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이병완,김진화,고승현,이병완,김난희,이상열,김현진,문민경,박석오,최경묵 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.5
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM. After a systematic search of recent evidence, the KDA updated and modified its clinical practice recommendations regarding the initiation, choice, and intensification of insulin and created an insulin treatment algorithm for the first time to guide physicians caring for adult Korean patients with T2DM.
이병완,고재현,Xiaobing Li,Haosu Luo 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.9
The elastic properties of lead-free (Na1/2Bi1/2)TiO3-BaTiO3 single crystals near the morphotropic phase boundary were investigated by using Brillouin spectroscopy at room temperature. The measured longitudinal elastic constants of unpoled single crystals with a BaTiO3 content of 5% exhibited large changes depending on the scattering geometry, indicating that a substantial acoustic dispersion effect exists in this system. This was attributed to the relaxor nature due to inherent disorder in the A-site of the perovskite structure.
이병완,강보현,강한욱,김형훈,김현진,노정현,지재환,하창영,정재훈,민용기,이명식,이문규,김광원 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.3
당뇨병은 관상동맥질환의 중요 위험인자이다. 당뇨병의 유병률의 증가와 더불어 관상동맥질환 환자에서의 당뇨병 환자 비율은 점차 증가추세에 있다. 본 연구에서 관상동맥질환의 위험인자는 당뇨병, 나이, 비만, 고혈압, 흡연 그리고 관상동맥질환의 가족력이었다. 관상동맥질환 환자에 서 당뇨병군과 정상 혈당군간에는 나이, 고혈압, 흡연, 관상동맥질환의 가족력, 고밀도지단백 콜레스테롤, 중성지방, fibrinogen, t-PA, PAI-1이 통계적 유의한 차이가 있었다. 심근경색 환자를 대상으로 시행한 연구에서 당뇨병군과 정상 혈당군간에는 흡연, 지질강하제 복용, homocysteine,t-PA, PAI-I 그리고 CRP가 유의한 차이를 보였다. 혈당조절을 잘된 환자군과 잘되지 못한 환자군의 비교에서는 요산과 고밀도지단백 콜레스테롤만이 유의한 차이를 보였다. 당뇨병 환자에서의 지질 수치 중 고밀도지단백 콜레스테롤이 관상동맥질환의 주요 예측인자이며 위험인자라고 생각된다. 당뇨병 환자에서는 특히 금연과 혈압 그리고 혈당수치를 철저히 조절해야 한다. 당뇨병이 발생한 이후 혈당조절을 잘하는 것이 관상동맥질환의 발생과 사망률을 감소시킬 수 있을 지, 그리고 당뇨병 환자에서 혈당조절 이외의 어느 인자를 교정하는 것이 관상동맥질환을 예방하는데 도움이 될지 앞으로 전향적 연구가 필요하리라 사료된다. Background: Diabetes is a very important risk factor of coronary artery disease. The prevalence of diabetes in Korea is increasing steadily. The objective of this study was to establish the prevalence and cardiovascular risk factors of diabetes in coronary artery disease in Korean type 2 diabetes. Methods: Of the patients enrolled in SMC-coronary artery angiography protocol, we investigated 1143 subjects (from Jan. 1st to Dec.31th, 2001) with suspicious coronary artery disease reflected from symptoms of chest pain, EKG and enzyme abnormalities, and thallium scan. Sociodemographic characteristics and laboratory data were investigated using retrospective analysis. Results: The prevalence of diabetes in coronary artery disease patients was 37.49 %. The risk factors of coronary artery disease were diabetes, old age, obesity, hypertension, smoking and family history of coronary artery disease in our study. Among patients with coronary artery disease, there were significant differences in age, hypertension, smoking, family history of coronary artery disease, and levels of HDL-C, triglyceride, fibrinogen, t-PA, PAI-1 between diabetic patients and normo-glycemic patients. In the comparison of patients with myocardial infarction, there were significant difference in smoking, prescription of lipid-lowering drugs, homocysteine, tPA, PAI-I, and CRP between diabetic patients and normo-glycemic patients. Only the levels of uric acid and HDL-C showed meaningful difference between diabetic patients with well-controlled blood sugar and poorly-controlled blood sugar. Conclusion: With the increase in the prevalence of diabetes, the proportion of diabetic patients in coronary artery disease has also increased. Among patients with coronary artery disease, the risk factors of coronary artery disease were age, hypertension, smoking, family history of coronary artery disease, and levels of HDL-C, triglyceride, fibrinogen, t-PA, PAI-1 in diabetic patients compared to normo-glycemic patients. Diabetic patients must stop smoking and maintain strict control of blood pressure and blood glucose level. In addition, HDL-C was very important predictive risk factor for coronary artery disease.
이병완,고재현,임준호,고영호,김광주 한국정보디스플레이학회 2014 Journal of information display Vol.15 No.4
The polyethylene terephthalate (PET) substrate is one of the key materials comprising optical films, which are essential componentsin various optical devices, such as displays. The elastic properties of oriented PET were investigated via Brillouinlight scattering spectroscopy. The high-frequency longitudinal and transverse sound velocities in the hypersonic region weredetermined using a special right-angle scattering geometry, where the information of the refractive index was not included inthe calculation. When the propagation direction of the acoustic modes was changed in the plane with respect to the stretchingdirections, the longitudinal and transverse sound velocities exhibited periodic modulations, clearly revealing the acousticanisotropy of the film arising from the stretching condition.
이병완,김규리,이용호,강은석,차봉수,이현철 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.6
Purpose: The objective of this study was to investigate clinical and laboratory parameters that could predict which patients could maintain adequate glycemic control after switching from initial insulin therapy to oral hypoglycemic agents (OHAs) among patients with type 2 diabetes (T2D). Materials and Methods: We recruited 275 patients with T2D who had been registered in 3 cohorts of initiated insulin therapy and followed up for 33 months. The participants were divided into 2 groups according to whether they switched from insulin to OHAs (Group I) or not (Group II), and Group I was further classified into 2 sub-groups: maintenance on OHAs (Group IA) or resumption of insulin (Group IB). Results: Of 275 patients with insulin initiation, 63% switched to OHAs (Group I) and 37% continued insulin (Group II). Of these, 44% were in Group IA and 19% in Group IB. The lowest tertile of baseline postprandial C-peptide-to-glucose ratio (PCGR), higher insulin dose at switching to OHAs, and higher HbA1c level at 6 months after switching to OHAs were all associated with OHA failure(Group IB; p=0.001, 0.046, and 0.014, respectively). The lowest tertile of PCGR was associated with ultimate use of insulin (Group IB and Group II; p=0.029). Conclusion: Higher baseline level of PCGR and lower HbA1c levels at 6 months after switching to OHAs may be strong predictors for the successful maintenance of OHAs after switching from insulin therapy in Korean patients with T2D.