에틸렌옥사이드(Ethylene oxide)에 노출된 병원 근로자들의 소핵 빈도와 유전적 감수성 지표와의 연관성

이선영,김양지,최영주,이중원,이영현,신미연,김원,윤충식,김성균,정해원,Lee, Sun-Yeong,Kim, Yang-Jee,Choi, Young-Joo,Lee, Joong-Won,Lee, Young-Hyun,Shin, Mi-Yeon,Kim, Won,Yoon, Chung-Sik,Kim, Sung-Kyoon,Chung, Hai-Won 한국환경보건학회 2011 한국환경보건학회지 Vol.37 No.6

Objectives: Ethylene oxide (EtO) is classified as a human carcinogen, but EtO is still widely used to sterilize heat-sensitive materials in hospitals. Employees working around sterilizers are exposed to EtO after sterilization. The aim of the present study was to assess the exposure of EtO level, coupled with occupationally induced micronuclei from hospital workers. The influence of genetic polymorphisms of detoxifying genes (GSTT1 and GSTM1) and DNA repair genes (XRCC1 and XRCC3) on the frequencies of micronuclei in relation to exposure of EtO was also investigated. Methods: The study population was composed of 35 occupationally exposed workers to EtO, 18 student controls and 44 unexposed hospital controls in Korea. Exposure to EtO is measured by passive personal samplers. We analyzed the frequencies of micronuclei by performing cytokinesis-block micronucleus assay (CBMN assay) and GSTM1, GSTT1, XRCC1, and XRCC3 were also genotyped by performing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of micronuclei in EtO exposure group, student controls and hospital controls were $18.00{\pm}7.73$, $10.47{\pm}7.96$ and $13.86{\pm}6.35$ respectively and their differences were statistically significant, but no significant differences according to the level of EtO were observed. There was a dose-response relationship between the frequencies of micronuclei and cumulative dose of EtO, but no significantly differences were observed. We also investigated the influence of genetic polymorphisms (GSTM1, GSTT1, XRCC1, and XRCC3) on the frequencies of micronuclei, but there were no differences in the frequencies of micronuclei by genetic polymorphisms. Conclusions: The frequencies of micronuclei in EtO exposure group was significantly higher than control groups. A dose-response relationship was found between the level of EtO exposure and the frequencies of micronuclei, but no statistically differences were observed. We also found that the frequencies of micronuclei were increased according to cumulative EtO level. There was no association of the genetic GSTM1, GSTT1, XRCC1, and XRCC3 state with the frequency of micronuclei induced by EtO exposure.

어두워진 실상과 밝혀진 허상

이선영(Lee, Sun Young) 한국예술종합학교 미술원 조형연구소 2013 Visual Vol.10 No.-

이예린의 작품은 군더더기 없이 단순명료한 인터페이스를 가지고 있지만, 내포적 다양성이 풍부하다. 대표적인 사진 작품들은 그림자이긴 하지만, 물에 비친 그림자이기에 거울 같은 반영상이다. 거기에는 재현의 기원이 되는 그림자와 거울의 모델이 동시에 작동한다. 배수가 잘 안되어 하수구로 빠져나가지 못한 물이 고여 생긴 이 순간의 연못은 다른 세상을 담는 틀이 되었다. 현실과의 최소한의 접점을 가지는 상상세계는 회화에서 극대화되고, 드로잉에서는 추상적 요소들로 분해되어 있지만, 사진 작업에서는 절묘한 균형을 이룬다. 현실과 상상은 이원론으로 완전히 분리되어 있기 보다는, 뫼비우스 띠처럼 연결된다. 모태 예술이었던 음악은 무의식과 몸속에 깊숙이 자리하며, 음악뿐 아니라 미술에서도 여러 장르를 두루 섭렵해온 작품은 공共감각적이다. 이예린의 작품 속 허상simulacre은 현실과 닮은 그림자eikônes와 닮지 않은 그림자phantasma가 모두 존재한다. 작가는 미술이라는 우회로를 통해서 순수한 생성의 세계에 가 닿으려고 한다. The works of Ye leen Lee feature simple and clear interfaces, while they imply abundant diversity. Her representative photo works show mirror-like shadows reflected on the surface of the water, embodying the origin of representation with shadows and mirrors. The pond or puddle made of stagnating water that failed to drain becomes a frame for another world. In the works of Lee, the imaginary world having minimal contact points with the reality becomes maximized in paintings, gets disassembled into abstract elements in drawings, and creates a subtle balance in photographs. However, the reality and the imagination are not separated by dualism but connected like a Möbius strip. Since the artist learned music from inside her mother’s womb, music is deeply rooted in her unconsciousness as well as in her body. The works of Lee are synesthetic, for she has experimented with diverse genres of art besides music. The simulacrum in her works contains both eikônes that is close to the reality and phantasm that is far from the reality. Using art as a detour, the artist attempts to reach a pure world of creation.

스펀본드 부직포의 흡음성에 대한 구조적 요인 효과 연구

이선영,이지은,변태웅,이승구,Lee, Sun Young,Lee, Ji Eun,Byun, Tae Woong,Lee, Seung Goo 한국섬유공학회 2015 한국섬유공학회지 Vol.52 No.6

Nonwovens have been proposed as a sound absorber in applications of home interior textile industry for effective noise control. Honeycomb cell blind textiles have been increasingly used in window covering for noise reduction. In this study, the effect of structural parameters of honeycomb cell-structured spunbond nonwoven on the sound absorption property was investigated. Spunbond nonwovens with various thicknesses, areal densities, and porosities were used, and they were joined in the form of a honeycomb cell structure with various cell widths and cell layering. The sound absorption property of the nonwoven improved with increasing thickness. The porosity of the nonwoven was shown to be proportional to the noise reduction coefficient (NRC). An increased air gap between two layers of the nonwoven shifted the maximum sound absorption coefficient toward a lower frequency range. The honeycomb cell structure was confirmed to contribute to an improvement of the sound absorption property. Layering of the honeycomb cell structure was also shown to be a critical factor in controlling the sound absorption property of the nonwoven.

저융점 폴리에스터와 텐셀을 이용한 싸이로필사의 제조와 물성 분석

이선영,유재정,홍윤광,이시우,이승구,Lee, Sun-Young,Yoo, Jae-Jung,Hong, Yun-Kwang,Lee, Si-Woo,Lee, Seung-Goo 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.2

The purposes of this study were to manufacture sirofil yarn using tencel roving and low melting polyester filaments and to analyze the physical properties of sirofil yarns with yarn count, in order to develop composite yarn for high glossy and luxury textile fabrics. The surface morphology of sirofil yarn was observed with the SEM. Tensile and bending properties of sirofil yarn were examined with the yarn count. The tensile fracture of sirofil yarn was shown with a two-step process. Firstly, tencel yarn having low elongation was broken and then the low melting polyester filaments were fractured with very high elongation. Bending properties of sirofil yarn were measured with the KES-FB. The bending rigidity of sirofil yarn was between that of tencel spun yarn and that of low melting polyester. Also, the surface property of sirofil yarn was evaluated in terms of the hairiness coefficient. It was shown that stress, strain, bending rigidity, bending hysteresis and surface hairiness coefficient of sirofil yarn decreased as yarn count increased.

조류제거를 위한 구리이온 발생 반응기의 특성 연구

이선영,김혜연,주재백,Lee, Sun-Young,Kim, Hae-Yon,Ju, Jeh-Beck 한국전기화학회 2012 한국전기화학회지 Vol.15 No.1

조류제거를 위한 구리이온을 생성하기 위한 환형 흐름 구리 전기분해 반응기 시스템을 구성하고 그 가동특성에 대하여 고찰하였다. 또한 구리이온이 조류에 미치는 영향도 살펴보았다. 인가전류를 증가하면 균등조로부터 배출되는 구리 이온 농도가 비례적으로 증가함을 알 수 있었다. 전류 밀도를 조절하여 원하는 구리농도를 얻을 수 있음을 알았으며 패러데이 효율은 90% 이상임을 알 수 있었다. 유량을 증가시키면 구리이온농도는 감소하였으며 이는 전극에서의 반응속도와는 상관없이 물의 증가량에 따른 희석 때문임을 알 수 있었으며 농도 과전위 영향은 미미하였다. pH가 증가할수록 생성되는 구리이온 농도는 이에 반비례하여 감소하였고 전기전도도의 변화는 배출되는 구리이온 농도에 별 영향을 미치지 않았다. 구리이온 농도가 증가시킬 경우 Chlorophyll-a 농도가 크게 감소함을 볼 수 있으며, 구리 이온 농도가 0.2 ppm 이상일 때 조류가 효과적으로 제거됨을 알 수 있다. 황산구리를 용해시킨 구리이온이나 전기분해를 통해 얻은 구리이온을 투여한 경우 별차이가 없었으며 5일 후 조류 제거효율은 0.4 ppm이상의 농도에서는 90%이상이었다. An annular flow type of copper electrolysis reactor was setup in order to generate the copper ions to remove algae in water. The operating characteristics of the reactor and the effect of copper ion on algae have been considered. By controling the applied current, the copper ion concentration could be obtained as desired level and the faradaic efficiency was above 90%. When the flow rate was increased, the copper ion concentration was linearly decreased due to the dilution effect and the effect of concentration overpotential was insignificant. With the increase of pH in water, the copper ion concentration was linearly decreased and not affected by the conductivity of the water. The concentration of chlorophyll-a was sharply decreased with the increase of copper ion concentration. The algae was effectively removed as the copper ion concentration was above 0.2 ppm. There was no difference between the copper ions obtained by dissolving copper sulfate and those produced by copper electrolysis. The algae removal efficiency was above 90% after 5 days as the copper ion concentration was above 0.4 ppm.

Sesaminol Glucosides의 기억력 회복능 및 ${\beta}$, ${\gamma}$-Secretase

이선영,손동주,하태열,홍진태,Lee, Sun-Young,Son, Dong-Ju,Ha, Tae-Youl,Hong, Jin-Tae 대한약학회 2005 약학회지 Vol.49 No.2

Alzheimers disease (AD) is the most prevalent form of neurodegenerations associated with aging in the human population. This disease is characterized by the extracellular deposition of beta-amyloid (A ${\beta}$) peptide in cerebral plaques. The A ${\beta}$ peptide is derived from the ${\beta}$-amyloid precursor protein ( ${\beta}$APP). Photolytic processing of ${\beta}$APP by ${\beta}$-secretase(beta-site APP-cleaving enzyme, BASE) and ${\gamma}$-secretase generates the A ${\beta}$ peptide. Several lines of evidence support that A ${\beta}$-induced neuronal cell death is major mechanisms of development of AD. Accordingly, the ${\beta}$-and ${\gamma}$-secretase have been implicated to be excellent targets for the treatment of AD. We previously found that sesaminol glucosides have improving effect on memory functions through anti-oxidative mechanism. In this study, to elucidate possible other mechanism (inhibition of ${\beta}$-and ${\gamma}$-secretase) of sesaminol glucosides, we examined the improving effect of sesaminol glucosides in the scopolamine (1 mg/kg/mouse)-induced memory dysfunction using water maze test in the mice. Sesaminol glucosides (3.75, 7.5 mg/kg/6ml/day p.o., for 3 weeks) reversed the latency time, distance and velocity by scopolamine in dose dependent manner. Next, ${\beta}$-and ${\gamma}$-secretase activities were determined in different regions of brain. Sesaminol glucosides dose-dependently attenuated scopolamine-induced ${\beta}$-secretase activities in cortex and hippocampous and ${\gamma}$-secretase in cortex. This study therefore suggests that sesaminol glucosides may be a useful agent for prevention of the development or progression of AD, and its inhibitory effect on secretase may play a role in the improving action of sesaminol glucosides on memory function.

기저세포암의 bcl - 2 발현에 대한 면역조직화학적 연구

이선영,최규철 ( Sun Young Lee,Kyu Chul Choi ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.2

Background: Basal cell carcinoma(BCC) is the most common tumor of light-skinned people. Most of them are relatively innocuous, but some may cause extensive tissue destruction, and result in death by local infiltration of vital structure or metastatic disease. The bcl-2 is a protooncogene involved in tumorigenesis by blocking apoptosis or programmed cell death. Objective : To investigate whether there was a difference in bcl-2 expression in different histopathological types of BCC. Method: We performed immunohistochemical staining by using a monoclonal mouse anti-human bcl-2 oncoprotein in 28 BCC(nodular: 7 cases, micronodular; 3 cases, adenoid; 1 case, infiltrative; 9 cases, and mixed; 8 cases). Result: All 28 BCC expressed bcl-2, and the degree of staining was different according to histopathological types; poor prognostic micronodular(100%) and infiltrative(73.3%) types were relatively strong, and nodular(66.7% ) and adenoid(75.0%) types were moderate. Conclusion . These results suggest that the degree of bcl-2 expression in BCC seems to be dependent to the histopathological types together with clinical behavior. (Kor J Dermatol 1997;35(2): 242-248)

복합레진의 미세누출에 관한 연구

이선영,양연미,백병주,전철완,김재곤,Lee, Sun-Young,Yang, Yeon-Mi,Baik, Byeong-Ju,Jeon, Cheol-Wan,Kim, Jae-Gon 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.4

치과의 수복재로 널리 쓰이는 복합레진의 미세누출에 대한 할로겐광과 플라즈마광의 영향을 비교하고, 유동성 복합레진과 할로겐광으로도 중합시간이 20초로 단축된 복합레진 $Filtek^{TM}$ Z250이 미세누출면에서 기존에 널리 쓰이던 복합레진인 Z100을 대체할 수 있을지를 평가하며, 미세누출에 미치는 adhesive resin의 영향을 알아보고자 본 실험을 수행하였다. 발거된 치아에 5급 와동을 형성하고 레진의 충전은 각 군에 따라 시행하였다. 유동성복합레진 $Filtek^{TM}Flow$와 Z100, $Filtek^{TM}Z250$을 이용하였고, 할로겐광과 플라즈마광을 이용하여 중합하였다 충전이 완료된 시편은 보관, 연마, 열순환을 시행하고, 1% methylene blue를 침투시킨 후 협설로 절단하여 미세누출 정도를 관찰하여 다음과 같은 결론을 얻었다. 1. $Filtek^{TM}Flow$와 $Filtek^{TM}Z250$ 모두 광원에 따른 미세누출의 차이는 없었다(p>0.05). 2. 유동성 복합레진인 $Filtek^{TM}Flow$는 복합레진 $Filtek^{TM}Z250$과 Z100에 비해 통계적으로 유의성있는 큰 미세누출을 보여(p<0.05) 유동성 복합레진만으로 수복한다면 미세누출의 위험이 커질 것이다. 3. Adhesive resin을 도포한 것이 할로겐광을 이용한 경우와 플라즈마광을 이용한 경우 모두에서 통계적으로 유의하게 미세누출을 감소시켰다.(p<0.05) The purposes of this study were to evaluate the microleakage of class V composite resin restorations utilizing the different curing lights, to assess the flowable resin, $Filtek^{TM}Flow$(3M Dental Products, USA) and composite resin, $Filtek^{TM}Z250$(3M Dental Products, USA) which need 20s curing time for halogen light could replace $Z100^{TM}$ Restorative(3M Dental Products, USA) for the microleakage, and to evaluate the effect of adhesive resin on marginal microleakage. Light curing units used in this study were conventional halogen light, XL3000(3M Dental Products, USA) and plasma arc light, Flipo(Lokki, France). Class V cavities were prepared and each cavity was filled with each composite resin. After being filled, the teeth were stored in distilled water, polished, thermocycled and soaked in 1% methylene blue solution. Following results were obtained from evaluation of the sectioned surface. 1. There was no statistically significant difference in microleakage of $Filtek^{TM}Flow$ and $Filk^{TM}Z250$ between two kinds of curing units(p>0.05). 2. Flowable resin, $Filtek^{TM}Flow$ showed more microleakage than Z100 and $Filtek^{TM}Z250$ regardless of curing units(p<0.05). 3. Adhesive resin reduced the microleakage of composite resin in both halogen light and plasma arc light(p<0.05).

뽕나무깍지벌레 1세대 부화 약충의 발생과 살충제 감수성

이선영,이성찬,양창열,서미혜,최병렬,윤정범,Lee, Sun Young,Lee, Seong Chan,Yang, Chang Yeol,Seo, Mi Hye,Choi, Byeong Ryeol,Yoon, Jung Beom 한국응용곤충학회 2019 한국응용곤충학회지 Vol.58 No.4

뽕나무깍지벌레는 장미과에 속하는 과수의 주요 해충이다. 뽕나무깍지벌레의 산란 및 부화특성과 복숭아 및 매실의 깍지벌레 방제용으로 등록된 살충제 10종(디노테퓨란 입상수화제, 벤퓨라카브 입상수화제. 피리플루퀴나존 입상수화제, 클로티아니딘 입상수용제, 뷰프로페진 수화제, 뷰프로페진+이미다클로프리드 액상수화제, 뷰프로페진+에토펜프록스 입상수화제, 뷰프로페진+티아클로프리드 액상수화제, 벤퓨라카브+뷰프로페진 유제)의 살충제 감수성을 조사였다. 뽕나무깍지벌레의 1세대 부화시기와 부화율을 조사한 결과 5월 초에 가장 많이 발생해서 약 14일 정도 연속적으로 부화하였다. 부화율은 77.7% 였으며, 월동 암컷 성충 1개체의 평균 총 산란수는 58.7개, 평균 부화약충수는 45.7마리였다. 시험에 사용한 살충제 10종 모두에서 100%의 부화 약충 살충효과가 나타났으며 이는 약충 부화시기에 맞추어 약제를 살포하면 효과적으로 방제가 가능한 것을 시사한다. The white peach scale (Pseudaulacaspis pentagona) is a significant pest of trees belonging to the Rosaceae family. We investigated the effect of ten insecticides on hatching rate of first instar white peach scale larvae (crawlers). The insecticides are Dinotefuran WG, Benfuracarb WG, Pyrifluquinazon WG, Clothianidin SG, Buprofezin WP, Buprofezin+Imidacloprid SC, Buprofezin+Etofenprox WG, Buprofezin+Thiacloprid SC, Benfuracarb+Buprofezin WG, Acetamiprid+Buprofezin EC. We observed that several crawlers emerged in early May, with the average number being 45.7. Hatching period was approximately 14 days, and the hatching success rate was approximately 77.7%. Overwintering females produced an average of 58.7 eggs. All insecticides achieved 100% mortality in crawlers. Our results suggest that these insecticides can effectively control white peach scale when used at the crawler stage.

일반인의 교정치료에 대한 지식수준, 태도에 대한 연구

이선영,Lee, Sun-Young 한국치위생학회 2012 한국치위생학회지 Vol.12 No.2

Objectives : The purpose of this study was to examine the knowledge of people in general about orthodontic treatment and their attitude to that by conducting a survey in a bid to provide information on the improvement of their incorrect awareness of orthodontics and on the development of clinical orthodontic treatment. Methods and Results : The subjects in this study were 389 people in general who resided in Seoul and Gyeonggi Province. A self-administered survey was conducted, and the findings of the study were as follows: 1. As for awareness of orthodontic treatment among the people in general by gender, the women knew better about orthodontic treatment than the men, and the gender gap was significant(p<0.05). 2. Concerning satisfaction with the shape and arrangement of the teeth by age, those who were in their 20s were most satisfied, and the teens were satisfied the least. There were significant gaps according to age (p<0.05). 3. As a result of checking the degree of their inconvenience about the use of chewing teeth by age, the people who were in their 30s felt the most inconvenience, and the gap between them and the others was significant(p<0.01). 4. As a result of asking them whether they had an intention to receive orthodontic treatment, the women had a more intention to do that than the men(p<0.001). By age, the younger respondents had a more intention, and the gaps between them and the others were significant(p<0.001). 5. As a result of analyzing their perception of the positives of orthodontics by gender, the women took a more positive view of it than the men, and their gap was significant(p<0.01). Conclusions : When orthodontic treatment or orthodontic treatment counseling is provided to orthodontic treatment patients or people in general in the field of clinical dentistry, it should be noted that the way patients and people in general look at orthodontic treatment is different according to their age and gender, and they should be informed of the positives of orthodontic treatment to step up the development of orthodontic treatment.