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폐 샘암으로 항암치료를 받던 환자에서 발생한 피부전이 샘편평세포암
강호송 ( Ho Song Kang ),이하은 ( Ha Eun Lee ),주민숙 ( Mihn Sook Jue ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Cutaneous metastasis originating from lung cancer is relatively rare and accounts for only 0.5~6.7% of of lung cancer metastases. In general, there is a histomorphologic resemblance between primary carcinoma and cutaneous metastatic carcinoma. A 45-year-old woman presented with a painless 0.8 cm erythematous nodule on her left shoulder. During the past 3 years, she had been receiving chemotherapy for the treatment of lung adenocarcinoma with bone metastases. A histopathological examination of the skin lesion showed adenocarcinoma and squamous cell carcinoma components, which were compatible with adenosquamous carcinoma. Herein, we report an interesting case of adenosquamous carcinoma showing cutaneous metastasis, which is a different pathologic subtype from primary lung adenocarcinoma.
강호송 ( Ho Song Kang ),최원준 ( Won Jun Choi ),노영석 ( Young Suk Ro ),김영훈 ( Young Hoon Kim ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.12
Eosinophilic cellulitis is also called Wells` syndrome, and this is an acute pruritic dermatitis that resembles cellulitis. It usually appears as well-circumscribed erythematous plaques, but bullous lesions have rarely been reported. There are several precipitating factors, including drugs, arthropod bites, viral infections, parasitic infestations, leukemia and other malignancies. A 21-year-old male presented with a mildly pruritic vesiculobullous eruption on the dorsum of left foot after he had been pricked by a twig. Histopathologic examination showed intraepidermal blisters and spongiosis of the epidermis and a mixed inflammatory cell infiltration that consisted mostly of eosinophils throughout the dermis. These findings were consistent with the diagnosis of bullous eosinophilic cellulitis. He was treated daily with prednisolone 30 mg and the lesions rapidly resolved. There has been no recurrence of the lesions for 1 year of follow-up. (Korean J Dermatol 2010;48(12):1128∼1131)
강호송 ( Ho Song Kang ),백준오 ( Jun Oh Paek ),박경태 ( Kyung Tae Park ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.1
Lichen planus is a chronic papulosquamous disease that affects the skin and mucous membranes. It is characterized by pruritic violaceous papules that are most commonly seen on the extremities of middle aged adults, but the elderly are rarely affected. Hypertrophic lichen planus usually occurs on the extremities and especially on the shins, and it tends to be the most pruritic variant. An 82-year-old female presented with severe pruritic multiple papules and plaques on the both the upper and lower extremities for 1 year. At first, the lesions began as small, polygonal papules that formed verrucous plaques over several months. Histopathologic examination showed marked hyperkeratosis, irregular acanthosis and wedge-shaped hypergranulosis. The vacuolar alteration and the lymphocytic inflammatory infiltrate were accentuated at the base of the rete ridge. From these findings, we diagnosed these lesions as hypertrophic lichen planus. The lesions were treated with topical steroid and intralesional injection of steroid, and they were slightly improved after 2 months of therapy. (Korean J Dermatol 2011;49(1):82~85)
외상에 의해 유발된 보행장애를 동반한 석회화 건막 섬유종
강호송 ( Ho Song Kang ),이민원 ( Min Won Lee ),박경태 ( Kyung Tae Park ),유희준 ( Hee Joon Yu ),김정수 ( Joung Soo Kim ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.7
A calcifying aponeurotic fibroma is a rare benign fibrous tumor with well-characterized histopathological features. Calcifying aponeurotic fibromas are generally slowly-growing lesions related to tendons and aponeuroses in the distal extremities of children and adolescents. While the neoplasm is usually asymptomatic, cases of progressive local discomfort have been reported. The exact etiology of this neoplasm is unknown, and there is frequently no history of trauma or local irritating factors. A 10-year-old female presented with a 2.5×2.0 cm, subcutaneous mass on the right sole 4 years after she bumped against a table. The histopathologic examination showed a poorly circumscribed fibrotic mass with foci of chondroid differentiation and calcification. These findings were consistent with the diagnosis of a calcifying aponeurotic fibroma. After total excision of the mass, there has been no recurrence of the lesion in 8 months of follow-up.
조민결,강호송,김민수,박향준,주민숙 대한피부과학회 2019 Annals of Dermatology Vol.31 No.6
Background: Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that alitretinoin is an effective and well-tolerated treatment for CHE. However, there is a relative lack of data on the effectiveness of alitretinoin in elderly patients. Objective: The aim of this study was to investigate the efficacy and safety of oral alitretinoin in elderly patients with moderate to severe CHE in Korea. Methods: We retrospectively investigated 46 CHE patients who were treated with either 10 mg or 30 mg of alitretinoin between June of 2016 and July of 2018. The physician’s global assessment (PGA) was used to evaluate treatment efficacy. All adverse events were retrospectively evaluated with respect to laboratory testing, including complete blood cell count, fasting blood chemistry, lipid profile, and liver and thyroid function tests. Results: The mean patient age in this study was 71.0±5.1 years. The treatment period was over eight weeks. A total of 38 of 46 patients (82.6%) exhibited clinical improvement with PGA ratings of ‘clear’ or ‘almost clear.’ There were 13 patients (28.3%) who experienced an adverse effect, with the most common being headache (13.0%) and gastrointestinal symptoms (8.7%) followed by xerosis (6.5%). A total of 13 patients developed or exhibited worsening hypertriglyceridemia (28.3%). Conclusion: Alitretinoin can be considered a safe and effective treatment option in elderly patients with moderate to severe CHE.