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- 저자 : Yuwei Sun (검색결과 11 건)
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Sun, Yuwei,Liu, Jiaomin,Li, Yonggang,Fu, Chao,Wang, Yi The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6
A power electronic transformer (PET) based on the cascaded H-bridge (CHB) and the isolated bidirectional DC/DC converter (IBDC) is capable of accommodating a large scale battery energy storage system (BESS) in the medium-voltage grid, and is referred to as a power electronic transformer based battery energy storage system (PET-BESS). This paper investigates the PET-BESS and proposes a coordinative control strategy for it. In the proposed method, the CHB controls the power flow and the battery state-of-charge (SOC) balancing, while the IBDC maintains the dc-link voltages with feedforward implementation of the power reference and the switch status of the CHB. State-feedback and linear quadratic Riccati (LQR) methods have been adopted in the CHB to control the grid current, active power and reactive power. A hybrid PWM modulating method is utilized to achieve SOC balancing, where battery SOC sorting is involved. The feedforward path of the power reference and the CHB switch status substantially reduces the dc-link voltage fluctuations under dynamic power variations. The effectiveness of the proposed control has been verified both by simulation and experimental results. The performance of the PET-BESS under bidirectional power flow has been improved, and the battery SOC values have been adjusted to converge.
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Yuwei Sun,Jiaomin Liu,Yonggang Li,Chao Fu,Yi Wang 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6
A power electronic transformer (PET) based on the cascaded H-bridge (CHB) and the isolated bidirectional DC/DC converter (IBDC) is capable of accommodating a large scale battery energy storage system (BESS) in the medium-voltage grid, and is referred to as a power electronic transformer based battery energy storage system (PET-BESS). This paper investigates the PET-BESS and proposes a coordinative control strategy for it. In the proposed method, the CHB controls the power flow and the battery state-of-charge (SOC) balancing, while the IBDC maintains the dc-link voltages with feedforward implementation of the power reference and the switch status of the CHB. State-feedback and linear quadratic Riccati (LQR) methods have been adopted in the CHB to control the grid current, active power and reactive power. A hybrid PWM modulating method is utilized to achieve SOC balancing, where battery SOC sorting is involved. The feedforward path of the power reference and the CHB switch status substantially reduces the dc-link voltage fluctuations under dynamic power variations. The effectiveness of the proposed control has been verified both by simulation and experimental results. The performance of the PET-BESS under bidirectional power flow has been improved, and the battery SOC values have been adjusted to converge.
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Sun, Chuanxi,Zhu, Tianyi,Zhu, Yuwei,Li, Bing,Zhang, Jiaming,Liu, Yixin,Juan, Changning,Yang, Shifa,Zhao, Zengcheng,Wan, Renzhong,Lin, Shuqian,Yin, Bin 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.3
Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives: This paper was designed to probe the toxicity of DFS exposure on the hepatic proteome of broiler chickens. Methods: Twenty 30-day-old broiler chickens were randomized evenly into two groups (n = 10). DFS was administered orally at 10mg/kg body weight in group A, while the chickens in group B were perfused with saline as a control. Histopathological observations, serum biochemical examinations, and quantitative real-time polymerase chain reaction were performed to assess the liver injury induced by DFS. Proteomics analysis of the liver samples was conducted using isobaric tags for relative and absolute quantification (iTRAQ) technology. Results: Ultimately, 201 differentially expressed proteins (DEPs) were obtained, of which 47 were up regulated, and 154 were down regulated. The Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to screen target DEPs associated with DFS hepatotoxicity. The regulatory relationships between DEPs and signaling pathways were embodied via a protein-protein interaction network. The results showed that the DEPs enriched in multiple pathways, which might be related to the hepatotoxicity of DFS, were "protein processing in endoplasmic reticulum," "retinol metabolism," and "glycine, serine, and threonine metabolism." Conclusions: The hepatotoxicity of DFS on broiler chickens might be achieved by inducing the apoptosis of hepatocytes and affecting the metabolism of retinol and purine. The present study could provide molecular insights into the hepatotoxicity of DFS on broiler chickens.
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Chuanxi Sun,Tianyi Zhu,Yuwei Zhu,Bing Li,Jiaming Zhang,Yixin Liu,Changning Juan,Shifa Yang,Zengcheng Zhao,Renzhong Wan,Shuqian Lin,Bin Yin 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.4
Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives: This paper was designed to probe the toxicity of DFS exposure on the hepatic proteome of broiler chickens. Methods: Twenty 30-day-old broiler chickens were randomized evenly into two groups (n = 10). DFS was administered orally at 10 mg/kg body weight in group A, while the chickens in group B were perfused with saline as a control. Histopathological observations, serum biochemical examinations, and quantitative real-time polymerase chain reaction were performed to assess the liver injury induced by DFS. Proteomics analysis of the liver samples was conducted using isobaric tags for relative and absolute quantification (iTRAQ) technology. Results: Ultimately, 201 differentially expressed proteins (DEPs) were obtained, of which 47 were up regulated, and 154 were down regulated. The Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to screen target DEPs associated with DFS hepatotoxicity. The regulatory relationships between DEPs and signaling pathways were embodied via a protein-protein interaction network. The results showed that the DEPs enriched in multiple pathways, which might be related to the hepatotoxicity of DFS, were “protein processing in endoplasmic reticulum,” “retinol metabolism,” and “glycine, serine, and threonine metabolism.” Conclusions: The hepatotoxicity of DFS on broiler chickens might be achieved by inducing the apoptosis of hepatocytes and affecting the metabolism of retinol and purine. The present study could provide molecular insights into the hepatotoxicity of DFS on broiler chickens.
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Yinhua Liu,Rui Sun,Yuwei Lu,Shiming Zhang 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.10
The real-time process fault detection in the multi-station assembly process is always a challenging problem for auto body manufactures. Traditionally, the fault diagnosis approaches for variation source identification are divided into two categories, i.e. the pattern matching methods and model-based estimation ones based on the collected data set. The measurements provide effective process monitoring, but the real-time process fault diagnosis in the assembly process is still difficult with the traditional diagnosis techniques, and always depends on the engineering experience in practice. Based on the assembly process knowledge, including multi-station assembly hierarchy, fixture scheme, measurement characteristics and tolerances etc. in the multi-station, a knowledge-based diagnostic methodology and procedures are proposed with the measurements of each body in white for part/component defections and faulty assembly station identification. For the station involved with defective parts/components, the sub-coordinate system of the part/component is established reflecting its position and pose in the space, and then the relative pose matrix to the “normally build” pose is calculated based on the deviations of sub-coordinates of the parts in this station. Finally, the assembly process malfunctions are determined by a proposed rule-based strategy with the relative pose matrix in real time. A simple 3 stations assembly process with 5 sheet metal parts was analyzed and compared with the traditional diagnostic method to verify the effectiveness and stability of the proposed method.
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Input-series hybrid dual active bridge DC-DC converter combined with LC resonant tank
Fu, Chao,Xu, Chongwei,Sun, Yuwei The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.8
This paper presents an input-series hybrid dual active bridge (DAB) converter for efficiency improvement. The proposed converter is achieved by integrating a series resonant tank (SRT) into a single phase-shift (SPS) controlled DAB that shares one H-bridge at the secondary side. By using the super-resonant state of the LC tank, the phase correction of the secondary side H-bridge current can be obtained to realize zero voltage switching (ZVS), zero current switching (ZCS), and full load ZVS for the primary side bridges. In addition, the circulating current is reduced when compared to that of the traditional input-series DAB converter based on SPS control, which improves the overall efficiency. The system modelling and parameters design procedures are provided. Finally, a 1-kW experimental prototype was built, and the soft-switching performance was tested. The obtained results verify the effectiveness of the proposed topology and demonstrate a significant efficiency improvement.
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Guo, Jia,Liu, Xin,Yang, Yuwei,Liang, Mengdi,Bai, Chunyan,Zhao, Zhihui,Sun, Boxing Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8
Objective: This study aimed to screen and identify the target genes of miR-375 in pig Sertoli (ST) cells and to elucidate the effect of miR-375 on the proliferation of ST cells. Methods: In this study, bioinformatics software was used to predict and verify miR-375 target genes. Quantitative polymerase chain reaction (PCR) was used to detect the relationship between miR-375 and its target genes in ST cells. Enzyme-linked immunosorbent assay (ELISA) of rearranged L-myc fusion (RLF) and hypoxia-induced gene domain protein 1A (HIGD1A) was performed on porcine ST cells, which were transfected with a miR-375 mimics and inhibitor to verify the results. Dual luciferase reporter gene assays were performed to assess the interactions among miR-375, RLF, and HIGD1A. The effect of miR-375 on the proliferation of ST cells was analyzed by CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS). Results: Five possible target genes of miR-375, including RLF, HIGD1A, colorectal cancer associated 2, POU class 3 homeobox 1, and WW domain binding protein 1 like, were found. The results of quantitative PCR suggested that mRNA expression of RLF and HIGD1A had a negative correlation with miR-375, indicating that RLF and HIGD1A are likely the target genes of miR-375. The ELISA results revealed that RLF and HIGD1A were negatively correlated with the miR-375 protein level. The luminescence results for the miR-375 group cotransfected with wild-type RLF and HIGD1A vector were significantly lower than those of the miR-375 group co-transfected with the blank vector or mutant RLF and HIGD1A vectors. The present findings suggest that RLF and HIGD1A are target genes of miR-375 and that miR-375 inhibits ST cell proliferation according to MTS analysis. Conclusion: It was speculated that miR-375 affects cell proliferation through its target genes, which play an important role in the development of testicular tissue.
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RNA binding protein QKI contributes to WT1 mRNA and suppresses apoptosis in ST cells
Xin Liu,Jia Guo,Mengjiao Zhou,Yuwei Yang,Mengdi Liang,Chunyan Bai,Zhihui Zhao,Boxing Sun 한국유전학회 2017 Genes & Genomics Vol.39 No.9
The RNA binding protein quaking (QKI), a key member of the STAR family, as an upstream gene could involve in much process including cell proliferation, apoptosis, differentiation and so on. However, the roles of QKI in germ cell, especially in swine testis (ST) cells, was not clear currently. And apoptosis plays important roles in the growth and development. The purpose of the present study was to clarify the relationship between QKI and apoptosis in ST cells. Firstly, our results showed that pEF1α- QKI and shQKI3 have clear effects on expression levels of QKI. Secondly, we established that QKI directly binds to WT1 3′UTR by binding with QRE-1 (2046–2052 bp, ACT AAC ) only. Furthermore, QKI overexpression significantly increased the expression levels of WT1 and Bcl-2. QKI also has the effect on delaying the degradation of WT1 mRNA. In addition, we verified that QKI had a significantly suppressed apoptosis in ST cells. Finally, pBI-WT1 could make up for shQKI3-induced decrease in WT1, Bcl-2 mRNA levels and suppress apoptosis in ST cells. The results demonstrated that QKI was an important regulatory factor that affects apoptosis by targeting WT1 gene.
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Qin Yunlong,Zhao Jin,Wei Xiao-fei,Wang Yuwei,Yu Zixian,Zhang Yumeng,Sun Shiren 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.1
Background: The spectrum of biopsy-confirmed kidney disease varies with regions and periods. We describe the distribution ofpathological types and epidemiological characteristics of kidney diseases in Northwest China due to regional differences in geographicalenvironment, social economy, and dietary habits.Methods: Kidney biopsy cases from 2005 to 2020 in Xijing Hospital were retrospectively analyzed. Pathological characteristics of patientsin different periods were analyzed using the t test or chi-square test. Joinpoint regression was used to analyze trends in pathologicaltypes and disease spectrum.Results: A total of 10,528 eligible patients were included. Primary glomerular disease (PGD) accounted for the majority of the casesand exhibited an obvious downward trend, whereas secondary glomerular disease (SGD) showed an obvious upward trend. AmongPGD, immunoglobulin A nephropathy (IgAN) remained the most common pathological type, and the detection rate of membranousnephropathy (MN) was significantly increased. Among SGD, Henoch-Schönlein purpura nephritis (HSPN) was the most commonpathological type and may present a significant characteristic of Northwest China. Diabetic nephropathy (DN) exhibited the most obviousupward trend in the whole process, whereas the fastest growth since 2012 was in hypertensive nephropathy.Conclusion: The proportion of SGD increased whereas PGD declined. IgAN remained the most common PGD, and HSPN was themost common SGD. MN and DN showed the most obvious upward trend among PGD and SGD, respectively. Changes in the spectrumof kidney disease, especially the constituent ratio of SGD, pose a great challenge to public health.
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