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O,p'-DDD가 흰쥐의 신장에 미치는 독성에 관한 면역조직화학적 및 초미세형태학적 연구
배재웅,최종범,임성철,김균홍,기근홍,박동수,전호종,박규호 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.2
o,P'-DDD, a derivative of insecticide DDT, which reveals the toxicity and adrenostatic effet by cortisol biosynthesis in the zona fasciculata of adrenal cortex has been used for the treatment of unoperable adrenocortical carcinoma. Adverse effects of o,P'-DDD were usually dose-related and reversible. Most untoward effects include gastrointestinal disturbances, neuromuscular disorders, depression of central nervous system and skin rash but there is a few reports on its nephrotoxicities. o,P'-DDD in corn oil was administered orally to rats for 28 days to investigate its nephrotoxicity by observation of the ultrastructural changes and immunoglobulin deposition in renal glomeuli. The results obtained were as follows. 1. The ultimate destructive target of intracytoplasmic organelle in endothelium and epithelium of renal glomeruli was mitochondria. The severity of the mitochondrial alterations was dependent of the dosages of o,p'-DDD. 2. The characteristic ultrastructural changes in endothelium of glomerular capillary were swelling and detachment from underlying basement membrane. The splitting and complete separations between endothelium and basement membrane were observed in more advanced lesions by the increased dosage of administration of o,p'-DDD and basement membrane in capillary wall of renal glomeruli was irregular and partly thickened. 3. Amorphous double ring formation, electron dense deposits and multiple myelin figures in mitochondria were characteristic ultrastructural findings in the epithelium of glomeruli. 4. Ig G and Ig M depositions were clearly observed in the capillary lumen, subendothelial area and epithelial cells of proximal convoluted tubule. These depositions were more prominent by the increased of o,p'-DDD dosage. From the above results it is suggested that o,P'-DDD exhibits nephrotoxicity by mitochondrial destruction in epithelium and endothelium of glomerular capillary and the severity of mitochondrial alterations was dose dependent of o,p'-DDD.
o,p'-DDD가 흰쥐 뇌하수체 전엽의 ACTH분비의 활성도에 미치는 영향에 관한 면역조직화학적 연구
기근홍,최종범,임성철,박동수,이병래,전호종,서재홍,박규호 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.2
It has been well known that the toxicity of o,p'-DDD on the zona fasciculata in adrenal gland. The toxicity revealed adrenostatic effect on the cortisol biosynthesis by mitochodrial destruction. So, o,p'-DDD was used for unoperable adrenocortical carcinoma and its metastasis. The secretory activity of cortisol in adrenal cortex depended on ACTH secretion in the adenohypophysis. o,p'-DDD was dissolved in corn oil and administered orally for 28 days by 75 ㎎ / ㎏, 150㎎ / ㎏ and 300 ㎎ / ㎏ to investigate the adrenostatic effect on the cortisol biosynthesis of o,p'-DDD by assesment of ACTH secretory activity in anterior lobe of pituitary gland of rats. The results obtained were that the secretory activity of ACTH and the number of ACTH secretory cells were increased according to the dosage of o,p'-DDD, especially 300㎎ / ㎏ administrated group. Therefore, the suppression of cortisol biosynthesis of o,p'-DDD was confirmed by increased secretory activity of ACTH and the number of ACTH secretory cells.