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- 주제어 : Kagam-bojungikgitang (검색결과 2 건)
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가감보중익기탕의 LPS 유도 염증성 매개물에 대한 억제 효과
장선일,김형진,김용준,배현옥,정헌택,정옥삼,김윤철,윤용갑 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
Kagam-bojungikgitang is the water extracts prepared from Ginseng Radix, Astragali Radix, Angelicae gigantis Radix, Astractylodis Rhizoma alba, Aurantii nobilis Pericarpium, Glycyrrhizae Radix, Artemisiae iwayomogii Herba, and Scutellariae Radix. This is a modified prescription of Bojungikgitang, which has been used for the treatment of indigestion, and immunological disease in oriental countries. In this study, the effects of Kagam-bojungikgitang and Bojungikgitang on the production of prostaglandin E_2 (PGE_2) and the expression of cyclooxygenase-2 (COX-2) were examined using Raw 264.7 macrophages activated with lipopolysaccharide (LPS). Both prescriptions dose-dependently reduced the release of PGE_2 and expression of COX-2 caused by stimulation of LPS without cytotoxic effect. Kagam-bojungikgitang's inhibitory effects were better than Bojungikgitang in PGE_2 production and COX-2 expression. Moreover, Kagam-bojungikgitang also attenuated markedly the production of tumor necrosis factor (TNF)-α, and IL-6 than Bojungikgitang in LPS-stimulated RAW 264.7 macrophages. These results suggest that Kagam-bojungikgitang decrease PGE_2 and pro-inflammatory cytokine production in macrophages and these properties may contribute to the anti-inflammatory activity of Kagam-bojungikgitang.
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DBA1J 마우스에서 가감보중익기탕이 콜라젠 유도 관절염 억제에 미치는 효과
장선일 ( Jang Seon Il ),윤용갑 ( Yun Yong Gab ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A Objectives : The present study has been undertaken to investigate the effect of Kagam-Bojungikgitang (KBT) decoction on development of collagen-induced arthrtis (CIA) in DBAl J mice. Methods : CIA was induced in UBAJ1 mice by immunization with bovine type II collagen (CIU and treatment with lipopolysacchride (LPS). KBT is the water extracts prepared from Ginseng Radix, Astragali Radix, Angelicae gigantis Radix, Astractylodis Rhizoma alba, Aurantii nobilis Pericarpium, Glycyrrhizae Radix, Artemisiae iwayomogii Herba, Scutellariae Radx. This is a modifitd prescription of Bojungikgitang, which has been used for the treatment of indigestion, and immunological disease in oriental countries. KBT was orally administered at difference doses. The incidence of arthritis, arthritis index, levels of tumor necrosis factor -alpha (TNF-a). interferon-gama (IFN-V), interleukin lbeta (IL-lP), IL - 3 . IL--10, II- 13. and prostaglandin E? (PGE.1 and cyclooxygenase~-2 (COX21 activity were investigated. Results : KBT dose- dependently suppressed the release of T h l cytokines (TNF-a, IFN-.v, and IL-1 8 ) and inflammatory mediators (PGE? and COX--2 caused by immunization of CII and stimulation of 1,PS. KUT without cytotoxic effext. Kagam-bojunyikgitang`s Inhibitory effects were better than Ehjungikgitang in PGEz production and COX-2 expression. However, KBT increased markedly the production of Th:! cytokines (IL-4, IL 10, and IL -13). Therefor , KBT suppressed markedly the incidence of arthritis and arthritis index caused by immunization of CII and stimulation of LPS. Conclusion : These results suggest that KBT suppress inflammatory mediators and regulates Th l and Th2 cytokmes. And these properties may contribute to the strong anti-arthritis of KBT.
RISS
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