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Yuri Jeong,Jeong Geun Oh,Jeong Ku Kang,Sun Rock Moon,Kang Kyoo Lee 대한방사선종양학회 2020 Radiation Oncology Journal Vol.38 No.1
Purpose: We performed three-dimensional (3D) dose reconstruction-based pretreatment verification to evaluate gamma analysis acceptance criteria in volumetric modulated arc therapy (VMAT) for prostate cancer. Materials and Methods: Pretreatment verification for 28 VMAT plans for prostate cancer was performed using the COMPASS system with a dolphin detector. The 3D reconstructed dose distribution of the treatment planning system calculation (TC) was compared with that of COMPASS independent calculation (CC) and COMPASS reconstruction from the dolphin detector measurement (CR). Gamma results (gamma failure rate and average gamma value [GFR and γAvg]) and dose-volume histogram (DVH) deviations, 98%, 2% and mean dose-volume difference (DD98%, DD2% and DDmean), were evaluated. Gamma analyses were performed with two acceptance criteria, 2%/2 mm and 3%/3 mm. Results: The GFR in 2%/2 mm criteria were less than 8%, and those in 3%/3 mm criteria were less than 1% for all structures in comparisons between TC, CC, and CR. In the comparison between TC and CR, GFR and γAvg in 2%/2 mm criteria were significantly higher than those in 3%/3 mm criteria. The DVH deviations were within 2%, except for DDmean (%) for rectum and bladder. Conclusions: The 3%/3 mm criteria were not strict enough to identify any discrepancies between planned and measured doses, and DVH deviations were less than 2% in most parameters. Therefore, gamma criteria of 2%/2 mm and DVH related parameters could be a useful tool for pretreatment verification for VMAT in prostate cancer.
Clinical Implication of Dacryoendoscopy in the Patients with Tearing: A Systematic Review
Yuri Kim(Yuri Kim),Jeong Yoon Park(Jeong Yoon Park),Helen Lew(Helen Lew) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.3
Purpose: A systematic review of the literature on diagnostic and therapeutic indications, techniques, and complications of dacryoendoscopy (DE) was performed. Methods: The authors performed a PubMed search of articles published in English on DE. Data were collected and classified according to the categories of the disease. The clinical outcomes and limitations were particularly analyzed. Results: The lacrimal drainage system from the canaliculus to the inferior meatus could be examined based on the specific anatomical features by DE. The canalicular mucosa is smooth and brightly colored, the lacrimal sac shows covering mucosa with good vascularization and the nasolacrimal duct is lined with bright tubular mucosal folds. DE allows direct visualization of the detailed internal condition of the lacrimal disorders, to directly diagnose the site of obstruction with accuracy and address the causes and recanalize the lacrimal drainage system using assisted micro lacrimal surgical instruments in the tearing patients. Conclusions: Better visualization of the lacrimal canal with DE improves the understanding of physiology and precise identification of the obstructing lesions, both of which are the key to a comprehensive management for the tearing patients.
Jeong, Yuri,Lee, Sang-wook The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.4
Purpose: We evaluated prognostic value of the 8th edition of the American Joint Committee on Cancer/International Union for Cancer Control (AJCC/UICC) staging system for nasopharyngeal cancer and investigated whether tumor volume/metabolic information refined prognostication of anatomy based staging system. Materials and Methods: One hundred thirty-three patients with nasopharyngeal cancer who were staged with magnetic resonance imaging (MRI) and treated with intensity-modulated radiotherapy (IMRT) between 2004 and 2013 were reviewed. Multivariate analyses were performed to evaluate prognostic value of the 8th edition of the AJCC/UICC staging system and other factors including gross tumor volume and maximum standardized uptake value of primary tumor (GTV-T and SUV-T). Results: Median follow-up period was 63 months. In multivariate analysis for overall survival (OS), stage group (stage I-II vs. III-IVA) was the only significant prognostic factor. However, 5-year OS rates were not significantly different between stage I and II (100% vs. 96.2%), and between stage III and IVA (80.1% vs. 71.7%). Although SUV-T and GTV-T were not significant prognostic factors in multivariate analysis, those improved prognostication of stage group. The 5-year OS rates were significantly different between stage I-II, III-IV (SUV-T ≤ 16), and III-IV (SUV-T > 16) (97.2% vs. 78% vs. 53.8%), and between stage I, II-IV (GTV-T ≤ 33 mL), and II-IV (GTV-T > 33 mL) (100% vs. 87.3% vs. 66.7%). Conclusion: Current anatomy based staging system has limitations on prognostication for nasopharyngeal cancer despite the most accurate assessment of tumor extent by MRI. Tumor volume/metabolic information seem to improve prognostication of current anatomy based staging system, and further studies are needed to confirm its clinical significance.
A Novel Synthesis of N-Sulfonylformamidines from N-Sulfonylsulfonamides
Jeong, Yuri,Ban, Jaeyoung,Lim, Minkyung,Rhee, Hakjune Georg Thieme Verlag 2018 Synthesis Vol.50 No.9
<P> N-Sulfonylformamidines were synthesized from N-sulfonylsulfonamides by reacting with p-toluenesulfonyl chloride (TsCl) and N,N -disubstituted formamides. In this reaction, it was expected that mixing TsCl with the N,N-disubstituted formamide would generate an iminium salt (Vilsmeier reagent). The reaction avoids the use of metal catalysts and hazardous reagents, and the desired N-sulfonylformamidines were obtained in 60% to quantitative yields.</P>
( Yuri Cho ),( Jeong Hoon Lee ),( Dong Hyeon Lee ),( Minjong Lee ),( Jeong Ju Yoo ),( Won Mook Choi ),( Young Youn Cho ),( Yun Bin Lee ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung Hwan Yoon ),( Chung Yong 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/aims: Entecavir (ETV) has an excellent efficacy in nucleos(t)ide analogue (NA)-naive chronic hepatitis B (CHB) patients, but data on the efficacy in patients who were exposed to lamivudine (LAM) but never developed LAM-resistance (LAM-R) are limited. In this study, we aimed to evaluate whether the probability of developing genotypic resistance to ETV in currently or previously LAM-exposed patients with/ without LAM-R is comparable to that in antiviral-naive patients. Methods: This study included 500 consecutive patients with CHB who started ETV monotherapy at a single tertiary hospital (Seoul, Korea) from 2007 to 2012. The patients were divided into three groups: NA-naive patients (group 1, n=142), patients who were ever exposed to LAM, but never developed LAM-R (group 2, n=233), and patients with LAM-R when starting ETV (group 3, n=125). The probabilities of developing ETV-resistance (ETV-R) were determined and compared by multivariate analysis. Results: Overall median treatment duration was 194.9 weeks (range, 41.4-337.0 weeks). The probabilities of virologic breakthrough were increased not only in group 3 (32.4%) but also in group 2 (10.3%), compared to group 1 (3.2%) (both P≤0.001). Genotypic ETV-R was more frequently developed in group 2 (odds ratio=17.3, P=0.006) as well as group 3 (odds ratio=57.4, P<0.001) than in group 1: the probabilities of developing ETVR in group 1, 2, and 3 were 0%, 33.7% and 49.8%, respectively, at week 192. Conclusions: This study indicates that ETV-R was developed more frequently in LAM-exposed patients, even though they never developed LAM-R, as compared to NA-naive patients. Therefore, LAM-exposed CHB patients, regardless of LAM-R, should be monitored more cautiously for the development of ETV-R during ETV monotherapy and further prospective studies on proper therapies in LAM-exposed patients are war ranted.