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이도윤,한재희,박재용 대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.1
Our previous report demonstrated that chick myoblasts are equipped with Ca2+-permeable stretch- activated channels and Ca2+-activated potassium channels (KCa), and that hyperpolarization-induced by KCa channels provides driving force for Ca2+ influx through the stretch-activated channels into the cells. Here, we showed that acetylcholine (ACh) also hyperpolarized the membrane of cultured chick myoblasts, suggesting that nicotinic acetylcholine receptor (nAChR) may be another pathway for Ca2+ influx. Under cell-attatched patch configuration, ACh increased the open probability of KCa channels from 0.007 to 0.055 only when extracellular Ca2+ was present. Nicotine, a nAChR agonist, increased the open probability of KCa channels from 0.008 to 0.023, whereas muscarine failed to do so. Since the activity of KCa channel is sensitive to intracellular Ca2+ level, nAChR seems to be capable of inducing Ca2+ influx. Using the Ca2+ imaging analysis, we were able to provide direct evidence that ACh induced Ca2+ influx from extracellular solution, which was dramatically increased by valinomycin-mediated hyperpolarization. In addition, ACh hyperpolarized the membrane potential from -12.5±3 to -31.2±5 mV by generating the outward current through KCa channels. These results suggest that activation of nAChR increases Ca2+ influx, which activates KCa channels, thereby hyperpolarizing the membrane potential in chick myoblasts.
청소년의 완벽주의적 자기제시가 사회불안에 미치는 영향에서 무조건적 자기수용의 매개효과
이도윤,이수림 한국청소년상담복지개발원 2022 청소년상담연구 Vol.30 No.1
The purpose of this study was to examine the effect of perfectionistic self-presentation on social anxiety among adolescents and to investigate the mediating effect of unconditional self-acceptance on the relationship between perfectionistic self-presentation and social anxiety. To this end, a survey was conducted with 259 middle and high school students under the age of 18 in Korea. The Korean version of the Perfectionist Self-Presentation Scale (PSPS-K), Unconditional Self-Acceptance Scale, and the Korean version of the Social Anxiety Scale (K-SAS-A) were used. The collected data were analyzed using SPSS 21.0 and SPSS PROCESS macro, and correlation, regression, and mediation analyses were performed. Findings of this study are as follows. First, perfectionistic self-presentation, unconditional self-acceptance, and social anxiety were significantly correlated to one another. Secondly, adolescents’perfectionistic self-presentation significantly affected their social anxiety. Third,unconditional self-acceptance partially mediated the relationship between perfectionistic self-presentation and social anxiety. This study expanded on the findings of existing research by identifying specific psychological mechanisms that adolescents’perfectionistic self-presentation can influence their social anxiety. Implications and limitations of the study as well as suggestion for future research were discussed. 본 연구에서는 청소년을 대상으로 완벽주의적 자기제시와 사회불안 간의 관계에서 무조건적 자기수용의 매개효과를 검증하고자 하였다. 이를 위해 국내에 거주하는 만18세 미만의 중・고등학생 259명을 대상으로 설문조사를 실시하였으며, 측정도구로 한국판 완벽주의적 자기제시 척도(PSPS-K), 무조건적 자기수용 척도, 한국판 청소년용 사회불안 척도(K-SAS-A)를 사용하였다. 분석을 위해 SPSS 21.0와 SPSS PROCESS macro를 사용하여 주요 변인들의 상관분석, 회귀분석, 매개효과분석을 실시였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 완벽주의적 자기제시, 무조건적 자기수용, 사회불안 간에 유의미한 상관관계가 나타났다. 둘째, 청소년의 완벽주의적 자기제시가 사회불안에 유의미한 영향을 미치는 것으로 확인되었다. 셋째, 완벽주의적 자기제시와 사회불안 간의 관계에서 무조건적 자기수용이 매개하는지 살펴본 결과 부분매개 하는 것으로 확인되었다. 본 연구는 청소년을 대상으로 완벽주의적 자기제시가 사회불안으로 이어지는 구체적인 심리적 기제를 조명함으로써 선행연구의 발견을 확장하였다. 마지막으로 본 연구 결과를 토대로 연구의 시사점과 제한점 그리고 후속연구 방향을 논의하였다.