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[P299] Hand-foot-mouth Disease in an Immunocompetent Adult
( Hyun Yi Suh ),( Jae In Lee ),( Joo Yoon Bae ),( Hong Lim Kim ),( Hye Jung Jung ),( Mi Youn Park ),( Jai Il Youn ),( Ji Young Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Hand-foot-mouth (HFM) disease is a highly infectious disease characterized by multiple vesicles on the hands, feet and in the oral cavity. It is primarily a disease of children and coxsackie virus A16 is the most common virus. Clinically, the onset is characterized by vesicles with fever and symptoms usually subside within 7 to 10 days. Although several cases of adult HFM disease have been reported, it has been rarely reported in healthy adults. We report a case of hand-foot-mouth disease in an immunocompetent adult. A 78-year-old female visited our clinic for multiple erythematous vesicular papules on the hands, feet and oral ulcer. The skin lesions developed the 3 days ago and were aggravated. Histopathological findings showed hyperkeratosis, parakeratosis, spongiosis, keratinocyte apoptosis in epidermis. Papillary dermal edema, perivascular lymphocytic infiltrates and dilated vessels were seen in the dermal layers. We did symptomatic treatments. Dermatologists should be aware that HFM disease can occur in adults with intact immune systems. We report this impressive case of hand-foot-mouth disease in an immunocompetent adult.
박기경,최성동,정승연,서병규,강진한,Park, Ki Kung,Choi, Sung Dong,Chung, Seung Yun,Suh, Byung Kyu,Kang, Jin Han 대한소아감염학회 1997 Pediatric Infection and Vaccine Vol.4 No.2
Hand-Foot-Mouth disease, which has a various enanthem-exanthem complex at the tongue, buccal mucosa, hands and feets and buttock area with febrile illness, is usually caused by Coxscakie virus type A(16). Generally, this disease shows self limited course and good prognosis without neurologic manifestations. However, enterovirus 71, which was newly discovered and reported in 1974, can cause the striking features of Hand-Foot-Mouth disease outbreaks and has neuropathogenic potentials of polio-like paralytic illness including aseptic meningitis, meningoencephalitis and respiratory disease. We experienced a case of Hand-Foot-Mouth disease with polyradiculitis manifestations, and a case of Hand-Foot-Mouth disease with meningoencephalitis. Therfore, we report these cases with brief review of related literatures.
No Tae-Hoon,Jo Kyeong Min,Jung So Young,Kim Mi Ra,Kim Joo Yeon,Park Chan Sun,Kym Sungmin 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.4
Hand-foot-and-mouth disease, a highly contagious viral infection, occurs more common in children than in adults. However, there was a recent outbreak of Coxsackievirus A6-induced infection with an atypical presentation among the adult population. Stevens–Johnson syndrome is a severe mucocutaneous disease characterized by extensive necrosis and detachment of the epidermis, and this condition is commonly caused by medications. Herein, we describe a 30-year-old male patient taking allopurinol for the management of gout. The patient presented with numerous erythematous papules, vesicles, and patches with mucosal eruptions on the whole body, oral mucositis, and fever, and he was finally diagnosed with hand-foot-and-mouth disease.
증례(證例) : 한방 치료로 호전된 수족구병(手足口病) 소아환자 1례에 대한 보고
주정현 ( Jung Hyun Joo ),박수완 ( Su Wan Park ),( So Yeon Lim ),곽민아 ( Min A Kwak ),우극청 ( Keh Ching Yu ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.4
Objectives: This case study was made to evaluate and observe the treatment for Hand-foot-and mouth disease in children by korean traditional medicine. Methods: Cheonggisanhapsodokum, Takrisodokyeum ointment and cupping therapy were applied for treating patient`s chief symptoms. Results: The patient was 2-years-old baby boy who had blisters on hands, feet and hips by hand-foot-and-mouth disease. He also had pyrexy. After the patient was treated with korean traditional medicine these clinical symptom was improved. Conclusions: Based on the clinical results, korean traditional medicine is believed to be effective for treating hand-foot-and-mouth disease and further studies should be conducted to provide more valuable information.
Case Report : A Case of Hand-foot-mouth Disease in an Immunocompetent Adult
( Jung U Shin ),( Sang Ho Oh ),( Ju Hee Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.2
Hand-foot-mouth (HFM) disease is primarily a disease of children, although it can be seen in immunocompromised adults. We describe a case of HFM disease in a 35-year-old immunocompetent male. He presented with multiple, 1~2 mm sized, erythematous vesicular papules on both hands and feet. Histopathological findings of a skin biopsy showed superficial perivascular lymphocytic infiltration, focal keratinocyte necrosis, and reticular degeneration. Because delayed diagnosis can cause spread of the disease to children, dermatologists should be aware that HFM disease can occur in adults with intact immune systems. (Ann Dermatol 22(2) 216~218, 2010)
A case of erythema-multiforme like lesions in a patient with hand-foot-mouth disease
( Hyoeun Park ),( Yujin Jung ),( Jongsic Kim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Hand-foot-mouth disease(HFMD) is a viral infection caused by Coxsackie virus and enterovirus that predominantly affects children. Typical symptoms include erythematous maculopapular or vesicular eruptions localized on palms, soles, and perioral skin. An increasing number of HFMD adults present with atypical exanthems similar to erythema multiform (EM), which is a mucocutaneous targeotid eruption caused by a hypersensitivity reaction due to infection. A 38-year-old male was presented with pruritic, multiple, variable-sized, erythematous maculopapular targetoid eruptions on both hands, feet, and trunk for 1 week. Initially, he experienced malaise, and his children were diagnosed with HFMD 3 weeks before. Histopathological examination showed neutrophils presented with necrosis in upper epidermis and vacuolar alteration on dermoepidermal junction. The laboratory examination showed positive titers of 1:128, 1:16, and 1:64 respectively, in Coxsackie virus A type 6, 10, and 16. The patient was diagnosed with HFMD based on characteristic clinical features and positive results in Coxsackie serologic markers. After treatment with antihistamine, the lesions completely resolved. The patient was presented with erythema-multiforme like lesions on the trunk without involvement of the mouth. As HFMD often affects children and sometimes immune-compromised adults, herein, we report the immune-competent adult patient with atypical clinical manifestations.
Five cases of onychomadesis after hand-foot-mouth disease
( You Bum Song ),( Ji Young Yoo ),( Jun Gyu Song ),( Moo Kyu Suh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Onychomadesis caused by a temporary arrest in nail matrix activity, and is characterized by the proximal nail plate detachment from the proximal nail fold by a whole-thickness sulcus. Beau’s line, a milder form of onychomadesis, appear as transverse groove. The most common systemic causes of onychomadesis are drugs, high fever, viral illness, surgery, and peripheral ischemia. Onychomadesis in children is often caused by recent coxsackievirus infection(hand-foot-mouth disease, HFMD). We report five Korean children who experienced onychomadesis about 1-2 months after HFMD. The patients were all diagnosed as HFMD at a pediatric clinic and presented with onychomadesis to the dermatologic department about 1-2 months later. They had no history of trauma, clinical features of other dermatologic and systemic disorders. Some were given antibiotic ointment whereas spontaneous regression was expected in others. All of them showed spontaneous recovery without deformity after about 2 months.
Cho, Hye-Kyung,Lee, Na-Yong,Lee, Hyun-Ju,Kim, Hae-Soon,Seo, Jeong-Wan,Hong, Young-Mi,Lee, Seung-Joo,Lee, Sun-Wha,Cheon, Doo-Sung,Hong, Ji-Young,Kang, Byung-Hak,Kim, Jong-Hyun,Kim, Kyung-Hyo The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.5
Purpose: Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have been reported. The clinical characteristics in children with neurologic manifestations of EV71 were studied in Ewha Womans University Mokdong Hospital. Methods: Examinations for EV71 were performed from the stools, respiratory secretion or CSF of children who presented neurologic symptoms associated with HFMD by realtime PCR. Clinical and radiologic data of the patients were collected and analyzed. Results: EV71 was isolated from the stool of 16 patients but not from respiratory secretion or CSF. Among the 16 patients, meningitis (n=10) was the most common manifestation, followed by Guillain-Barre syndrome (n=3), meningoencephalitis (n=2), poliomyelitis-like paralytic disease (n=1), and myoclonus (n=1). Gene analysis showed that most of them were caused by EV71 subgenotype C4a, which was prevalent in China in 2008. Conclusion: Because EV71 causes severe complications and death in children, a surveillance system to predict upcoming outbreaks should be established and maintained and adequate public health measures are needed to control disease.
김성수 순천향대학교 순천향의학연구소 2021 Journal of Soonchunhyang Medical Science Vol.27 No.1
Onychomadesis is characterized by proximal nail plate separation from the nail matrix and nail bed. It has been associated with autoimmune disease, medications, severe systemic diseases, trauma, periungual dermatitis, nutritional deficiency, and infection. Hand-foot-mouth disease is most frequently caused by coxsackievirus A16 and is associated with a number of other coxsackieviruses and enterovirus 71. It particularly affects children under 5 years of age and is characterized by vesicular eruptions on the hands, feet, and buttocks and ulcerations of the tongue, soft palate, buccal mucosa, or gingiva. Onychomadesis after recovering from hand-foot-mouth disease is a rare and late complication. It occurs several weeks after the onset of hand-foot-mouth disease. The mechanism is still unknown. Generally, there is no need for treatment and there is spontaneous resolution within 1 to 2 months.
( Wonkyung Lee ),( So Hee Park ),( Do Hyeong Kim ),( In Ho Park ),( Jeong Nan Kang ),( Jung Eun Seol ),( Hyojin Kim ),( Ho Suk Sung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
A 22-year-old female presented with erythematous macules and papules on her both palms and erythematous scaly papules on whole body that developed 6 days ago. She had been treated with psoriasis vulgaris since about 10 years ago and kept in good condition recently. Before the skin lesion developed, she had history of direct contact with the infant with hand-foot-mouth disease 1 week ago. On histopathologic examination, spongiosis and exocytosis of inflammatory cells were shown in epidermis and lymphocytic infiltration in dermis. Considering early stageof enterovirus infection, real time polymerase chain reaction was performed and coxsackievirus A16 was identified. Eczema coxsackium caused by coxsackievirus A16 was finally diagnosed. Eczema coxsackium is caused by enterovirus and presented with fever, sore throat and generalized cutaneous eruption. It usually occurred in children but rarely reported in adult who had underlying disease such as Darier’s disease, eczema or human immunodeficiency virus infection . Herein, we report a rare case of eczema coxsackium in adult patient after direct contact with hand-foot-mouth disease patient.