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Kwon, Soonbum,Kwon, Dah In,Jung, Youngeun,Kim, Ju Hee,Lee, Yeongcheol,Lim, Bumhee,Kim, Ikyon,Lee, Jeeyeon Elsevier 2017 Sensors and actuators. B, Chemical Vol.252 No.-
<P><B>Abstract</B></P> <P>Live cell imaging using small organic fluorophores has emerged as a powerful non-invasive approach to visualizing a variety of cellular processes. We recently reported the design and synthesis of indolizino[3,2-<I>c</I>]quinolines (IQs), a fused heterocyclic system, as a potential candidate for novel fluorescent probes. Here, we explored the environment-sensitive features of the IQs in a cellular context using fluorescent microscopy to achieve no-wash live cell imaging with precise spatial control. Elucidating the cellular targets of IQs based on their chemical structures has enabled us to develop organelle-specific fluorophores that target DNA (3C2), RNA (3B1 and 3H1), and lysosomes (IQ-MP1 and IQ-MP2) in live cells. These compounds exhibit good cell membrane permeability, high photostability, and low cytotoxicity with good compatibility in aqueous systems, properties that are rarely encountered together. 3H1, with a large Stokes shift, exhibits counterstain compatibility when combined with DNA probes (Hoechst 33258) in live cells. The properties of the IQs described here suggest that these compounds may serve as important tools for investigating dynamic processes in live cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The optical properties and live cell imaging properties of indolizino[3,2-<I>c</I>]quinolines (IQs) were explored. </LI> <LI> The environment-sensitive features of IQs yielded desirable properties for no-wash live cell imaging. </LI> <LI> Organelle-specific IQ fluorophores that target DNA, RNA, and lysosomes in live cells were developed. </LI> </UL> </P>
A1B 시나리오 자료를 이용한 우리나라 아열대 기후구 전망
권영아(Young-Ah Kwon),권원태(Won-Tae Kwon),부경온(Kyung-On Boo),최영은(Youngeun Choi) 대한지리학회 2007 대한지리학회지 Vol.42 No.3
지구 온난화의 영향으로 임업 뿐 아니라 농업, 수산업, 보건 등 여러 분야에서 피해가 발생하고 있어, 사회·경제 전분야에 걸쳐 기후변화에 대한 적응 대책이 필요하다. 기후변화의 영향을 평가하고 적응 방안을 마련하기 위해서는 미래 기후가 어떻게 변할 것인지 미리 전망하는 일은 필수적이다. 본 연구에서는 트레와다의 기후 지역 구분 기준(최한월 평균기온이 18℃ 이하이면서 월평균기온 10℃ 이상인 달이 8-12개월)을 적용하여 아열대 기후 지역을 정의하고 A1B 시나리오에 근거한 아열대 기후구의 변화를 전망하기 위하여 기온 관측 자료와 모델 시나리오자료를 분석하였다. 아열대 기후에 관한 트레와다의 정의를 적용하여 현재 아열대 기후구와 미래 아열대 기후구의 변화를 전망해 본 결과 현재는 제주도를 포함한 남해안 일부 지역(부산, 통영, 거제, 여수, 완도, 목포)에 해당하던 것이 2100년에는 태백산맥과 소백산맥을 중심으로 한 산지 주변을 제외하고는 대부분 아열대 기후에 포함된다. 즉, 현재의 온난화가 지속된다면 제주도와 울릉도를 포함한 도서지역은 물론, 동해안으로는 속초, 서해안으로는 강화에 이르기까지 해안지역을 모두 포함하며, 서울, 인천, 수원 등 대도시 지역도 아열대 기후 지역에 포함될 것이다. As the global warming has been influenced on various sectors including agriculture, fisheries and health, it is essential to project more accurate future climate for an assessment of climate change impact and adaptation strategy. The purpose of this study is to examine the boundary changes in the subtropical climate region in South Korea using observed 30-year(1971-2000) data and projected 100-year data based on the IPCC SRES A1B emission scenario. We have selected Trewartha’s climate classification among various climate classification, defining the subtropical climate region as the region with monthly mean temperature 10℃ or higher during 8-12 months. By observed data, the subtropical climate region was only limited in Jeju-do and the farmost southern coastal area(Busan, Tongyeong, Geoje, Yeosu, Wando, Mokpo) of South Korea. The future projected climate region for the period of 2071-2100 included have shown that subtropical climate region extended to most of stations except for the ares of Taebaeksan and Sobaeksan Mountains.
Kwon, Soonbum,Lee, Yeongcheol,Jung, Youngeun,Kim, Ju Hee,Baek, Byungyeob,Lim, Bumhee,Lee, Jungeun,Kim, Ikyon,Lee, Jeeyeon Elsevier 2018 European journal of medicinal chemistry Vol.148 No.-
<P><B>Abstract</B></P> <P>To achieve efficient photodynamic activity, substantial effort has been dedicated to precise control of the intracellular localization of current photosensitizers (PSs). Given the extremely small radius of action of singlet oxygen, the direct targeting of PSs to the mitochondria is expected to greatly enhance the photodynamic therapy (PDT) activity. Here, we report mitochondria-targeting 6-(furan-2-yl)- and 6-(thiophen-2-yl) indolizino[3,2<I>-c</I>]quinolines (IQs) as novel PSs. IQ derivatives containing 5-membered heterocyclic aromatic rings were synthesized, and their photophysical properties as PSs were characterized. The anticancer potentials of <B>2a</B>-<B>2f</B> were investigated using various cancer cell lines, and they exhibited dose-dependent and light exposure time-dependent cytotoxicity. Among the synthesized compounds, <B>2b</B>, which contains a furan ring, showed dual functions as an imaging probe as well as a PS. Real-time confocal fluorescence images revealed the mitochondrial localization of <B>2b</B> as a primary site of photodamage in live cells. Targeted reactive oxygen species (ROS)-generation capabilities and the photoinduced DNA cleavage of IQs led to mitochondrial dysfunction and photoinduced apoptosis via the intrinsic pathway. 3D RI tomograms of individual live HeLa cells treated with <B>2b</B> showed that the progress of photoinduced apoptosis was affected by the PS concentration and light irradiation time. The studied IQs (<B>2b, 2d,</B> and <B>2e</B>) are expected to serve as a new class of heavy-atom-free PSs with low molecular weights less than 350.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 6-(furan-2-yl)- and 6-(thiophen-2-yl) indolizino[3,2<I>-c</I>]quinolines (<B>2a</B>-<B>2f</B>) were synthesized as novel photosensitizers (PSs). </LI> <LI> Compounds <B>2a</B>-<B>2f</B> exhibited dose-dependent and light exposure time-dependent cytotoxicity, demonstrating anticancer potentials in cancer cells. </LI> <LI> Real-time confocal fluorescence images revealed the mitochondrial localization of <B>2b</B> as a primary site of photodamage. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kwon, Youngjoo,Sohn, Sung-Hwa,Lee, Gihyun,Kim, Youngeun,Lee, Hyejung,Shin, Minkyu,Bae, Hyunsu Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P>A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes. In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated with CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> regulatory T cells (Treg). Cellular profiles and histopathologic analysis demonstrated that peribronchial and perivascular inflammatory cell infiltrates were significantly decreased in the EA-treated groups when compared to the OVA and anti-CD25 Ab-injected (Treg depletion) groups. Furthermore, total BAL cells were reduced in the EA groups when compared to other groups. Interestingly, the population of CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP>Tregs in pneumonocytes increased in EA-treated group when compared to OVA and Treg depletion groups. These results imply that EA stimulation at ST 36 may affect CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg in an OVA-induced experimental model and may enhance Treg function by suppressing other T cells and limiting the immune response.</P>