cheol Jeong),정성학(Seong Hak Jeong),심성보(Sung Bo Shim) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2
The hepatoprotective activity of six extracts (BE, EE, HH, PS-1, PS-2, KP) from Artemisia iwayomogi was investigated against experimentally produced hepatic damages. Silymarin, DDB and UDCA were used as reference compounds. Treatment with PS-1 extract reduced hepatic demages induced by CCl₄, acetaminophen and ANIT but it did not alter ethionine-induced hepatotoxicity. In addition, PS-1 extract showed a protective effect against chronic CCl₄-induced hepatotoxicity as well as liver regeneration. PS-2 and KP extracts exhibited significant antihepatotoxic effects on D-galactosamine-induced hepatitis. Treatment with EE extract inhibited ethionine-induced fatty liver. These data indicate that the PS-1 extract is the most hepatoprotective constituent and rationalize the traditional use of this plant in hepatobiliary disorders.
이순복(Soon Bok Lee),이선미(Sun Mee Lee),조태순(Tai Soon Cho),심성보(Sung Bo Shim),윤기욱(Ki Wook Yoon),이종찬(Jong Chan Lee) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2
The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 mg/kg b.wt. in CCl₄-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 mg/kg b.wt. in CCl₄-induced chronic liver disease, 30 mg/kg b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These Findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.
랫드와 마우스에서 DA-3030 ( G-CSF ) 의 급성독성에 관한 연구
이순복(Soon Bok Lee),이영순(Yong Soon Lee),조재진(Jae Jin Cho),김영석(Yong Suk Kim),박재학(Jae Hak Park),남정석(Jeong Seok Nam) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3
This study was performed to evaluate the acute toxicity of DA-3030(granulocyte-colony stimulating factor, G-CSF) in mice and rats via intragastrical and intravenous routes. DA-3030(G-CSF) in the acute toxicity study did not induce any toxic signs in the mice and rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_(50) values in mice and rats would be > 13,800 ㎍/㎏ in the oral route and >6,900 ㎍/㎏ in the intravenous route.
온톨로지를 이용한 S/W Product line 도메인의 명시적 feature 분석 모델
이순복 ( Soon-bok Lee ),이태웅 ( Tae-woong Lee ),김진우 ( Jin-woo Kim ),백두권 ( Doo-kwon Baik ) 한국정보처리학회 2006 한국정보처리학회 학술대회논문집 Vol.13 No.1
현재 제품계열 공학에서 feature 중심의 공통성 및 가변성 분석을 통한 재사용성에 대한 연구가 활발히 이루어지고 있다. 지금까지는 도메인 전문가의 직관 및 경험에 의해 feature가 분석되어 그 개념의 불명확함으로 재사용 측면에서 제한점을 내포하고 있다. 본 논문에서는 개별 feature 속성 List 작성을 통해 feature간의 의미관계를 중심으로 한 Pattern 분석 방법을 제시하고, 의미 유사성 관계를 적용한 feature 온톨로지 그래프를 이용하여 S/W 제품계열 도메인 공학에서 사용자와 개발자간의 동일한 해석이 가능하고 재사용성을 위한 명시적 feature를 분석 및 추출하는 모델을 제안한다.