두경부암의 기능보존수술

노종렬,한명월 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.1

Organ preservation strategy in treatment of the head and neck cancer (HNC) has led to an increase in the use of primary chemoradiation in both laryngeal and extralaryngeal sites for recent two decades. Primary non-surgical chemoradiotherpay has replaced the traditional gold standard of surgery followed by postoperative radiation with saving the organ and no compromising oncological outcomes. In accompany with wide clinical extension of primary chemoradiation, organ preservation surgery through open transcervical or transoral route has been increasingly used in the patients with HNC at both primary and salvage settings. Minimally invasive transoral approach using lasers or robots has been more spotlighted as a sensible strategy for organ preservation of the HNC patients. There is, however, a paucity of randomized controlled clinical trial data comparing primary organ-preserving chemoradiation to organ preservation surgery. Future direction leads to conduct well-designed clinical trials to establish the functional and oncological benefits of the organ preservation surgery. This article reviews the role of organ preservation surgery in head and neck cancer.

1910년대 新知識層의 國粹觀과 國粹保存運動

李智媛(Lee Ji-Won) 역사교육연구회 2002 역사교육 Vol.84 No.-

In 1910"s Korean new intellectuals who accepted European individualism and conservatism systematically, was being extension of HanMal social darwinism, developed the modern bourgeois thoughts. And they made progress than a former generation. Though they made much of a value to pursue personal profit and development, they recognized an individuality and a society to be an organism, and they emphasized personal moral duty for the nation and the society. This thought of social organism made much of a tradition. Because a society was the creature which was living and not machine, and was taking down a root like a tree in the past, the traditional succession is indivisible relationship with the development of person combined with a society. They regarded a nation as that kind of a personal gathering, too. Under imperialism world system of the law of the jungle in particular, it was aimed at through the individual awareness that is a social member and the development of a personality, because the nation which was an actual survival competition unit was a personal gathering. It was the existence to have the durability that was not only the area range or instantaneous group, and formed history for a long time in the same area at this time. This understanding about the nation was to do a communication a bit with the national organism of German romanticism. On the view of social darwinistic, conservative, romantic nationalism, the preservation of tradition was for proof to do the national survival ability, and it was a way to keep national identity and union. In these intentions it was attempted to preserve the national essence on the SIN MUN KWAN(新文館) and CHOSUN KWANG MUN HOE(朝鮮光文會) where were Choe, Nam-Seon(崔南善) executed the center. The SIN MUN KWAN was as if salon and the place where intellectuals had been study in Japan haunted. They reissued all kinds of culture books and a Korean classics, and published Korean ethnic culture studies. It was a purpose to improve personal culture and civilization through "worship about ancestors" and "preservation of old culture", and it was for the nation composed with individual to keep national cultural subjectivity and identity. In a word, the "civilization" and "preservation of national essence" were necessary for an national modern survival together. Thus the "national essence" recognition that was formed at the middle of HanMal nationalism thought was readjusted as the theme of the national modern awareness since under the Japanese imperialism. And it was basic to oppose a destruction of ethnic culture by other nation because these preservation of national essence made much of singularity of a national organism. Therefore, they criticized that Japanese imperialism colonized the Korean tradition culture, for example IlSeonDongJoRon and the assimilation of national culture. However, their movement of preservation of national essence emphasized an economic cultural progress of the national organism than independence. While a landlord and a capitalist kept the existing system to lead, they made much of a union of Kurturnation. And they were off national political pending problem and weaken recognition of class problem and meaning of ethnic independence. Their this cultural and conservative inclinations are advanced with the movement of enhancement of traditional Korean culture which strengthens the class of oneself and a location of thoughts when capital-nationalists performed "Culture movement" within the system under "Culture politics" of the Japanese imperialism in 1920"s.

가토 적출 폐장의 장시간 보존에 관한 실험적 연구

이종국,서재성,Lee, Jong-Guk,Seo, Jae-Seong 대한흉부심장혈관외과학회 1994 Journal of Chest Surgery (J Chest Surg) Vol.27 No.9

We have modified the isolated perfused working rabbit lung model [IPWL] by perfusing the isolated lung with a hollow fiber membrane deoxygenator.For assessment the stored lung was ventilated with FIO2 0.4 and perfused with 37$^{\circ}$C deoxygenated circulating blood at a rate 5ml/kg/min for several hours until lung failure.We chose to compare our developing solution which contained low potassium and pentastarch with the modified Euro-Collins solution .Experiments were divided into four groups[n=6] based on the type of flushing preservation solution and preservation time.The flushed lungs were then preserved into same solution at 8~10$^{\circ}$C with 100% O2 inflated condition for 1 or 20 hours.These following results were obtained.The IPWL model requires only one animal per experiment and allows for the continuous assessment of aerodynamic performance. This should therefore be used as screening test in lung preservation.One hour preservation groups, there were no significant difference in recovery rates of PaO2, PAP and Paw. Survival time in the one hour preservation groups were very significant long in the Group II[LPPS, p<0.01]. Twenty hours preservation groups, there were no significant difference in the recovery rates of PAP and Paw between Group III[m-ECS] and Group IV[NS], but PaO2 was significantly worse at onset of reperfusion in Group III when compared with Group IV [p<0.05]. And also survival time in the 20 hours preservation groups were significant long in the Group IV [p<0.05].

Clinical Efficacy of Organ-Preserving Pancreatectomy for Benign or Low-Grade Malignant Potential Lesion

이승은,장진영,황대욱,이건욱,김선회 대한의학회 2010 Journal of Korean medical science Vol.25 No.1

The clinical usefulness of organ-preserving pancreatectomy is not well established due to technical difficulty and ambiguity of functional merit. The purpose of this study is to evaluate the clinical efficacy of organ-preserving pancreatectomy such as duodenum-preserving resection of the head of the pancreas (DPRHP), pancreatic head resection with segmental duodenectomy (PHRSD), central pancreatectomy (CP)and spleen-preserving distal pancreatectomy (SPDP). Between 1995 and 2007,the DPRHP were performed in 14 patients, the PHRSD in 16 patients, the CP in 13patients, and the SPDP in 45 patients for preoperatively diagnosed benign lesions or tumors with low-grade malignant potential. The clinical outcomes including surgical details, postoperative complications and long-term functional outcomes were compared between organ-preserving pancreatectomy and conventional pancreatectomy group. Major postoperative complications constituted the following: bile duct stricture (7.1% [1/14]) in DPRHP, delayed gastric emptying (31.2% [5/16]) in PHRSD, pancreatic fistula (21.4% [3/14]) in CP. There were no significant differences in postoperative complications and long-term functional outcomes between two groups. Organ-preserving pancreatectomy is associated with tolerable postoperative complications, and good long-term outcome comparing to conventional pancreatectomy. Organ-preserving pancreatectomy could be alternative treatment for benign or low-grade malignant potential lesion of the pancreas or ampullary/parapapillary duodenum.

중국 민간사회조직의 `자기보존` 지향 전략: 배경, 양상, 전망

김성민 ( Kim Sung Min ) 한중사회과학학회 2016 한중사회과학연구 Vol.14 No.4

China`s state system fundamentally imposes constraint on growth and development of civil society. So the way of surviving of China`s civil social organizations differs from other nations. This article began with the above-stated fact. What is the surviving strategy of China`s civil social organizations? What kind of awareness brings the surviving strategy? And how the strategy turns out in their behavior? What is the structural background factors generate these awareness, behavior and strategy of China`s civil social organizations? And what kind of future waits for the civil social organizations in China? This article shows answers to these questions.

수사과정에서의 전세사기 피해자 보호대책에 관한 고찰: 몰수보전을 중심으로

최재훈 경찰대학 경찰대학 2023 경찰학연구 Vol.23 No.2

Recently, there has been a growing demand for government-wide protective measures for victims of Jeonse fraud, which has emerged as a serious social issue. The National office of investigation is also making efforts to recover damages for victims through confiscation preservation by applying the 'criminal organization' to Jeonse fraud. However, there are limitations in applying confiscation preservation to Jeonse fraud under current law, as the scope of application is limited and timeliness is lacking. In this regard, this study has proposed a legislative theory on the expansion of special cases of crime victim’s property applied to criminal organizations to criminal groups, and temporary confiscation preservation procedures as an urgent measure prior to confiscation preservation. Although it is not appropriate for criminal law enforcement agencies to excessively intervene in civil relations, the current situation of Jeonse fraud is not only causing severe damage nationwide, but also criminals are systematically hiding their criminal proceeds. Therefore, it is necessary for the state to actively intervene. 최근 심각한 사회문제로 제기되고 있는 전세사기에 대해 범정부적 차원의 피해자 보호대책이 요구되고 있다. 경찰청 국가수사본부도 전세사기에 대해 범죄단체조직죄를 적용하여 몰수보전을 통해 피해자들의 피해회복을 위해 노력하고 있다. 그러나 현행법상 전세사기에 대해 몰수보전을 적용하는 것은 적용범위가 제한적이고 적시성이 떨어진다는 점에서 한계가 있다. 이와 관련하여 본 연구는 범죄단체에 적용되는 범죄피해재산의 특례를 범죄집단으로 확대할 것과 몰수보전 이전의 긴급한 조치로서 긴급몰수보전 절차에 대한 입법론을 제시하였다. 민사관계에 있어 형사사법기관이 과도하게 개입하는 것은 적절하지 않지만, 현 상황의 전세사기는 사적자치만을 강조하기에는 국가 전반의 피해가 극심할 뿐만 아니라 범죄자들은 조직적으로 범죄수익을 은닉하고 있는 상황이므로 국가가 적극적으로 개입할 필요가 있다.

Bacterial Species and Biochemical Characteristic Investigations of Nostoc flagelliforme Concentrates during its Storage

( Lifang Yue ),( Hexin Lv ),( Jing Zhen ),( Shengping Jiang ),( Shiru Jia ),( Shigang Shen ),( Lu Gao ),( Yujie Dai ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.4

Preservation of fresh algae plays an important role in algae seed subculture and aquaculture. The determination and examination of the changes of cell viability, composition, and bacterial species during storage would help to take suitable preservation methods to prolong the preservation time of fresh algae. Nostoc flagelliforme is a kind of edible cyanobacterium with important herbal and dietary values. This article investigated the changes of bacterial species and biochemical characteristics of fresh N. flagelliforme concentrate during natural storage. It was found that the viability of cells decreased along with the storage time. Fourteen bacteria strains in the algae concentrate were identified by PCR-DGGE and were grouped into four phyla, including Cyanobacteria, Firmicutes, Proteobacteria, and Bacteroidetes. Among them, Enterococcus viikkiensis may be a concern in the preservation. Eleven volatile organic compounds were identified from N. flagelliforme cells, in which geosmin could be treated as an indicator of the freshness of N. flagelliforme. The occurrence of indole compound may be an indicator of the degradation of cells.

Oncologic Outcomes of Organ Preserving Approaches in Patients With Rectal Cancer Treated With Preoperative Chemoradiotherapy

박인자,이종률,윤용식,김찬욱,임석병,유창식,김진천 대한대장항문학회 2019 Annals of Coloproctolgy Vol.35 No.2

Purpose: We evaluated the oncologic outcomes of organ-preserving strategies in patients with rectal cancer treated with preoperative chemoradiotherapy (PCRT). Methods: Between January 2008 and January 2013, 74 patients who underwent wait-and-watch (WW) (n = 42) and local excision (LE) (n = 32) were enrolled. Organ-preserving strategies were determined based on a combination of magnetic resonance imaging, sigmoidoscopy, and physical examination 4–6 weeks after completion of PCRT. The rectum sparing rate, 5-year recurrence-free survival (RFS), and overall survival (OS) were evaluated. Results: The rectum was more frequently spared in the LE (100% vs. 87.5%, P = 0.018) at last follow-up. Recurrence occurred in 9 (28.1%) WW and 7 (16.7%) LE (P = 0.169). In the WW, 7 patients had only luminal regrowth and 2 had combined lung metastasis. In the LE, 2 (4.8%) had local recurrence only, 4 patients had distant metastasis, and 1 patient had local and distant metastasis. Among 13 patients who indicated salvage surgery (WW, n = 7; LE, n = 11), all in the WW received but all of LE refused salvage surgery (P = 0.048). The 5-year OS and 5-year RFS in overall patients was 92.7% and 76.9%, respectively, and were not different between WW and LE (P = 0.725, P = 0.129). Conclusion: WW and LE were comparable in terms of 5-year OS and RFS. In the LE group, salvage treatment was performed much less among indicated patients. Therefore, methods to improve the oncologic outcomes of patients indicated for salvage treatment should be considered before local excision.

폐장의 허혈-재관류 손상과 세포간부착물질-1의 발현

성숙환,김영태,김문수,이재익,강문철,서정욱 대한흉부외과학회 2002 Journal of Chest Surgery (J Chest Surg) Vol.35 No.2

=Expression of Intercellular Adhesion Molecule-1 after Ischemia Reperfusion Injury of the Canine Lung 흉골 절개술 후 종격동염은 드물게 발생하나 심장 수술 후 생명을 위협하는 합병증으로 발전 할 수 있다. 지금까지는 흉골 절개술 후 발생한 창상 감염의 치료로서 창상 세척과 변연 절제술 후 직접 상처 부위를 봉합하거나 근육 피판을 사용하여 왔다. 흉골 절개술 후 발생한 창상 감염의 새로운 치료로서 VAC (Vacuum-assisted closure) 술기에 대해 기술 하고자 한다. 이 술기를 흉골 절개술 후 발생한 창상감염 및 종격동염 환자 3명에게 성공적으로 적용하였고, 이러한 새로운 방식으로 흉골 부위 상처를 치유할 수 있었다.

국소 진행성 구강암에서 선행 항암 화학 요법의 효과

조요한(Yo Han Joh),최인실(In Sil Choi),이근욱(Keun Wook Lee),오도연(Do Youn Oh),김병수(Byung Su Kim),이대호(Dae Ho Lee),김태유(Tae You Kim),방영주(Yung Jue Bang),우홍균(Hong Gyun Wu),성명훈(Myung Whun Sung),이철희(Chul Hee Lee),김광현(N 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2

Objective: The role of chemotherapy in locally advanced head and neck cancer has been established in nasopharynx and larynx as definitive therapy and organ preserving therapy, respectively. Oral cavity cancers are relatively uncommon and local recurrence is the main cause of treatment failure. We planned this retrospective study to evaluate the role of neoadjuvant chemotherapy in locally advanced oral cavity cancer patients. Materials and Methods: From 1988 March to 2001 February, locally advanced, previously untreated oral cavity cancer patients who received neoadjuvant chemotherapy were examined. Chemotherapy had been done in the following patients: Histologically proven squamous cell or poorly differentiated carcinoma, stage 3 or 4, and performance state 0-2 patients. Chemotherapy regimen consisted of cisplatin and infusional 5-fluorouracil. Response was evaluated after 2 cycles and in case of no response, definitive local therapy was done; otherwise 3 cycles was done before local treatment. Results: 48 patients were treated and 47 patients were evaluable for responses. Complete response rate was 6.4%(3/47) and partial response 80.0%(38/47), scoring overall response rate of 87.2%. Median time to progression was 27.0 months (95% CI : 0-58months) and overall 5 year survival was 54.8%. 5-year disease-free survival in the patients in remission after local treatment was 51.9%. In multivariate analysis, contributing factor to the survival were response to neoadjuvant chemotherapy and local treatment modalities. Extensive surgery was done in 10 patients and 25 patents (52.1%) was followed up with preserved function. With median follow-up of 57.0 months, 19 recurrences were detected, most of which were local or regional type. Conclusion: Neoadjuvant chemotherapy followed by local treatment in oral cavity cancer showed high response rate and was thought to be effective therapeutic approach especially in view of organ preservation.