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A New Cytotoxic Spiroketal from the Myxobacterium Sorangium cellulosum
곽종환,Jong-Woong Ahn 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.6
A new spiroketal, spirodienal B (1), was isolated from culture extracts of S. cellulosum. Its structure was elucidated by spectroscopic analysis. In addition to 1, the strain produced a second, closely related antibiotic, spirodienal. Both compounds demonstrated potent cytotoxicity against human tumor cells. Against human tumor cells such as HCT-15, the activity of 1 was more than 4000 times stronger than that of doxorubicin in terms of IC50.
Structure determination of two new compounds isolated from a marine sponge Haliclona(Gellius) sp.
이경,Yun Na Kim,정은주 한국자기공명학회 2021 Journal of the Korean Magnetic Resonance Society Vol.25 No.2
Two new sesterterpenes, including a known ses-terterpene, were isolated from the marine sponge Haliclona sp. collected in the Gageo island, Korea. One of the new sesterterpenes (1) was an unusual compound possessing a spiroketal moiety and the other (2) represented a four ring-fused skeleton. The planar structure of compound 1 was identical to gombaspiroketals A and B isolated from the marine sponge Clathria gombawuiensis, but the configuration for the two chiral centers was dif-ferent each other. On the other hand, the skeletal structure of compound 2 was similar to that of phorone A isolated from Phorbas sp. and a com-pound from C. gombawuiensis, except for one configuration at C-8. However, in comparing the 1H and 13C NMR spectral data, the proton and carbon chemical shifts for the three compounds were almost consistent. The NOESY spectrum re-vealed that the C-8 configuration of 2 was re-versed to that of the two reported compounds. The configuration for compound 2 was supported by quantum mechanical calculation for the carbon chemical shifts and DP4+ probability for the pro-tons and carbons of 2.