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Yun, Ji Young,Jeong, Jin Boo,Eo, Hyun Ji,Kwon, Kun Woo,Hong, Se Chul,Jeong, Hyung Jin,Koo, Jin Suk The Korea Association of Herbology 2012 大韓本草學會誌 Vol.27 No.6
Objectives : Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods : Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and $Fe^{2+}$ chelating assay. Anti-oxidative effect of PL was evaluated by ${\varphi}X$-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results : PL had a dose-dependent hydroxyl radical scavenging and $Fe^{2+}$ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system. Conclusion : Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.
격자기반 분석을 통한 위치기반 소셜 미디어 데이터와 부동산 가격지수 간의 공간적 상관성 분석 연구
박우진(Park, Woo Jin),어승원(Eo, Seung Won),유기윤(Yu, Ki Yun) 대한공간정보학회 2015 대한공간정보학회지 Vol.23 No.1
본 연구에서는 위치기반 소셜 미디어 데이터의 공간적 분포가 지역별 부동산 지수와 어떠한 공간적 관련성을 가지는지에 대해 알아보고자 한다. 두 데이터는 상이한 자료 형식을 가지고 있어, 이를 보완할 수 있는 방법론으로 본 연구에서는 격자 기반의 공간분석 방법을 적용하였다. 대상 데이터로는 2013년 8월 한 달간의 지오태그된 트윗 데이터와 행정구역별 주택가격지수(매매, 전세)를 이용하였으며, 공간적 범위는 서울과 수도권 일부를 포함하도록 하였다. 두 데이터 간의 상이한 공간적 단위를 고려하여 2,000m 단위의 격자망을 구성하고 이에 맞게 두 데이터를 격자 데이터 형태로 변환하였다. 변환된 두 데이터에 대하여 Hot spot 분석을 실시하여 공간적 분포를 시각적으로 비교하였으며, 공간시차를 고려한 이변량 공간적 상관계수를 측정함으로써 정량적 분석을 실시하였다. 시각적, 정량적 분석 결과, 서초구 지역이 트윗 데이터와 주택매매가격지수 데이터에서 공통적인 Hotspot 지역으로 탐색되었으나 주택전세가격지수 데이터와는 뚜렷한 공간적 상관성이 탐색되지 않았다. In this study, the spatial relevance between the regional housing price data and the spatial distribution of the location-based social media data is explored. The spatial analysis with rasterization was applied to this study, because the both data have a different form to analyze. The geo-tagged Twitter data had been collected for a month and the regional housing price index about sales and lease were used. The spatial range of both data includes Seoul and the some parts of the metropolitan area. 2,000m grid was constructed to consider the different spatial measure between two data, and they were combined into the constructed grids. The Hotspot Analysis was operated using the combined dataset to see the comparison of spatial distribution, and the bivariate spatial correlation coefficients between two data were measured for the quantitative analysis. The result of this study shows that Seocho-gu area is detected as a common hotspot of tweet and housing sales price index data. though the spatial relevance is not detected between tweet and housing lease price index data.
Ji Young Yun,Jin Boo Jeong,Hyun Ji Eo,Kun Woo Kwon,Se Chul Hong,Hyung Jin Jeong,Jin Suk Koo 대한본초학회 2012 大韓本草學會誌 Vol.27 No.6
Objectives: Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods: Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and Fe2+ chelating assay. Anti-oxidative effect of PL was evaluated by φX-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results: PL had a dose-dependent hydroxyl radical scavenging and Fe2+ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system. Conclusion: Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.
대체서식지 조성 현황 및 개선방안 연구 - 환경영향평가 대상 사업을 중심으로 -
심윤진 ( Shim Yun-jin ),정규종 ( Jung Gyu-jong ),어양준 ( Eo Yang-joon ),유윤진 ( Ryu Yoon-jin ),박현경 ( Park Hyun-kyung ),김동환 ( Kim Dong-hwan ),조영호 ( Cho Young-ho ),윤주덕 ( Yoon Ju-duk ),우승현 ( Woo Seung-hyun ),박수곤 ( 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2018 한국환경복원기술학회지 Vol.21 No.2
The intensive habitats loss of natural organisms as a consequence of anthropogenic activities has lead to the use of alternative habitats for species conservation. We reviewed the current status of alternative habitats and suggest the improvement of alternative habitats. Most of alternative habitats regarded in this study are not following the pre-arranged consultation at environmental impact assessment. These alternative habitats are rendered useless due to the insufficient consideration of ecological characteristics of species and lack of detailed plans. A number of alternative habitats are influenced by disturbance such as environmental pollution and construction. Post-monitoring of alternative habitats are needed to estimate immigration rate of species. Post management is also needed to assess the status of population stability. Overall, low effectiveness of alternative habitats is presented in this study. According to the status survey, methods for improvement of alternative habitats are required such as detailed guidelines, establishment of post-monitoring system, improvement of habitat restoration techniques, and guidelines for management and operation of alternative habitats.
Surgical approach for venous malformation in the head and neck
Ryu, Jeong Yeop,Eo, Pil Seon,Lee, Joon Seok,Lee, Jeong Woo,Lee, Seok Jong,Lee, Jong Min,Lee, Sang Yub,Huh, Seung,Kim, Ji Yoon,Chung, Ho Yun Korean Cleft Palate-Craniofacial Association 2019 Archives of Craniofacial Surgery Vol.20 No.5
Background: Treatment for venous malformations of the head and neck includes sclerotherapy, surgical resection, or a combination of both. Surgical resection can remove or reduce the volume of vascular lesions; however, surgery can cause postoperative scarring and potential surgical complications. This study sought to determine the effectiveness of surgery for the treatment of venous malformations of the head and neck. Methods: A retrospective review of the medical records of patients who received surgeries for venous malformations of the head and neck from January 2011 to July 2019 was performed. Using clinical photographs, preoperative and postoperative Doppler ultrasonography, outpatient clinic records, and operation records, the postoperative result and complications were evaluated for each case. Results: Among patients who visited our vascular anomalies clinic, 43 patients (ratio of male to female= 24:19) received surgeries for venous malformations of the head and neck. Twenty-nine patients had undergone surgery only, five patients received sclerotherapy after surgery, and nine patients received surgery after preoperative sclerotherapy. In postoperative evaluations, the result was excellent in 24 patients, good in 18 patients, and poor in one patient. Four patients experienced a recurrence of lesions with lagophthalmos, drooping of the corner of the mouth, partial wound necrosis, and scar widening found in one patient each. Conclusion: Because the head and neck region is the most exposed area in the body, more active implementation of surgical treatments with or without sclerotherapy is essential to reduce the functional and cosmetic impairments associated with venous malformations.
Surgical correction for Tessier number 7 craniofacial cleft using a medially overcorrected design
Ryu, Jeong Yeop,Eo, Pil Seon,Tian, Lulu,Lee, Joon Seok,Lee, Jeong Woo,Choi, Kang Young,Yang, Jung Dug,Chung, Ho Yun,Cho, Byung Chae Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.1
Background Various surgical techniques have been used to correct Tessier number 7 craniofacial cleft, which involves macrostomia, ear deformity, and hemifacial microsomia. To achieve symmetrical and satisfactory results in patients with macrostomia, the authors performed a 1-mm medial overcorrection on the cleft side and evaluated the results of this procedure. Methods A retrospective medical record review of patients diagnosed with Tessier number 7 craniofacial cleft from March 1999 to February 2017 was performed. Using clinical photographs, outpatient clinic records, and operative records, information was recorded regarding concurrent congenital anomalies, postoperative complications, and follow-up. Using Photoshop CS2, the length of both sides of the lip was compared. The ratio of these lengths was calculated to evaluate lip symmetry. Results Of the patients treated at the Department of Plastic and Reconstructive Surgery at Kyungpook National University Chilgok Hospital, 11 (male-to-female sex ratio, 7:4) were diagnosed with Tessier number 7 craniofacial cleft. Concurrent congenital anomalies included skin tag, hemifacial microsomia, and cleft palate. The mean duration of follow-up was $78.273{\pm}72.219$ months and the mean ratio of the lengths of both sides of the lip was $1.048{\pm}0.071$. Scar widening occurred as a postoperative complication in some patients. No cases of wound infection, bleeding, or wound dehiscence occurred. Conclusions For the successful correction of macrostomia, plastic surgeons should consider both functional and aesthetic problems of the lip. Adequate repair of the orbicularis oris muscle, skin closure with Z-plasty, and medial overcorrection of the neo-oral commissure led to good results in our patients.
Expression of Human Endogenous Retrovirus <i>env</i> Genes in the Blood of Breast Cancer Patients
Rhyu, Dong-Won,Kang, Yun-Jeong,Ock, Mee-Sun,Eo, Jung-Woo,Choi, Yung-Hyun,Kim, Wun-Jae,Leem, Sun-Hee,Yi, Joo-Mi,Kim, Heui-Soo,Cha, Hee-Jae MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.6
<P>Human endogenous retroviruses (HERV) <I>env</I> proteins have been recently reported to be significantly up-regulated in certain cancers. Specifically, mRNA and protein levels of HERV-K (HML-2) are up-regulated in the blood plasma or serum of breast cancer patients. Here, we collected blood samples of 49 breast cancer patients and analyzed mRNA expressions of various HERVs <I>env</I> genes including HERV-R, HERV-H, HERV-K, and HERV-P by real-time PCR. The expression of <I>env</I> genes were significantly increased in the blood of primary breast cancer patients but were decreased in patients undergoing chemotherapy to a similar level with benign patients. When we compared the group currently undergoing chemotherapy and those patients undergoing chemotherapy simultaneously with radiotherapy, HERVs <I>env</I> genes were reduced more in the chemotherapy only group, suggesting that chemotherapy is more effective in reducing HERV <I>env</I> gene expression than is radiotherapy. Among chemotherapy groups, HERV <I>env</I> gene expression was the lowest in the taxotere- or taxol-treated group, suggesting that taxotere and taxol can reduce HERVs <I>env</I> expression. These data suggest the potential to use HERVs <I>env</I> genes as a diagnosis marker for primary breast cancer, and further studies are needed to identify the mechanism and physiological significance of the reduction of HERV <I>env</I> gene expression during chemotherapy.</P>