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P279 : The effects of freeze dried extract of dangyuja (citrus grandis osbeck) on melanogenesis
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Although previous studies have identified that both the fruit and leaf of dangyuja (Citrus grandis Osbeck) exhibits anticancer, antioxdant and anti-inflammatory effect, the inhibitory effect of melanogenesis have not been reported. Objectives: In this study, freeze dried extract of dangyuja was evaluated for their potential to inhibit melanogenesis. Methods: Cytotoxicity and melanin content in mouse B16F10 melanoma cells were assayed after treatment with the freeze dried extracts of dangyuja. Results: Freeze dried extracts of dangyuja strongly decreased the tyrosinase activity for catalysis of L-dihydroxyphenylalanine (L-DOPA) oxidation in a dose- dependent manner. The results demonstrate that extracts possessed low cytotoxic activity and that melanin content was reduced. Conclusion: Freeze dried extracts of dangyuja is a safe natural materials that show an effective inhibition of melanogenesis. These results suggest that freeze dried extracts of dangyuja can be considered as an effective skin whitening reagent for application in cosmetics.
Screening of Korea medicinal plants for possible osteoclastogenesis effects in vitro
Youn, Yu Na,Lim, Erang,Lee, Nari,Kim, Young Seop,Koo, Min Seon,Choi, Soon Young Research Institute of Women's Health Sookmyung Wom 2007 WOMEN And HEALTH Vol.3 No.1
Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-κB ligand (RANKL), a member of tumor necrosis factor family When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanoops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKL induced osteoclast differentiation.
P135 : Analysis of the safety and efficacy of three natural extracts in cosmetics
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The function of sebum in human is reducing water loss from the skin``s surface and protecting the skin from infection by microorganism. However, when there is excessive secretion of sebum, it will cause black heads and expansion of the pores so that waste will be accumulated. Objectives: To develop cosmetics for sebum removal and pore improvement that can improve limitations of the existing products. The ingredients include Diospyros kaki (D. kaki ), Castanea crenata (C. crenata), and Polygonum cuspidatum (P. cuspidatum) and to verify the safety and human efficacy evaluation. Methods: Bacteria microbial limit test and patch test performed with 31 participants. Also, with 23 participants who have oily skin, efficacy evaluation was performed. Changes in the amount of sebum, moisture, dead skin condition, blackhead, skin roughness between before and after the test were compared for control group. Results: As a result of safety assessment, there was no pathogenic microorganism for microbial limit test and, there was no skin reactions for patch test. For changes in the amount of sebum and black head from efficacy evaluation,there was temporary improvement for the experimental group. For the amount of moisture, dead skin, and skin roughness of the experimental group showed improvement. Conclusion: When being complemented with body application test for long-term usage, they can be used as natural ingredients when cosmetic manufacturers or sellers are developing new products.
Na Young Jin,Mi Jin Jeon,You Kyoung Lee,San Na Oh,Mi Ja Seo,Young Nam Youn,Yong Man Yu 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Bacillus thuringiensis (Bt) is a gram-positive bacterium that produces parasporal crystal proteins known as endotoxins or Cry proteins. The Cry protoxins are then cleaved by insect midgut proteinases to form active Bt toxins. The activated Cry protein then binds to specific receptors at the midgut epithelium. Cadherin-like and aminopeptidase N (APN) proteins are involved in Bt toxin binding by interacting sequentially with different toxin structures. Aminopeptidase N (APNs) from several insect species have been shown to be putative receptors for these toxins. We have characterized four different midgut APNs(APN1, APN2, APN3, APN4) cDNAs from S. exigua. Forward primers and reverse primers for confirmation of four different midgut APNs were designed based on their sequences cloned from the cDNA libraries. Quantitative RT-PCR procedures includes 42℃ for 20min (cDNA synthesis), 99℃ for 5min, and 35 cycles (94℃ for 1min, and 60℃ for 50 s) for collection. Four aminopeptidase N isoforms were confirmed with qRT-PCR. Sequence analysis was performed by BlastX search the National Center for Biotechnology Information(NCBI) nucleotide. Furthermore, double-stranded RNAs(dsRNAs) were synthesized. DsRNAs were determined for bioassay.
북한강 수계에서 Dolichospermum의 유전생태학적 특성 연구
유미나 ( Yu Mi Na ),변정환 ( Byun Jeong-hwan ),백준수 ( Baek Jun Soo ),윤석제 ( Youn Seok Jea ),유순주 ( Yu Soon-ju ),변명섭 ( Byeon Myeong Seop ) 한국물환경학회(구 한국수질보전학회) 2019 한국물환경학회지 Vol.35 No.1
This study analyzed the occurrence pattern of Dolichospermum (= Anabaena) in the Bukhan river from March 2012 to December 2014 in order to identify the genotypes of Dolichospermum. Furthermore, 16S rRNA were analyzed to identify the genotypes of Dolichospermum that occurred in 2015 which were then compared to the reference sequence deposited at NCBI. During this period, the occurrence of Dolichospermum was highly correlated to water temperature. In the year 2012 and 2013, Dolichospermum appeared in Lake Cheongpyeong (CP), Sambong (SB), and Lake Paldang (P2) between July and August. However, in 2014, it appeared in SB and P2, but not in CP. This reduction in appearance was attributed to the decreased inflow to Lake Uiam as a result of low rainfall in 2014 as compared to 2012. In July 2015, the Dolichospermum 16S rRNA genotype was confirmed in five locations; Lake Cheongpyeong (CP), Seojong (SJ), Songchon Sewage Treatment Plant (SC), Joan (P4), and Lake Paldang (PD). Anabaena crassa of spiral clone, A. planctonica of linear clone, and A. circinalis of spiral clone exhibited high genetic similarity with the reference sequence. The 16r RNA genotype showed approximately 3 % sequence variation between the locations and were more similar to each other in locations that were closer.
Isolation and characterization of a novel H9N2 influenza virus in Korean native chicken farm.
Lee, Yu-Na,Lee, Dong-Hun,Park, Jae-Keun,Lim, Tae-Hyun,Youn, Ha-Na,Yuk, Seong-Su,Lee, Youn-Jeong,Mo, In-phil,Sung, Haan-Woo,Lee, Joong-Bok,Park, Seung-Yong,Choi, In-Soo,Song, Chang-Seon American Association of Avian Pathologists [etc.] 2011 Avian diseases Vol.55 No.4
<P>An outbreak of avian influenza, caused by an H9N2 low-pathogenic avian influenza virus (AIV), occurred in a chicken farm and caused severe economic losses due to mortality and diarrhea. AIV was isolated and identified in a sample from an affected native Korean chicken. Genetic analysis of the isolate revealed a high sequence similarity to genes of novel reassortant H9N2 viruses isolated from slaughterhouses and live bird markets in Korea in 2008 and 2009. Animal challenge studies demonstrated that the replication kinetics and pathogenicity of the isolate were considerably altered due to adaptation in chickens. Vaccine protection studies indicated that commercial vaccine was not able to prevent virus shedding and clinical disease when chickens were challenged with the isolate. These results suggest that the novel H9N2 virus possesses the capacity to replicate efficiently in the respiratory system against vaccination and to cause severe disease in domestic chickens. The results also highlight the importance of appropriate updating of vaccine strains, based on continuous surveillance data, to prevent the possibility of a new H9N2 epidemic in Korea.</P>