o,p'-DDD가 흰쥐 뇌하수체 전엽의 ACTH분비의 활성도에 미치는 영향에 관한 면역조직화학적 연구 = Immunohistochemical study of effect on the ACTH secretory activity in the rat adenohypophysis by o,p'-DDD

다국어 초록 (Multilingual Abstract)

It has been well known that the toxicity of o,p'-DDD on the zona fasciculata in adrenal gland. The toxicity revealed adrenostatic effect on the cortisol biosynthesis by mitochodrial destruction. So, o,p'-DDD was used for unoperable adrenocortical carcinoma and its metastasis. The secretory activity of cortisol in adrenal cortex depended on ACTH secretion in the adenohypophysis.
o,p'-DDD was dissolved in corn oil and administered orally for 28 days by 75 ㎎ / ㎏, 150㎎ / ㎏ and 300 ㎎ / ㎏ to investigate the adrenostatic effect on the cortisol biosynthesis of o,p'-DDD by assesment of ACTH secretory activity in anterior lobe of pituitary gland of rats.
The results obtained were that the secretory activity of ACTH and the number of ACTH secretory cells were increased according to the dosage of o,p'-DDD, especially 300㎎ / ㎏ administrated group. Therefore, the suppression of cortisol biosynthesis of o,p'-DDD was confirmed by increased secretory activity of ACTH and the number of ACTH secretory cells.