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      • KCI우수등재

        일부지역 대본업소의의 환경위생학적 조사 (조명과 CO를 중심으로)

        원종만 한국환경보건학회 1981 한국환경보건학회지 Vol.7 No.1

        This survey was carried out for a month from Jan. 15th, 1979 to Feb, 15th, 1979 to study the sanitary environments of the "book-lending" shops (comic-book shops) in Inchon area, and the special emphasis was placed on their illumination and carbon monoxide gas, which plays an important part in the whole sanitary environment. 120 shops surveyed were chosen at random from 4 administrative districts, 30 shops from one district respectively. The results of the survey were as follows:1) The average space of the book-lending shops (63.3%) was 2.0~3.9 pyung, at 21 number of shops (17.5%) was 1.0~1.9 pyung, at 53 number of shops (10.8%) was 4.0~5.9 pyung, at 9 number of shops (7.5%) was 6.0~7.9 pyung. 2) The ages of 42.8 percent of the whole 888 customers range from 10 to 14 and those of 36.5 percent from 15 to 19, and those of 11.9 percent from 20 to 24, and 89.2 percent were male and 10.8 percent were females and the percent of spending time in shops was shown 10.2% in under 1 hr, 25.4% in 1 hr to 2 hrs, 46.5% in 2 hrs to 3 hrs and 17.8% in over 3 hrs. 3)The CO pollution was quite different by shops where the ventilator was equipped and where not equipped. In the shops equipped shown 36 shops (80.8%) and non-equipped shown 65 shops (86.7%), the pollution ratio of all the shops (120 shops) was 84.2 percent. 4) The CO Concentration of the ventilator equipped shops was shown 44.5 percent in 100~149 ppm, 150~199 ppm shown 33.3 percent and 22.2 percent was 200~250 ppm, In the non-equipped shops the CO concentration was shown 36.9 percent was 150~199 ppm and 200~250 ppm was 25.6 percent. The totally was 39.6 percent in 100~149 ppm. 5) 37.5 percent of the book-lending shops had the ventilation facilities but 62.6 percent had no ventilators. 6) The maxmum average illumination of the shops was 38.5 Lux and the minimum average illumination was 14.1 Lux, and the mean average illumination S.D. was 24.6\pm38.4. 7) 35.8 percent of the shops had the illumination of 20~29 Lux and 8.3 percent had that of more than 40 Lux. In other words 91.7 percent had the illumination of less than 40 Lux.

      • KCI우수등재
      • KCI등재

        육군자탕(六君子湯)이 흰쥐의 위(胃) 배출능(排出能)에 미치는 영향

        원종만,윤상협,Won, Jong-Man,Yoon, Sang-Hyub 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2

        Backgrounds & Objectives : Yukgunjatanggranule (YGJT) ha been used for the treatment of functional dyspepsia, regarded as one of the gastric dysmotility diseases, but its mechanisms of cation are not yet well known, We investigated the effects of YGJT on gastric emptying and its mechanisms of action in rats. Methods : Gastric emptying was measured by glass beads (1mm in diameter) expelled from the stomach for 1 hour and 2 hours after administration ofnormal saline (NS) or YGJT 41.6mg/kg or 124.8mg/kg in rats. By the same method, gastric emptying was measured only for 2 hours after administration of NS of YGJT 124.8mg/kg in rats treated with atropine sulfate (1mg/kg, s.c), quinpirole HCl(0.3mg/kg, i.p.), NAME (NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin (10mg/kg, i.p.) to delay gastric emptying. Results : YGJT 124.8mg/kg improved gastric emptying more than NS or YGJT 41.6mg/kg (p=0.046). Under delayed gastric emptying, YGJT 124.8mg/kg improved gastric emptying in the group treated with cisplatin ($3.1{\pm}1.3$ vs. $6.6{\pm}3.1$, p=0.015), quinpirole HCl ($4.7{\pm}2.8$ vs. $5.5{\pm}5.6$, p=0.874) and NAME ($2.2{\pm}1.4$ vs. $4.7{\pm}6.0$, p=0.414), but aggravated it with atropine sulfate ($1.8{\pm}0.9$vs. $1.7{\pm}1.0$, p=0.957). Conclusions : YGJT improves gastric emptying through the cholinergic pathwas, and shows some effect against the toxicity of cisplatin. Therefore, we expect that it would be effective in relieving gastrointestinal symptoms in functional dyspepsia patients and cisplatin-treated patients.

      • KCI등재

        쥐의 동맥손상후 Angiotensin 전환효소 억제제와 Heparin의 내막 과대비후 억제효과

        원종만,박장상,고용복,한동률 대한혈관외과학회 1994 Vascular Specialist International Vol.10 No.1

        Intimal hyperplasia, smooth muscle cell migration and proliferation with the formation of extracellular matrix, is a frequent cause of failure of vascular surgery and angioplasty. Local angiotensin II effects in the artery wall may participate in regulation of the vascular response to arterial injury, apparently independent of the plasma renin and angiotensin system. This is supported by the observation that angiotensin converting enzyme (ACE) inhibitors have been shown to block intimalhyperplasia after arterial iniury in the rat. This examination was intiated to prove that previous observations with use of ACE inbibitors are a result of effects on local angiotensin levels versus nonspecific drug effects, and we tested the ability of an unrelated drug, auticoagulant heparin, to similarly block intimal hyerplasia induced by aortic injury in the rat. We also investingate if the synergic effect is to be seen when ramipril and heparin were given together. Balloon catheter aortic denudation was performed in 25 rats pharmacologically treated from 6 days before to 14 days after surgery and split into four groups: group A(control group), normal feeding; group B(ramipril^ⓡ group), ramipril^ⓡ 10 mg/kg/day orally, group C (heparin group), heparin 1200 u/kg/day subcutaneously ; group D(combined group), both ramipril^ⓡ and heparin. Animals were killed and aortas were perfused and fixed at physiologic pressure 14 days after denudation. Cross-sectional intima-to-media ratios(I-M ratio) were calculated by image analyzer system. The results were as follows: 1) Marked intimal thickening with a mean I-M ratio of 95.1±2.76% in the control group. In contrast, the I-M ratio in the ramipril group were reduced to 37.3±2.06% (P$lt;0.001), heparin group 29.7±1.58% (P$lt;0.001), and combined group 16.6±1.3% significantly. 2) Blood pressure in ramipril group decreased from l11.7±5.16mmHg to 95.8±5.84mmHg (P$lt;0.001) and in combined group from 111.7±6.06mmHg to 92.5±5.24mmHg after 6 days, whereas heparin had no effect on blood pressure (114.2±8.6mmHg to 111.7±6.06mmHg). This study shows that attenuating the angiotensin system at the level of production reduces the intimal hyperplasia induced by aortic injury. These results further support the hypothesis that angiotensin II induces smooth muscle cell prolifertion and that the heparin also block the intimal hyperplasia by inhibiting smooth muscle cell proliferation independent of anticoagulation after aortic injury in the rat.

      • 흡연이 체격발달에 미치는 영향 : 일부지역 고교생을 중심으로

        원종만,이옥경 中央醫學社 1994 中央醫學 Vol.59 No.10

        To study the effect smoking for physical development. 309 of the third: year if boys senior high school students around Nonson area were randomly selected were given the questioners and we's asked to submit their physical examination records from the age of 7(elementary school) to 17(second year in senior high school). The relationship between the smoking and reduced height or weight of the students were examined. The conclusions obtained from this study were as follows: 1. The average heights of the students in the nonsmoking group at the age of 12 and 13 were 147.9±7.1cm and 155.4±7.4cm respectively, and those of the students who smoked for under two years were 145.7±7.2 cm and 152.5±8.3 cm respectively. It was show that the average heights of the students at the ages of 12 and 13 were smaller in the smoking group and this difference was statistically significant(p>0.05). However, at other ages, there was no significant differences in the height between the two groups. 2. The average weight of the students in the nonsmoking group at the age of 13 was 43.8±7 kg and that of the group who smoked for under two years was 41.2±6.9kg. This lower value in the smoking group is statistically significant(p>0.05). But in the group who smoked for more than five years. The average weights at the ages of 14,15, and 16 were 52.4 ± 8.9 kg, 57.2 ± 8.0 kg and 60.6 ± 8.7 kg respectively and these values were higher than J the corresponding values 50.7 ± 8.7 kg, 56.4 ± 8.4 kg, and 59.1 ± 7.7 kg, of the nonsmoking students. However these lower value in nonsmoking group was not statistically significant. 3. The relationships between the height and he weight. The amount and the length of smoking and the weight and the length of smoking were examined at the age of 17. The values were 0.4941, 0.4971(p<0.01) and 0.1966(p<0.05) respectively and the relationship in each case was shown to be normal. However, the values between the height and the amount of smoking. The height and the length of smoking and the weight and the amount of smoking were 0.0183.. 0.1274 and 0.1704 respectively, and there was no significant relationships between these values. 4. When the average height and weight of the students at the age of 17 were compared according to the their parents job, medicare insurance fee, and the habit of eating and smoking, there was no significant difference between the values of the nonsmoking and smoking group. 5. When the complications of the smoking were examined. the coughing and asthmatic pain was the most prominent one(0.6049?0.4) and dizziness(0.2927?0.4). difficulty in breathing(0.2146±0.4), and shaking of hands(0.1951?0.3) ,were next common complications. The coughing and asthmatic pain was show to be highest in the group who smoked for under two years(0.7463?0.4), high in the group who smoked for less than one year(0.4667? 0.5). These values were statistically significant. But in the case of the other complications, there was no significant values. This the above results suggest that there seems to be no significant deleterious effects of smoking on the development of heights and weight of youngsters at their early ages. But it is likely that if the length of smoking is extended toward the middle age of their lives, the effects of smoking on their health could be more serious at their later stage of lives.

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