RISS 검색 - 국내학술지논문

다국어 입력

あぁかがさざただなはばぱまやゃらわゎんいぃきぎしじちぢにひびぴみりうぅくぐすずつづっぬふぶぷむゆゅるえぇけげせぜてでねへべぺめれおぉこごそぞとどのほぼぽもよょろを

アァカサザタダナハバパマヤャラワヮンイィキギシジチヂニヒビピミリウゥクグスズツヅッヌフブプムユュルエェケゲセゼテデヘベペメレオォコゴソゾトドノホボポモヨョロヲ ―

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)

中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.

ㅥ ㅦ ㅧ ㅨ ㅩ ㅪ ㅫ ㅬ ㅭ ㅮ ㅯ ㅰ ㅱ ㅲ ㅳ ㅴ ㅵ ㅶ ㅷ ㅸ ㅹ ㅺ ㅻ ㅼ ㅽ ㅾ ㅿ ㆀ ㆁ ㆂ ㆃ ㆄ ㆅ ㆆ ㆇ ㆈ ㆉ ㆊ ㆋ ㆌ ㆍ ㆎ

Α Β Γ Δ Ε Ζ Η Θ Ι Κ Λ Μ Ν Ξ Ο Π Ρ Σ Τ Υ Φ Χ Ψ Ω α β γ δ ε ζ η θ ι κ λ μ ν ξ ο π ρ σ τ υ φ χ ψ ω

á à Á À é è É È ç Ç ê

Ä Ö Ü ä ö ü ß

ְ ֳ ֲ ֱ ָ ַ ֵ ֶ ִ ֹ ּ ֻ ׂ ׁ ּ פ ם ן ו ט א ר ק ף ך ל ח י ע כ ג ד ש ץ ת צ מ נ ה ב

‘ ’ “ ” 〔〕〈〉「」『』【】＂（）［］｛｝

± × ÷ ≠ ≤ ≥ ∞ ∴ ♂ ♀ ∠ ⊥ ⌒ ∂ ∇ ≡ ≒ ≪ ≫ √ ∽ ∝ ∵ ∫ ∬ ∈ ∋ ⊆ ⊇ ⊂ ⊃ ∪ ∩ ∧ ∨ ￢ ⇒ ⇔ ∀ ∃ ∮ ∑ ∏ ＋－＜＝＞

、。 · ‥ … ¨ 〃 ― ∥ ＼ ∼ ´ ～ ˇ ˘ ˝ ˚ ˙ ¸ ˛ ¡ ¿ ː ！＇，．／：；？＾＿｀｜

½ ⅓ ⅔ ¼ ¾ ⅛ ⅜ ⅝ ⅞ ¹ ² ³ ⁴ ⁿ ₁ ₂ ₃ ₄

Æ Ð Ħ Ĳ Ł Ø Œ Þ Ŧ Ŋ æ đ ð ħ ı ĳ ĸ ŀ ł ø œ ß þ ŧ ŋ ŉ

А Б В Г Д Е Ё Ж З И Й К Л М Н О П Р С Т У Ф Х Ц Ч Ш Щ Ъ Ы Ь Э Ю Я а б в г д е ё ж з и й к л м н о п р с т у ф х ц ч ш щ ъ ы ь э ю я

′ ″ ℃ Å ￠￡￥ ¤ ℉ ‰ ＄％Ｆ￦㎕㎖㎗ ℓ ㎘㏄㎣㎤㎥㎦㎙㎚㎛㎜㎝㎞㎟㎠㎡㎢㏊㎍㎎㎏㏏㎈㎉㏈㎧㎨㎰㎱㎲㎳㎴㎵㎶㎷㎸㎹㎀㎁㎂㎃㎄㎺㎻㎽㎾㎿㎐㎑㎒㎓㎔ Ω ㏀㏁㎊㎋㎌㏖㏅㎭㎮㎯㏛㎩㎪㎫㎬㏝㏐㏓㏃㏉㏜㏆

§ ※ ☆ ★ ○ ● ◎ ◇ ◆ □ ■ △ ▽ → ← ↑ ↓ ↔ 〓 ◁ ◀ ▷ ▶ ♤ ♠ ♡ ♥ ♧ ♣ ⊙ ◈ ▣ ◐ ◑ ▒ ▤ ▥ ▨ ▧ ▦ ▩ ♨ ☏ ☎ ☜ ☞ ¶ † ‡ ↕ ↗ ↙ ↖ ↘ ♭ ♩ ♪ ♬ ㉿㈜ № ㏇ ™ ㏂㏘ ℡ ＃＆＊＠ ª º

ⅰ ⅱ ⅲ ⅳ ⅴ ⅵ ⅶ ⅷ ⅸ ⅹ Ⅰ Ⅱ Ⅲ Ⅳ Ⅴ Ⅵ Ⅶ Ⅷ Ⅸ Ⅹ

ا ب ت ث ج ح خ د ذ ر ز س ش ص ض ط ظ ع غ ف ق ک ل م ن ه و ی

닫기

최근 검색 목록
전체삭제 닫기

RISS 인기검색어

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
위 평활근에서 비교감성 비콜린성 이완반응과 Substance P에 의한 조절

허광식 ( Gwang Sik Heo ),장성종 ( Sung Jong Chang ),박찬국 ( Chan Guk Park ),김만우 ( Man Woo Kim ),장인엽 ( In Youb Jang ),김진호 ( Jin Ho Kim ),신무경 ( Moo Kyoung Shin ),염철호 ( Cheol Ho Yeum ),윤평진 ( Pyung Jin Yoon ),전제열 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5
- 원문보기
Background/Aims: In a gastric fundic strip, electrical field stimulation (EFS) evokes TTX-sensitive biphasic responses, consisting firstly of cholinergic contraction followed by a transient relaxation. It is well known that nonadrenergic noncholinergic (NANC) inhibitory nerve mediates a transient relaxation. This study was performed to investigate the characterization of relaxation and its modulation by substance P. Methods: Using Guinea-pig gastric fundic smooth muscle tissues, we recorded mechanical contractions induced by EFS in the organ bath with platinum. Results: NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, reduced EFS-induced relaxation and these effects were reversed by L-arginine, a precursor of nitric oxide (NO). Sodium nitroprusside, a NO-donor, suppressed the fundic basal tension. Cell permeable 8-bromo-cGMP inhibited noradrenaline-induced contraction. The application of substance P increased basal tension and EFS-induced contraction and relaxation. NK-1 receptor antagonist ([D-Pro9-(spiro--lactam)9,10-Trp11]-Substance P) inhibited substance P-induced effects. TEA and apamin, K+ channel blockers, increased basal tension and EFS-induced relaxation. Conclusions: These results indicate that NANC inhibitory responses are mainly mediated by NO in the guinea-pig fundus and the release of NO is modulated by substance P through NK-1 receptor and by prejunctional K+ channels. (Korean J Gastroenterol 2003;41:358-365)
2
생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구

김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
- 원문보기
Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.
3
Effects of Imipramine on A-type K^+ Current in Murine Proximal Colon

Yoon, Hong,Choi, Hyun-Dong,Lee, Jeong-Hoe,Cho, Cheoi-Hee,Kim, Gi-Sig,Shin, Moo-Kyoung,Yeum, Cheol-Ho,Yun, Pyung-Jin,Jun, Jae-Yeoul 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2
- 원문보기
목적 : Imipramine은 널리 쓰이는 항우울제로 알려져 있으나 상대적으로 위장관 운동성에 대한 부작용을 빈번히 보이는 바 대장 평활근 세포에서 외향성 칼륨 통로에 대한 imipramine의 효과를 관찰하고 그 조절기전을 알아보고자 하였다. 재료 및 방법 : Collagenase를 사용하여 생쥐 대장 평활근에서 단일세포를 분리한 다음 역상 현미경하에서 세포막전압 고정법(Whole-cell patch clamp)을 시행하였다. Ca2+-의존성 칼륨 전류를 배제하기 위하였다. 결과: 유지전압 80 mV에서 10 mV씩 단계별로 저분극 자극를 주게 되면 자극 초기에 큰 전류가 발생되면서 빠르게 비활성화 되는 전류가 기록되었다. 이 전류는 4-aminopyridine (4-AP) 5 mM를 투여한 경우 억제되어 A-형의 칼륨 전류임을 확인하였으며 tetraethylammonium (TEA) 10 mM 투여시 전류의 후반부가 억제되는 지연 정류성 칼륨 전류임을 확인하였다. Imipramine은 A-형 칼륨 전류를 농도-의존적으로 억제하였다. 이 전류의 halfinactivation은 42.5±2.9 mV를 보였으며 imipramine은 45.1±1.7 mV로서 비활성화 과정에는 아무런 영향을 나타내지 않았다. Recovery time에서도 대조군은 50% 전류가 회복되는 데 있어 23 sec를 보였으며 imipramine은 24 sec로서 통계학상 차이가 없었다. Imipramine에 의한 A-형 칼륨 전류의 억제 현상은 세포내 1 mM guanosine 5-O-(2-thiodiphosphate)(GDPβS)를 첨가한 경우에서도 변화하지 않았다. 또한 protein kinase C 억제제인 chelerythrine이 존재한 경우에서도 변화되지 않았다. 결론 : 이상의 실험결과를 종합해보면 항우울제인 imipramine은 G-단백과 protein kinase C와 무관하게 A-형의 외향성 칼륨 통로를 차단하며 이러한 효과가 위장관 운동성 부작용에 대한 한 기전으로 설명될 수 있으리라 생각된다. To investigate of effects of imipramine, an antidepressant agent, on delayed rectifier K+ currents in murine proximal colonic smooth muscle cells, A-type delayed rectifier K+ currents were recorded from isolated cells using the standard whole-cell configuration. Depolarizing test pulses between -80 mV and +30 mV with 10 mV increment from the holding potential of -80 mV activated voltage-dependent outward K+ currents that peaked within 50 ms followed slow decreasing sustained currents. Early peak currents were inhibited by the application of 4-AP, whereas sustained currents were inhibited by the application of TEA. Bath application of imipramine inhibited the 4-AP sensitive A-type K+ currents, dose-dependently. But, half-inactivation potential and half-recovery time were not changed by imipramine. The imipramine-induced inhibition was not changed when 1 mM guanosine 5-O-(2-thiodiphosphate) (GDPβS) was in the pipette. Also, in the presence of chelerythrine, a protein kinase C inhibitor, imipramine-induced inhibition was not changed. These results suggest that imipramine inhibits A-type delayed rectifier K+ currents by G-protein and protein kinase C- independent manner.