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Strategies to Find Candidate Genes for Bipolar Disorder
배치운 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.4
Definitely today is just preparing the first puzzle but not finding the final one. I believe that the efficient strategies and tactics to find precise implications through stepwise integration of currently available findings are more important than finding a new candidate gene today.
주요 우울장애가 동반된 혈액 종양 환자에서 Paroxetine의 효과 및 안정성
배치운,이혁재,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4
Objectives : The efficacy and safety of paroxetine in the treatment of depressive disorders are well known, however its efficacy and safety for the treatment of depression in patients with cancer has been poorly studied. This study therefore aimed to evaluate the efficacy and safety of paroxetine in treatment of depressed patients with hematological malignancy (HM). Methods : Fifty-two patients with major depressive disorder (MDD) based on DSM-IV criteria along with comorbid HM were allotted to 8 weeks trial with a flexible-dose regime of paroxetine in combination with their chemotherapy or supportive pharmacotherapy. Treatment response was assessed at baseline, week 2, week 4, and week 8 with 17-item Hamilton Rating Scale for Depression (HAM-D17), Montgomery A sberg Depression Rating Scale (MADRS), and Clinical Global Impression-severity (CGI-S). Side effects were collected with the reported adverse events and laboratory test throughout the study period. Results : 44.2% of 52 patients completed the eight weeks trial. Scores on the HAM-D17, MADRS, and CGI-s (last Observation carried forward, LOCF) at baseline were significantly reduced with mean reduction of 30.5%, 32.8%, and 39.1%, respectively, after 8 weeks treatment with paroxetine. Forty-six patients (88.5%) reported at least one adverse event. The most common adverse event observed in this study was nausea and no serious adverse event was found. Conclusion : In this preliminary study, overall results showed paroxetine could be used for the treatment of depressed patients with HM, but more controlled study is needed to confirm the efficacy and safety of paroxetine in this area.
Fluoxetine 투여와 관련된 양측 측두하악관절 손상 1예
배치운,김연주,김태석,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
We hereupon present a case of injured temporomandibular joint (TMJ) associated with fluoxetine monotherapy-inducedrepeated yawning. Further information is needed regarding the relationship between fluoxetine administration and clinically significant yawning. Clinicians should be more careful to listen to their patients when they describe unexpected reactions to medications.
-G308A Tumor Necrosis Factor-α 유전자 다형성과 주요 우울장애의 연합연구
배치운,오해정,채정호,박원명,전태연,한훈,김광수 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2
Objectives : The present study was to examine possible association between the - G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean. Methods : 108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results : Genotype and allele distributions in patients with MDD (p=0.02, P=0.01, respectively), were significantly different from those of the controls. Conclusion : The present study suggests that the -G308A TNF-α gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.
양극성 장애 환자에서 Quetiapine 병합 치료:6개월 전향적 개방 연구
배치운,김태석,이영지,김정진,이수정,이창욱,이철,백인호 대한정신약물학회 2005 대한정신약물학회지 Vol.16 No.4
Objectives: This study was conducted to evaluate the overall effectiveness and tolerability of adjunctive quetiapine in the long-term treatment of bipolar disorder as a continuation therapy. Methods: Twenty-three bipolar I patients participated and required to have quetiapine add-on treatment in combination with existing or new mood stabilizers. Clinical assessment was carried out using Young Mania Rating Scale(YMRS), Clinical Global Impression(CGI), Hamilton Depression Rating Scale-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at baseline, 1, 4, 12 and 24 weeks. Results: The YMRS and CGI decreased significantly from baseline to endpoint by 89.7% and 78.3%, respectively (p<0.0001; p<0.0001). Twenty-two patients exhibited at least 50% improvement on YMRS score by the end of the study. Conclusion: This study suggests that quetiapine may hold a promise as an adjunct in the long-term treatment of bipolar disorder. 연구목적:본 연구에서는 양극성 장애 환자를 대상으로 하여 기분안정제와의 병합요법으로서 quetiapine의 장기적인 효과와 내약성을 평가하였다. 방 법:DSM-Ⅳ 진단 기준상 1형 양극성 장애를 만족시키는 23명의 환자에게 24주 동안 기분안정제에 더하여 quetiapine을 병합 투여하였다. 환자의 증상 정도와 내약성 평가는 Young 조증 평가 척도(YMRS), 임상전반인상척도(CGI) 및 Hamilton 우울증 척도(HDRS-17)와 Simpson-Angus 평가척도(SARS)와 Barnes 정좌불능 평가척도(BARS)를 기저 시점, 1주, 4주 12주 그리고 24주에 실시하였다. 결 과:기저 시점에 비하여 YMRS 점수의 89.7% 그리고 CGI 점수의 78.3%가 각각 종료 시점까지 유의하게 감소하였다(p<0. 0001;p<0.0001). 기저 시점과 비교 하였을 때, 2명(95.7%)은 종료시점에서 YMRS 점수가 50% 이상 감소하였다. 과도한 진정을 호소한 2명의 환자가 연구를 중단하였지만, quetiapine은 전반적으로 좋은 내약성을 보였다 결 론:본 연구의 결과는 quetiapine을 기분안정제에 병합투여 하여 장기간 투여할 때 양극성 장애 환자의치료에 효과적이며 안전함을 시사한다.
양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성
배치운,김태석,장우영,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5
Objectives : Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter-2518 and BD. Methods : Patients with BD (n=92) in accordance with DSM-FV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results : Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587 ; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion : Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.
Management of Social Phobia in Clinical Practice
배치운 대한우울조울병학회 2012 우울조울병 Vol.10 No.3
Two cases were selected to illustrate the tendency for social phobia to present as secondary depressive symptoms or as comorbid with mood disorders. It is important for clinicians to correctly diagnose social phobia in patients presenting with other syndromes, and also to find comorbid conditions among patients presenting with social phobia. In addition, personalized and timely intervention based on the presenting symptoms and signs of social phobia as well as the presence of comorbidities should be carefully considered to enhance patient’s clinical outcomes in clinical practice.