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직장 탈출증에 대한 보중익기탕과 수술 치료 병용요법의 임상 연구 고찰 - 무작위 대조군 연구를 중심으로
공경환,김도현 한의병리학회 2024 동의생리병리학회지 Vol.38 No.2
Rectal prolapse is a condition where the rectal wall protrudes outside the anus. While it is a rare condition, it can cause discomfort for patients due to the protrusion of the rectal structure, discharge of mucus and blood, fecal incontinence, constipation, and other inconveniences. In this review, we analyzed a randomized controlled trial (RCT) study that used the herbal medicine Bojungikgi-tang(Buzhongyiqi-tang) as a complementary therapy to improve the weaknesses and side effects of the standard treatment, surgical therapy, for rectal prolapse. The analysis included 12 RCT studies, and in all studies, the prescription involved the use of Astragali Radix at the highest dosage. Among the 11 studies that evaluated efficacy, 7 studies showed a significant effect compared to the control group. In all 3 studies that evaluating recurrence rates and all 5 studies investigating complications after surgery, the experimental group showed significant effects. Based on these findings, this study could be considered as a foundational evidence for the application of bojungikgi-tang(Buzhongyiqi-tang) in clinical practice in Korean medicine for patients with rectal prolapse. It could also serve as foundational data for future research.
비위(脾胃)와 간(肝)과의 상관성(相關性)에 관한 문헌고찰(文獻考察)
공경환,지현철,백태현,하장,Kong, Kyung-Hwan,Jee, Hyun-Chol,Baek, Tae-Hyun,Ha, Jang 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4
Objectives : It was designed for making theoretical base about the relation of the Spleen, Stomach and the liver which could be used in clinic. Methods : Including Huang Di Nei Jing(黃帝內經), the 22 kinds of books written about the relation of the Spleen, Stomach and the Liver, and 2 kinds of papers were referenced. They were divided and studied according to physiology, pathology, meridian system and treatment. This study is focused on internal organ theory. Conclusion 1. In physiology, the Liver has the function of smoothing and regulating the flow of vital energy(Ki), while the Spleen is in charge of digestion and transportation. 2. In pathology, there can be informed disharmony of the Spleen, Stomach and the Liver, blood deficiency in the Liver and Spleen, jaundice, and bleeding etc. 3. In meridian system, the junction points of Spleen Meridian and Liver Meridian are Liv14, SP6, SP12, SP13. 4. In treatment, 1) If there is disharmony of the Liver and Spleen, the Liver must be soothed and the function of Spleen invigorated. 2) If there is disharmony of the Liver and Stomach, the Liver must be soothed and the function of Stomach invigorated.
DSS으로 유발된 생쥐의 대장점막손상에 대한 도체탕(導滯湯)의 효과
이주아,공경환,Lee, Ju-Ah,Kong, Kyung-Hwan 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3
Objectives : This study was carried out to investigate the effects of Doche-tang on colonic mucosal ulcer induced by dextran sulfate sodium(DSS). Method : The group was divided into three. The normal group consisted of mice that were not inflammation-induced. The control group was composed of untreated colitis elicited mice. The sample group was administered Doche-tang after colitis elicitation. The effects on colonic mucosal ulcers were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, $NF-{\kappa}B$, COX-1, COX-2 and iNOS. Results : In terms of immunohistochemical findings, the distribution of COX-1 in mice treated with Doche-tang noticeably increased more than that in the control group. The distribution of HSP70, $NF-{\kappa}B$, COX-2, iNOS in mioe treated with Doche-tang decreased more than that in the control group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope. Conclusion : According to the results, Doche-tang is practicable treatment for colonic mucosal ulcer.
제7혈액응고인자 결핍증 환자에서 발생한 성인 장중첩증의 복강경보조 장절제술
서병선,공경환,조준호 대한내시경복강경외과학회 2012 Journal of Minimally Invasive Surgery Vol.15 No.2
Factor VII deficiency is a rare congenital bleeding disorder characterized by episodes of spontaneous bleeding in severely affected individuals. It is rare intussusception due to submucosal hematoma in coagulation factor deficiency patient. We recently experienced an adult small bowel intussusception in a patient with factor VII deficiency. A 36-yr old female patient with coagulation factor VII deficiency who was referred to our hospital underwent emergency surgery for treatment of the small bowel intussusceptions. Emergency laparoscopy- assisted small bowel resection was performed for treatment of small bowel intussusception caused by submucosal hematoma. The patient was successfully treated with close laboratory monitoring and laparoscopy-assisted small bowel resection.
향사육군자탕(香砂六君子湯)의 Indomethacin 유발 위점막 손상에 대한 효과
백태현,공경환,Baik, Tae-Hyun,Kong, Kyung-Hwan 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4
Objective: This study was carried out to investigate the effects of Hyangsayukgunja-tang extract on indomethacin-induced gastric mucosal lesions of mice. Methods: To evaluate the effects of Hyangsayukgunja-tang extract and Misoprostol, the morphology of gastric mucosa, and the distribution of mucose cells, PNA(Peanut Agglutinin), ICAM(intercellular adhesion molecule), and apoptotic cells were observed. Hyangsayukgunja-tang extract and Misoprostol were intragastric injected to the test groups at hour 72 before and just before indomethacin treatment(HYT-J, HYT-72, M-J, M-72), while the INDO group was injected only with indomethacin and the control group was subcutaneously injected only with saline. Results: The gastric mucosal lesions incresed in the fundus and body of INDO group, but softened in HYT group and M group, the effects were more excellent in the HYT-72, M-72 groups than the HYT-J, M-J groups and in the HYT group than M group. The disappearance of surface and neck mucose cells were shown in INDO group, but softened in HYT group and M group. The mucosal configuration of HYT-72 group was the same as control group. The numerical increase of PNA positive reaction in cytoplasm of perietal cells were appeared in INDO group. The PNA positive reaction in HYT group and Miso-group were shown in surface mucous cells and microvilli of apical surface in chief cells as control group, and were the same as control group in all mucosa of HYT-72 group. The distribution of ICAM positive cells, increased in INDO group, but decreased in M-72 group, and were the same as control group in HYT-72 group. The apoptotic cells, increased noticeably in gastric mucosa of INDO group, decreased in HYT group and M group, and decreased noticeably in HYT-72 group. Conclusions: Hyangsayukgunja-tang extract had excellent effects on indomethacin-induced gastric mucosal lesions.
Schizencephaly(분열뇌증)환자에 있어 구음 장애 치험 1례
김동조,공경환,경혁수,Kim, Dong-Jo,Gong, Gyeong-Hwan,Kyung, Hyuk-Su 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
Schizencephaly is a form of the porencephaly in which there is a cystic cavity in the cerebral hemispheres. Schizencephaly is a congenital disease which consist of clefts that extend through the entire hemisphere from the ependymal lining of the lateral ventricles to the pial covering of the cortex. The etiology and the pathogenesis of this malady are not clearly estalilished. Typical symtoms is seizures, mental retardation, spastic tetraplegia and blindness. A case of schizencephaly which was treated through methods of the Oriental Medicine, and that met with good results, is reported.
단시간의 경련성 실어증을 반복적으로 보이는 초점성 경련환자의 치험 1례
유희정,공경환,경혁수,Yoo, Hee-Jeong,Kong, Kyung-Hwan,Kyung, Hyuk-Su 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Seizure can be categorized in various ways. Seizures are divided into those that are generalized and those affecting only part of the brain (focal seizure). Focal (partial) seizures are subdivided into simple seizures and complex seizures. Simple focal seizures may be manifested by focal motor, sensory or autonomic symptoms and consciousness is preserved. The above symptoms may be preceded, accompanied or followed by, and consciousness is impaired in, complex focal seizures. Ictal aphasia can arise from epileptiform discharge on cortical language areas. Generally next to the ictal aphasia, generalized seizures occur, but without losing consciousness, only aphasia takes place. A 61-year-old woman was admitted due to ictal aphasia and facial spasm, and she showed a little palpitation and was startled easily. We diagnosed her as Shimdamgiheo (心膽氣虛) and Damhwashimyo (痰火心擾), so we prescribed Chungsimondam-tang. It was effective on that case. so we report.