유,무기 혼성 메조포러스 물질의 휘발성 유기화합물 제거능

정한모 ( Han Mo Jeong ),라영수 ( Young Soo La ),안진희 ( Jin Hee An ),조아영 ( Ah Young Jo ),최미연 ( Mi Yeon Choi ),김석만 ( Suck Man Kim ),문남구 ( Nam Gu Moon ),윤영호 ( Young Ho Yoon ) 한국공업화학회 2005 공업화학 Vol.16 No.5

油劑性 軟膏 O/W型과 O/W型의 Penetration의 比較試驗.

金石萬 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.26 No.-

Ointment has different penetration by bases. Emulsion bases have two types. One type is oil in water (O/W) type, another is water in oil (W/O) type. In Experimentation, we had comparatove test of oil in water intment and water in oil ointment containing principle drug. We had also the comparative test of water soluble ointment and oleaginous ointment with emulsion ointment.

注射劑가 各血液型에 미치는 溶血理想에 관한 硏究

金石萬 梨花女子大學校 韓國生活科學硏究院 1975 韓國生活科學硏究院 論叢 Vol.15 No.-

The Hemolytic action of Parenteral solution is closely related to the concentratian of drug solution, Therefore isotonic solution generally decrcases the hemolytic degree. In such a view point, the hemolytic degree of each blood form (A.B.O.AB) was tested under the same condition by 5 kinds of drug solution usually used. We found that there are some differenus of Hemolytic degree according to each blood form. Upon practise, it is noted that there are two groups of drugs, one is a group of drugs which are not hemolysis in isotonic solution, but the other is a group of drugs which have specific hemolys is in spite of isotonic sotution. Calcium chloride, sod. citrate, sod. bicarbonate, and calcium gluconate belong to the former category, and V.B_1, in the latter. We determined to review the method of optical absorption studying by OKano.

라우릴황산에스텔과 라우릴아마이드의 알킬롤황산에스텔과의 活性能에 관한 比較詩驗

金石萬,崔英淑 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.24 No.-

음이온성활성제는 고급지방산 또는 고급 알코올은 황상 easter型 또 sulornate 型 등 다양하며, 본 실험에서는 고급지방산에 직접 황상을 결합시킨 황상 ester과 간접으로 amide를 결합시킨 다음 황상 ester로 한 활성제의 활성능을 비교 시험한 결과 세정력, 경수성은 황상 ester가 약간 우수하고 침투력, 내산성을 amide 결합 황상 ester가 약간 우수하였다. A study of the comparative test of Sodium lauryl sufate and Sodium alkylol sulfate of laurylamide in their activities. The activities of Former are better in detergent power and hard water properties than the latter, but the latter is better in penetration and acidity.

芳香性 精油의 可溶化에 관한 硏究

金石萬 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.23 No.-

정유의 큰 결점은 용해도이다. 정유는 물에 난용성으로 극미량이 물에 포함될 뿐 임의로 필요한 농도로 가용화가 어려워 사용면에 지장이 많다. 이런 점을 감안하여 정유와 물만으로는 필요한 농도로 가용화가 곤란하므로 제3자인 비어온성 계면활성제를 사용하여 정유의 용해를 촉진 증가하고자 본 실험을 했다. 정유는 terpen계와 지방족계2동이 있어 우리 terpen계와 지방족계 2종이 있어 우선 terpene계의 박하율(pepeprmint oil)와 지방족계의 methyl salieylate를 선정하여 실험하기로 하고 계면활성제는 sorbitol화합물인 tween 20과 tween 80을 가용화제로 사용했다. 그 결과 박하유는 tween 80이 양호했으며, tween류의 농도를 증가함에 따라 정유를 고노동로 가용화할 수 있음을 확인했다. Essential oils can not be dissolved in satisfactory concentrations owing to their very slight solubility in water. We determined to dissolue freely them by use of nonionlisurfactants in water. peppermint and methyl salicylate were used as essential oils and tween systems were used as surfactants. Consequently, we observed that tween20 is more suitable to pepperimint than to tween 80, and tween 80 is more suitable to methyl subeylate than to tween 20. then, essential oil can be dissolved at high concentration by increasing subfastants.

Acetyl Saliylic acid의 粒子度에 따른 Bio-availability에 關한 硏究

金石萬 梨花女子大學校 韓國生活科學硏究院 1978 韓國生活科學硏究院 論叢 Vol.20 No.-

해열 진통제의 一種인 Aspirin(Acetyl Salicylic acid)을 粒子度를 달리하여 生物學的 實驗法을 選擇하여 時間當 尿中 藥物排泄量을 측정하였다. 50mesh, 100mesh, 200mesh 粒子度의 Aspirin 一定量을 건강한 成人 男女에게 隔主間으로 投與한 후 尿中의 藥物排泄量을 비교 관찰하였다. 그 결과 尿中의 總 Aspirin 排泄量은 95% 이상이었으며, 藥物 服用後 4時間後에 100mesh, 200mesh 粒子度의 Aspirin은 最大의 排泄量을 나타냈으며, 50mesh 粒子度의 Aspirin은 6時間後에 最大의 排泄量을 나타내었다. 또한 粒子度가 가장 작은 200mesh 粒子度의 Aspirin은 아주 급작한 排泄量 curve를 나타내나 粒子度가 클수록 즉 100mesh, 50mesh 粒子度 順으로 다소 완만한 排泄量 curve를 나타낸다. 이러한 점으로 미루어 볼 때 藥物의 粒子度가 작을수록 吸收, 排泄이 신속하게 일어나며 粒子度가 클수록 吸收, 排泄이 느리게 나타냄을 알 수 있다. 또한 粒子度가 작을수록 藥物作用은 빨리 나타나며 藥物作用 持續時間이 짧고, 粒子度가 클수록 藥物作用은 늦게 나타나며 藥物作用 持續時間이 길다는 것을 알 수 있다. In order to examine the rapidity of absorption of drugs into the blood and the operating time of drugs, a dose of Aspirin powders of different sizes, was orally ad-ministered to a healthy man and woman every other week, and the amount of total Aspirins excreted into the urine according to the particle sizes was measured by the hour. The total amount of Aspirin excreted into the urine showed more than 95% of that administered orally. The measurement of Aspirin excretion indicated that ad-ministration of particle sizes 100 mesh and 200 mesh resulted in the largest amount of Aspirin in the excretion 4 hours after administration, and particle sizes 50 mesh resulted n the largest amount of Aspirin in the excretion 6 hours after administration. In the relation diagram of time and excretion, the case of particle sizes 200 mesh showed an abrupt curve. In the other words, the administration of particle sizes 200 mesh caused the fastest excretion and the largest amount of Aspirin. On the other hand, the administration of particle sizes 100 mesh and 50 mesh showed the relatively smooth curves. As a result, the measured value indicated that as the particle sizes became smaller, the time required to absorb drugs into the blood and to excrete into the urine lessend gradually, and that as the particle size became larger, the time required increased gradually.

Ointment Bases의 生體內 Penetration에 關한 硏究

김석만 梨花女子大學校 韓國生活科學硏究院 1977 韓國生活科學硏究院 論叢 Vol.18 No.-

軟膏의 經皮吸收에 관한 연구 방법에는 여러加지加 있으나 그중 生物學的 실험법을 選擇하여 一定量의 軟膏를 一定 時間 건강한 人體 피부면에 貼布하여 尿中 藥物 排泄量을 測定하였다. 즉 Salicylic acid를 主成分 약물로 하고 몇 加지 基劑를 選擇하였다. 基劑들은 Vaseline, Olive oil in Vaseline, Cotton seed oil in Vaseline, Lanoline, Lanoline in Vaseline 等이다. 그 結果 Vaseline 單味일 때보다는 植物性油를 加했을 때 吸收效果가 좋은 것 같았으며 특히 Olive oil을 加했을 경우 Vaseline 單味에서 보다 110%, Peanut oil의 경우 89% 尿中 Salicylic acid 排泄量이 증가하였다. 또 Lanoline 單味의 경우 尿中 Salicylic acid 排泄量은 Vaseline 單味의 2.1培였는데, Lanoline과 Vaseline을 同量混合한 基劑일 경우 Lanoline 單味일 때보다 尿中 Salicylic acid 排泄量이 43% 증가하였다. 한편 Salicylic acid 混合方法에 있어 Salicylic acid를 100 mesh의 微細分末로 한 것과 Alcohol에 溶解시킨 것을 各各 Vaseline 基劑에 혼합하여 비교한 結果 Alcohol에 溶解시켰을 때 吸收效果가 더 좋은 것 같았다. There are many kinds of research methods for the absorption of ointment through skin. Among these the biological testing method was used: a certain amount of the ointment was applied on the normal human skin during a certain period and the amount of excretion of the medicine in the urine was measured. The principal medicine, salicylic acid, was mixed with the bases, such as, vaseline, olive oil in vaseline, peanut oil in vaseline, cotton seed oil in vaseline, lanoline, and lanoline in vaseline. The effects of absorption of the bases were compared with the amount of excretion of salicylic acid in the urine. The results of the study are: (1) The effect of absorption of vegetable oil in vaseline seems to be better than of vaseline only. For example, the amount of excretion of salicylic acid in the urine increased 110% when olive oil was added and 89% when peanut oil was added. (2) The amount of excretion of salicylic acid in the urine of lanoline base was 2.1 times higher than vaseline base, and that of lanoline in vaseline base increased 43% than lanoline base itself. (3) To mix the salicylic acid with vaseline, two types of salicylic acid were tried-fine powder (100 mesh) and the alcoholic solution. The amount of excretion of sali-cylic acid in the urine increased when alcoholic salicylic acid was added to vase-line than the powdered one.

制酸劑와 消化酵素劑配合에 依한 PH 및 糠化力變動에 關한 硏究

金石萬 이화여자대학교 한국문화연구원 1966 韓國文化硏究院 論叢 Vol.8 No.-

Digestants are usually used with antiacids to aid digestion. However, in many case, digestants do not aid in the breakdown of starch into bloodsugar, because they are destroyed by gastric juice prior to its neutralization by the antiacids. This is a report of a study seeking the optimal pH for the best digestive effect of antiacids and digestants. The complex antiacids increase starch digestion and prolong the duration of enzyme activity more than is seen with simple antiacids. The breakdown of starch due to the digestant is more influenced by the concentration of the gastric juice than by the dose of digestant.