후두 결핵의 후두 내시경 소견과 임상 양상 분석

이상혁,이승석,이노희,반재호,이경철,진성민,Lee, Sang-Hyuk,Lee, Seung-Suk,Lee, No-Hee,Ban, Jae-Ho,Lee, Kyung-Chul,Jin, Sung-Min 대한후두음성언어의학회 2006 대한후두음성언어의학회지 Vol.17 No.1

Background and Objectives: There has been a gradual decline in the incidence of laryngeal tuberculosis due to effective an-tituberculous chemotherapy and improvement in the standard of living. During the last decade, however, the disease has changed its clinical pattern. We aimed to study a clinical and telescopic evaluation of laryngeal tuberculosis. Materials and Method: A retrospective clinical analysis was done for 16 patients who diagnosed laryngeal tuberculosis from January 2000 through December 2004. All patients had a complete clinical and laboratory work-up including telescopy, chest X-rays, sputum cultures, Tbc PCR(polymerase chain reaction). Laryngeal biopsies were performed in some cases. All the patients received proper antituberculous chemotherapy. Results: The patients age ranged from 21 to 59 with a mean age 43. The male to female ratio was 10:6. The prominent presenting symptom was hoarseness. The various telescopic findings were categorized: 7 patients showed ulcerative, 4 patients granulomatous, 3 patients ulcerofungative, 2 patients had nonspecific inflammatory lesions. Involving sites were true vocal cord most commonly in 12 patients. Three of 16 patients had normal chest X-ray fmding. Among 16 patients, 4 patients showed positive response for AFB stain, 13 patients showed positive for Tbc PCR. Biopsy was done for 3 patients who were not confirmed in initial tuberculous test. All patients responded satisfactorily to antituberculous medication. Conclusion: The telescopic findings and clinical manifestations of laryngeal tuberculosis have changed and seemed to be different from those of classic reports. Thus, the clinicians who deal with the various symptoms and diseases should be aware of the existence of laryngeal tuberculosis and the changing patterns of the disease.

육군 전자식 기술교범 표준 S/W 개발 및 운용에 관한 연구

이상혁,오세준,Lee, Sang-Hyeok,O, Se-Jun 한국방위산업진흥회 2003 國防과 技術 Vol.- No.297

최근의 국내.외에서는 정보의 보관 및 활용측면에서 CALS의 일환인 전자식 기술교범에 관한 개발이 활발하게 이루어지고 있다. 이미 국내에서도 K9 자주포에서 기술교범을 개발하여 운용중에 있으며, 해.공군에서도 전자식 기술교범을 개발 중 혹은 계획중에 있는 실정이다. 그러나 이러한 전자식 기술교범 구축을 위해 필요한 소프트웨어는 해외 도구를 활용중이거나 국내의 업체에서 개발된 표준화되지 않은 소프트웨어를 활용하고 있는 실정이다. 이에 따라 전자식 기술교범 개발비 상승, 상호 활용성 미확보, 기술교범 국방규격서 충족의 어려움 등 여러 가지 문제점을 내포하고 있다. 따라서 이러한 문제점을 해결하기 위해 국내의 육군 지상무기체계 전자식 기술교범 개발시 공통으로 적용이 가능한 표준 소프트웨어를 개발하게 되었다. 이 글에서는 이렇게 개발된 육군 전자식 기술교범 표준 소프트웨어(,KAIS : Korean Army IETM Software)에 대해 기술하고자 한다.

공황장애 치료에 대한 한국형 알고리듬 개발(1) - 배경, 조직구성, 알고리듬 개발의 원칙, 개발계획, 개발방법

이상혁,유범희,김찬형,윤세창,Lee, Sang-Hyuk,Yu, Bum-Hee,Kim, Chan-Hyung,Yoon, Se-Chang 대한불안의학회 2007 대한불안의학회지 Vol.3 No.2

In this special article, we presented the organization of the work group, basic principles of the algorithm, future plan and methods for developing a treatment algorithm for panic disorder in Korea. The psychiatrist work group from the Korean Association of Anxiety Disorders began to develop a treatment algorithm designed to improve the management of Korean patients with panic disorder by incorporating better evaluation techniques and treatment procedures. We have reviewed the treatment guidelines and algorithms for panic disorder published thus far, including the Practice Guideline for the Treatment of Patients with Panic Disorder established by the American Psychiatric Association, the Management of Anxiety (Panic Disorder, with or without Agoraphobia, and Generalized Anxiety Disorder) in Adults in Primary, Secondary and Community Care established by the National Institute for Clinical Excellence, and the Clinical Practice Guidelines established by the Canadian Psychiatric Association. We developed the basic materials to be used in the treatment algorithm for the management of panic disorder in Korea. Therefore, in this special article, we intro-duce the goal of the algorithm and the details of the algorithm development.

보간법을 이용한 효율적인 모니터링 시스템 구성

이상혁,강필순,Lee, Sang-Hyeok,Kang, Feel-Soon 한국정보통신학회 2008 한국정보통신학회논문지 Vol.12 No.2

본 논문에서는 모니터링 시스템의 데이터 취득과 처리 과정에 있어 데이터를 효율적으로 저장, 복원시킬 수 있는 방법을 제시한다. 타겟 시스템에서 취득된 원시 데이터로부터 보간법을 기반으로 최소의 데이터를 추출한다. 이는 TCP/IP 통신에 의해 모니터링 PC로 전송되어 저장되며, 보간법을 통해 다시 원 신호로 복원된다. 따라서 통신 패킷양이 저감되어 데이터 통신 속도가 향상되며, 데이터 저장 공간을 줄일 수 있어 장시간에 걸쳐 취득되는 데이터를 효율적으로 관리할 수 있는 모니터링 시스템 설계가 가능하다. 제안된 데이터 취득과 복원 알고리즘은 큐빅 헤르미트 보간법에 기반을 둔다. 데이터 처리 방법의 타당성을 검증하기 위해 시뮬레이션 결과를 제시하며, 타 보간법 적용에 의한 결과와 비교하여 우수성을 검증한다. 계통연계형 태양광 발전 인버터의 모니터링 시스템에 적용하여 제안된 방식의 효율성을 실험적으로 검증한다. This paper presents an efficient data storage and reconstruction method in data acquisition and processing of monitoring system. The proposed method extracts minimum data using an interpolation from raw data which are acquired from a target system. They are transferred and saved in a monitoring PC via TCP/IP communication, and then reconstructed as original signals. Therefore, it is possible to design an efficient monitoring system by the improved data communication speed due to the reduced communication packet, and it reduces the storage space. The algorithm for data acquisition and reconstruction is based on Cubic Hermite interpolation. To verify the validity of the proposed scheme, we presents simulation results compared with other interpolation based approaches. Finally, it is applied to a monitoring system for grid-connected photovoltaic power generation system to prove the high-performance of the proposed method.

VMS 교통정보의 교통안전효과에 관한 연구

이상혁,조혜진,Lee, Sang Hyuk,Cho, Hye Jin 한국ITS학회 2015 한국ITS학회논문지 Vol.14 No.1

최근 교통문제를 완화하기 위하여 ITS를 적용하는 도로가 늘어나고 있다. 특히 가변전광표지(VMS: Variable Message Sign)는 전방도로상황, 기상상황 등 교통정보를 제공하여 교통흐름관리 및 교통안전관리를 하는 ITS 중 하나이다. 이런 VMS의 교통정보제공의 교통안전효과를 분석하기 위하여 현장조사를 통해 데이터를 수집하고 수집된 데이터에 대한 통계학적 검증을 시행하였다. VMS 교통정보제공 전 후의 차량주행특성은 교통정보제공 시 1차로와 2차로 모두 평균주행속도가 감소하고 차로 내 차량통행이 차로중심을 기준으로 통행하는 것으로 나타났다. 또한 VMS 교통정보제공이 교통안전효과에 미치는 영향을 분석하기 위하여 교통위험지역을 선정하고 구간을 통과하는 차량에 대한 확률분포를 Anderson-Darling Test를 통해 산정하여 비교하였다. 비교결과 1차로에서 VMS 교통정보제공으로 인해 교통안전효과가 차로양쪽 각각 0.69%와 7.07% 향상되는 것으로 나타났으며, 2차로의 경우 차로양쪽 각각 2.71%와 0.02% 향상되는 것으로 분석되었다. Recently ITS have been increasingly applied on the roads to resolve traffic problems. Especially, Variable Message Sign (VMS), which is the one of ITS for traffic management and traffic safety, can be used for providing information about road conditions, climate conditions. In this study, data acquisition and statistical analysis were conducted for estimating safety impacts of providing traffic information through VMS. As a result of analyzing traffic characteristics before and after providing traffic information through VMS, average travel speed was decreased and vehicles tended to drive on centerline of lanes in 1st and 2nd lane after providing traffic information through VMS. Also, in order to analyze safety impacts of provided VMS traffic information, traffic safety hazard zone was established in each lane and probability distributions of passing traffic on the study area was estimated through Anderson-Darling Test. As a result of this, safety impacts of VMS traffic information in 1st lane could, on average, increase in left and right side of the lane by 0.69% and 7.07%, respectively. In case of 2nd lane, safety impacts could, on average, increase in left and right side of the lane by 2.71% and 0.02%, respectively.

공황장애 약물 치료에 대한 한국형 알고리듬 개발(3) - 인지행동치료 -

이상혁,양종철,윤세창,서호석,김찬형,유범희,김민숙,Lee, Sang-Hyuk,Yang, Jong-Chul,Yoon, Se-Chang,Suh, Ho-Suk,Kim, Chan-Hyung,Yu, Bum-Hee,Park, Min-Sook 대한불안의학회 2008 대한불안의학회지 Vol.4 No.1

Objective : A working group of psychiatrists from the Korean Academy of Anxiety Disorders was established to determine the appropriate medication algorithm for treating patients with panic disorder. In this article, we discussed the consensus among psychiatrists regarding the use of cognitive behavior therapy (CBT) in the development of a treatment algorithm for panic disorder in Korea. Methods : Based on the guidelines or algorithms published by the American Psychiatric Association, National Institute for Clinical Excellence, and Canadian Psychiatric Association, we constructed questionnaires regarding the core components and contents of CBT for patients with panic disorder. Fifty-four experts in panic disorder completed the questionnaires. Results : There was statistically significant consensus among the experts in the belief that cognitive reconstruction and psychological education are the core components of CBT for the treatment of patients with panic disorder. However, there was some inconsistency between the opinions of some experts regarding the content and frequency of CBT and the results of studies published outside of Korea. Conclusions : CBT, especially the psychological education and cognitive reconstruction components, should be considered when treating patients with panic disorder. However, further consideration needs to be put into the design of a more detailed treatment guideline for the use of CBT in the treatment of patients with panic disorder.

포커스 - 국내 농산물 안전성 수준 어떠한가?

이상혁,Lee, Sang-Hyeok 한국작물보호협회 2015 자연과 농업 Vol.310 No.-

보툴리눔 독소의 약리

이상혁,이현섭,진성민,Lee, Sang Hyuk,Lee, Hyun Sub,Jin, Sung Min 대한후두음성언어의학회 2012 대한후두음성언어의학회지 Vol.23 No.2

Botulinum toxins are the most potent toxins known to mankind. Botulinum toxin acts by blocking the cholinergic neuromuscular or the cholinergic autonomic innervation of exocrine glands and smooth muscles. Seven distinct antigenic botulinum toxins (A, B, C, D, E, F and G) produced by different strains of Clostridium botulinum have been described and only A and B type of botulinum toxins were clinically used. Toxins were consisted of a heavy chain with a molecular weight of 100 kD and a light chain with a molecular weight of 50 kD. Toxins are bound with an astounding selectivity to glycoprotein structures located on the cholinergic nerve terminal. Subsequently light chain of toxin is internalized and cleaves different proteins of the acetylcholine transport protein cascade transporting the acetylcholine vesicle from the intracellular space into the synaptic cleft. After a decade of therapeutic application of the toxin, no anaphylaxis or deaths have been reported and systemic adverse effects have not been reported so far. However the toxin's immunologic properties can lead to the stimulation of antibody production, potentially rendering further treatments ineffective. Botulinum toxin is a safe and effective treatment. Use of botulinum toxin in clinical medicine has grown exponentially in recent years, and many parts of the human body are now being targeted for therapeutic purposes.

21세기 보병전투차량(IFV/ICV)의 발전 방향

이상혁,Lee, Sang-Hyeok 한국방위산업진흥회 1999 國防과 技術 Vol.- No.241

현대전은 군수면에서의 기술적 우세에 의해 전쟁의 승패가 결정된다는 걸프전의 교훈을 바탕으로, 주요 선진국들은 나름대로의 계획과 형편에 따라 주변기술의 발전과 더불어 21세기를 대비하는 보병전투차량의 연구.개발을 수행하고 있다. 이러한 주요 선진국들의 IFV/ICV의 발전 추세를 철저하게 분석하여, 우리 군의 현 실태와 앞으로의 나아갈 바를 판단할 수 있는 계기를 마련하고, 이에 적극적으로 대처하는 연구.개발 활동과 접근자세가 내부적으로 더욱 필요하다고 판단된다

신뢰성 있는 정보의 추출을 위한 퍼지집합의 유사측도 구성

이상혁,Lee Sang-Hyuk 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.9C

모호함의 측도를 위하여 퍼지 엔트로피와 거리측도 그리고 유사측도와의 관계를 이용하여 새로운 퍼지 측도를 제안하였다. 제안된 퍼지 엔트로피는 거리측도를 이용하여 구성된다. 거리측도는 일반적으로 사용되는 해밍 거리를 이용하였다. 또한 집합사이의 유사성을 측정하기 위한 유사측도를 거리 측도를 이용하여 구성하였고, 제안한 퍼지 엔트로피와 유사측도를 증명을 통하여 타당성을 확인하였다. We construct the fuzzy entropy for measuring of uncertainty with the help of relation between distance measure and similarity measure. Proposed fuzzy entropy is constructed through distance measure. In this study, the distance measure is used Hamming distance measure. Also for the measure of similarity between fuzzy sets or crisp sets, we construct similarity measure through distance measure, and the proposed 려zzy entropies and similarity measures are proved.